KEGG   Monodelphis domestica (gray short-tailed opossum): 100010412
Entry
100010412         CDS       T01031                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo00562  Inositol phosphate metabolism
mdo01100  Metabolic pathways
mdo01521  EGFR tyrosine kinase inhibitor resistance
mdo01522  Endocrine resistance
mdo01524  Platinum drug resistance
mdo04012  ErbB signaling pathway
mdo04014  Ras signaling pathway
mdo04015  Rap1 signaling pathway
mdo04024  cAMP signaling pathway
mdo04062  Chemokine signaling pathway
mdo04066  HIF-1 signaling pathway
mdo04068  FoxO signaling pathway
mdo04070  Phosphatidylinositol signaling system
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04081  Hormone signaling
mdo04140  Autophagy - animal
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04152  AMPK signaling pathway
mdo04210  Apoptosis
mdo04211  Longevity regulating pathway
mdo04213  Longevity regulating pathway - multiple species
mdo04218  Cellular senescence
mdo04360  Axon guidance
mdo04370  VEGF signaling pathway
mdo04380  Osteoclast differentiation
mdo04510  Focal adhesion
mdo04550  Signaling pathways regulating pluripotency of stem cells
mdo04611  Platelet activation
mdo04613  Neutrophil extracellular trap formation
mdo04620  Toll-like receptor signaling pathway
mdo04625  C-type lectin receptor signaling pathway
mdo04630  JAK-STAT signaling pathway
mdo04650  Natural killer cell mediated cytotoxicity
mdo04660  T cell receptor signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04664  Fc epsilon RI signaling pathway
mdo04666  Fc gamma R-mediated phagocytosis
mdo04668  TNF signaling pathway
mdo04670  Leukocyte transendothelial migration
mdo04722  Neurotrophin signaling pathway
mdo04725  Cholinergic synapse
mdo04750  Inflammatory mediator regulation of TRP channels
mdo04810  Regulation of actin cytoskeleton
mdo04910  Insulin signaling pathway
mdo04914  Progesterone-mediated oocyte maturation
mdo04915  Estrogen signaling pathway
mdo04917  Prolactin signaling pathway
mdo04919  Thyroid hormone signaling pathway
mdo04923  Regulation of lipolysis in adipocytes
mdo04926  Relaxin signaling pathway
mdo04929  GnRH secretion
mdo04930  Type II diabetes mellitus
mdo04931  Insulin resistance
mdo04932  Non-alcoholic fatty liver disease
mdo04933  AGE-RAGE signaling pathway in diabetic complications
mdo04935  Growth hormone synthesis, secretion and action
mdo04960  Aldosterone-regulated sodium reabsorption
mdo04973  Carbohydrate digestion and absorption
mdo05010  Alzheimer disease
mdo05017  Spinocerebellar ataxia
mdo05020  Prion disease
mdo05100  Bacterial invasion of epithelial cells
mdo05132  Salmonella infection
mdo05135  Yersinia infection
mdo05142  Chagas disease
mdo05146  Amoebiasis
mdo05160  Hepatitis C
mdo05161  Hepatitis B
mdo05162  Measles
mdo05163  Human cytomegalovirus infection
mdo05164  Influenza A
mdo05165  Human papillomavirus infection
mdo05166  Human T-cell leukemia virus 1 infection
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05168  Herpes simplex virus 1 infection
mdo05169  Epstein-Barr virus infection
mdo05170  Human immunodeficiency virus 1 infection
mdo05171  Coronavirus disease - COVID-19
mdo05200  Pathways in cancer
mdo05203  Viral carcinogenesis
mdo05205  Proteoglycans in cancer
mdo05206  MicroRNAs in cancer
mdo05207  Chemical carcinogenesis - receptor activation
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05210  Colorectal cancer
mdo05211  Renal cell carcinoma
mdo05212  Pancreatic cancer
mdo05213  Endometrial cancer
mdo05214  Glioma
mdo05215  Prostate cancer
mdo05218  Melanoma
mdo05220  Chronic myeloid leukemia
mdo05221  Acute myeloid leukemia
mdo05222  Small cell lung cancer
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
mdo05226  Gastric cancer
mdo05230  Central carbon metabolism in cancer
mdo05231  Choline metabolism in cancer
mdo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mdo05415  Diabetic cardiomyopathy
mdo05417  Lipid and atherosclerosis
mdo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100010412 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100010412 (PIK3CA)
   04014 Ras signaling pathway
    100010412 (PIK3CA)
   04015 Rap1 signaling pathway
    100010412 (PIK3CA)
   04370 VEGF signaling pathway
    100010412 (PIK3CA)
   04630 JAK-STAT signaling pathway
    100010412 (PIK3CA)
   04668 TNF signaling pathway
    100010412 (PIK3CA)
   04066 HIF-1 signaling pathway
    100010412 (PIK3CA)
   04068 FoxO signaling pathway
    100010412 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100010412 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100010412 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100010412 (PIK3CA)
   04024 cAMP signaling pathway
    100010412 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100010412 (PIK3CA)
   04152 AMPK signaling pathway
    100010412 (PIK3CA)
   04150 mTOR signaling pathway
    100010412 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100010412 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100010412 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    100010412 (PIK3CA)
   04218 Cellular senescence
    100010412 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100010412 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100010412 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100010412 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100010412 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    100010412 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100010412 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    100010412 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100010412 (PIK3CA)
   04660 T cell receptor signaling pathway
    100010412 (PIK3CA)
   04662 B cell receptor signaling pathway
    100010412 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100010412 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100010412 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100010412 (PIK3CA)
   04062 Chemokine signaling pathway
    100010412 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100010412 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    100010412 (PIK3CA)
   04929 GnRH secretion
    100010412 (PIK3CA)
   04915 Estrogen signaling pathway
    100010412 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100010412 (PIK3CA)
   04917 Prolactin signaling pathway
    100010412 (PIK3CA)
   04926 Relaxin signaling pathway
    100010412 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    100010412 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100010412 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100010412 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100010412 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    100010412 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100010412 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100010412 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    100010412 (PIK3CA)
   04380 Osteoclast differentiation
    100010412 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    100010412 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100010412 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100010412 (PIK3CA)
   05206 MicroRNAs in cancer
    100010412 (PIK3CA)
   05205 Proteoglycans in cancer
    100010412 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    100010412 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    100010412 (PIK3CA)
   05203 Viral carcinogenesis
    100010412 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100010412 (PIK3CA)
   05231 Choline metabolism in cancer
    100010412 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100010412 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100010412 (PIK3CA)
   05212 Pancreatic cancer
    100010412 (PIK3CA)
   05225 Hepatocellular carcinoma
    100010412 (PIK3CA)
   05226 Gastric cancer
    100010412 (PIK3CA)
   05214 Glioma
    100010412 (PIK3CA)
   05221 Acute myeloid leukemia
    100010412 (PIK3CA)
   05220 Chronic myeloid leukemia
    100010412 (PIK3CA)
   05218 Melanoma
    100010412 (PIK3CA)
   05211 Renal cell carcinoma
    100010412 (PIK3CA)
   05215 Prostate cancer
    100010412 (PIK3CA)
   05213 Endometrial cancer
    100010412 (PIK3CA)
   05224 Breast cancer
    100010412 (PIK3CA)
   05222 Small cell lung cancer
    100010412 (PIK3CA)
   05223 Non-small cell lung cancer
    100010412 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100010412 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    100010412 (PIK3CA)
   05161 Hepatitis B
    100010412 (PIK3CA)
   05160 Hepatitis C
    100010412 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    100010412 (PIK3CA)
   05164 Influenza A
    100010412 (PIK3CA)
   05162 Measles
    100010412 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    100010412 (PIK3CA)
   05163 Human cytomegalovirus infection
    100010412 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100010412 (PIK3CA)
   05169 Epstein-Barr virus infection
    100010412 (PIK3CA)
   05165 Human papillomavirus infection
    100010412 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100010412 (PIK3CA)
   05135 Yersinia infection
    100010412 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    100010412 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100010412 (PIK3CA)
   05142 Chagas disease
    100010412 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100010412 (PIK3CA)
   05017 Spinocerebellar ataxia
    100010412 (PIK3CA)
   05020 Prion disease
    100010412 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100010412 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    100010412 (PIK3CA)
   05415 Diabetic cardiomyopathy
    100010412 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100010412 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    100010412 (PIK3CA)
   04931 Insulin resistance
    100010412 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100010412 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100010412 (PIK3CA)
   01524 Platinum drug resistance
    100010412 (PIK3CA)
   01522 Endocrine resistance
    100010412 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdo04131]
    100010412 (PIK3CA)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100010412 (PIK3CA)
Membrane trafficking [BR:mdo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100010412 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 100010412
NCBI-ProteinID: XP_001362549
Ensembl: ENSMODG00000021305
UniProt: F7G3I5
LinkDB
Position
7:202267886..202347626
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASTKSLWVVNSALRIRILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SNPVKFPDMAVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVSIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaactgtggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactacctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacacgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagcgttactcaagaagcagaaagggaa
gaattttttgatgaaactcgacgactttgtgacctacggctttttcagccttttctaaaa
gtcatcgaaccagtaggcaaccgagaagaaaagattctcaatcgagaaattggttttgct
attggtatgcctgtttgtgaatttgatatggttaaagatccagaagtacaagatttccga
agaaatattcttaatgtttgtaaagaggctgtggacctgagggatgtccatgcaccccat
agtagagcattatatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcat
atatacaataaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aacaatgacaagcagaagtacactttaaaaatcaatcatgactgtgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacgcggagtatgttgctgtcatcggagcagctgaag
ctctgcgttttagagtatcagggcaaatacattttaaaagtgtgtggatgtgatgagtat
ctgctagaaaaatatcctcttagccaatataagtacataagaagctgtataatgcttggt
cggatgcccaatctgatgctgatggctaaagaaagtctttacacccagctaccactggat
acttttacaatgccatcttattccagacgaatctccacagccacaccatacatgaatgga
gaagcttcaaccaaatccctttgggtcgtaaatagtgcactccggataagaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tgccatgggggagagccattatgtgacaatgtgaatactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgatgtatgatatatacattcctgatcttccacgagctgct
cgactttgcctttccatttgttctgttaaaggcaggaaaggtgcaaaagaggaacactgt
ccattggcttggggaaatataaacctctttgattatacggacactctggtatcggggaaa
atggctttgaatctgtggccagtacctcatggattagaagatttgctcaatcctattgga
gttactgggtcaaatcccaataaggaaactccatgtttagagctggaatttgactggttt
agcaatcctgtaaagttcccagatatggcagtgattgaagaacatgcgaattggactgta
tctcgagaactaggatttaactattcccatgctgggctgagtaataggatagctcgagat
aatgaattaagagaaaacgacaaagaacaacttcgagcaatttgtactcgagaccctctg
tctgagatcactgagcaagaaaaggactttctttggagtcacaggcattattgtgtcagt
atcccagaaattctacctaaacttcttttatccgttaaatggaattctagagatgaagta
gcccagatgtattgcttagtaaaagattggcccccaatcaaaccagaacaggccatggaa
cttttggactgtaattatccagaccctatggttcgagcttttgctgttcgctgcctggaa
aaatatttaactgatgacaaactttctcagtacttaattcaactagttcaggttctgaag
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggataggacactttttcttttggcatttaaagtctgagatgcataataaaactgtc
agtcaaagatttggcttacttttggagtcctattgccgagcgtgtgggatgtatctaaag
catttgaatcggcaggtggaggccatggagaaactgattaacctcactgacattctcaaa
caggagaagaaggatgagactcaaaaggtacaaatgaagttcttggttgaacaaatgagg
cggcctgattacatggatgctttacaaggctttatctctccccttaatcctgctcatcaa
ctaggaaatctcaggcttgaggagtgtcggattatgtcttctgcaaaaagaccactctgg
ttgaattgggagaacccagacatcatgtcagagttactatttcagaacaatgagatcatc
tttaaaaatggggatgacttacgacaagatatgctaactcttcagatcattcgaattatg
gaaaatatctggcaaaatcagggtcttgatcttcggatgctgccttatggttgcctatca
attggggactgtgttggcctcattgaggtggtcagaaattctcatactatcatgcagatt
caatgtaaagggggcctaaagggggccttgcagttcaacagccatacattacatcagtgg
ctcaaagacaagaataaaggagaaatatacgatgcagccattgatttgtttacacgttca
tgtgctggatactgcgtggctaccttcattttgggaatcggtgaccggcacaatagtaat
atcatggtgaaggatgatggacaattatttcatatagactttggacactttttggatcac
aaaaagaagaaatttggttataaacgagagcgtgtgcccttcgtcttgacacaagatttc
ttgattgtaataagcaaaggagcccaagaatgcacaaagacgagagaatttgagagattt
caggaaatgtgctataaggcgtacttagctattcggcaacatgccaatctcttcatcaat
cttttctccatgatgcttggctctggaatgcccgaactacaatcatttgatgatattgca
tacattcgaaagaccctggccttggataaaactgagcaggaggctttggagtatttcatg
aagcagatgaatgatgctcatcatgggggctggacaaccaaaatggattggattttccat
acaataaagcagcacgctttgaactga

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