KEGG   Monodelphis domestica (gray short-tailed opossum): 100015410
Entry
100015410         CDS       T01031                                 
Symbol
RAF1
Name
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo01521  EGFR tyrosine kinase inhibitor resistance
mdo01522  Endocrine resistance
mdo04010  MAPK signaling pathway
mdo04012  ErbB signaling pathway
mdo04014  Ras signaling pathway
mdo04015  Rap1 signaling pathway
mdo04022  cGMP-PKG signaling pathway
mdo04024  cAMP signaling pathway
mdo04062  Chemokine signaling pathway
mdo04068  FoxO signaling pathway
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04140  Autophagy - animal
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04210  Apoptosis
mdo04218  Cellular senescence
mdo04270  Vascular smooth muscle contraction
mdo04360  Axon guidance
mdo04370  VEGF signaling pathway
mdo04371  Apelin signaling pathway
mdo04510  Focal adhesion
mdo04540  Gap junction
mdo04550  Signaling pathways regulating pluripotency of stem cells
mdo04613  Neutrophil extracellular trap formation
mdo04625  C-type lectin receptor signaling pathway
mdo04630  JAK-STAT signaling pathway
mdo04650  Natural killer cell mediated cytotoxicity
mdo04660  T cell receptor signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04664  Fc epsilon RI signaling pathway
mdo04666  Fc gamma R-mediated phagocytosis
mdo04720  Long-term potentiation
mdo04722  Neurotrophin signaling pathway
mdo04726  Serotonergic synapse
mdo04730  Long-term depression
mdo04810  Regulation of actin cytoskeleton
mdo04910  Insulin signaling pathway
mdo04912  GnRH signaling pathway
mdo04914  Progesterone-mediated oocyte maturation
mdo04915  Estrogen signaling pathway
mdo04916  Melanogenesis
mdo04917  Prolactin signaling pathway
mdo04919  Thyroid hormone signaling pathway
mdo04921  Oxytocin signaling pathway
mdo04926  Relaxin signaling pathway
mdo04928  Parathyroid hormone synthesis, secretion and action
mdo04929  GnRH secretion
mdo04935  Growth hormone synthesis, secretion and action
mdo05010  Alzheimer disease
mdo05022  Pathways of neurodegeneration - multiple diseases
mdo05034  Alcoholism
mdo05132  Salmonella infection
mdo05152  Tuberculosis
mdo05160  Hepatitis C
mdo05161  Hepatitis B
mdo05163  Human cytomegalovirus infection
mdo05164  Influenza A
mdo05165  Human papillomavirus infection
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05170  Human immunodeficiency virus 1 infection
mdo05200  Pathways in cancer
mdo05205  Proteoglycans in cancer
mdo05206  MicroRNAs in cancer
mdo05207  Chemical carcinogenesis - receptor activation
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05210  Colorectal cancer
mdo05211  Renal cell carcinoma
mdo05212  Pancreatic cancer
mdo05213  Endometrial cancer
mdo05214  Glioma
mdo05215  Prostate cancer
mdo05218  Melanoma
mdo05219  Bladder cancer
mdo05220  Chronic myeloid leukemia
mdo05221  Acute myeloid leukemia
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
mdo05226  Gastric cancer
mdo05230  Central carbon metabolism in cancer
mdo05231  Choline metabolism in cancer
mdo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100015410 (RAF1)
   04015 Rap1 signaling pathway
    100015410 (RAF1)
   04630 JAK-STAT signaling pathway
    100015410 (RAF1)
   04068 FoxO signaling pathway
    100015410 (RAF1)
   04072 Phospholipase D signaling pathway
    100015410 (RAF1)
   04071 Sphingolipid signaling pathway
    100015410 (RAF1)
   04024 cAMP signaling pathway
    100015410 (RAF1)
   04022 cGMP-PKG signaling pathway
    100015410 (RAF1)
   04151 PI3K-Akt signaling pathway
    100015410 (RAF1)
   04150 mTOR signaling pathway
    100015410 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100015410 (RAF1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100015410 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100015410 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    100015410 (RAF1)
   04660 T cell receptor signaling pathway
    100015410 (RAF1)
   04662 B cell receptor signaling pathway
    100015410 (RAF1)
   04664 Fc epsilon RI signaling pathway
    100015410 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    100015410 (RAF1)
   04062 Chemokine signaling pathway
    100015410 (RAF1)
  09152 Endocrine system
   04929 GnRH secretion
    100015410 (RAF1)
   04915 Estrogen signaling pathway
    100015410 (RAF1)
   04917 Prolactin signaling pathway
    100015410 (RAF1)
   04921 Oxytocin signaling pathway
    100015410 (RAF1)
   04926 Relaxin signaling pathway
    100015410 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    100015410 (RAF1)
   04919 Thyroid hormone signaling pathway
    100015410 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    100015410 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    100015410 (RAF1)
   04720 Long-term potentiation
    100015410 (RAF1)
   04730 Long-term depression
    100015410 (RAF1)
   04722 Neurotrophin signaling pathway
    100015410 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    100015410 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100015410 (RAF1)
   05206 MicroRNAs in cancer
    100015410 (RAF1)
   05205 Proteoglycans in cancer
    100015410 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    100015410 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100015410 (RAF1)
   05230 Central carbon metabolism in cancer
    100015410 (RAF1)
   05231 Choline metabolism in cancer
    100015410 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100015410 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100015410 (RAF1)
   05212 Pancreatic cancer
    100015410 (RAF1)
   05225 Hepatocellular carcinoma
    100015410 (RAF1)
   05226 Gastric cancer
    100015410 (RAF1)
   05214 Glioma
    100015410 (RAF1)
   05221 Acute myeloid leukemia
    100015410 (RAF1)
   05220 Chronic myeloid leukemia
    100015410 (RAF1)
   05218 Melanoma
    100015410 (RAF1)
   05211 Renal cell carcinoma
    100015410 (RAF1)
   05219 Bladder cancer
    100015410 (RAF1)
   05215 Prostate cancer
    100015410 (RAF1)
   05213 Endometrial cancer
    100015410 (RAF1)
   05224 Breast cancer
    100015410 (RAF1)
   05223 Non-small cell lung cancer
    100015410 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100015410 (RAF1)
   05161 Hepatitis B
    100015410 (RAF1)
   05160 Hepatitis C
    100015410 (RAF1)
   05164 Influenza A
    100015410 (RAF1)
   05163 Human cytomegalovirus infection
    100015410 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100015410 (RAF1)
   05165 Human papillomavirus infection
    100015410 (RAF1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100015410 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100015410 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    100015410 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    100015410 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100015410 (RAF1)
   01522 Endocrine resistance
    100015410 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mdo01001]
    100015410 (RAF1)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100015410 (RAF1)
Protein kinases [BR:mdo01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100015410 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100015410
NCBI-ProteinID: XP_001366041
Ensembl: ENSMODG00000006307
LinkDB
Position
6:complement(246143189..246208125)
AA seq 647 aa
MEHFQGAWKTISNGFGFKDSVFDGSGCISPTLVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKTRLDWNTDAAS
LVGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSNVGDSGVPALPPLTMRRMRESVSQIPISSQHRYSTPHAFTF
STSPPSSEGSLSQRQRSTSTPNVHMVSTTMPVDSRIIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAHRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVIDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINSCTLTSTRLPVF
NT seq 1944 nt   +upstreamnt  +downstreamnt
atggagcattttcagggagcttggaagactatcagtaatggttttggattcaaagattca
gtctttgatggctctggctgtatatctcctactcttgttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaacttacagattcctccaaaacaagtaacactatccgagtt
ttcttgccaaacaagcaaaggactgtggttaatgttcgaaatggaatgagcttacatgat
tgtcttatgaaagctcttaaagtgcgaggcctccagccagagtgttgtgcagtttttagg
cttctccatgaacacaaagggaaaaaaacacgtttagattggaatactgatgcagcctct
ttggttggagaagaacttcaagtagattttctggatcatgttcccctcacaacacacaat
tttgctcgaaaaactttcctgaagcttgccttctgtgatatttgtcagaagttcctgctg
aatggatttcgatgtcagacatgtggctacaagtttcatgaacattgtagcactaaagtc
cccacgatgtgcgtggattggagtaacatcagacagctcttattgtttccaaattccaat
gttggtgatagtggggtaccagcactacctcccctaacaatgcgtcggatgcgagagtct
gtttcccaaatccctattagttcccaacacaggtattctacgccccacgccttcacgttc
agcacgtcacctccatcctcagaggggtccctttcccagaggcaaagatctacatctacc
ccgaatgtccatatggtcagcaccaccatgccagtggacagtaggattatagaggatgca
attcgaagtcacagtgagtcagcctcaccttcagctctgtccagtagtccaaacaacctg
agtccaactggctggtctcagcccaaaacccctgttccagcacacagagaaagagcccca
gggtccggtacacaagagaaaaataaaattaggccacggggacagagagattcaagttat
tactgggaaatcgaagccagtgaagtcatgctatccaccagaatagggtcgggttcattt
gggacggtgtacaagggtaaatggcatggagatgttgccgtgaagatattaaaggtcatc
gatccaaccccagaacagtttcaggctttcaggaacgaagtggccgtcttgagaaaaaca
aggcatgttaacattctgttgttcatgggctatatgactaaagataacctggcgattgtg
acccagtggtgtgaggggagcagcctctacaaacaccttcatgtccaggagaccaaattt
caaatgttccagcttattgatattgcccggcagacagcacaaggaatggattatttacat
gcaaaaaacatcatccacagagacatgaaatcaaataatatatttcttcatgaaggtttg
acagtgaaaataggagactttggtttggcaacagtgaaatctagatggagtggctctcaa
caagtggaacagccgacaggctccattctctggatggctccagaggtgatccgcatgcag
gacaataatccgttcagctttcagtctgatgtctattcctatggcattgtgctatatgaa
ctgatgacaggggaactaccatattcacatatcaacaaccgagatcagattatatttatg
gttggtcgagggtacgcatctccagatctcagtaagctatacaagaattgccctaaagct
atgaagaggcttgtagcagattgtgtgaagaaagttaaggaagaaagacctcttttccca
cagatactgtcttccatcgaactactacaacattctttaccgaaaatcaaccgcagtgct
tccgaaccatctctgcaccgtgcagcccacacagaggacataaactcatgcacattgacg
tccaccagactcccggttttctag

DBGET integrated database retrieval system