Monodelphis domestica (gray short-tailed opossum): 100018410
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Entry
100018410 CDS
T01031
Symbol
MAP2K1
Name
(RefSeq) mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
mdo
Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo01521
EGFR tyrosine kinase inhibitor resistance
mdo01522
Endocrine resistance
mdo04010
MAPK signaling pathway
mdo04012
ErbB signaling pathway
mdo04014
Ras signaling pathway
mdo04015
Rap1 signaling pathway
mdo04022
cGMP-PKG signaling pathway
mdo04024
cAMP signaling pathway
mdo04062
Chemokine signaling pathway
mdo04066
HIF-1 signaling pathway
mdo04068
FoxO signaling pathway
mdo04071
Sphingolipid signaling pathway
mdo04072
Phospholipase D signaling pathway
mdo04114
Oocyte meiosis
mdo04140
Autophagy - animal
mdo04148
Efferocytosis
mdo04150
mTOR signaling pathway
mdo04151
PI3K-Akt signaling pathway
mdo04210
Apoptosis
mdo04218
Cellular senescence
mdo04270
Vascular smooth muscle contraction
mdo04370
VEGF signaling pathway
mdo04371
Apelin signaling pathway
mdo04380
Osteoclast differentiation
mdo04510
Focal adhesion
mdo04540
Gap junction
mdo04550
Signaling pathways regulating pluripotency of stem cells
mdo04613
Neutrophil extracellular trap formation
mdo04620
Toll-like receptor signaling pathway
mdo04650
Natural killer cell mediated cytotoxicity
mdo04660
T cell receptor signaling pathway
mdo04662
B cell receptor signaling pathway
mdo04664
Fc epsilon RI signaling pathway
mdo04666
Fc gamma R-mediated phagocytosis
mdo04668
TNF signaling pathway
mdo04720
Long-term potentiation
mdo04722
Neurotrophin signaling pathway
mdo04725
Cholinergic synapse
mdo04726
Serotonergic synapse
mdo04730
Long-term depression
mdo04810
Regulation of actin cytoskeleton
mdo04910
Insulin signaling pathway
mdo04912
GnRH signaling pathway
mdo04914
Progesterone-mediated oocyte maturation
mdo04915
Estrogen signaling pathway
mdo04916
Melanogenesis
mdo04917
Prolactin signaling pathway
mdo04919
Thyroid hormone signaling pathway
mdo04921
Oxytocin signaling pathway
mdo04926
Relaxin signaling pathway
mdo04928
Parathyroid hormone synthesis, secretion and action
mdo04929
GnRH secretion
mdo04934
Cushing syndrome
mdo04935
Growth hormone synthesis, secretion and action
mdo05010
Alzheimer disease
mdo05022
Pathways of neurodegeneration - multiple diseases
mdo05034
Alcoholism
mdo05132
Salmonella infection
mdo05135
Yersinia infection
mdo05160
Hepatitis C
mdo05161
Hepatitis B
mdo05163
Human cytomegalovirus infection
mdo05164
Influenza A
mdo05165
Human papillomavirus infection
mdo05166
Human T-cell leukemia virus 1 infection
mdo05167
Kaposi sarcoma-associated herpesvirus infection
mdo05170
Human immunodeficiency virus 1 infection
mdo05200
Pathways in cancer
mdo05205
Proteoglycans in cancer
mdo05206
MicroRNAs in cancer
mdo05207
Chemical carcinogenesis - receptor activation
mdo05208
Chemical carcinogenesis - reactive oxygen species
mdo05210
Colorectal cancer
mdo05211
Renal cell carcinoma
mdo05212
Pancreatic cancer
mdo05213
Endometrial cancer
mdo05214
Glioma
mdo05215
Prostate cancer
mdo05216
Thyroid cancer
mdo05218
Melanoma
mdo05219
Bladder cancer
mdo05220
Chronic myeloid leukemia
mdo05221
Acute myeloid leukemia
mdo05223
Non-small cell lung cancer
mdo05224
Breast cancer
mdo05225
Hepatocellular carcinoma
mdo05226
Gastric cancer
mdo05230
Central carbon metabolism in cancer
mdo05231
Choline metabolism in cancer
mdo05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mdo00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100018410 (MAP2K1)
04012 ErbB signaling pathway
100018410 (MAP2K1)
04014 Ras signaling pathway
100018410 (MAP2K1)
04015 Rap1 signaling pathway
100018410 (MAP2K1)
04370 VEGF signaling pathway
100018410 (MAP2K1)
04371 Apelin signaling pathway
100018410 (MAP2K1)
04668 TNF signaling pathway
100018410 (MAP2K1)
04066 HIF-1 signaling pathway
100018410 (MAP2K1)
04068 FoxO signaling pathway
100018410 (MAP2K1)
04072 Phospholipase D signaling pathway
100018410 (MAP2K1)
04071 Sphingolipid signaling pathway
100018410 (MAP2K1)
04024 cAMP signaling pathway
100018410 (MAP2K1)
04022 cGMP-PKG signaling pathway
100018410 (MAP2K1)
04151 PI3K-Akt signaling pathway
100018410 (MAP2K1)
04150 mTOR signaling pathway
100018410 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100018410 (MAP2K1)
04148 Efferocytosis
100018410 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
100018410 (MAP2K1)
04210 Apoptosis
100018410 (MAP2K1)
04218 Cellular senescence
100018410 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100018410 (MAP2K1)
04540 Gap junction
100018410 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
100018410 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100018410 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100018410 (MAP2K1)
04620 Toll-like receptor signaling pathway
100018410 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
100018410 (MAP2K1)
04660 T cell receptor signaling pathway
100018410 (MAP2K1)
04662 B cell receptor signaling pathway
100018410 (MAP2K1)
04664 Fc epsilon RI signaling pathway
100018410 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
100018410 (MAP2K1)
04062 Chemokine signaling pathway
100018410 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
100018410 (MAP2K1)
04929 GnRH secretion
100018410 (MAP2K1)
04912 GnRH signaling pathway
100018410 (MAP2K1)
04915 Estrogen signaling pathway
100018410 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
100018410 (MAP2K1)
04917 Prolactin signaling pathway
100018410 (MAP2K1)
04921 Oxytocin signaling pathway
100018410 (MAP2K1)
04926 Relaxin signaling pathway
100018410 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
100018410 (MAP2K1)
04919 Thyroid hormone signaling pathway
100018410 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
100018410 (MAP2K1)
04916 Melanogenesis
100018410 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100018410 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
100018410 (MAP2K1)
04726 Serotonergic synapse
100018410 (MAP2K1)
04720 Long-term potentiation
100018410 (MAP2K1)
04730 Long-term depression
100018410 (MAP2K1)
04722 Neurotrophin signaling pathway
100018410 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
100018410 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100018410 (MAP2K1)
05206 MicroRNAs in cancer
100018410 (MAP2K1)
05205 Proteoglycans in cancer
100018410 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
100018410 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
100018410 (MAP2K1)
05230 Central carbon metabolism in cancer
100018410 (MAP2K1)
05231 Choline metabolism in cancer
100018410 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100018410 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
100018410 (MAP2K1)
05212 Pancreatic cancer
100018410 (MAP2K1)
05225 Hepatocellular carcinoma
100018410 (MAP2K1)
05226 Gastric cancer
100018410 (MAP2K1)
05214 Glioma
100018410 (MAP2K1)
05216 Thyroid cancer
100018410 (MAP2K1)
05221 Acute myeloid leukemia
100018410 (MAP2K1)
05220 Chronic myeloid leukemia
100018410 (MAP2K1)
05218 Melanoma
100018410 (MAP2K1)
05211 Renal cell carcinoma
100018410 (MAP2K1)
05219 Bladder cancer
100018410 (MAP2K1)
05215 Prostate cancer
100018410 (MAP2K1)
05213 Endometrial cancer
100018410 (MAP2K1)
05224 Breast cancer
100018410 (MAP2K1)
05223 Non-small cell lung cancer
100018410 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100018410 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
100018410 (MAP2K1)
05161 Hepatitis B
100018410 (MAP2K1)
05160 Hepatitis C
100018410 (MAP2K1)
05164 Influenza A
100018410 (MAP2K1)
05163 Human cytomegalovirus infection
100018410 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
100018410 (MAP2K1)
05165 Human papillomavirus infection
100018410 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100018410 (MAP2K1)
05135 Yersinia infection
100018410 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100018410 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
100018410 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
100018410 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100018410 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100018410 (MAP2K1)
01522 Endocrine resistance
100018410 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mdo01001
]
100018410 (MAP2K1)
Enzymes [BR:
mdo01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100018410 (MAP2K1)
Protein kinases [BR:
mdo01001
]
Serine/threonine kinases: STE group
STE7 family
100018410 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Seadorna_VP7
Kinase-like
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
100018410
NCBI-ProteinID:
XP_001367233
Ensembl:
ENSMODG00000009715
UniProt:
F6XT65
LinkDB
All DBs
Position
1:152604810..152717842
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPMPIQLNPTPDGSTINGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPMEGDAAETSPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagcctatgcccattcagctgaacccgaccccggatggctccacgatt
aacgggaccagctcggcggagactaaccttgaagcactacagaagaaattggaggagttg
gaattggatgaacaacagcgtaagcgtctggaggctttcctcacccagaaacagaaagtg
ggcgagctgaaggatgatgactttgagaagattagtgaactgggagctggaaatggtggt
gtggtgttcaaggtttcacacaaaccctctggcctaatcatggcaaggaagctaattcac
ctggagataaagccagcaattcggaaccagattatacgggagctgcaagtcctgcatgag
tgcaactccccatatattgtagggttttatggggccttttacagtgatggagagatcagt
atctgcatggagcacatggatggtggatctttggatcaggtccttaagaaagctggaaga
attcctgagcagatcttggggaaagttagcattgctgtaataaagggtcttacatatctg
agagagaagcataagataatgcacagagatgtcaagccatccaacatcttggtgaactca
cgtggagagatcaaactttgtgactttggtgtcagtgggcagctgattgattccatggct
aactctttcgtggggacaaggtcttatatgtcgccagaaagactccagggaactcactac
tcagtacagtcggacatctggagcatggggctttctttggtagagatggcaattggacga
tatcccattccaccaccagattccaaggagctagagctaatgtttggctgtccaatggag
ggagatgctgctgagacgtcgccacgaccaagaactcctgggaggcccctcagttcttat
ggaatggatagccgaccacctatggcaatttttgagctgctggattacattgtcaatgag
cctcctccgaagttgcccagtggagtcttcagtctggaatttcaagattttgtgaataaa
tgcctaataaaaaatccagccgagagagctgatttgaagcaacttatggttcatgccttt
atcaagaggtctgacgccgaggaagttgattttgcaggctggctctgctccaccataggc
cttaaccagcccagcacaccaactcatgctgctggcatctga
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