KEGG   Myotis daubentonii (Daubenton's bat): 132214156
Entry
132214156         CDS       T10294                                 
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
mdt  Myotis daubentonii (Daubenton's bat)
Pathway
mdt00562  Inositol phosphate metabolism
mdt01100  Metabolic pathways
mdt04014  Ras signaling pathway
mdt04015  Rap1 signaling pathway
mdt04020  Calcium signaling pathway
mdt04024  cAMP signaling pathway
mdt04070  Phosphatidylinositol signaling system
mdt04919  Thyroid hormone signaling pathway
mdt04933  AGE-RAGE signaling pathway in diabetic complications
mdt05205  Proteoglycans in cancer
Module
mdt_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mdt00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132214156 (PLCE1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    132214156 (PLCE1)
   04015 Rap1 signaling pathway
    132214156 (PLCE1)
   04020 Calcium signaling pathway
    132214156 (PLCE1)
   04070 Phosphatidylinositol signaling system
    132214156 (PLCE1)
   04024 cAMP signaling pathway
    132214156 (PLCE1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    132214156 (PLCE1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    132214156 (PLCE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    132214156 (PLCE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdt04131]
    132214156 (PLCE1)
Enzymes [BR:mdt01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     132214156 (PLCE1)
Membrane trafficking [BR:mdt04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    132214156 (PLCE1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    132214156 (PLCE1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 132214156
NCBI-ProteinID: XP_059516819
LinkDB
Position
13:41112124..41404321
AA seq 2296 aa
MTSEEMAASDLIPVTQRKVVSSQSAADESSEKASGVSVPKTHTPGQSRPTSHTISKLNKP
KEETSGSNLPRIFSTTRGKIMSDENSNETCWEKNMPDSVKNLNVNGNNILENRQCGLPQS
QFYKTCDSVVEEGLHLETGISSSLERKVFPGIQLELDEPPMGIRPLENQSATGRAHPDSD
LAVFHFHYELDRRMSDSVSTLSDNLILDDCGNCVSLPDVGREQKKNYMAYTCKLMELAKS
CDNENKQLQGDHCDALNDEYMCCEASCRKASVVCSSDSFCREGFTDSPSAETFLSHFEDF
PDNCEDVEDYFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLAAWSYI
DMKRSGSLLPCGRVTGQLSTVLVRQDGSPCLSEAQWYPIYNAVRRGEETEDTIGSLLHFF
TKLPASETAYERINVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGL
LSTFGGSTGRMMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQFPEEVASILMEQE
QNIYRRVLPVDYLCFLTQNLSTPECQRSLPCLKASISASILNSQNREHNALEDLVMRFNE
VSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNTVMEFLAGLRSRKVLKMWQFM
DQSDLETMRSLKDAMAQHESSCEYRKVVTRALHIPGCRVVPFCGVFLKELCEVLDGASGL
VKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQIIRSCSRSLEA
EDEDSPSEGSGSRKNSLKDKAPRCQFVIGDLLDTENDIFEQPKEWDPHGLEEPQKAFDHG
IELIPWYVLSIRADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWIKPTTASPA
SAKAKLGMPTATSEPGKFPLLGNAGLSGLAEGVLDLFSVKAVYMGHPSIDIHTVCVQNKL
SSMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQW
LRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSAEKPNMQRNNTLGIS
TAKKKKKILMRGESGEATDDEMATRKAKLHKECRSWSGSDPQDINEQEESEANAITSPPN
PLPSRRAHSLTTAGSPILAAGTSSPIRPVSSPVLSSNKSPSSAWSSSSWHGRIKGGMRGF
QSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDLYAVPCNRSGSESAPLYTNLTIDEN
TSGLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGVESTSLGVFG
VGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKDNFASK
NDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG
DDGMPIIYHGHTLTTKIPFKDVIEAIDRSAFINSDLPIIISIENHCSLPQQRKMADIFKT
VFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQ
AQAYNGGNVNPPPTNNEEEEDEEDEYDYDYESLSDDNILEDRPESKSCSDKLQFEYNEEI
PKRIKKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTL
NASGSNRGKERKSRKSIFGNNPGRMSPGETASLNKTSGKSSYEGMRQAWEESSSPLSPAT
SLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLM
FWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDL
DNMEPAVYSLTIVSGQNVCPSNSTGSPCIEVDILGMPLDSCHFRTKPIHRNTLNPMWNEQ
FFFRVHFEDLIFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFV
NSRRMEEISSGSSVPASLMFSTEERKCLQTHRVTVHGVPGPEPFTVFSINGGTKAKQLLQ
QILTTEQDTKPIAADYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIVQILSSWFPEEGY
VGRIVLKTQQENLEEKSIVQDDREVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQD
VIQQTLCKAKYSYSILSNPNPNDYVLLEEVVKDTANKKSSTPKSSQRVLLDQECVFQAQS
KWKGAGKFILKLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLTSPSQVLVSESVQN
KEERPVGGSDTMDYRQ
NT seq 6891 nt   +upstreamnt  +downstreamnt
atgacttctgaagaaatggcagcttctgatctcatacctgtgactcagagaaaagtggtg
tcttctcagtcagctgcagatgaaagtagtgaaaaggcctcaggcgtcagtgttccaaag
acacatactcctgggcagagtaggccgacttctcataccatctcaaaactgaacaaaccc
aaagaggaaacttctggaagcaacttgcctaggattttctcaacaacaagggggaaaatc
atgagtgatgagaacagtaatgaaacgtgctgggagaaaaacatgcccgattctgtgaag
aaccttaacgtgaacggcaacaacatattggaaaaccgtcagtgtggtcttcctcagagc
cagttttacaaaacatgcgattctgttgtagaggaaggcctgcatttggaaactggaatc
tcttcttccctggaaagaaaggtgttccctgggattcaactggaactagacgaacctccc
atgggcattcgtcccttagaaaatcagtcagcaacaggcagggcacaccctgacagtgat
ttggcagtatttcactttcattatgaacttgacagaagaatgtcagacagtgtctctacc
ctatcagacaacttgattttggatgattgtggaaactgtgtatcactgcctgatgttggt
agggagcaaaagaaaaattatatggcatatacttgcaaactgatggaattggcaaaaagc
tgtgataatgagaacaagcagctacagggtgatcattgtgacgccttgaacgatgaatac
atgtgctgcgaagcttcctgccgaaaagccagcgtggtatgttctagtgacagcttctgc
agggagggttttactgatagtccatctgccgagacttttctgagccattttgaggacttc
cctgataactgtgaagatgtagaagattattttaaaagtaaaaaggagcgatccactttg
ttagtgaggagattttgtaaaaatgacagagaagttaagaaatctgtgtatactgggaca
agggcaattgtgaggactctgccttctggtcacattggactggcagcttggagttacatt
gatatgaagagaagtggaagcttgttgccttgtgggagagtaacgggccagctatcaaca
gtgctggttaggcaagatgggagcccctgtctgtcagaagcccagtggtatccgatctac
aatgcagtgagaaggggagaagaaacagaagacacaattggatctcttctccatttcttc
acaaagctcccagcctctgagacagcctatgaaaggattaatgttggtccctgcttaaag
caatgtgttcgagacaccgtatgtgagtatcgtgccaccctccaacggacctccatatct
cagtacatcacgggttctctcctagaagcaaccacatctttaggagcaagaagtgggctt
ctcagtacttttggaggatccaccggacgaatgatgctgaaagaacgccaaccgggcacc
tctatggccaattccagtgccctcccttcaagttcagctgggatcagcaaggagctgatt
gatctgcagcccctcatccagttccccgaggaagtcgccagcatcctgatggagcaggaa
cagaatatctaccggagggtcttgccggttgactatctttgcttcttgacccagaacttg
agcactccagaatgtcagaggtccctgccctgcctcaaagcatccatctcagcatcaatt
cttaactcccagaacagagagcacaatgcccttgaagatcttgtgatgagatttaatgag
gtgagctcctgggtgacgtggctgatcctcacagccggctccatggaggagaagcgggaa
gtcttctcatatttggtgcatgtggccaaatgctgctggaacatgggcaactacaacacc
gtcatggagttcttggccggcctcaggtcaagaaaagttttaaaaatgtggcagttcatg
gaccagtctgacctggagaccatgaggagtctgaaggatgccatggctcagcacgaatcc
tcctgcgagtacaggaaggtggtgacgcgggcgctgcacatcccgggctgcagggtggtc
ccgttctgcggggtgtttctgaaggagctctgtgaagtgctggacggcgcctccggcctc
gtgaagctctgccccagatacaattcccaggaggaaaccctagagtttgtagctgactac
agtggacaagataattttttacaacgcgtgggacaaaatggcttgaagaattcggaaaaa
gagtccaccgtcaacagcatctttcagatcatcaggagctgcagccgcagtctggaggcg
gaggacgaggacagccccagtgaggggagcggctctcggaaaaactccctgaaggacaaa
gctcctcgctgccagtttgtaattggagatttgctagatacagaaaatgacatctttgag
cagcccaaagagtgggaccctcatggattagaagagccacagaaggcctttgaccacggg
atagagctcatcccatggtatgtgctgtccatccgagctgacgtgcaccagttcctgctg
cagggggccacggtcatccactatgaccaggacacgcacctctctgcccgctgcttcctc
cagcttcagcctgacaatagcaccttgacctggataaagcccaccacagcctccccagcc
agtgcaaaagcaaaacttggtatgcctactgccacgtccgagcctggcaaattcccatta
ctgggcaacgctggattaagtggcctggcggagggggtcttggatctgttttccgtaaag
gctgtgtacatggggcaccctagcattgatatacacactgtgtgtgttcagaacaaactg
agtagcatgcttctctcggagactggtgtgacactgctctatgggcttcagaccacggac
aatagattactgcactttgtggcaccgaagcacacagctaaaatgctcttcagtggattg
ttggaactcactagagctgtgagaaagatgaggaagttccctgaccaaagacagcagtgg
ctgcggaaacagtacgtcagcctctatcaggaggatggacggtatgaaggcccaactttg
gctcacgctgtggagttgtttggtggcagacgatggagtactcgaaaccccagccctggg
acatcagcaaagagtgccgagaagcccaacatgcagaggaacaacaccctgggcatcagt
actgccaagaagaagaagaaaatccttatgaggggtgagagtggagaggccaccgacgac
gagatggccacccgaaaggccaaactgcacaaagagtgtcgaagctggagtggctctgat
cctcaggacattaacgagcaagaggagtcagaggcgaatgccatcacaagcccgcctaac
cctctcccttccagaagagcccattctctgactacggctgggtcccccatcttggctgcc
gggacgtcatctcccatcaggccagtgtcctcccctgtgctgtcttcaaacaagagcccg
tccagtgcctggagcagcagcagctggcacggccgcatcaaaggaggaatgagaggcttc
cagagcttcatggtttccgacagcaacatgagtttcgttgaatttgtggagctgttcaaa
tccttcagtgtaaggagccgcaaggacctgaaggatctcttcgacctctacgccgtgccc
tgcaaccggtcgggctctgagtcggccccgctctacaccaacctaaccattgacgagaac
accagcggtcttcagcctgatctagatttgttgaccagaaatgtctcagatttggggctg
ttcattaagagtaaacagcagctgtcagacaaccagaggcagatctctgacgccattgct
gctgcaagcatcgtgacgaatggcactggggtcgagagcacatccctgggcgtgtttggg
gtcggcatacttcagctcaatgacttcctagtgaactgccagggagaacactgcacttac
gatgaaatcctcagcatcatccagaagtttgagcctagcattagtatgtgtcatcagggc
ctaatgtcatttgaaggatttgcaaggtttctgatggataaagacaactttgcttcgaaa
aacgatgaatcacaggagaacattaaagaattacagctgcccctctcctactattacatt
gaatcttcacacaatacctacctcacaggccatcagctcaaaggagaatcctcagtagaa
ctctatagccaggtcctcctgcaaggctgtaggagcgtagagttggactgctgggacgga
gatgatgggatgcccatcatttaccatggacatacactgacaaccaagatccccttcaag
gacgtgatcgaagccattgatcgcagtgccttcatcaactctgacctgccaatcatcata
tcaattgaaaaccactgttcattgcctcagcaacgaaaaatggcagacattttcaagact
gtatttggagaaaaactggtggctaagttcttatttgaaagtgatttctcagatgatcca
atgcttccttcccctgaccaacttagaaggaaggtgcttctcaaaaataagaagctaaaa
gcccaccagacgccggtggatatcttaaagcaaaaggctcatcagttagcatccatgcaa
gctcaggcttacaatggtgggaatgtcaaccccccacctactaataatgaggaggaggaa
gatgaagaagacgagtatgattatgactatgaatctctctctgatgataacattctagaa
gacagacctgaaagcaaatcgtgtagcgacaagcttcagtttgagtataatgaagaaatc
cccaagaggataaagaaagcagataactctgcttgcaacaaaggaaaggtgtatgacatg
gagttgggagaagaattttatcttcctcagaataaaaaggaaagcagacagattgcacca
gagctttccgaccttgtcatctattgccaagcagtaaaattcccaggcctgtcaactcta
aatgcatctggctctaacagaggaaaagaaaggaaaagcaggaagtccatttttggcaac
aatccgggcagaatgagccctggggagacggcatcacttaacaaaacgtctggaaaaagt
tcctatgaaggaatgcgacaggcctgggaggagtcttcttcccccctcagcccagccacg
tccctcagcgctatcattagaactcccaaatgttaccatatctcatcgctgaatgaaaat
gccgccaaacgtctgtgtcgcaggtattctcagaaactgatccagcacaccgcctgccag
ctgctgaggacttacccggctgccacccgcatcgactcctccaaccccaaccccctcatg
ttctggctgcacgggatacagctcgtggcactcaactaccagacagatgatctcccttta
catttaaacgctgccatgtttgaggccaacggtggctgtggctatgtgttgaaaccccca
gttctgtgggacaagaactgccccatgtatcagaagttttctcccctggaaagagacctg
gacaacatggagcccgctgtctactctttgactattgtctctggccagaacgtgtgcccg
agcaacagcacaggaagcccgtgcatcgaggtcgacatcctgggcatgccgctggacagc
tgccacttccgcacgaagcccatccaccggaacactctgaaccccatgtggaacgagcag
tttttcttccgggttcactttgaagacctcatatttcttcgttttgcagttgtggaaaac
aacagctcggcggtcactgctcagaggatcatcccgctcaaggctctaaagcgaggatat
cgacatcttcagctgcgaaacctccacaatgaagtcttggaaatctctagtttattcgta
aacagcagaaggatggaagaaatctcctctggcagttccgtgccagcctctttgatgttt
agtacagaagaaagaaagtgtctgcagactcacagagtcacggtgcatggggtcccaggt
ccggagcccttcactgttttctctataaatggaggcaccaaggcaaagcaacttctccag
caaattctgaccactgaacaagacaccaaacctattgccgcagactactttttgatggaa
gaaaaatattttatatctaaagaaaagaatgaatgcagaaaacagccgttccagagggcc
attggtcccgaggaagagatcgtgcagattttaagcagctggtttccagaagagggctat
gttggcaggattgtcttaaaaacccagcaggaaaacctggaagagaaaagcattgttcaa
gatgacagggaggtgatcttgagctcggaggaggagagtttctttgtccaagtgcacgac
gtttctccagagcagccgcggacagtcatcaaagcgccgcgcgtcagcaccgcacaggac
gtcattcagcaaaccttatgcaaagccaagtactcctacagcatcctgagcaaccccaac
ccgaacgactacgtacttttggaagaggtggtgaaagacacagccaacaagaagtcttct
acccccaagtcctcccagcgtgtccttctggatcaggagtgtgtgtttcaagcccaaagc
aagtggaaaggtgcaggaaaattcatccttaaactaaaggagcaggtgcaggcatcccga
gaagacaagagaaaaggcatttcttttgcaagtgaattcaagaagttcaccaagtcaact
aaacagccccgaggactcacatcaccttctcaggtcttggtttcggaaagtgtccaaaac
aaagaggagagacctgtgggtggcagcgacacgatggactatcgacagtga

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