Myotis daubentonii (Daubenton's bat): 132227454
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Entry
132227454 CDS
T10294
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mdt Myotis daubentonii (Daubenton's bat)
Pathway
mdt05012
Parkinson disease
mdt05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mdt00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
132227454 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
132227454 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mdt01001
]
132227454 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mdt04131
]
132227454 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mdt04147
]
132227454 (LRRK2)
Enzymes [BR:
mdt01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
132227454 (LRRK2)
Protein kinases [BR:
mdt01001
]
Serine/threonine kinases: TKL group
LRRK family
132227454 (LRRK2)
Membrane trafficking [BR:
mdt04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
132227454 (LRRK2)
Exosome [BR:
mdt04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
132227454 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR-B
COR-A
Ras
LRR_14
LRR_9
Beta-prop_EML_2
Arf
Ank_2
Beta-prop_RSE1_2nd
WDR55
LRR_13
LRR_NXF1-5
nSTAND3
Beta-prop_WDR36-Utp21_1st
AAA_22
T2SSE
WD40_Prp19
WD40_CDC20-Fz
Beta-prop_THOC3
ABC_tran
TrwB_AAD_bind
AAA_7
Kdo
MobB
Beta-prop_BBS7
AAA_16
PduV-EutP
Septin
SRPRB
TniB
G-alpha
NACHT
MMR_HSR1
TsaE
ANAPC4_WD40
Beta-prop_WDR5
GTP_EFTU
cobW
Beta-prop_WDR3_1st
Beta-prop_RIG_2nd
ARM_LIN_2nd
AAA_29
FtsK_SpoIIIE
NB-ARC
nSTAND_NTPase5
ResIII
AAA_23
AAA_14
WD40_WDHD1_1st
ARM_CUL7_CUL9
Beta-prop_WDR3_2nd
Motif
Other DBs
NCBI-GeneID:
132227454
NCBI-ProteinID:
XP_059538557
LinkDB
All DBs
Position
2:42663276..42786334
Genome browser
AA seq
2528 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNLQEGKQIETLVQILEDMQVFTYADHAAKLFQGKN
VHVPLLIVLDSYVRVACVQQVGWSLLCKLIEICPDTMQSLTGPQDIGCDWEVLGIHQLII
KMLTVHNASINLSMVGLKALDLLLTSGKITLLILDEDSDIFLLIFEAMKKFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLTALKNFKDEEEIVLYVLRCLHSLASPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVEAV
QRYSENATLQIAGLSCLALLTETIFLNQDLEVKNENEENEDDEEEDKLFWLEACYKALTW
HRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASA
NALCTLLEQNVNFRKILLSKGIYLNVLELMKRHLHSPEVAESGCKMLNHLFEGSNISLDV
MAAVAPKIITVMKSHGTSLSVQLEALRAILHFMLPGMPEEFTEDAEYQHKLKMVTNQCFR
NDIHKLVLGSLNRFIGNPGIQKCGLKVISSIARFPDALEVLSLEGAIESVLQTLKMYPDD
QEIQRLGLSLIGCLITKKNIILGIENLLAKILVSSLQRFKDITELQTKGFQTVLTVLECS
ESFSKLLVHYSFDSVIFHQMSSSLMEQKDQQFLNLCCKCFAKLAMDDELKGVMLERACDQ
NNSIMVECLLLLGADANRAKEGTSLICQVCEKASSPKLVELLLNSGSREQDVRKALAISI
RKGDSQIISLLLKRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTCNSRKEINIGSTL
ARMVLRYQMKSSVAEGAASGSDGDFSEQVLDKFDQWTFIPESYVDSVFGQSDDLDSEGSE
GSFLVKKKSSSISVGEFYRDPALQRCSPNLQSHSSSLGPIFDQEDLLKRKRKILSSDDSL
RSSKLPSHMRNSDSTSSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLARLELH
QNALTGFPQRLCEVLKCLTHLDLHSNKFTAFPSYLLKMNCIANLDVSRNDIGPSIVLDPA
VKCPTLKQFNLSYNQLSSVPENLGNVAEKLEQLTLEGNKISGMCSPLSLKELKILNLSKN
NISSLSEDFLEACPKVESFSARMNSLDAMPFLPSSMTNIKLSQNRFTCVPEAILNLPHLR
SLDMSSNEIKYLPSPAHWKSLNLRELLFSHNQISILDLGEKAHAWSRVEKLHLSHNKLKE
IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDII
RFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDAGMQSATVGIDVKDWPIQ
IRGKRKKDLILNVWDFAGREEFYSTHPHFMTPRSLYLAIYDLSKGQAEVDAMKPWLFNIK
ARASSSPVILVGTHLDVSDEKQRKACISKINKELLNKRGFPAIRDYHFVNATEESDALAK
LRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKE
NQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTEKVEGGP
KYPKGIISRRSVEKFLSKKKRFPKNYTQQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPV
IELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIY
LNWSPEAYCLVESEVLDNHPESFLKITVPSCRKGCIILGQVVDHIDSLMEEWFPGLLEID
ICGEGETLLKKWALYSFNDGEEHEKILLDDLMKKAEEGDLLVNPDQPRLTLPISQIAPDL
ILADLPRNIMLNSDKLEFEQAPEFLLGDGSFGSVYRATYEGDEVAVKIFNKHTSLRLLRQ
ELVVLCHHHHPSLVFLLAAGIRPRMLVMELAPKGSLDRLLQQDTASLTRTLQHRIALHVA
DGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAVIAKIADYGIAQYCCRMGIKTSEGTPGFR
APEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEY
GCAPWPMVEKLIKRCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFTVECMVAAN
QSGKNVSVWLGCGPRDRGQLSLLDLTTERLTSEEVTNSRILCLALVHLPVEKESWIVSGT
QSGELIVINSEDGKKMHTLEKMTDSVTCLHCNSNSKQSKQKNFLLVGTADGNLAIFEDKS
VKCKGAAPLKILNIGNISTPLMCLSESVNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETR
TTQVFSYAAVSDSNIIAVVADRALYIAKKNSPFVEVWDKKTEKLCELIDCAHFLKEEMVK
VNKESKHSMSYSGRVKTLCLQKNSALWIGTGGGYMLLLDLSTLRLIRIIQDFCDSVRVMM
TAQIGTLKNAMLVLGYTWKNTEDMQHQKELQSCLSIWDINLPHEVQNLEKHIEVRKELAE
RMRRITVE
NT seq
7587 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactttgaagaagttg
atagtcaggctgaacaatctccaggaaggaaagcagatagagacgctggtccaaattctg
gaggatatgcaggtgttcacctacgctgaccacgccgccaagttatttcaaggcaaaaat
gtccacgtgcctctgttgatcgtcttggactcctatgtgagagtggcctgcgtgcagcag
gtgggttggtcacttctatgcaaattaatagaaatctgtccagatacaatgcaaagctta
acgggaccccaggacattggatgcgattgggaagtccttggtattcaccaactgattatt
aaaatgcttacagttcataatgccagtataaacctgtcaatggttggactgaaggcctta
gatctccttctaacttcaggtaaaatcaccttgctgatattggatgaagacagcgatatt
ttcttattaatttttgaggccatgaaaaagttttcagccaatgacgaggtccagaaactt
ggatgcaaagctttacatgtgctatttgagagagtttcagaggagcaactgactgaattt
gtcgagaataaagattatatgatattgctaactgcgttaaaaaactttaaagatgaggag
gaaattgtgctttacgtactgcgctgtttacattcgctagcaagtccttgcaacaatgtt
gaagtcctcatgagtggcaacgtcaggtgttacaacattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtgagttgctgcttgctccatagacttacgtta
ggtaatttttttaatatcctggtattaaacgaggtccatgagtttgtggtggaagctgtg
cagcggtattcagagaatgcaacgctgcaaatcgcagggctcagctgtttagcgctcctc
actgagaccatttttttaaatcaagacttagaggtaaagaatgaaaatgaggagaatgaa
gatgatgaggaagaagataagttgttttggctagaagcctgttacaaagccctaacttgg
catagaaagaacaagcatgtgcaggaggctgcctgctgggccttaaacaatctccttatg
taccagaacagtttgcatgagaagattggagatgaagatggccagttcccagctcatcgg
gaagtgatgctctccatgctgatgcattcttcgtcaaaagaagtctttcaggcatctgcg
aacgctttgtgcactctcctagaacaaaatgttaatttcagaaaaatcctgttgtcaaaa
ggaatctacctgaatgtgctggagttgatgaagaggcatctacactcccctgaagtggct
gaaagtggctgcaaaatgctgaatcatctttttgaaggaagtaacatttccctggatgta
atggcagcagtggcccccaaaataataacagttatgaaaagtcacgggacatcattgtca
gtgcagctggaggcacttcgagccattttacattttatgcttccaggcatgccagaagaa
ttcacagaagatgccgaataccaacacaagctaaaaatggttacaaatcagtgtttcagg
aatgatattcacaaactggtcctgggatctttaaacaggttcattggaaatcctgggatt
cagaaatgtggattaaaagtaatttcttctatagcacgttttcctgatgccttagaggtg
ttatctctggaaggtgctattgaatcagtgctgcaaacactgaagatgtacccggatgac
caagaaattcagcgtctgggtttaagtcttataggatgcttgattacaaagaagaatata
atcctaggaattgagaatctgctagcaaaaattctggtttccagtttgcaacgatttaag
gatattactgaattacagactaaaggatttcagacagtcttgaccgtgctggaatgctca
gagtctttttccaagctgttggtgcattattcctttgactcagtaatattccatcagatg
tcctccagtctcatggaacagaaggatcaacagtttctaaacctttgttgcaagtgcttt
gcaaaattagccatggatgatgagttaaaaggtgtgatgctagagagagcatgcgatcag
aataacagcatcatggttgaatgcttgcttctgttgggagcagacgccaatcgagcaaag
gagggaacttctttaatttgtcaggtgtgcgaaaaagcaagcagtcctaaactggtggaa
ctgctactgaatagtgggtcccgtgaacaagatgtacggaaagcactggcaataagcatc
aggaaaggcgacagccagatcatcagtttgctcttaaagagacttgccctggatctggcc
aataacagcatatgcctcggaggattttgtattgggaaaatcgaaccttcttggcttggt
cctttatttccagacaagacatgcaattcaagaaaagaaataaatataggatccacacta
gcaagaatggtcctcagataccagatgaaaagttctgtggcagagggagcagcctcaggc
agcgatggggatttttctgagcaagtacttgataaatttgaccaatggaccttcattcct
gagtcctacgtggacagtgtgtttggacaaagtgatgacctagatagtgaaggaagtgaa
ggctcatttcttgtgaaaaagaagtcaagttcgattagtgtaggagaattttaccgagat
cctgccttgcaacgttgttcaccaaatttgcaaagtcattccagttcattgggacccatt
tttgatcaagaagacttactgaagcgaaaaagaaaaatattgtcttcagatgattcactc
aggtcatcaaaacttccatcccatatgaggaattcagacagcacttcttccctggcttct
gagagagaatatattacatccttagatctttcagccaacgaactcagagatattgatgcc
ctaagccagaagtgctgcatcagtggtcatctggagcacctggcaaggctggagcttcac
cagaacgcactcacgggcttcccacagcggctatgtgaagtgctgaagtgtttgacgcac
ttggacttgcacagtaataagttcacagcgtttccctcctacttgttgaaaatgaattgt
attgccaaccttgatgtctctcgaaatgatattgggccctcaatagttttggatcctgca
gtgaagtgtccgaccttgaaacagttcaacctgtcatataaccagctgtcttctgttccc
gagaacctgggcaatgtggcagagaaactggagcagctgactttagaaggaaataaaata
tcaggaatgtgttctcccctgagcctgaaggaactgaagattttaaatcttagtaaaaac
aacatttcatccctgtcagaggactttcttgaggcttgtcctaaagtggagagtttcagc
gccagaatgaactctcttgatgctatgccttttttaccttcttctatgacaaacatcaaa
ttatctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcga
tcattagacatgagcagcaacgaaattaaatatctaccaagtcctgcacactggaaatct
ttgaacttaagggaactcttgtttagtcataatcagatcagcatcttggacttgggcgaa
aaagcacatgcatggtctagagtagagaaactacatctttctcataataaactgaaagag
attcctcctgagatcggctgtcttgaaaacctgacatctcttgatgttagttacaacttg
gaactgagatcctttcccaatgaaatggggaaattgagcaaaatatgggatcttcctttg
gatgagctgcgtcttaattttgattttaagcatataggatgtaaagccaaagacatcata
aggtttcttcaacagcggttaaaaaaggctgtgccctataaccgcatgaaacttatgatt
gtgggaaacactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaa
tcagatgctgggatgcagagtgccaccgttggcatagacgtgaaggactggcctatccaa
ataagaggcaaaaggaagaaagacctgattctaaatgtgtgggatttcgcaggtcgggag
gaattctacagcacgcacccgcacttcatgaccccgcgatccctgtacctcgccatctat
gacctcagcaaagggcaggctgaagttgatgctatgaagccttggctattcaatataaag
gctagagcttcctcttcccctgtgattcttgtgggcacacatttggatgtgtctgatgag
aagcagcgcaaagcctgcatcagtaaaatcaacaaggagctcttgaacaagcgggggttt
cccgcaatccgcgattaccactttgtgaacgccaccgaggaatccgatgctttggcaaaa
cttcggaaaaccatcataaatgagagcctcaatttcaagatccgagatcagcctgttgtt
gggcagctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaa
aatgtgccaattgaatttcctgtaattgaccggaaacgattattacaactcgtgaaagaa
aatcaactgcagttagatgaaaatgagcttcctcatgcagtgcacttcctaaatgaatca
ggggtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtggaa
cccaagtggctttgtaaagtcatggcacagattttgacagagaaagtagaaggtggtcca
aaatatcctaaaggaattatttcacgtagaagtgtggaaaaatttctttcaaagaaaaag
agatttccaaagaactacacacaacagtacttcaaactcctagaaaaatttcagattgcc
ttgccaataggagaagaatatttgctggttccaagcagtctgtctgaccacaggcctgtg
atagagcttccccattgtgagaactctgaaattatcattcgactttatgaaatgccttat
tttccaatgggattttggtcaagattaatcaatcgattacttgaaatttcaccttacatg
ctttcaggtagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctat
ttgaattggtctcctgaagcttattgcctggtagaatctgaagtcttagataatcatcca
gagagtttcctaaaaattacagttccttcttgtagaaaaggctgtattattttgggacaa
gttgtggaccacattgattctctcatggaagaatggtttcctgggttattggagattgat
atttgtggtgaaggagaaactttgttgaagaaatgggcattatatagttttaatgatggc
gaagaacatgaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggggacctc
ctagtaaatccagatcaaccaaggctcacccttccaatatcccagattgctcctgacttg
attttggctgacctgcctagaaatattatgttgaatagtgataaattggaatttgaacaa
gctccggaatttctcttaggtgatggcagttttggatcagtttatcgagcaacctacgaa
ggagatgaagtggctgtaaagatatttaataaacatacatcacttagactattaagacag
gagctggtggtgctttgccaccaccaccaccccagcttggtctttttgctggcggctggg
attcgtccccggatgctggtgatggagctggcccccaagggctccctggaccgcctgctg
cagcaggacacagccagtctcacgcggactctgcagcataggatcgcactccatgtggct
gacggcttgaggtacctccactcggccatgatcatataccgggatttgaagccgcacaac
gtgctgctcttcaccttgtatcccaatgccgccgtcatcgccaagatcgctgactacggg
attgctcagtactgctgcagaatgggcatcaaaacatcggagggcacaccaggctttcgt
gcacctgaagttgctagaggaaatgtaatttataaccaacaggctgatgtttattcattt
ggtttactactgtatgacattttgacaactggaggtagaatagcagagggtttgaagttt
ccaaatgagtttgatgaattggcaatacaaggcaaattaccagatccagttaaagaatat
ggttgtgccccgtggcctatggttgagaagttaattaaaaggtgtttaaaagaaaatcct
caagaaaggcctacatctgcccaggtctttgacattttgaactcggcggagttaatctgt
ctgatgagacacatatccatacccaaaaacttcactgtggagtgcatggttgctgcaaat
cagagcggcaagaatgtcagcgtctggctgggctgcgggcccagggacagaggccaactc
tcccttcttgacttaactactgaaagacttacttcggaggaagttaccaatagtagaata
ctgtgcctcgccttggtgcacctgcctgtggaaaaggaaagctggattgtgtctgggaca
cagtctggcgagctcatcgtcattaattctgaagatgggaaaaagatgcatacccttgaa
aagatgactgattctgttacttgcttgcattgcaattccaattccaaacaaagcaagcaa
aaaaattttcttttggtgggaactgctgatggcaacttagcaatttttgaagataaaagt
gttaagtgtaaaggagctgctcctttgaagatactcaatataggaaatatcagcactcca
ctcatgtgtttgagtgaatccgtgaattcaactgaaaaaaacattatgtggggaggatgt
ggcacaaaacttttctcgttttctgatgatttcaccattcagaaactcattgagaccagg
acgactcaggtgttttcttatgcagctgtcagtgactccaacatcatagcagtggtggcg
gacagggctctctacattgctaagaagaatagcccatttgtggaagtgtgggataagaaa
acggaaaaactctgtgaactaatagactgtgcgcactttttaaaggaggaaatggtgaaa
gtgaacaaggagtccaaacacagtatgtcttactcggggagagtgaaaactctctgccta
cagaagaacagtgctctctggattggaaccgggggaggctacatgctactccttgacctt
tcgactctcaggctcatccgtataattcaggacttctgtgactctgtccgagtcatgatg
acagcgcagataggcacccttaaaaatgccatgttggttttgggatatacctggaaaaat
actgaagatatgcaacaccaaaaagaattacaatcttgcttgtctatttgggacatcaat
cttccacacgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaa
agaatgagaagaataactgttgaataa
DBGET
integrated database retrieval system
