KEGG   Myotis daubentonii (Daubenton's bat): 132230128
Entry
132230128         CDS       T10294                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mdt  Myotis daubentonii (Daubenton's bat)
Pathway
mdt00562  Inositol phosphate metabolism
mdt01100  Metabolic pathways
mdt01521  EGFR tyrosine kinase inhibitor resistance
mdt01522  Endocrine resistance
mdt01524  Platinum drug resistance
mdt04012  ErbB signaling pathway
mdt04014  Ras signaling pathway
mdt04015  Rap1 signaling pathway
mdt04024  cAMP signaling pathway
mdt04062  Chemokine signaling pathway
mdt04066  HIF-1 signaling pathway
mdt04068  FoxO signaling pathway
mdt04070  Phosphatidylinositol signaling system
mdt04071  Sphingolipid signaling pathway
mdt04072  Phospholipase D signaling pathway
mdt04081  Hormone signaling
mdt04140  Autophagy - animal
mdt04150  mTOR signaling pathway
mdt04151  PI3K-Akt signaling pathway
mdt04152  AMPK signaling pathway
mdt04210  Apoptosis
mdt04211  Longevity regulating pathway
mdt04213  Longevity regulating pathway - multiple species
mdt04218  Cellular senescence
mdt04360  Axon guidance
mdt04370  VEGF signaling pathway
mdt04380  Osteoclast differentiation
mdt04510  Focal adhesion
mdt04550  Signaling pathways regulating pluripotency of stem cells
mdt04611  Platelet activation
mdt04613  Neutrophil extracellular trap formation
mdt04620  Toll-like receptor signaling pathway
mdt04625  C-type lectin receptor signaling pathway
mdt04630  JAK-STAT signaling pathway
mdt04650  Natural killer cell mediated cytotoxicity
mdt04660  T cell receptor signaling pathway
mdt04662  B cell receptor signaling pathway
mdt04664  Fc epsilon RI signaling pathway
mdt04666  Fc gamma R-mediated phagocytosis
mdt04668  TNF signaling pathway
mdt04670  Leukocyte transendothelial migration
mdt04722  Neurotrophin signaling pathway
mdt04725  Cholinergic synapse
mdt04750  Inflammatory mediator regulation of TRP channels
mdt04810  Regulation of actin cytoskeleton
mdt04910  Insulin signaling pathway
mdt04914  Progesterone-mediated oocyte maturation
mdt04915  Estrogen signaling pathway
mdt04917  Prolactin signaling pathway
mdt04919  Thyroid hormone signaling pathway
mdt04923  Regulation of lipolysis in adipocytes
mdt04926  Relaxin signaling pathway
mdt04929  GnRH secretion
mdt04930  Type II diabetes mellitus
mdt04931  Insulin resistance
mdt04932  Non-alcoholic fatty liver disease
mdt04933  AGE-RAGE signaling pathway in diabetic complications
mdt04935  Growth hormone synthesis, secretion and action
mdt04960  Aldosterone-regulated sodium reabsorption
mdt04973  Carbohydrate digestion and absorption
mdt05010  Alzheimer disease
mdt05017  Spinocerebellar ataxia
mdt05020  Prion disease
mdt05100  Bacterial invasion of epithelial cells
mdt05132  Salmonella infection
mdt05135  Yersinia infection
mdt05142  Chagas disease
mdt05146  Amoebiasis
mdt05160  Hepatitis C
mdt05161  Hepatitis B
mdt05162  Measles
mdt05163  Human cytomegalovirus infection
mdt05164  Influenza A
mdt05165  Human papillomavirus infection
mdt05166  Human T-cell leukemia virus 1 infection
mdt05167  Kaposi sarcoma-associated herpesvirus infection
mdt05168  Herpes simplex virus 1 infection
mdt05169  Epstein-Barr virus infection
mdt05170  Human immunodeficiency virus 1 infection
mdt05171  Coronavirus disease - COVID-19
mdt05200  Pathways in cancer
mdt05203  Viral carcinogenesis
mdt05205  Proteoglycans in cancer
mdt05206  MicroRNAs in cancer
mdt05207  Chemical carcinogenesis - receptor activation
mdt05208  Chemical carcinogenesis - reactive oxygen species
mdt05210  Colorectal cancer
mdt05211  Renal cell carcinoma
mdt05212  Pancreatic cancer
mdt05213  Endometrial cancer
mdt05214  Glioma
mdt05215  Prostate cancer
mdt05218  Melanoma
mdt05220  Chronic myeloid leukemia
mdt05221  Acute myeloid leukemia
mdt05222  Small cell lung cancer
mdt05223  Non-small cell lung cancer
mdt05224  Breast cancer
mdt05225  Hepatocellular carcinoma
mdt05226  Gastric cancer
mdt05230  Central carbon metabolism in cancer
mdt05231  Choline metabolism in cancer
mdt05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mdt05415  Diabetic cardiomyopathy
mdt05417  Lipid and atherosclerosis
mdt05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mdt00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132230128 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    132230128 (PIK3CA)
   04014 Ras signaling pathway
    132230128 (PIK3CA)
   04015 Rap1 signaling pathway
    132230128 (PIK3CA)
   04370 VEGF signaling pathway
    132230128 (PIK3CA)
   04630 JAK-STAT signaling pathway
    132230128 (PIK3CA)
   04668 TNF signaling pathway
    132230128 (PIK3CA)
   04066 HIF-1 signaling pathway
    132230128 (PIK3CA)
   04068 FoxO signaling pathway
    132230128 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    132230128 (PIK3CA)
   04072 Phospholipase D signaling pathway
    132230128 (PIK3CA)
   04071 Sphingolipid signaling pathway
    132230128 (PIK3CA)
   04024 cAMP signaling pathway
    132230128 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    132230128 (PIK3CA)
   04152 AMPK signaling pathway
    132230128 (PIK3CA)
   04150 mTOR signaling pathway
    132230128 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    132230128 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    132230128 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    132230128 (PIK3CA)
   04218 Cellular senescence
    132230128 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    132230128 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    132230128 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    132230128 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132230128 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    132230128 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    132230128 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    132230128 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    132230128 (PIK3CA)
   04660 T cell receptor signaling pathway
    132230128 (PIK3CA)
   04662 B cell receptor signaling pathway
    132230128 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    132230128 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    132230128 (PIK3CA)
   04670 Leukocyte transendothelial migration
    132230128 (PIK3CA)
   04062 Chemokine signaling pathway
    132230128 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132230128 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    132230128 (PIK3CA)
   04929 GnRH secretion
    132230128 (PIK3CA)
   04915 Estrogen signaling pathway
    132230128 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    132230128 (PIK3CA)
   04917 Prolactin signaling pathway
    132230128 (PIK3CA)
   04926 Relaxin signaling pathway
    132230128 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    132230128 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    132230128 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    132230128 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    132230128 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    132230128 (PIK3CA)
   04722 Neurotrophin signaling pathway
    132230128 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    132230128 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    132230128 (PIK3CA)
   04380 Osteoclast differentiation
    132230128 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    132230128 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    132230128 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132230128 (PIK3CA)
   05206 MicroRNAs in cancer
    132230128 (PIK3CA)
   05205 Proteoglycans in cancer
    132230128 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    132230128 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    132230128 (PIK3CA)
   05203 Viral carcinogenesis
    132230128 (PIK3CA)
   05230 Central carbon metabolism in cancer
    132230128 (PIK3CA)
   05231 Choline metabolism in cancer
    132230128 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132230128 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    132230128 (PIK3CA)
   05212 Pancreatic cancer
    132230128 (PIK3CA)
   05225 Hepatocellular carcinoma
    132230128 (PIK3CA)
   05226 Gastric cancer
    132230128 (PIK3CA)
   05214 Glioma
    132230128 (PIK3CA)
   05221 Acute myeloid leukemia
    132230128 (PIK3CA)
   05220 Chronic myeloid leukemia
    132230128 (PIK3CA)
   05218 Melanoma
    132230128 (PIK3CA)
   05211 Renal cell carcinoma
    132230128 (PIK3CA)
   05215 Prostate cancer
    132230128 (PIK3CA)
   05213 Endometrial cancer
    132230128 (PIK3CA)
   05224 Breast cancer
    132230128 (PIK3CA)
   05222 Small cell lung cancer
    132230128 (PIK3CA)
   05223 Non-small cell lung cancer
    132230128 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    132230128 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    132230128 (PIK3CA)
   05161 Hepatitis B
    132230128 (PIK3CA)
   05160 Hepatitis C
    132230128 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    132230128 (PIK3CA)
   05164 Influenza A
    132230128 (PIK3CA)
   05162 Measles
    132230128 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    132230128 (PIK3CA)
   05163 Human cytomegalovirus infection
    132230128 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132230128 (PIK3CA)
   05169 Epstein-Barr virus infection
    132230128 (PIK3CA)
   05165 Human papillomavirus infection
    132230128 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    132230128 (PIK3CA)
   05135 Yersinia infection
    132230128 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    132230128 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132230128 (PIK3CA)
   05142 Chagas disease
    132230128 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132230128 (PIK3CA)
   05017 Spinocerebellar ataxia
    132230128 (PIK3CA)
   05020 Prion disease
    132230128 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132230128 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    132230128 (PIK3CA)
   05415 Diabetic cardiomyopathy
    132230128 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    132230128 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    132230128 (PIK3CA)
   04931 Insulin resistance
    132230128 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    132230128 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    132230128 (PIK3CA)
   01524 Platinum drug resistance
    132230128 (PIK3CA)
   01522 Endocrine resistance
    132230128 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdt04131]
    132230128 (PIK3CA)
Enzymes [BR:mdt01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     132230128 (PIK3CA)
Membrane trafficking [BR:mdt04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    132230128 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 132230128
NCBI-ProteinID: XP_059543061
LinkDB
Position
3:38922892..38999918
AA seq 1069 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWGINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLEMEFDWF
SSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaggaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgcgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagacccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcac
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaattgccaaaacac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgattatgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctttgtgttctagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtatatcagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaggaaagcctttactcgcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacttctacaaaatccctttggggtataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccactggcgtggggaaatataaacttgtttgattatacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagatggagtttgactggttc
agcagcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtct
gtgtcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctaga
gacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcct
ctctctgaaatcactgagcaggagaaagattttctttggagccacagacactattgtgta
actatccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagactggcctccaatcaaacctgaacaagctatg
gagcttctggactgcaactacccagaccctatggttcgaagttttgctgttcgatgctta
gaaaaatatttaacagatgacaaactttctcagtatctaattcagctagtacaggtcctg
aaatatgaacagtatttggataacctgctggtgaggtttttactcaaaaaagcgttgact
aatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaaca
gttagtcagaggtttggcctgcttttggaatcctactgccgtgcatgtgggatgtatttg
aagcacctgaacaggcaagtcgaggctatggaaaagctcatcaacttgactgacattctc
aaacaagagaagaaggatgagactcaaaaggtacagatgaaatttttagttgagcagatg
cggcgaccagatttcatggatgctctacagggctttctatctcctctaaatcctgctcat
caattaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatc
atctttaaaaacggggatgatttgcggcaagatatgctaacacttcaaattattcgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttgccttatggctgcctg
tccattggggactgtgtggggctcattgaggtggtgagaaactctcacaccatcatgcag
atccagtgcaaagggggcctgaaaggggccctgcagttcaacagccacacgctgcaccag
tggctcaaggacaagaacaaaggggaaatatacgatgcagccattgatctgtttacacgt
tcatgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagc
aacatcatggttaaagatgatggacaactgttccatatagattttggacactttttggat
cacaagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaagat
ttcttaatagtgattagtaaaggagcccaggaatgcaccaagacaagagaatttgagagg
tttcaggagatgtgttacaaagcttatctagctatccggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctgggatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttc
atgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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