Mycolicibacterium duvalii: MDUV_37250
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Entry
MDUV_37250 CDS
T06492
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mdu
Mycolicibacterium duvalii
Pathway
mdu00860
Porphyrin metabolism
mdu01100
Metabolic pathways
mdu01110
Biosynthesis of secondary metabolites
mdu01120
Microbial metabolism in diverse environments
mdu01240
Biosynthesis of cofactors
Module
mdu_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mdu_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mdu00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MDUV_37250 (hemD)
Enzymes [BR:
mdu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MDUV_37250 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MDUV_37250 (hemD)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX18865
UniProt:
A0A7I7K464
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All DBs
Position
complement(3903338..3905011)
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AA seq
557 aa
AA seq
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MSLRGRKGKPGRITFVGSGPGDPGLLTTRARAVLANAALVFTDPDVPEAVLGLVGTELPP
PSGPLPDVAAGATKTDDADGAKGAAEPMIPGGPDVRPALGDPTEVAKTLATEARTGVDVV
RLVAGDPLSVDSVITEVNALARTQLAFEIVPGLPGTTAVPTYAGLPLGSSHTVADVRDPD
VDWAALAAAPGPLILHATASHLPEAARTLIEYGLAESTPAVVTGNGTTCQQRSVETTLAG
LLDKAVLDKPALAEPAGPLTGTLVVTIGRTVSHRAKLNWWESRALYGWTVLVPRTKDQAG
EMSDRLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF
NEFGLDARAFSGVKIACVGQATADRVRAFGINPELVPSGEQSSLGLLDDFPPYDDVFDPV
NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTS
SSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAAR
LRAEGALPPPRKKSRRR
NT seq
1674 nt
NT seq
+upstream
nt +downstream
nt
atgagcttgcgaggacgcaagggcaagcccggccgcatcacgttcgtcggctccgggccc
ggtgatccgggcctgttgaccacacgagcccgcgcggtgctggccaacgccgccctggtg
ttcaccgatcccgacgtgcccgaggcggtcctggggctggtgggcaccgaattgccgccg
ccgtcgggcccgctgcccgacgtggccgccggtgcgaccaagaccgacgacgccgacggc
gccaagggcgccgccgagccgatgattcccggtggccccgatgtgcgcccggccctgggc
gaccccaccgaggtcgccaagacgctggccaccgaagcccgtaccggggtcgacgtggtg
cgcctggtcgccggtgatccgctgtcggtggattcggtgatcaccgaggtcaacgcgctg
gcgcggacccaactggctttcgagatcgtgcccggcctgcccggcaccaccgcagtgccc
acctacgcgggtctgccgctgggttcctcgcacacggtcgccgacgtgcgggatcccgac
gtggactgggcggcgctggccgccgctcccggcccgctgatcctgcacgccaccgcatcg
catctgcccgaggcggcgcgcaccctgatcgaatacggattggccgagtccaccccggcg
gtggtgaccggcaacggcaccacctgccagcagcggtcggtggagaccacgctggccggt
ctgctcgacaaggcggtgctcgacaagccggcgctggccgagcccgccggtccgctgacc
ggaacgctggtggtcaccatcgggcgcaccgtctcccaccgggcgaagctcaactggtgg
gagagccgcgcgctgtacggctggaccgtgttggtgccgcgcaccaaggatcaggccggg
gagatgagcgaccggctggtcacccacggcgcgctgcccatcgaggtgcccaccatcgcc
gtggaacccccgcgcagcccggcccagatggaaagagccgtcaagggtttggtggacggc
cggttccagtgggtggtgttcacctccaccaacgcggtgcgtgcggtgtgggagaagttc
aacgagttcggtctggatgcccgcgcgttctccggtgtgaagatcgcctgcgtcggtcag
gcgactgccgatcgggtccgcgccttcggcatcaaccccgagctggtgcccagcggcgaa
cagtcctcgctcgggctgctcgacgacttcccgccctacgacgacgttttcgatccggtg
aaccgggtgctgctgccccgcgccgacatcgccaccgagaccctggccgagggcctgcgg
gaacgcggctgggagatcgaggatgtcaccgcctaccggacggtgcgtgcggccccgccg
ccggcgcacacccgcgagatgatcaagacgggcggcttcgacgcggtctgcttcacgtcc
agctcgacggtgcgcaatctcgtcggcatcgccggaaagccgcacgcccgcaccatcgtt
gcgtgcatcgggcccaagaccgccgagacggctgcggaattcggcctgcgcgtcgatgtg
cagcccgaggtggccgcggtcggtccgctggtcgaggcgctcgccgagcacgccgcccgg
ttgcgggccgaaggggccctgcccccgccgcgcaagaagagccgtcgccgctag
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