Methylobacterium sp. 4-46: M446_0259
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Entry
M446_0259 CDS
T00679
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
met
Methylobacterium sp. 4-46
Pathway
met00300
Lysine biosynthesis
met00550
Peptidoglycan biosynthesis
met01100
Metabolic pathways
met01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
met00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
M446_0259
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
M446_0259
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
M446_0259
Enzymes [BR:
met01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
M446_0259
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
FinO_N
Motif
Other DBs
NCBI-ProteinID:
ACA14830
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Position
complement(317314..318771)
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AA seq
485 aa
AA seq
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MTEPLWTLDAVLAATGGRALDGAPDAPLSGLSIDTRTLKVGDLFFAIRGEQRDGHDFVRD
ALARGAGAAVVSQARAADLAGAGPLVAVPEAGEDPVLAAMRKLAAAARARSRARIVAVTG
SVGKTGTKEALRHVLAAQGATHASVASYNNHWGVPLTLGRMPAASAFGVFEIGMNHAGEI
APLTRLVRPEVAVVTTVEPVHIEHFRALSGIADAKGEIFCGLEPGGVAVINRDNPHFERL
RDHALASRAGRIVSFGEHPRADVRAERVVMRPDLSIVDARVMGIPVTYQLGTPGRHTALN
SLAVMAAVHALGADLALAALSLAQLRPPVGRGERTLLRLRDGEALLVDESYNANPASVRA
ALATLAGIEVQGRARRIAVLGDMLELGAEAARLHRDLAAAVAEHGIDLVFVAGPLMAELF
EALPAGTRGVAAASSADLLDAVVAEIRPGDAVMVKGSNSTRMGRIVEALKARYGGGADAI
AARPT
NT seq
1458 nt
NT seq
+upstream
nt +downstream
nt
atgaccgagcctctctggaccctggacgcggtgctggccgccaccggcggccgcgcgctc
gacggcgcgcccgacgcgccgctctccggcctgtcgatcgacacccgcaccctgaaggtc
ggcgacctgttcttcgccatccggggcgagcagcgcgacggccacgacttcgtccgcgac
gcgctcgcgcgcggcgcgggcgccgccgtggtgtcgcaggcgcgcgccgcggacctcgcc
ggcgccggcccgctcgtcgcggtgccggaggcgggcgaggatccggtgctcgccgccatg
cggaagctcgcggcggcggcgcgggcgcgcagccgcgcccgcatcgtcgcggtgacgggc
tcggtcggcaagaccggcaccaaggaggccctgcgccacgtcctggcggcgcagggcgcc
acccacgcctcggtcgcctcctacaacaaccattggggcgtgcccctgacgctcgggcgc
atgccggcggcgagcgccttcggggtgttcgagatcggcatgaaccacgcgggcgagatc
gccccgctcacccgcctggtccggcccgaggtcgccgtcgtgacgacggtcgagccggtc
cacatcgagcatttccgcgccctctcgggcatcgcggacgccaagggcgagatcttctgc
ggcctggagcccggcggggtcgcggtgatcaaccgagacaacccgcatttcgagcgcctg
cgcgaccacgcgctggcctcgcgggcgggccggatcgtcagcttcggcgagcatccgcgg
gcggatgtgcgggccgagcgcgtggtgatgcgccccgacctctcgatcgtggacgcgcgg
gtgatgggcatcccggtcacctaccagctcggcacgccgggccgccacacggccctgaac
tcgctcgccgtgatggcggccgtgcacgcgctcggggccgacctcgcgctcgcggccctg
tcgctggcgcagctgcgcccgccggtcgggcgcggcgagcgcacgctgctgcgcctgcgc
gacggcgaggcgctgctcgtcgacgagagctacaacgccaacccggcctcggtgcgggcg
gcgctcgcgacgctcgcggggatcgaggtccagggccgggcgcgccggatcgccgtgctc
ggcgacatgctggagctcggcgcggaggcggcgcgcctgcaccgcgacctcgccgccgcc
gtggcggagcacgggatcgacctcgtcttcgtggccggaccgctgatggcggagctgttc
gaggcgctgccggccggcacgcggggcgtcgcggcggcgagttccgccgatctcctcgac
gcggtcgtggccgagatccgccctggcgacgcggtcatggtgaagggatcgaacagcacc
cgcatgggccggattgtcgaggccctgaaagcccgctacgggggcggcgcggacgccatc
gccgcgcgaccgacctga
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