Candidatus Methylacidiphilum fumarolicum: MFUM_2037
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Entry
MFUM_2037 CDS
T09357
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
mfh
Candidatus Methylacidiphilum fumarolicum
Pathway
mfh00290
Valine, leucine and isoleucine biosynthesis
mfh00620
Pyruvate metabolism
mfh01100
Metabolic pathways
mfh01110
Biosynthesis of secondary metabolites
mfh01210
2-Oxocarboxylic acid metabolism
mfh01230
Biosynthesis of amino acids
Module
mfh_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mfh00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
MFUM_2037 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MFUM_2037 (leuA)
Enzymes [BR:
mfh01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
MFUM_2037 (leuA)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
CAI9086356
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All DBs
Position
MFUM:complement(1996458..1997972)
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AA seq
504 aa
AA seq
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MAENRLIIFDTTLRDGEQCPGASMTARQKLEVAKQLARLGVDVIEAGFPVISQGDYQSVR
EIASQVKGPKICGLSRCLPKDIEAAASALEPAGSAARIHVFLATSQIHRRYKLAKDEEEI
IQIAVNGVRLAKSFVEDVEFSAEDASRTEPEFLARILQQVIEAGATTVNIPDTVGYAVPE
EFASLIRYLFENVPNIHKAIVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGN
ASLEEIIMAIHTRPDFFGKMELGIQLKEILRTSRLVSRMSGLAVQRNKAIVGENAFAHAA
GIHQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLRMLGFELEKDEIDNIF
SQFKDIGDKKKFIYDDDLIALVEGQISRIKETYQLEYMAVADCSGGIPMATIKLRRGQEL
LVDASTGDGAVDAAMKAVDRITGLHGHLVEYEVRSVTEGKDAIGEVTVKVNFDSKHLVTG
KAASTDVFEASIRAYLNAVNKALL
NT seq
1515 nt
NT seq
+upstream
nt +downstream
nt
atggctgaaaatcggcttattatctttgatacaactttgagggatggagaacaatgtcct
ggagcgagcatgactgccaggcagaagttagaagtggctaaacagttagccaggcttggg
gtcgatgtgattgaagcaggatttccggttataagccaaggagattatcaatcagtccga
gaaatagcttcgcaagtgaaaggaccaaagatttgtgggctttctcgctgcttacctaaa
gacattgaagcagcagcatcggccttggagccagctgggagtgcggcaaggattcatgta
tttcttgctacctctcaaattcatcgtcgctataaacttgctaaggatgaagaagaaatt
atccagattgcagttaatggggtacgtttggcaaaaagttttgtggaagatgtggagttt
tcagcagaagatgcttctaggactgagccagaatttttagctagaatccttcagcaggtc
atagaagcaggggcgactactgttaatattcctgatacagttggatatgctgttccagaa
gaatttgcttctttaatccgctatctttttgaaaatgtccccaatattcataaggccatt
gttagtgtgcattgccataacgatttaggcctggctgtttctaactctctggcagcaata
aaagctggagcaagacaggtcgagggaaccatcaatggaattggagaaagagcggggaat
gcttctcttgaagaaattattatggccatacacacccgtcctgatttttttgggaaaatg
gagttgggcattcaactgaaagaaattcttaggacttctaggcttgtttcaagaatgtcg
ggtttggctgtccagagaaataaagcgatagtcggagaaaatgcctttgcccatgctgct
ggcatccatcaagatggaatcttaaagaaaagggaaacttacgagattatcgatccgaaa
ataattggatgggagcaaagcgagctgcctttgacaaaacatagtggaagagccgcgctg
gaaaacagactgcgcatgttaggcttcgaattagaaaaagatgaaatagataacattttc
tcccagtttaaagacataggagataagaaaaagtttatttatgatgatgatttgattgct
cttgttgagggacaaatctctcggatcaaagagacttatcagctggaatatatggctgtt
gctgattgtagtggagggattccaatggctacgataaaattacggcgtggccaagaattg
ctcgtggatgcgagtaccggagatggagcggtggatgcagcaatgaaagctgtagatagg
attactggtctgcatgggcatttagttgaatatgaagtcagatcagtgacagaggggaaa
gatgccattggagaagtgaccgtcaaagtgaattttgactcaaaacatttagtaacaggg
aaagcagcttccaccgatgtctttgaggctagtatcagagcctatcttaatgcagtcaat
aaagccttgttatag
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