Mycobacterium florentinum: MFLOJ_27420
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Entry
MFLOJ_27420 CDS
T06524
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mfj
Mycobacterium florentinum
Pathway
mfj00860
Porphyrin metabolism
mfj01100
Metabolic pathways
mfj01110
Biosynthesis of secondary metabolites
mfj01120
Microbial metabolism in diverse environments
mfj01240
Biosynthesis of cofactors
Module
mfj_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mfj_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mfj00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MFLOJ_27420 (hemD)
Enzymes [BR:
mfj01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MFLOJ_27420 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MFLOJ_27420 (hemD)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX78955
LinkDB
All DBs
Position
complement(2877559..2879226)
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AA seq
555 aa
AA seq
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MTTRGRKPRPGRITFVGSGPGDPGLLTTRAATVLANAALVFTDPDVPEPVLALIGKDLPP
VSGPAPAEPPPATTDGSPHADPPPAAPTVLSGGADIRPALGEPAEVAKTLTAEARTGVDV
VRLVSGDPLTLDAVISEVNAVARTHLHVEIVPGLAATSAVPTYAGLPLGSSHTVADVRGD
VDWEALAAAPGPLILQATPTHLADAARTLIEHELSETTPCVVTAQGTTCQQRSIETTLHG
LTDAAVVAGAGDPAGPLTGPLVVTIGKTVHSRSKLNWWESRALYGWTVLVPRTKDQAGEM
SERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGE
FGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSIFDPVNR
VLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSS
TVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAIGPLVDALAEHAARLR
AEGALPPPRKKSRRR
NT seq
1668 nt
NT seq
+upstream
nt +downstream
nt
atgacgacgcgagggcgcaagccgagaccgggccgcatcacgttcgtgggttccggcccg
ggtgatccgggattgttgaccacgcgggcagccacagtgctggccaatgcggccctggta
ttcaccgatcccgacgtacccgaaccggtgctggcgctgatcggcaaggacctaccgccc
gtttcgggcccggcgcctgccgaaccaccgcccgcgacgaccgatgggtcaccccacgcg
gacccgcctccggccgcgcccacggtgctgtccggtggcgccgacatccgcccggcgctg
ggtgagcccgccgaggtggccaagacgctgaccgccgaggcccgcacgggcgtcgacgtg
gtgcggctggtgtccggtgacccgctcacgctcgacgcggtgatcagcgaggtgaacgcc
gtcgcgcgcactcacctgcacgtcgagatcgtgccgggtctggccgcgaccagcgcggtg
cccacgtatgcgggtctgccgctgggctcctcgcacacggtggccgacgtgcgcggcgac
gtggactgggaggcgctggcggcggctcccggaccgctgatcctgcaggccaccccgacg
cacctggccgacgcggcccggaccctgatcgagcacgagctgtcggagaccactccgtgc
gtggtgaccgcccagggcaccacctgtcagcagcgttcgatcgagaccacgctgcacggg
ctgaccgatgcggccgtcgtggccggcgccggcgaccccgcgggcccgctgactggaccg
ctggtggtgaccatcggcaagacggtgcacagccggtcgaagctgaactggtgggaaagc
cgcgccctgtacggctggaccgtcctggtgccgcgcaccaaggaccaggccggcgagatg
agcgagcggctgacgtcgtacggcgcgctgccggtcgaggtgccgacgatcgccgtcgag
ccgccgcgcagccccgcccagatggagcgtgccgtcaagggattggtcgacggccggttc
cagtgggtggtgttcacctccaccaacgccgtccgcgcggtgtgggagaagttcggcgag
ttcgggctcgacgcccgcgcgttctccggcgtgaagatcgcctgcgtcggtgagtcgacg
gccgaccgggtccgggcattcgggatcagcccggagctggtgccggccggggagcagtcc
tcgctgggcctgctggacgacttcccgccctacgacagcattttcgatccggtgaaccgg
gtcttgctgccgcgtgccgacatcgccaccgagacgctggccgaagggctgcgcgaacgt
ggttgggagatcgaggatgtcaccgcataccggacggtgcgtgcggcaccgccgccggcg
accacccgcgagatgatcaagacgggcggcttcgacgcggtgtgcttcacctccagctcg
acggtgcgcaacctggtcggcatcgccggtaaaccccacgcgcgcaccatcattgcctgc
atcggccccaagacggccgagaccgctgccgagttcggcctacgggtggatgtgcagccc
gaaaccgctgccattggcccgctggtcgacgcgctggccgaacacgccgcgcggttgcgc
gccgagggcgcgctgccaccgccgcgcaagaagagtcgcaggcgctag
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