KEGG   Alexandromys fortis (reed vole): 126496688
Entry
126496688         CDS       T08493                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mfot  Alexandromys fortis (reed vole)
Pathway
mfot00562  Inositol phosphate metabolism
mfot01100  Metabolic pathways
mfot04015  Rap1 signaling pathway
mfot04020  Calcium signaling pathway
mfot04022  cGMP-PKG signaling pathway
mfot04062  Chemokine signaling pathway
mfot04070  Phosphatidylinositol signaling system
mfot04071  Sphingolipid signaling pathway
mfot04072  Phospholipase D signaling pathway
mfot04081  Hormone signaling
mfot04082  Neuroactive ligand signaling
mfot04261  Adrenergic signaling in cardiomyocytes
mfot04270  Vascular smooth muscle contraction
mfot04310  Wnt signaling pathway
mfot04371  Apelin signaling pathway
mfot04540  Gap junction
mfot04611  Platelet activation
mfot04613  Neutrophil extracellular trap formation
mfot04621  NOD-like receptor signaling pathway
mfot04713  Circadian entrainment
mfot04720  Long-term potentiation
mfot04723  Retrograde endocannabinoid signaling
mfot04724  Glutamatergic synapse
mfot04725  Cholinergic synapse
mfot04726  Serotonergic synapse
mfot04728  Dopaminergic synapse
mfot04730  Long-term depression
mfot04742  Taste transduction
mfot04750  Inflammatory mediator regulation of TRP channels
mfot04911  Insulin secretion
mfot04912  GnRH signaling pathway
mfot04915  Estrogen signaling pathway
mfot04916  Melanogenesis
mfot04918  Thyroid hormone synthesis
mfot04919  Thyroid hormone signaling pathway
mfot04921  Oxytocin signaling pathway
mfot04922  Glucagon signaling pathway
mfot04924  Renin secretion
mfot04925  Aldosterone synthesis and secretion
mfot04926  Relaxin signaling pathway
mfot04927  Cortisol synthesis and secretion
mfot04928  Parathyroid hormone synthesis, secretion and action
mfot04929  GnRH secretion
mfot04933  AGE-RAGE signaling pathway in diabetic complications
mfot04934  Cushing syndrome
mfot04935  Growth hormone synthesis, secretion and action
mfot04961  Endocrine and other factor-regulated calcium reabsorption
mfot04970  Salivary secretion
mfot04971  Gastric acid secretion
mfot04972  Pancreatic secretion
mfot04973  Carbohydrate digestion and absorption
mfot05010  Alzheimer disease
mfot05016  Huntington disease
mfot05017  Spinocerebellar ataxia
mfot05022  Pathways of neurodegeneration - multiple diseases
mfot05142  Chagas disease
mfot05143  African trypanosomiasis
mfot05146  Amoebiasis
mfot05163  Human cytomegalovirus infection
mfot05200  Pathways in cancer
mfot05415  Diabetic cardiomyopathy
mfot05417  Lipid and atherosclerosis
Module
mfot_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mfot00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126496688
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    126496688
   04310 Wnt signaling pathway
    126496688
   04371 Apelin signaling pathway
    126496688
   04020 Calcium signaling pathway
    126496688
   04070 Phosphatidylinositol signaling system
    126496688
   04072 Phospholipase D signaling pathway
    126496688
   04071 Sphingolipid signaling pathway
    126496688
   04022 cGMP-PKG signaling pathway
    126496688
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    126496688
   04081 Hormone signaling
    126496688
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    126496688
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126496688
   04613 Neutrophil extracellular trap formation
    126496688
   04621 NOD-like receptor signaling pathway
    126496688
   04062 Chemokine signaling pathway
    126496688
  09152 Endocrine system
   04911 Insulin secretion
    126496688
   04922 Glucagon signaling pathway
    126496688
   04929 GnRH secretion
    126496688
   04912 GnRH signaling pathway
    126496688
   04915 Estrogen signaling pathway
    126496688
   04921 Oxytocin signaling pathway
    126496688
   04926 Relaxin signaling pathway
    126496688
   04935 Growth hormone synthesis, secretion and action
    126496688
   04918 Thyroid hormone synthesis
    126496688
   04919 Thyroid hormone signaling pathway
    126496688
   04928 Parathyroid hormone synthesis, secretion and action
    126496688
   04916 Melanogenesis
    126496688
   04924 Renin secretion
    126496688
   04925 Aldosterone synthesis and secretion
    126496688
   04927 Cortisol synthesis and secretion
    126496688
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    126496688
   04270 Vascular smooth muscle contraction
    126496688
  09154 Digestive system
   04970 Salivary secretion
    126496688
   04971 Gastric acid secretion
    126496688
   04972 Pancreatic secretion
    126496688
   04973 Carbohydrate digestion and absorption
    126496688
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    126496688
  09156 Nervous system
   04724 Glutamatergic synapse
    126496688
   04725 Cholinergic synapse
    126496688
   04728 Dopaminergic synapse
    126496688
   04726 Serotonergic synapse
    126496688
   04720 Long-term potentiation
    126496688
   04730 Long-term depression
    126496688
   04723 Retrograde endocannabinoid signaling
    126496688
  09157 Sensory system
   04742 Taste transduction
    126496688
   04750 Inflammatory mediator regulation of TRP channels
    126496688
  09159 Environmental adaptation
   04713 Circadian entrainment
    126496688
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126496688
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    126496688
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    126496688
   05142 Chagas disease
    126496688
   05143 African trypanosomiasis
    126496688
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126496688
   05016 Huntington disease
    126496688
   05017 Spinocerebellar ataxia
    126496688
   05022 Pathways of neurodegeneration - multiple diseases
    126496688
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126496688
   05415 Diabetic cardiomyopathy
    126496688
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    126496688
   04934 Cushing syndrome
    126496688
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mfot04131]
    126496688
Enzymes [BR:mfot01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     126496688
Membrane trafficking [BR:mfot04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    126496688
 Endocytosis
  Macropinocytosis
   Phospholipase C
    126496688
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7
Other DBs
NCBI-GeneID: 126496688
NCBI-ProteinID: XP_049990181
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLYKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMRIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESADQEEEAHPEYKFGSELSADDYSHKEAVANSVKKTSD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQ
SSSELRPTTTAALGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLNQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGGRDGPQTSNSSM
KLQSAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagtgccgtccttcttgcaagaaggg
gcagtttttgaccgatacgaagaggaatctttcgtgtttgaacccaactgcctcttcaaa
gtggacgaatttggtttttttctgacctggaagagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcggctggcagccataccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc
tgcagtggtacagatctggtgaacattggcttcacttacatggtggctgaaaacccagaa
gtaactaagcaatgggtggaaggcctgagatcaatcattcacaacttcagggcaaacaac
gtcagtccgatgacatgcctcaagaaacactggatgaaactggcgtttctgaccaacacg
agtggtaaaattccagtgagaagtattactagaacctttgcatcagggaaaacggaaaag
gtgatctttcaagccctcaaggaattgggtctgcccagcggaaagaacgatgaaattgag
cctgccgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gacatagaagacctttataaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaacgaacaccagcgagatcctcggctgaatgaaattttattc
ccattttatgatgcgaaaagagcaatgcggatcattgagatgtatgagcccgacgaagac
ttgaagaaaaaaggccttatatcaagtgatggattttgcagatatctgatgtccgatgaa
aatgccccagtcttcctagatcgcttagaactttaccaggagatggatcaccccctggct
cactacttcatcagttcttcccacaatacctatctcaccggccggcagtttggcggaaag
tcttccgtggagatgtacagacaagttctcctggctgggtgcaggtgtgtggagcttgac
tgttgggatggaaaaggtgaagatcaggaaccaataataactcatgggaaggcaatgtgt
acggatatcctgtttaaggatgtgatccaagccatcaaggaaacagcgtttgtcacatca
gagtatcctgtaatcctctcctttgaaaaccactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggggatctcctgttgaaacaagccctcgaatcacat
ccacttgaaccaggcagacctttaccatcccctaatgacctcaaaagaaaaatactcatc
aaaaacaaaaggctgaaacctgaagtggaaaaaaagcagcttgaagctctgaagagcatg
atggaagccggagaatcagccgccccagcgagcatcttagaagatgacaacgaggaggag
atagaaagcgctgatcaagaagaagaagcccacccagagtacaaatttggaagtgaactg
tctgctgatgactacagtcacaaggaagcagttgccaacagcgtcaagaagacctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcatgg
atggcatcttataaatacgtaggtgctaccacgaatatccatccatacttgtccacaatg
atcaactacgcgcagcctgtgaagtttcaaggtttccatgtggctgaagagcgcaatatt
cactataacatgtcttcttttaacgagtcagttggccttggctacttgaagacacacgcg
attgaatttgtaaattacaataagcgacaaatgagccgcatttaccccaagggaggccga
gttgattccagtaattacatgcctcagattttctggaacgctggttgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaactgaatcagggaaaatttgagtataat
ggatcctgcgggtaccttctcaagccagatttcatgaggcggcctgaccggacgtttgat
cccttctctgaaacccctgtggatggggttattgcagccacatgctcagtacaggttata
tcagggcaattcctatcagataagaagatcggcacatacgtggaagtagacatgtatgga
ttgcctaccgacaccatacggaaggagttccggactcgcatggttatgaacaatggactc
aacccagtttacaatgaagaatcgttcgtgtttcggaaggtgatcctgcctgacctggcc
gtcctgagaattgcagtgtatgatgacaacaacaagctgattggccagcgaatccttcct
ttggatggcctccaagcaggctaccgacacatctccctaagaaatgaggggaacaaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatgggttc
ggagatattgtggatgctctatctgacccaaagaagtttctttcaatcacggaaaaaaga
gccgaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagcgac
acttccaaaaatgacaagaaaggcaaagccaacccagccaaagcaaacgtgacacctcag
agcagctctgagctcagaccgaccaccacggccgccctgggctctggccaggaagccaag
aaaggtattgaacttatccctcaagtgaggatagaagatttaaagcaaatgaaggcttac
ttgaagcatttaaagaaacaacagaaagagttaaactcattaaagaagaaacacgcaaag
gagcacagcaccatgcagaagttacactgcacacaagttgacaaaatcgtggcccagtac
gacaaagagaagtcaactcatgagaaaatactggagaaggcgatgaagaagaagggggga
agtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagaccctgacatcagat
cacaaatctaaggtcaaagagattgttgcccagcacacaaaagagtggtcagaaatgatc
aacacgcacagtgccgaggagcaagaaatccgggatctgcacttgaaccagcagtgtgag
ctgctgagaaagctgctcatcaacgctcatgagcaacagacccagcagctgaaactctcc
catgacagggaaagcaaggagatgcgagcccaccaggctaagatttctatggaaaatagt
aaagccatcagtcaagataaatctatcaagaataaggcagaaagggaaaggcgagtcagg
gagttgaacagcagcaacactaaaaagtttctagaagaaagaaagagactggcgatgaaa
cagtcgaaagaaatggatcaattgaaaaaagtccaactcgagcacctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaaattggaggccgagatggaccgcagaccagcaacagtagtatg
aaactccagagtgcaaactga

DBGET integrated database retrieval system