KEGG   Alexandromys fortis (reed vole): 126499912
Entry
126499912         CDS       T08493                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mfot  Alexandromys fortis (reed vole)
Pathway
mfot00562  Inositol phosphate metabolism
mfot01100  Metabolic pathways
mfot01521  EGFR tyrosine kinase inhibitor resistance
mfot01522  Endocrine resistance
mfot01524  Platinum drug resistance
mfot04012  ErbB signaling pathway
mfot04014  Ras signaling pathway
mfot04015  Rap1 signaling pathway
mfot04024  cAMP signaling pathway
mfot04062  Chemokine signaling pathway
mfot04066  HIF-1 signaling pathway
mfot04068  FoxO signaling pathway
mfot04070  Phosphatidylinositol signaling system
mfot04071  Sphingolipid signaling pathway
mfot04072  Phospholipase D signaling pathway
mfot04081  Hormone signaling
mfot04140  Autophagy - animal
mfot04150  mTOR signaling pathway
mfot04151  PI3K-Akt signaling pathway
mfot04152  AMPK signaling pathway
mfot04210  Apoptosis
mfot04211  Longevity regulating pathway
mfot04213  Longevity regulating pathway - multiple species
mfot04218  Cellular senescence
mfot04360  Axon guidance
mfot04370  VEGF signaling pathway
mfot04380  Osteoclast differentiation
mfot04510  Focal adhesion
mfot04550  Signaling pathways regulating pluripotency of stem cells
mfot04611  Platelet activation
mfot04613  Neutrophil extracellular trap formation
mfot04620  Toll-like receptor signaling pathway
mfot04625  C-type lectin receptor signaling pathway
mfot04630  JAK-STAT signaling pathway
mfot04650  Natural killer cell mediated cytotoxicity
mfot04660  T cell receptor signaling pathway
mfot04662  B cell receptor signaling pathway
mfot04664  Fc epsilon RI signaling pathway
mfot04666  Fc gamma R-mediated phagocytosis
mfot04668  TNF signaling pathway
mfot04670  Leukocyte transendothelial migration
mfot04722  Neurotrophin signaling pathway
mfot04725  Cholinergic synapse
mfot04750  Inflammatory mediator regulation of TRP channels
mfot04810  Regulation of actin cytoskeleton
mfot04910  Insulin signaling pathway
mfot04914  Progesterone-mediated oocyte maturation
mfot04915  Estrogen signaling pathway
mfot04917  Prolactin signaling pathway
mfot04919  Thyroid hormone signaling pathway
mfot04923  Regulation of lipolysis in adipocytes
mfot04926  Relaxin signaling pathway
mfot04929  GnRH secretion
mfot04930  Type II diabetes mellitus
mfot04931  Insulin resistance
mfot04932  Non-alcoholic fatty liver disease
mfot04933  AGE-RAGE signaling pathway in diabetic complications
mfot04935  Growth hormone synthesis, secretion and action
mfot04960  Aldosterone-regulated sodium reabsorption
mfot04973  Carbohydrate digestion and absorption
mfot05010  Alzheimer disease
mfot05017  Spinocerebellar ataxia
mfot05020  Prion disease
mfot05100  Bacterial invasion of epithelial cells
mfot05132  Salmonella infection
mfot05135  Yersinia infection
mfot05142  Chagas disease
mfot05146  Amoebiasis
mfot05160  Hepatitis C
mfot05161  Hepatitis B
mfot05162  Measles
mfot05163  Human cytomegalovirus infection
mfot05164  Influenza A
mfot05165  Human papillomavirus infection
mfot05166  Human T-cell leukemia virus 1 infection
mfot05167  Kaposi sarcoma-associated herpesvirus infection
mfot05168  Herpes simplex virus 1 infection
mfot05169  Epstein-Barr virus infection
mfot05170  Human immunodeficiency virus 1 infection
mfot05171  Coronavirus disease - COVID-19
mfot05200  Pathways in cancer
mfot05203  Viral carcinogenesis
mfot05205  Proteoglycans in cancer
mfot05206  MicroRNAs in cancer
mfot05207  Chemical carcinogenesis - receptor activation
mfot05208  Chemical carcinogenesis - reactive oxygen species
mfot05210  Colorectal cancer
mfot05211  Renal cell carcinoma
mfot05212  Pancreatic cancer
mfot05213  Endometrial cancer
mfot05214  Glioma
mfot05215  Prostate cancer
mfot05218  Melanoma
mfot05220  Chronic myeloid leukemia
mfot05221  Acute myeloid leukemia
mfot05222  Small cell lung cancer
mfot05223  Non-small cell lung cancer
mfot05224  Breast cancer
mfot05225  Hepatocellular carcinoma
mfot05226  Gastric cancer
mfot05230  Central carbon metabolism in cancer
mfot05231  Choline metabolism in cancer
mfot05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mfot05415  Diabetic cardiomyopathy
mfot05417  Lipid and atherosclerosis
mfot05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mfot00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126499912
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    126499912
   04014 Ras signaling pathway
    126499912
   04015 Rap1 signaling pathway
    126499912
   04370 VEGF signaling pathway
    126499912
   04630 JAK-STAT signaling pathway
    126499912
   04668 TNF signaling pathway
    126499912
   04066 HIF-1 signaling pathway
    126499912
   04068 FoxO signaling pathway
    126499912
   04070 Phosphatidylinositol signaling system
    126499912
   04072 Phospholipase D signaling pathway
    126499912
   04071 Sphingolipid signaling pathway
    126499912
   04024 cAMP signaling pathway
    126499912
   04151 PI3K-Akt signaling pathway
    126499912
   04152 AMPK signaling pathway
    126499912
   04150 mTOR signaling pathway
    126499912
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    126499912
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    126499912
  09143 Cell growth and death
   04210 Apoptosis
    126499912
   04218 Cellular senescence
    126499912
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    126499912
   04550 Signaling pathways regulating pluripotency of stem cells
    126499912
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    126499912
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126499912
   04613 Neutrophil extracellular trap formation
    126499912
   04620 Toll-like receptor signaling pathway
    126499912
   04625 C-type lectin receptor signaling pathway
    126499912
   04650 Natural killer cell mediated cytotoxicity
    126499912
   04660 T cell receptor signaling pathway
    126499912
   04662 B cell receptor signaling pathway
    126499912
   04664 Fc epsilon RI signaling pathway
    126499912
   04666 Fc gamma R-mediated phagocytosis
    126499912
   04670 Leukocyte transendothelial migration
    126499912
   04062 Chemokine signaling pathway
    126499912
  09152 Endocrine system
   04910 Insulin signaling pathway
    126499912
   04923 Regulation of lipolysis in adipocytes
    126499912
   04929 GnRH secretion
    126499912
   04915 Estrogen signaling pathway
    126499912
   04914 Progesterone-mediated oocyte maturation
    126499912
   04917 Prolactin signaling pathway
    126499912
   04926 Relaxin signaling pathway
    126499912
   04935 Growth hormone synthesis, secretion and action
    126499912
   04919 Thyroid hormone signaling pathway
    126499912
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    126499912
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    126499912
  09156 Nervous system
   04725 Cholinergic synapse
    126499912
   04722 Neurotrophin signaling pathway
    126499912
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126499912
  09158 Development and regeneration
   04360 Axon guidance
    126499912
   04380 Osteoclast differentiation
    126499912
  09149 Aging
   04211 Longevity regulating pathway
    126499912
   04213 Longevity regulating pathway - multiple species
    126499912
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126499912
   05206 MicroRNAs in cancer
    126499912
   05205 Proteoglycans in cancer
    126499912
   05207 Chemical carcinogenesis - receptor activation
    126499912
   05208 Chemical carcinogenesis - reactive oxygen species
    126499912
   05203 Viral carcinogenesis
    126499912
   05230 Central carbon metabolism in cancer
    126499912
   05231 Choline metabolism in cancer
    126499912
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126499912
  09162 Cancer: specific types
   05210 Colorectal cancer
    126499912
   05212 Pancreatic cancer
    126499912
   05225 Hepatocellular carcinoma
    126499912
   05226 Gastric cancer
    126499912
   05214 Glioma
    126499912
   05221 Acute myeloid leukemia
    126499912
   05220 Chronic myeloid leukemia
    126499912
   05218 Melanoma
    126499912
   05211 Renal cell carcinoma
    126499912
   05215 Prostate cancer
    126499912
   05213 Endometrial cancer
    126499912
   05224 Breast cancer
    126499912
   05222 Small cell lung cancer
    126499912
   05223 Non-small cell lung cancer
    126499912
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126499912
   05170 Human immunodeficiency virus 1 infection
    126499912
   05161 Hepatitis B
    126499912
   05160 Hepatitis C
    126499912
   05171 Coronavirus disease - COVID-19
    126499912
   05164 Influenza A
    126499912
   05162 Measles
    126499912
   05168 Herpes simplex virus 1 infection
    126499912
   05163 Human cytomegalovirus infection
    126499912
   05167 Kaposi sarcoma-associated herpesvirus infection
    126499912
   05169 Epstein-Barr virus infection
    126499912
   05165 Human papillomavirus infection
    126499912
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    126499912
   05135 Yersinia infection
    126499912
   05100 Bacterial invasion of epithelial cells
    126499912
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    126499912
   05142 Chagas disease
    126499912
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126499912
   05017 Spinocerebellar ataxia
    126499912
   05020 Prion disease
    126499912
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126499912
   05418 Fluid shear stress and atherosclerosis
    126499912
   05415 Diabetic cardiomyopathy
    126499912
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    126499912
   04932 Non-alcoholic fatty liver disease
    126499912
   04931 Insulin resistance
    126499912
   04933 AGE-RAGE signaling pathway in diabetic complications
    126499912
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126499912
   01524 Platinum drug resistance
    126499912
   01522 Endocrine resistance
    126499912
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mfot04131]
    126499912
Enzymes [BR:mfot01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     126499912
Membrane trafficking [BR:mfot04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    126499912
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 126499912
NCBI-ProteinID: XP_049995367
LinkDB
Position
Unknown
AA seq 1070 aa
MCLGSIMPPAMADILDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISSIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNLTPIKINELAIQKRLTIHGKEDE
VSPYDCVLQVSGRVEYVFGEYPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRVISHVWDNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKMHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPDNKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALDNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYSSRGFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgccttggctctataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatcgcatctgatggcgccatatctgtggatttccttctgcccactgggatc
tatatccagctggaagtacctcgggaagctaccatttcttctattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggacattgactcctacatgttt
gcatgtgtgaatcaaactgctgtatacgaggaacttgaagatgaaactcgaagactttgt
gatgtcagaccttttcttcctgttctaaaactagtgacaagaagttgtgacccagcagaa
aaattggactcaaaaattggagtacttatagggaaaggtcttcatgaatttgatgccttg
aaggatcctgaagtgaatgagtttagaagaaaaatgcgcaaattcagtgaggacaagatt
cagtctctggtggggctgtcttggattgactggctgaagcacacgtacccacctgagcac
gagccgtctgtcctggagaacttggaggataaactttatggagggaagctgattgtggct
gtgcattttgaaaatagccaggatgtatttagttttcaagtgtctcccaatttaactcct
ataaaaataaatgaattggcaatccagaaacgcttgactattcatggaaaggaagatgaa
gttagcccctatgactgtgtgttacaagtcagcgggagagtggagtatgtatttggagaa
tacccactaattcagttccagtatatccggaactgtgtgatgaataggaccctgccccat
ttcatcctcgtggaatgttgcaagatcaagaaaatgtatgagcaagaaatgattgccata
gaggctgccatcaaccggaactcatctaaccttcctctgcccttaccaccaaagaaaacg
cgagttatttctcatgtctgggacaacaacaaccctttccaaattgtcttggtgaaagga
aataagcttaacacagaagaaactgtgaaagttcatgtcagagctggtctttttcatgga
actgagctcctgtgcaaaactgttgtaagctcggagatatcaggaaaaaacgaccatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgctgttttggataaagtaaaaacgaagaaatcaacaaaaactatt
aatccctctaaatatcagaccatcaggaaagctgggaaaatgcattatcctgtagcgtgg
gtaaataccatggtttttgacttcaaaggacagttgagatctggagacgtcatactgcac
agctggtcgtcctttcctgatgagctggaagagatgctaaatcccatgggcactgtgcag
acgaacccatatactgaaaatgcaactgccttgcatattaagttcccagataataaaaag
cagccttattactaccctcccttcgataagatcattgagaaggcagctgagattgccagc
ggcgacagtgctaatgtgtcaagtcgtggtggaaaaaaattcctcgctgtactgaaagaa
atcttggacagggaccccctgtctcagctatgtgagaacgaaatggatcttatttggact
ctacggcaagattgccgagaaaatttcccacagtcactgccaaaactactcctgtcaatc
aagtggaataaactcgaagatgttgctcagcttcaggcactcctgcagatttggcccaaa
ctgccccccagggaagcactggagctcctggatttcaactatccagatcagtacgtccgg
gaatatgctgtgggctgcctgcgacagatgagtgatgaagagctctctcagtatcttcta
cagttggtgcaagttttgaaatacgagccttttcttgattgtgccctctctagattcctg
ctagaaagagcacttgataatcgaaggattgggcagttcctgttttggcatcttaggtca
gaagtgcatattcccgccgtgtctgtccagtttggggtcatccttgaagcgtactgtcga
ggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
acgttaaatagcttaatcaaattgaatgccgtgaagctcaacagagctaaaggaaaggag
gctatgcacacctgtttaaagcagaacgcttaccgggaggccctctctgaccttcagtcg
cctctgaatccgtgtgtcatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaagatgaagcccttgtggctggtctacagcagcagaggttttggagaggactcggtt
ggagtgatctttaaaaatggtgatgatttgcggcaggacatgctgacgctgcagatgcta
cgcctgatggatctactctggaaagaggctggtttggaccttcggatgcttccctatggc
tgtttagcaacaggagatcgctctggcctcattgaggttgtgagtacctctgagacaatc
gctgacattcagctgaacagtagcaatgtggctgccacagcagccttcaacaaagacgca
ctcctgaactggcttaaggagtacaactctggggatgacctggaccgagcaattgaggag
ttcaccctgtcctgtgctggctactgtgtagcttcttatgtccttggcattggtgacagg
catagtgacaacatcatggtgaaaaaaaccggccagctcttccacatagattttggacat
attcttggaaatttcaaatctaaatttggcattaaaagagagcgagtaccttttatcctt
acttatgacttcattcatgtcattcagcaaggaaaaacaggaaatacagaaaaatttggc
aggtttcgccagtgctgtgaagatgcctatctgattttaaggcggcatgggaacctcttc
atcactctctttgcactgatgttgactgcagggcttcctgagcttacgtcagtcaaagat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacag
tttaagcagaaatttgatgaggccctcagggaaagctggactaccaaggtgaactggatg
gctcacacagttcgcaaagactacaggtcttag

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