Alexandromys fortis (reed vole): 126500753 Help Entry 126500753         CDS       T08493                                  Name (RefSeq) huntingtin isoform X1   KO K04533   huntingtin Organism mfot  Alexandromys fortis (reed vole) Pathway mfot05016   Huntington disease mfot05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mfot00001]  09160 Human Diseases   09164 Neurodegenerative disease    05016 Huntington disease     126500753    05022 Pathways of neurodegeneration - multiple diseases     126500753  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03019 Messenger RNA biogenesis [BR:mfot03019]     126500753    04131 Membrane trafficking [BR:mfot04131]     126500753    03029 Mitochondrial biogenesis [BR:mfot03029]     126500753 Messenger RNA biogenesis [BR:mfot03019]  Eukaryotic type   mRNA surveillance and transport factors    mRNA cycle factors     Common to processing body (P body) and stress granule      126500753 Membrane trafficking [BR:mfot04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     126500753 Mitochondrial biogenesis [BR:mfot03029]  Mitochondrial quality control factors   Regulator of mitochondrial biogenesis    Other regulator of mitochondrial biogenesis     126500753 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Htt_C-HEAT Htt_N-HEAT Htt_bridge Htt_N-HEAT_1 HEAT HEAT_GCN1 HEAT_EF3_N Motif Other DBs NCBI-GeneID:  126500753 NCBI-ProteinID:  XP_049996848 LinkDB All DBs Position Unknown AA seq 3119 aa AA seqDB search MATLEKLMKAFESLKSFQQQQQQQQQPPPPPPPPQPPQPPPQGQPPPHAPPPPPLPGPAE EPQNRPKKELSATKKDRVSHCLTICENIVAQSLRNSPEFQKLLGIAMELFLLCSDDAESD VRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC RPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSS SPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLGLLVPIEEEHSTLLILGVLLTLRCLV PLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQ LFRTPPPELLQALTTPGGLGQLAVVQEEARGRGRSGSIVELLAGGGSSCSPVLSRKQKGK VLLGEEEALEDDSESRSDVSSSAFAASVKSEIGGELATSSGVSTPGSVSHDIITEQPRSQ HTLQADSVDLSSCDLTSAATDGDEEDILSHSSSQFSAVPSDPAMDLNDGTQASSPISDSS QTTTEGPDSAVTPSDSSEIVLDGADSQYLGMQIGQPQEEDEEEAAGVLSSEVSDVFRNSS LALQQAHLLERMGHNRQPSDSSIDKLISRDEVAEANDPESKACRIKGDIGQPNDDDSAPL VHCVRLLSASFLLTGEKKALVPDRDVRVSVKALALSCIGAAVALHPESFFGKLYKVPLDT MESAEEQYVSDILNYIDHGDPQVRGATAILCGTLIYSILSRSRLRVGDWLGNIRTLTGNT FSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSY WLVRTELLETLAEIDFRLVSFLEAKAESLHRGAHHYTGFLKLQERVLNNVVIYLLGDEDP RVRHVAAASLTRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTIT RIYRGYSLLPSITDVTMENNLSRVVAAVSHGLITSTTRALTFGCCEALCLLSAAFPVCSW SLGWHCGVPPLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASA PRSLRSSWACEEEANSASTRQEEVWPALGDRTLVPMVEQLFSHLLKVINICAHVLDDVTP GPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASAPMSPKKGGEASAASRQSDTSGPVTA SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELA TLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLASNPSKSQCR AQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQEHDASGWFDVLQKVSAQL KTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVN YCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKII QLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQY HQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMHIDSHEALGVLNTLFEIL APSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSF SPYLISCPVISRLREGDGNSTLGERSEGRQTKNLPEETFSRFLLQLVGILLEDIVTKQLK VEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTSDGCEGSFYTLENLNAR VRSMVPTHPALVLLWCQILLLINHTDHRWWAEVQQTPKRHSLSCTKSLNPQMSGEEEDSG SAAQLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFIS AIHRNSAASGLFIQAIQSRCENLSTPTTLKKTLQCLEGIHLSQSGAVLTLYVDRLLGTPF RALARMVDTLACRRVEMLLAANLQSSMAQLPVEELNRIQEHLQNSGLAQRHQRLYSLLDR FRLSTVQDSLSPLPPVTSHPLDGDGHTSLETVIPDKDWYLQLVRSQCWTKSDSALLEGAE LVNRIPAEDMNDFMMSSEFNLSLLAPCLSLGMSEIATGQKSHLFEAARGVTLDRVTSVVQ QLPAVHQVFQPSLPIEPTAYWSKLNDLLGDAASYQSLTTLARALAQYLVVVSKVPAHLHL PPDKEGDIVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQVPGLWGLLSSPEYV THACSLIHCVRFILEAIAVQPGDQLLGPESRSDTPRAIRKEGGDSNIQNPSYITSACEMV AEMVESLQSLLALGHKRNSTLPSFLTAVLKNIVISLARLPLVNSYTRVPPLVWKLGWSPK PGGDFGTVFPEIPVEFLQEKEILKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVME QEENPPEEDTERTQIHVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRNKPLKVLDTRF GRKLSMIRGIVEQEIQEMVSQRENTATHHSHQAWDPVPSLLPATTGALISHDKLLLQINS ERELGNMSYKLGQVSIHSVWLGNNITPLREEEWDEEEEEEADVPAPTSPPVSPVNSRKHR AGVDIHSCSQFLLELYSRWILPSSTARKTPVILISEVVRSLLVVSDLFTERTQFEMMYLT LTELRRVHPSEDEILIQYLVPATCKAAAVLGMDKTVAEPVSRLLESTLRSSHLPSQIGAL HGILYVLECDLLDDTAKQLIPVVSEYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLMENY PLDVGPEFSASVIQMCGVMLSGSEESTPSIIYHCALRGLERLLLSEQLSRLDTESLVKLS VDRVNVQSPHRAMAALGLMLTCMYTGKEKASPGRTSDPSPATPDSESVIVAMERVSVLFD RIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYPQFMATVVYKVFQTL HSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHIISRMGKL EQVDVNLFCLVATDFYRHQIEEEFDHRAFQSVFEVVAAPGSPYHRLLACLRNVHKVTTC NT seq 9360 nt NT seq  +upstreamnt  +downstreamnt atggcaacccttgaaaagctgatgaaggctttcgagtcgctcaagtcgttccaacagcag caacagcagcagcagcagccgccgccaccaccgccaccgcctcaaccccctcagccgccg cctcaggggcagccgccaccgcatgcaccgccgccaccgccgctgccgggtccggccgag gagccgcagaaccgaccaaagaaggaactctcagccaccaagaaggaccgtgtgagtcat tgtctaacaatatgtgaaaatattgtggcacagtctctcagaaattctccagaatttcag aaactcttgggcattgctatggaactgtttctgctgtgcagcgacgatgcggagtcagac gtcaggatggtagctgatgagtgcctcaacaaagtcatcaaagcattgatggattctaat cttccaaggctacagctagaactctataaggaaattaaaaagaatggtgctcctcgaagt ttgcgtgcagccctgtggaggtttgctgagctggctcacctggttcgacctcaaaaatgc aggccttacctagtgaaccttcttccgtgcctgacccgaacaagcaagagacctgaggaa tcagttcaggagaccttggctgcagctgttcccaaaattatggcttcttttggaaatttt gcaaatgacaatgaaattaaggttctgttgaaagctttcatagcaaatctgaagtcaagt tctcccactgtccgacggacagcagctggctcagcagtgagcatctgccagcactccagg aggacacagtacttctataattggctcctaaatgtgctcctaggtctgctggttcccata gaagaagaacattccactctcctgatcctcggtgtcttgctcacattgaggtgtctagtg cccttgctccagcagcaggtcaaggacacaagtctaaaaggcagttttggagtaacacgg aaagaaatggaagtttctccttctgcagagcagcttgtccaggtttatgagctgactttg catcacacgcagcaccaagaccacaatgtggtgacaggggctctggagctcttgcagcag ctcttccgtactcctcctcctgagctgctgcaagcactgacaacaccaggtggtcttggg cagctcgctgtggttcaagaggaggccaggggccgaggccgcagtgggagcattgtggaa cttttagctggagggggttcctcgtgcagccctgttctctcaagaaaacaaaaaggcaaa gtgctcctaggagaagaagaagccttggaagatgactcggagtccaggtcagatgtcagc agctcagcctttgcagcctctgtgaagagtgagattggtggagagcttgctacttcttca ggtgtctccactcctggttctgtaagtcatgacatcatcactgagcagccacggtcccag cacacacttcaagcagactctgtggatttgtcgagctgtgacttgaccagtgctgctact gatggagatgaggaggacatcttgagccatagctccagccagttcagtgctgtcccatcc gaccctgctatggacctgaatgatgggacccaggcctcctcacccatcagtgacagctct cagaccaccactgaagggcctgattcagctgtgactccttcagacagttctgaaattgta ttagatggtgctgacagccagtatttaggcatgcagataggacagccacaggaggaagat gaggaggaggctgcgggtgttctttccagtgaagtatcagatgttttcagaaactcttcc ctggcccttcaacaagcacacttactggagagaatgggtcataacagacaaccttctgat agcagtatagataagcttatatccagagatgaagttgctgaagcgaatgacccagaaagc aaggcttgccgaatcaaaggtgacatagggcagcctaatgatgatgattctgctcctctg gtccattgtgtccgcctgttatctgcttcctttttgttaactggggaaaagaaagcactg gttccagacagagatgtgagggtcagtgtgaaggccctggccctcagctgtattggtgca gccgtggcccttcatccagaatctttcttcggcaaactgtataaagtacctcttgacacc atggaaagtgctgaggaacagtatgtctctgacatcttgaactacatcgatcatggagac ccacaggtccgaggagctactgccattctctgtggaaccctcatctactcgatactcagc aggtctcgactccgtgttggcgactggctgggcaacattagaacactgacaggaaataca ttctctctggtggactgcattcctttgctgcagaaaactttgaaggatgagtcttctgtt acttgcaagttggcttgtacagctgttaggcactgtgtcctgagtctttgcagtagcagc tacagtgacttgggattacaactgctcattgatatgttgcctctgaagaacagctcctac tggttggtgaggactgaactgctggaaacccttgcagagattgacttcaggctggtgagt tttttggaggcaaaagcagaaagcttacaccgaggggctcatcattatacagggttttta aaactacaagaacgagtgcttaataatgtggtcatttatttgcttggagatgaagacccc agggtgcgacatgttgccgcagcatcgctaacaaggcttgtcccaaagctgttctataaa tgtgaccaaggacaggctgatccagtagtggctgtagcaagagatcaaagcagtgtttac ctgaaactcctcatgcacgagacgcagccaccatcacacttctctgtcagcaccataacc agaatctatagaggttatagtttactaccaagcataacagatgtcactatggaaaacaac ctctcaagagttgttgctgcagtttctcatggactcattacatccaccacacgggcactc acatttggatgttgtgaagccttgtgtcttctttcagcagcctttccagtttgcagttgg agcttaggttggcattgtggagtgcccccactgagtgcctctgatgagtccaggaagagc tgcactgttgggatggcttccatgattctcaccctgctttcatcagcttggttcccattg gatctctcagcccatcaggatgccttgattttggctggaaacttgcttgcggccagtgcc cccaggtctctgagaagttcatgggcctgtgaagaagaagccaattcagcatctaccaga caggaggaagtttggcctgctctgggtgaccggacactggtgcccatggtagaacagctt ttctcccacctgctgaaagtgatcaatatctgtgctcacgtcttggatgatgtgactcct ggaccagcaatcaaggcagctttgccttctctaacaaaccccccttctctaagtcctatt cgtcggaaagggaaagagaaagaaccaggagaacaagcttctgctccaatgagtcccaag aaaggtggtgaggccagtgcagcctctcgacaatcagacacctcaggacctgtcacagca agtaaatcttcttcattggggagtttctaccatctcccttcctacctcaaactccatgat gtcctgaaagccactcatgccaactataaggtcaccttagatcttcagaacagcactgaa aagtttggggggttcctgcgctctgccttggacgtcctctctcagattctagagctggca acactgcaggacattggaaagtgtgttgaagaggtccttggatacctgaaatcctgcttt agtcgagaaccgatgatggcaactgtctgtgttcagcagctattgaagactctctttggg acaaacttggcctcacagtttgatggcttggcttccaaccccagcaagtctcaatgccga gcacagcgtcttggctcttccagtgtgaggccaggcttatatcactactgcttcatggca ccatacacgcacttcacgcaggccttggctgatgccagcctgaggaacatggtgcaggcg gagcaggagcatgatgcctcggggtggtttgatgtactccagaaagtatctgcccaactg aagacgaacctcacaagcgtcacaaagaaccgtgcagataagaatgctattcacaatcac attagattatttgagcctcttgttataaaagctttgaagcagtacaccaccacgacatct gtacagttacagaagcaggttttggatttgcttgcacaactggttcagctgcgggtcaat tactgtctgctggattcggatcaggtgttcatcggttttgtgctgaagcagtttgagtac attgaagtgggccagttcagggaatcagaggcaattattccaaatatatttttcttcctg gttttactgtcttatgagcgctaccattcaaaacagatcattggaattcctaaaatcatc cagctatgtgatggcatcatggccagtggaaggaaggctgttacacatgccatacctgct ctgcagcccattgtccatgacctgtttgtgttaagaggaacaaacaaagctgatgcaggg aaagagcttgaaacccagaaggaggtggtggtgtcgatgcttttgagactcatccagtac catcaggtgctggagatgtttatcctcgttctgcagcagtgccacaaagagaacgaggac aagtggaaacggctatctcggcaggtcgccgacatcatcctgcccatgttagccaagcag cagatgcacattgattctcatgaagcccttggagtattaaataccttgtttgagattctg gctccttcctcactacgtcccgtggatatgcttttgcggagtatgttcatcactccaagc actatggcttctgtaagcaccgtgcagctgtggatatctggaatcctagccattctgagg gttctcatttcccagtcaaccgaagatattgttctttctcgtattcaggaactctccttc tctccatatttaatctcctgtccagtaattagcaggttaagagagggagacggtaattca acattaggagaacgcagtgaagggagacaaacgaagaatttgccagaagaaacattctca aggtttcttttacagttagttggaattcttttagaagacattgtcacaaaacagctcaaa gtggaaatgagtgaacagcagcatacattctactgtcaagagctaggcacactgctcatg tgtctcatccacatcttcaaatctggaatgtttcggagaatcacagcagctgccactaga ctcttcaccagtgatggctgtgaaggcagcttctatactctagagaacctcaatgcacgg gttcgatccatggtgcccacgcacccagccctggtactgctctggtgtcagatcctgctg ctcatcaatcacactgaccaccgatggtgggcagaggtgcagcaaacacccaaaaggcac agtttgtcctgcacgaagtcacttaacccccagatgtctggtgaagaggaggattctggc tcagcagctcagcttggaatgtgcaatagagaaatagtgcgaagaggggcccttattctc ttctgtgattatgtctgtcagaatctccatgactcagaacacttaacgtggctcattgta aatcacattcaagatctgatcagcttgtcccatgagccaccagtacaagactttattagt gccattcatcgtaattctgcggctagtggccttttcatccaggcaattcagtctcgttgt gaaaatctttcaactccaaccactctgaagaaaacacttcagtgcttggaaggcatccat ctcagccagtctggtgctgtgctcacgttgtatgtggacaggctcctgggcactcccttc cgtgcgctggctcgcatggtcgacactctggcctgtcgccgcgtagaaatgcttttggca gcaaatttacagagcagcatggcccagttgccagtggaagaactgaacagaatccaggag cacctccagaatagtgggcttgcacaaagacaccaaaggctctactccctgctggacagg ttccgactctctaccgtgcaggactcacttagccccttgcccccagttacttcccaccca ctggatggggatgggcacacatctttggaaacagtgattccagacaaagactggtacctt cagcttgtaagatcccagtgttggaccaaatcagattctgcactgctggaaggtgcagag ttggtgaatcgcatccctgctgaagacatgaatgacttcatgatgagctcggagttcaac ctaagccttttggctccttgcttaagccttggcatgagtgagattgctactggccagaag agtcacctttttgaagcagcccgtggtgtgactctggaccgggtgaccagtgttgttcag cagcttcctgctgtccatcaagtcttccagccttctctgcctatagagcccacagcctac tggagcaagttgaatgatctacttggtgatgctgcatcataccagtctctgaccacactt gcccgtgccctggcacaatacctggtggtggtctccaaagtgcctgctcatttgcacctt ccccctgacaaggagggggacatagtgaagtttgtggtaatgacacttgaggctctgtca tggcatttgatccatgagcagatcccactgagtctggacctccaagccgggctagactgc tgctgcctggcactacaggtgcctggcctctggggactgctgtcctccccagagtatgtg acccatgcctgctccctcatccactgcgtgcgattcatcctggaagccattgcagtgcag cctggggaccagcttctcggtccagaaagcaggtcagatactccaagggctatcagaaag gaaggaggagactcaaacatacaaaatcccagttatatcacttcagcctgcgagatggtg gcagagatggtggaatccctgcagtcactgctggccttgggccacaaaaggaacagtact ctgccttcattcctcacggcagtgcttaagaatattgtcatcagtctggcgcgtctcccc ctggtcaacagctatacgcgtgttccccctctggtatggaaacttgggtggtcacccaaa cctggaggggattttggcacagtgttccctgagatccctgtagaattcctccaggagaag gagatcctcaaggagttcatctatcgcatcaacaccctagggtggaccagtcgtacccag tttgaagaaacttgggccaccctccttggtgtcttggtgacccagcccctggtgatggaa caggaggagaacccaccagaggaagatacagaaaggacccagatccatgtcctggctgtg caggccatcacctctctagtgctcagtgcaatgactgtgcctgtggctggcaatccagct gtaagctgcttggagcaacagccccggaacaagcctctgaaggttctcgataccagattt ggaagaaaattgagcatgatcagagggattgtagaacaagagatccaagaaatggtttcc cagagagagaatactgccactcaccattctcaccaagcctgggatcctgtcccttccctg ttgccagctactacaggtgccctcatcagccatgacaaactactactgcagatcaactca gagcgggagctaggcaacatgagctacaagctgggccaggtatccatacactctgtgtgg ctagggaacaatatcacacccctgagagaggaggaatgggatgaagaggaagaggaagag gctgatgttcctgcaccaacatcaccacctgtgtctccagtcaattccagaaaacaccgt gctggggttgatattcactcctgttcgcagtttctgcttgaattgtacagccgctggatc ctgccatccagtacagccagaaagacccctgtcatcctgatcagtgaagtggttcgatct cttctcgtggtgtcagacttattcactgaacgcacccagtttgaaatgatgtatctaacg ctgacagaacttcggagagtgcacccttcagaagatgaaatcctcattcagtacctagta cctgccacttgtaaggcagctgctgtccttggtatggacaaaactgtggcagaaccagtc agccgcctactggagagcacactcaggagcagccacctccccagccagatcggagccctg catggcatcctttatgtgttggagtgtgaccttttggatgacactgcaaagcagctcatt ccagttgttagtgaatatctactgtccaacctcaaaggaatagcccactgcgtgaacatt cacagccagcagcatgtgctggtgatgtgtgccactgcgttctatctgatggaaaactat cctctggatgtggggccagaattttcagcatctgtgatacagatgtgtggagttatgctg tctggaagtgaagagtccaccccctccatcatttaccactgtgccctccggggtctggag cgtctcctgctgtctgagcaactctctcgcttagatacagagtctttggtcaagctaagc gtggacagagtcaatgtacaaagcccacatcgggccatggcagccctaggcctgatgctc acctgcatgtacacaggaaaagaaaaagctagtccgggcagaacctctgaccccagccct gctacgcctgatagtgagtctgtgatcgttgctatggagcgggtgtctgttctctttgac aggatccgcaaggggtttccctgtgaagccagggtcgtggcaaggatcctgcctcagttc ctagacgacttcttcccaccccaagatgtcatgaacaaagtcattggagagtttctgtcc aaccagcagccatacccacaattcatggccactgtcgtatacaaggtttttcagactctg cacagtgctgggcagtcatccatggtcagggactgggtcatgctgtccctgtccaacttc acacaaagaactccagttgccatggccatgtggagcctctcctgcttccttgtcagcgca tctaccagcccatgggtttcagcgatcctcccacacatcatcagcaggatgggcaaactg gagcaggtggatgtgaaccttttctgcctggttgccacagacttctacagacaccagata gaggaggaattcgaccacagggctttccagtctgtgtttgaggtggtggcggcaccagga agtccataccaccggctgcttgcttgtttgcgaaatgtccacaaggtcaccacctgctga

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