Alexandromys fortis (reed vole): 126515251
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Entry
126515251 CDS
T08493
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
mfot
Alexandromys fortis (reed vole)
Pathway
mfot00230
Purine metabolism
mfot00670
One carbon pool by folate
mfot01100
Metabolic pathways
mfot01523
Antifolate resistance
Module
mfot_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mfot00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
126515251
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
126515251
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
126515251
Enzymes [BR:
mfot01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
126515251
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
126515251
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
126515251
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_2
ATP-grasp_3
Dala_Dala_lig_C
ATP-grasp_4
RimK
ATP-grasp_5
LUD_dom
Motif
Other DBs
NCBI-GeneID:
126515251
NCBI-ProteinID:
XP_050020741
LinkDB
All DBs
Position
Unknown
AA seq
1004 aa
AA seq
DB search
MAARVLVIGSGGREHTLAWKLAQSLHVKQVLVAPGNAGTACSGKISNAAVSVDDHAVLAQ
FCKDEKIEFVVVGPEAPLAAGIVGDLTCAGVRCFGPTAQAAQLESSKKFAKEFMERHGIP
TAQWRAFTKPEDACSFIMSANFPALVVKASGLAAGKGVIVAKNKEEACKAVREIMQEKSF
GAAGETVVVEEFLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDEGPNTGGMGAYCPTP
QVPKDLLLKIKDTILQRTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIRSTLDGQLSASLPVWLENHTAITVVMASKGYPGAYSKGVEITGFPEA
QALGLQVFHAGTALKDGRVVTSGGRVLTVTAVQENLESARDEARKGLAAIKFEGAVYRKD
IGFRAVAFLQRPRGLTYKESGVDIAAGNMLVKKIQPLAKATSRPGCTVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHGTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLTTTEAVIAGIAGACRQAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
QLERIVEGDVVVGVASSGLHSNGFSLVRKIVARSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVIRSGRVKALAHITGGGLLENIPRVLPRELGVDLDAGTWRIPKVFSWLQQEG
QLSEEEMARTFNCGVGAALVVSKDQADQILHDIRQRQEEAWVIGSVVACPKDSPRVRVKN
LIETMQVNGSVVSNGFLRSKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVVVISNKAG
VAGLDKAEKAGIPTRVINHKLYKNRVEFDNAVDLVLEEFSVDMVCLAGFMRILSGPFVRK
WDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRG
DTVATLSERVKVAEHKIFPAALQLVASGAVRPGEDGKVHWVREQ
NT seq
3015 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagttcttgtgattggcagtggaggaagggaacatactctggcctggaaa
cttgcacagtctcttcatgtcaaacaagtgttggttgcccccggaaatgcaggcactgcc
tgttctggaaagatctcaaatgctgctgtctccgtcgatgatcatgctgtccttgctcag
ttctgcaaagatgagaagatcgagtttgtggtggttggaccagaggcccctctcgctgca
gggattgttggggacctgacctgtgcaggagtacggtgctttggccccacagcacaagca
gctcagttagagtccagtaaaaagtttgccaaagaatttatggagcgacatggaatccca
actgcacagtggagagcattcaccaaacctgaagatgcctgcagctttattatgagcgca
aactttcctgctttggttgtgaaggccagtggccttgcagctgggaaaggggtgattgtt
gcaaagaacaaagaggaggcctgcaaagctgtacgggagatcatgcaggaaaagtctttt
ggagcagctggagaaacggttgttgtggaagagttcctggacggggaagaagtgtcttgt
ctgtgtttcactgatgggaagacagtggccccaatgcctccagcacaggaccataagcga
ttgctggatggggatgagggccccaacacagggggaatgggagcctactgccctacacct
caggttcctaaggatttgttactaaaaattaaagacactattcttcagagaacagtagac
ggcatgcagcaggaaggtgtgccttacacaggaattctctatgctggtataatgctgacc
aaagatggcccaaaagttttggagtttaattgccgttttggtgatccagaatgccaagta
atcctcccacttcttaaaagtgacctttatgaagtgattcggtccaccttagatggccag
ctgagtgcgtctctgcctgtttggctagaaaaccacactgccataaccgttgtcatggca
agtaaagggtatcctggagcctacagcaagggtgtggagataacaggctttcctgaggcc
caagctttaggactccaggtattccatgcgggcactgctcttaaagatggcagagtggtg
actagcgggggcagagtcctcacggtaacagccgtccaggagaatcttgagtcagcccgt
gacgaagccaggaaaggccttgctgccataaagtttgagggcgcagtttataggaaggac
attggcttccgtgctgtagccttcctccagcggcccaggggcctgacttacaaggaatct
ggggtagacattgcagccggaaatatgctggttaagaaaattcagcctttagcaaaagcc
acctccagaccaggctgcactgttgaccttggaggctttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctctcctggcgtctggaacagatggtgttgggactaaactg
aagattgcccagctgtgcaataagcatggcaccatcggtcaggatctggtcgcaatgtgt
gtaaacgacatcctcgcacagggagctgagcccctcttcttcctcgattacttttcctgt
ggaaaactcgacctcactacgactgaagctgtcatcgctggaattgctggagcctgtaga
caagctggctgtgctctcctgggtggagagaccgcagagatgcccgacatgtaccctcct
ggcgagtatgacctcgctgggtttgctgttggcgctatggagagggatcagaaactccct
cagctagaaaggattgtcgaaggggatgttgtggttggggtagcctcgtctggtcttcac
agcaatggctttagccttgtgaggaagattgtggcgaggtcttctctccagtactcctct
ccagcgcctgatggatgtggcgaccagactttaggggacttgcttctaactccaaccagg
atctacagccattcgctgttgcctgtcatacggtcaggacgtgtcaaagccttggctcac
attactggaggtggattgctggaaaacatccccagagtccttcctcgggagcttggagta
gatttagatgctggcacctggaggatccccaaggtcttttcatggttacagcaggaagga
cagctctctgaagaagaaatggccagaactttcaactgtggggttggagctgccttggtg
gtgtctaaggaccaggcagaccagattctgcatgacattcggcagcgccaggaggaagcc
tgggtgataggcagtgttgtggcatgtcctaaagattcccctcgtgtcagagtcaagaat
ttgattgaaaccatgcaagtaaatgggtcagtggtgtcaaatggtttcctgagaagtaag
aaggccagagtggctgtcttaatatctggaacagggtccaacctccaggctctcatagac
agcactcgggatccaaagagctcctcacacattgttgttgtcatctccaacaaagctggg
gtcgctggcttagacaaagcagaaaaggctggcattcccaccagagtgattaatcataaa
ttatataagaaccgtgttgaatttgacaatgctgttgacctcgtcctggaagagttctct
gtagacatggtctgtcttgctgggttcatgaggattctctctggcccttttgtcaggaaa
tgggatggtaaaatgctcaacatccacccttccttgctcccttctttcaagggttcaaat
gctcatgagcaagtcctggaagctggagtcacagttaccgggtgtaccgtacattttgtg
gccgaggatgtagatgccggacagatcatcctacaagaagctgtccctgtgaagaggggt
gacactgttgccactttgtctgagcgagtcaaagtagcagagcataaaatctttcccgca
gccctccagctggtggccagcggggccgtgcggccgggagaagacggcaaggtccactgg
gtcagggagcagtaa
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