Mycolicibacterium gadium: MGAD_49350
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Entry
MGAD_49350 CDS
T07053
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mgad
Mycolicibacterium gadium
Pathway
mgad00860
Porphyrin metabolism
mgad01100
Metabolic pathways
mgad01110
Biosynthesis of secondary metabolites
mgad01120
Microbial metabolism in diverse environments
mgad01240
Biosynthesis of cofactors
Module
mgad_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mgad_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mgad00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MGAD_49350 (hemD)
Enzymes [BR:
mgad01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MGAD_49350 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MGAD_49350 (hemD)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBZ20600
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Position
4972473..4974155
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AA seq
560 aa
AA seq
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MTGQGSGRGRKPKPGRITFVGSGPGDPGLLTTRARTVLANAALVFTDPDVPEAVLALAGS
ELPPPSGPEPADPPAPVDGDAAGNVAPTIFPNLRGGPGGPDIRPALGDPAEVAKTLAAES
RAGADVVRLVAGDPLSVDAVITEVTALAKTHLDFEIVPGLPDTTAVPTYAGLPLGSAHTV
ADVRGDVDWESLAAAPGPLILHATASHLPDAARTLIEYGLAENTQTVVTANGTTCQQRSV
ETTLAGLLDKATLAGAESSGPFAGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKD
QAGEMSEKLVSHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVW
EKFNEFGLDARAFSGVKIACVGQATADRVRAFGINPELVPVGEQSSIGLLDEFPPYDDVF
DPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGFDAVC
FTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEH
AARLRAEGALPPPRKKSRRR
NT seq
1683 nt
NT seq
+upstream
nt +downstream
nt
atgacaggccaagggagcgggcgagggcgtaagccgaagccgggccgcatcacgttcgtc
ggttcgggcccgggcgatccgggtctgctgacgacgcgggcccgcacggtgctagccaac
gccgccctggtgttcacagatcccgacgtgccggaagcggtgctcgccctcgcgggttct
gagctgccgccgccgtcgggccccgaacccgccgatccgccggcacccgtcgacggcgac
gcagccgggaatgtggcacccacgattttccccaacttgcgcgggggtccaggcggtccc
gacatccggcccgcgctgggcgatccggccgaagtcgccaagacgctggcggccgaatcg
cgcgccggcgccgacgtcgtgcgtctggtggctggtgatccactttcggtggatgcggtg
atcaccgaggtgacggcgctggcgaagacgcacctggatttcgagatcgtgccgggcctg
cccgacaccaccgcggtgcccacgtatgcgggcctgccgctggggtcggcgcacaccgtc
gccgatgtccgcggcgacgtggactgggagtccctggccgcggcgccgggaccactgatc
ttgcacgccaccgcatctcaccttcccgatgcggcgcgcacgctcatcgagtacggcctc
gccgagaacacccagaccgtggtgaccgcgaacggtacgacgtgccaacagcgttcggtc
gagacgacgctggccgggctgttggacaaggcgacactggccggtgcagagtcctccggt
ccgtttgccgggccgctggtggtcacgatcggcaagaccgtcgccaaccgcgccaagctg
aactggtgggagagtcgcgctctgtacggctggaccgtattggtgccgcgcaccaaggac
caggccggcgagatgagcgaaaagctggtgtcccacggcgcattgccgatcgaggtgccg
accatcgccgtcgagccgccgcgcagccccgcgcagatggagcgcgcggtcaagggcctc
gtcgacggacggttccagtgggtcgtgttcacctccaccaacgcggtgcgtgcggtgtgg
gagaagttcaacgagttcggcctcgatgcccgcgcattctccggagtgaagatcgcgtgc
gtcggtcaggcgaccgccgatcgggtgcgcgctttcggtatcaaccccgagctggtacct
gtcggtgaacagtcgtcgatcggcttgctcgacgagttccccccgtacgatgacgtgttc
gatccggtgaaccgggtgctgctgccacgcgccgacatcgccaccgagacgctggccgaa
ggtctgcgtgaacgcggttgggagatcgaggatgtcaccgcgtaccgcacggtgcgggcg
gcaccgccgccggcgcagacgcgcgagatgatcaagaccggtggtttcgacgcggtgtgc
ttcacctcgagttcaacggtgcgcaatctcgtcggcatcgccggcaagccgcacgcacgc
acgatcgtggcgtgcatcgggcccaagaccgctgaaaccgcagcggagttcggcctgcgt
gtcgatgtgcagcctgaggtcgccgccgtcggtccactggtcgaggcgctcgccgagcac
gcagcccggttgcgcgccgaaggtgcgttgcccccgccgcgtaagaaaagtcgtcgccgc
taa
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