Mycobacterium gallinarum: MGALJ_50930
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Entry
MGALJ_50930 CDS
T07342
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mgau
Mycobacterium gallinarum
Pathway
mgau00860
Porphyrin metabolism
mgau01100
Metabolic pathways
mgau01110
Biosynthesis of secondary metabolites
mgau01120
Microbial metabolism in diverse environments
mgau01240
Biosynthesis of cofactors
Module
mgau_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mgau_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mgau00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MGALJ_50930 (hemD)
Enzymes [BR:
mgau01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MGALJ_50930 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MGALJ_50930 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBY95424
UniProt:
A0A9W4FHQ5
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All DBs
Position
5157728..5159389
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AA seq
553 aa
AA seq
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MTGQGSGRGRKPKPGRITFVGSGPGDPGLLTTRARTVLANAALVFTDPDVPEAVLALAGS
ELPPPSGPEPADPPAPVDGDAAENPAPTISGGPDIRPALGDPAEVAKTLAAESRTGADVV
RLVAGDPLSVDAVITEVTALAKTHLDFEIVPGLPDTTAVPTYAGLPLGSAHTVADVRGDV
DWESLAAAPGPLILHATASHLPDAARTLIEYGIAENTQTVVTANGTTCQQRSVETTLAGL
LDKATLIGAEPAGPLPGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSE
KLVSHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFG
LDARAFSGVKIACVGQATADRVRAFGINPELVPVGEQSSIGLLDEFPPYDDVFDPVNRVL
LPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTV
RNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRAE
GALPPPRKKSRRR
NT seq
1662 nt
NT seq
+upstream
nt +downstream
nt
atgacaggccaagggagcgggcgagggcgtaagccgaagccgggccgcatcacgttcgtc
ggttcgggcccgggtgatccgggtctgctgacgacgcgggcccgcacggtgttggccaac
gccgccctggtgttcacagaccccgacgtgccggaagcggtgctcgccctcgcgggttct
gagctgccgccgccgtcgggccccgaacccgccgatccgccggcacccgtcgacggcgac
gcagccgagaatccggcacccacgatttcaggtggtcccgacatccggcccgcgctgggc
gatccggccgaggtcgccaagacactggcggccgaatcgcgcaccggtgccgacgtcgtg
cgtctggtggccggtgatccactttcggtggacgcggtgatcaccgaggtgacggcgctg
gcgaagacccatctggatttcgagatcgtgccgggactgcccgacaccaccgcggtgccc
acatatgcgggtctgccgctggggtcggcgcacaccgtcgcggacgtccgcggcgacgtg
gactgggagtcgctggccgccgcgccgggcccactgatcctgcacgccaccgcatctcac
cttcccgacgcggcgcgcacgctgatcgagtacggcattgccgagaacacccaaaccgtg
gtgaccgcgaacggcacgacgtgccaacagcgttcggtcgagacgacgctggccgggctg
ctggacaaggcgacgctgatcggcgccgaaccggcgggaccattgcccggaccgctggtg
gtcacgatcggcaagaccgtcgccaaccgcgccaagctgaactggtgggagagtcgcgca
ctgtacggctggaccgtattggtgccgcgcaccaaggaccaggccggcgagatgagcgaa
aagctggtgtcccacggcgcattgccgatcgaggtacccaccatcgccgtcgagccgccg
cgcagccccgcgcagatggagcgtgcggtcaagggtctcgtcgacggccggttccagtgg
gtggtgttcacctccaccaacgcggtgcgtgcggtgtgggagaagttcaacgagttcggc
ctcgatgcccgcgcattctcgggagtgaagatcgcgtgcgtcggtcaggcgaccgccgat
cgggtgcgcgctttcggtatcaaccccgagctggtacctgtcggtgaacagtcatcgatc
ggcttgctcgacgagttcccgccctacgatgacgttttcgatccggtgaaccgagtgctg
ctgccgcgcgccgacatcgccaccgagacgctggccgaaggtctgcgtgaacgcggttgg
gagatcgaggatgtcaccgcgtaccgcacggtgcgtgcggcgccgccgcctgcgcacaca
cgcgagatgatcaagaccggtggcttcgacgcagtgtgcttcacctcgagctcgacggtg
cgcaacctcgtcggcatcgccggcaagccgcacgcacgcacgatcgtggcgtgcatcggg
cccaagaccgctgaaaccgctgcggaattcggcctacgcgtggacgtgcagcccgaggtc
gccgcggtcggtccgctggttgaggcgctcgccgagcatgcggccagactgcgtgccgag
ggtgcgctgcccccgccgcgtaagaagagccgtcgccgctag
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