Mannheimia haemolytica USMARC_2286: N220_10325
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Entry
N220_10325 CDS
T02758
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
mhal
Mannheimia haemolytica USMARC_2286
Pathway
mhal00260
Glycine, serine and threonine metabolism
mhal00261
Monobactam biosynthesis
mhal00270
Cysteine and methionine metabolism
mhal00300
Lysine biosynthesis
mhal01100
Metabolic pathways
mhal01110
Biosynthesis of secondary metabolites
mhal01120
Microbial metabolism in diverse environments
mhal01230
Biosynthesis of amino acids
Module
mhal_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
mhal_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
mhal00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
N220_10325 (thrA)
00270 Cysteine and methionine metabolism
N220_10325 (thrA)
00300 Lysine biosynthesis
N220_10325 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
N220_10325 (thrA)
Enzymes [BR:
mhal01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
N220_10325 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
N220_10325 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
ACT_9
AA_kinase
NAD_binding_3
ACT_7
ACT
Sacchrp_dh_NADP
DUF1131
DapB_N
DUF4781
Motif
Other DBs
NCBI-ProteinID:
AGR75671
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All DBs
Position
1953174..1955630
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AA seq
818 aa
AA seq
DB search
MRVLKFGGTSLANPERFMQAAEIIEKAHLADQAAGVLSAPAKITNHLVAIVDKAIAGESF
QSNLSEATEIFHNIINGLYATNNHFAKEALLALVEAELNQIQQVAAEAAQTKSLSDKIAA
TIHCRGEKLSIAMMQAWFEAKGYEVTRIDPVEKLLAHGSYLESSVDIAESTKRVDAGSIP
KKNIVLMAGFTAGNEQGELVLLGRNGSDYSAACLAACLKADVCEIWTDVDGVYTCDPRLV
PDAVCLETMSYQEAMELSYFGAKVIHPRTIGPLVPLNIPCLIKNTGNPDGKGTLIDGNVA
NDNLKVKGITNLDNVAMFNVSGSGMQGMVGMAARVFSTMSKAGISVILITQSSSEYSISF
CVPAKSAEKALAALNTEFAQELSENLLDPIDIIKDLSIVSVVGDGMRTAKGIAARFFSAL
AQANISIVAIAQGSSERSISAVVPLNKAIEAVKATHKSLFNSKRVVDMFLVGVGGVGSEL
IEQVKQQKEFLAKKDIEIRVCALANSDKMLLNENGLNLDNWKEDLEKAIQPSDFDVLLSF
IKFHHVVNPVFVDCTSAQSVANLYARALKEGFHVVTPNKKANTSGYDYYLEMRENARQSQ
HKFLYETNVGAGLPVIENLQNLLAAGDEVEKFEGILSGSLSFIFGKLEEGLTLSQATLIA
KEKGFTEPDPRDDLSGADVARKLLILVRETGLPLEFEDIEIEGVLPKGFSEGMSRDEFLQ
ALPSLDEEFSKRVEAAKAEGKVLRYVGSITGDKCRVAIEAVDENHPLYKVKDGENALAFL
TRYYNPIPLLLRGYGAGNSVTAAGIFADILRTLQGGVN
NT seq
2457 nt
NT seq
+upstream
nt +downstream
nt
atgcgagttcttaaatttggaggcacttctcttgccaaccctgaacgctttatgcaagcg
gcagagattatcgagaaagctcatttggcagatcaagctgccggcgtattatccgcccca
gccaaaattaccaatcatcttgtcgctattgtagataaagcgattgccggtgaatcattt
caatctaacctttctgaagctaccgagattttccacaacatcattaacggcttatatgct
acaaataatcactttgctaaagaagcactgttagccttagtggaagcggaattaaaccaa
attcagcaagtggctgcagaagcagctcaaactaaatcgttgtcagataaaattgctgcc
actattcactgccgtggtgaaaaactctctattgcgatgatgcaagcgtggttcgaggca
aaaggctatgaagtcactcgtatcgaccctgttgaaaaattattggctcacggcagctat
ttggaatcttcggtcgatattgccgaatccaccaagcgagttgatgcaggttcaattcca
aagaaaaatatcgtgctaatggctggttttaccgcaggtaatgagcaaggcgaactggtg
ttattagggcgtaacggttcagattattctgccgcttgtttggcagcgtgtttaaaagcc
gatgtttgtgaaatctggacggacgtagatggcgtttacacctgcgaccctcgtttggtg
cctgatgcagtatgcttagaaacaatgagctatcaagaggcaatggagctttcctacttt
ggggcgaaagtgatccaccctcgcaccatcgggccattagtgccgctcaatattccttgt
ttaatcaaaaataccggcaatccggacggaaaaggcacattaattgatggcaatgtggca
aacgataatctcaaagtaaaagggattaccaaccttgataacgtggcgatgttcaacgtt
tcaggttcaggaatgcagggaatggtgggcatggctgcccgtgtgttctcgacgatgtca
aaagccggtatttcggtgattttaattacccaatcatcatcagaatatagcatcagcttc
tgcgtgccggcaaaatcggcagaaaaagcgttagcggctctaaatactgaatttgcacaa
gagttatctgaaaacttacttgacccgattgatattattaaagatttatccattgtttcg
gtagtgggtgatggtatgcgtaccgccaaaggaattgcggctcgcttcttctctgcccta
gcccaagccaacatcagtattgtggcaattgcacagggttcatctgagcgttccatttct
gctgtcgtgccgttaaacaaagcgattgaagcagtaaaagcaactcacaaatcgctattt
aacagtaaacgtgtggtggatatgtttttagtgggtgtaggcggtgtgggtagcgaactc
atcgagcaagtcaaacaacaaaaggagtttttggcaaagaaggatattgagatccgtgtg
tgtgctttagctaattcagataaaatgttactcaacgaaaacggcttaaatttagacaac
tggaaagaagatttagaaaaagcaattcagccgtcagactttgatgtattgctttctttc
atcaaattccaccacgtggtaaacccagtatttgtagattgcacttcggcacaatcggtg
gcgaacctgtacgcacgagccttaaaagagggcttccacgtggtaacaccaaacaaaaaa
gccaatacatcaggttacgattactacttagaaatgcgtgaaaacgcccgccaaagccag
cacaaattcctctacgaaactaatgtaggggcaggtttaccggtaattgaaaacttacaa
aacctattagctgccggtgacgaagtagagaaatttgaagggattttatccggctcgctc
tctttcattttcggcaaattagaagaaggtttaaccctttcgcaagcaactttaatcgcc
aaagaaaaaggctttaccgagccagatccacgagatgatttatccggtgcagatgttgct
cgtaaactcttaattcttgttcgtgaaaccggcttaccgcttgaatttgaagatattgaa
attgaaggcgtattgccaaaaggcttctcggaaggaatgagtcgtgatgagtttttacaa
gctctaccgtctttagacgaagaattcagcaagcgtgtagaagctgccaaggctgaaggc
aaagtgttgcgttatgtgggctcgatcacaggtgataaatgccgagttgccattgaagcc
gtggacgaaaaccacccactttacaaagttaaagacggcgaaaatgcccttgcttttctc
acacgttactacaaccctattccattattattgcgtgggtatggtgcgggcaatagcgta
accgctgccggtatctttgcagatattctgcgtactttacaaggaggagtgaactaa
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