Mannheimia haemolytica 89010807N lktA-: VK67_02105
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Entry
VK67_02105 CDS
T03750
Name
(GenBank) bifunctional glutamate--cysteine ligase/glutathione synthetase
KO
K01919
glutamate--cysteine ligase [EC:
6.3.2.2
]
Organism
mhay
Mannheimia haemolytica 89010807N lktA-
Pathway
mhay00270
Cysteine and methionine metabolism
mhay00480
Glutathione metabolism
mhay01100
Metabolic pathways
mhay01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mhay00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
VK67_02105
09106 Metabolism of other amino acids
00480 Glutathione metabolism
VK67_02105
Enzymes [BR:
mhay01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
VK67_02105
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Glu_cys_ligase
ATP-grasp_6
RimK
ATP-grasp_3
Dala_Dala_lig_C
GARS_A
ATPgrasp_ST
ATP-grasp
Motif
Other DBs
NCBI-ProteinID:
AKA13137
UniProt:
A0A378NG59
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Position
complement(407831..410107)
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AA seq
758 aa
AA seq
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MKLQKLIRENHLALLFQQGNFGLEKESQRVDRNGNIVTTPHPAVFGNRSYHPYIQTDFAE
SQLELITPPNAKLEDSFRWLSAIHEVVLRSLPEEEYIFPLSMPAGLPPEEQIQEAQFDNP
EDVQYRQHLSKNYGKYKQMVSGVHYNFQLSTEFVEKAFALQTEYSELKAFQNALYMKLAN
NFLRYQWILLYLLAATPTVESQYFYEKSPLARGQLVRSLRSSPYGYVNSEKVVVNHDSLE
SYVESLEANVANGLLIAEKEFYSNVRLRGGKKARELLENGVKYAEFRLFDLNPFAPYGIE
LNDAKFIHYFLLGMLWLEETSGQKEVEIGKQKLYQVALEDPRTETAFRAEGEAILNQLLA
MLEELSAGQESLDLVREKLAQFADPSKTLNGRLIAAIEEVGSYKALGAKLAQTYKAQAFE
RFYALSAFDNMELSTQALFFDLIQQGIEVEVLDENDQFLALKFGDHLEYVKNGNMTSRDQ
YISPLIMENKVVTKKVLAKAGFNVPKSVEFTNLEQAVAHYPLFEGKAVVIKPKSTNYGLG
ITIFQQAVKNREDFAKAVEIAFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVV
GDGIHSVKELVERKNDDPLRGDGSRSPLKKIALGEIEQLQLKEQGLTVDSVPAKGQTVQL
RANSNISTGGDSIDMTDQMHESYRQIAVGIAQAMGAKVCGVDLIIPDLTKPAEPNLSSWG
VIEANFNPMMMMHIFPYQGKSRRLTKAVIKMLFPEIGN
NT seq
2277 nt
NT seq
+upstream
nt +downstream
nt
atgaaactacaaaaacttatccgagaaaatcatttagcattgctgtttcaacaagggaat
tttgggcttgagaaagagagccaacgggttgatcgcaacggcaatatcgttactactccc
caccctgccgtattcggtaatcgctcttaccacccttatattcaaaccgattttgccgaa
agtcagctagagttaatcactcccccgaatgctaaattagaagacagttttcgttggctc
tctgctattcacgaagtggtattgcgttcgttgccagaggaggaatatatcttccctctc
agtatgccggcaggcttgccgccggaagagcaaattcaagaagcacaatttgacaaccct
gaagatgtgcaatatcgccaacacctttccaaaaactatgggaaatataagcaaatggta
agcggcgtgcattataattttcaactttcaacggaatttgtcgaaaaagcctttgcttta
caaacggaatatagcgagctgaaagccttccaaaacgcactttatatgaagttagctaat
aactttttgcgttatcaatggattttgctctatttattggctgccacgcctacggtggaa
tcgcaatatttttatgaaaaatcaccgcttgcgagagggcaacttgtccgcagcttgcgt
tcaagcccttatggttatgtgaattcggaaaaagtggtggttaatcacgacagcttagaa
agctatgttgaaagccttgaagccaatgttgccaacggattattaattgccgaaaaagaa
ttctattccaatgtgcgtttacgagggggcaaaaaagcccgtgagctattggaaaacggt
gtgaaatacgccgaattccgtttatttgatttaaaccctttcgccccttacggcattgag
ctgaatgatgccaaatttatccattatttcttactcggtatgctttggctggaggaaaca
agcggtcaaaaagaggtcgaaatcggcaaacagaaactttaccaagtcgcacttgaagat
ccaagaacagaaaccgctttccgtgccgaaggtgaagccattttaaatcaacttttagcg
atgcttgaagaattatctgccggtcaggaaagcctagatttggtgcgggaaaaattagct
caatttgctgatccaagcaaaaccctgaacggacgtttaattgccgcaatagaggaagtc
ggcagttataaagcattgggggctaaattggctcaaacctataaggcacaagcctttgag
cgtttttatgcgttatcggcatttgataatatggaactttccactcaagccctgtttttt
gatttgatccaacaagggattgaggtggaagtactggacgaaaacgatcaattcctcgcc
ctaaaatttggcgatcatttggaatatgtgaaaaacggcaatatgaccagccgagatcaa
tacatttcaccgctgattatggaaaacaaagtggtgacgaaaaaagtattggcaaaagcc
ggctttaacgtgccgaaaagcgttgaatttaccaaccttgaacaggctgtggcacattat
ccgctatttgaaggcaaagcggtggtgattaagccgaaatcgactaactatggtttaggg
attaccatcttccaacaagcggtcaaaaatcgagaagattttgcaaaagcggttgaaatt
gcgttccgtgaagacaaagaggtgatggtggaagactatttagtcggtactgaataccgc
ttctttgtactgggcgatgaaacccttgcggtgttactgcgtgtaccggcgaatgtagtg
ggagatggcattcacagtgtaaaagagctggtggagcgtaaaaatgacgatccgctacgt
ggcgatggctctcgtagcccgttgaaaaaaattgccttaggtgaaattgagcagttacaa
cttaaagagcaaggcttaaccgtagattccgtaccggcgaaaggtcaaacagttcaactg
cgtgccaattccaacatcagcaccggcggcgattcgattgatatgaccgaccaaatgcac
gaaagctatagacaaattgcagtgggaattgctcaggcaatgggggctaaagtgtgtggg
gtggatttgatcattcctgatctcaccaaacctgccgagccaaatttaagctcttggggc
gtcattgaggcaaacttcaacccaatgatgatgatgcacattttcccttaccaaggcaaa
tcccgccgtttaaccaaagcggtaatcaaaatgctgtttcctgagataggcaattaa
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