Mycolicibacterium helvum: MHEL_42640
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Entry
MHEL_42640 CDS
T07064
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
mhev
Mycolicibacterium helvum
Pathway
mhev00290
Valine, leucine and isoleucine biosynthesis
mhev00660
C5-Branched dibasic acid metabolism
mhev01100
Metabolic pathways
mhev01110
Biosynthesis of secondary metabolites
mhev01210
2-Oxocarboxylic acid metabolism
mhev01230
Biosynthesis of amino acids
Module
mhev_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mhev00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
MHEL_42640 (leuC)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MHEL_42640 (leuC)
Enzymes [BR:
mhev01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
MHEL_42640 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
MHEL_42640 (leuC)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Aconitase
AcnX
Motif
Other DBs
NCBI-ProteinID:
BBY66021
UniProt:
A0A7I7TC06
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All DBs
Position
4538540..4539973
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AA seq
477 aa
AA seq
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MAQSDQPRTLPEKVWHDHLVVTGAGSGASREPDLIYIDLHLIHEVTSPQAFDGLRLAGRP
LRRPDLTIATEDHNVPTVDIDKPIADPISRTQVETLRRNCAEFGVRLHPMGDVEQGIVHV
MGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEVEHVLATQTLPLQPFKTMAVNV
DGVLPPGVSAKDIILAVIAKIGTGGGQGYVIEYRGSTIESLSMESRMTICNMSIEAGARA
GLVAPDEITYEFLRGRPYAPTGADWDAAVASWEALKTDEGAEFDTEVYIDATTLSPFVTW
GTNPGQGVPLSEAVPDPEMMTSDSERQAAEKALAYMDLRAGTPMRDVAVDAVFVGSCTNG
RIEDLRVVADVLRGRTVADGVRMLIVPGSMRVRAQAESEGLGEIFTAAGADWRQAGCSMC
LGMNPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLKN
NT seq
1434 nt
NT seq
+upstream
nt +downstream
nt
atggctcagtccgaccagcccaggacactgcccgagaaggtgtggcacgaccacctcgtc
gtcaccggcgcaggcagcggtgcatcgcgtgaacccgacctgatctacatcgatctccat
ctcatccacgaggtgaccagcccacaggccttcgacgggctgcggctggctggccgcccg
ctgcgccgtcccgatctcacgatcgccaccgaggatcacaacgtgccgacggtcgacatc
gacaagccgatcgccgacccgatatcgcgcactcaggtcgagacgttgcggcgcaactgc
gccgaattcggtgtgcggctgcacccgatgggtgacgtcgaacaggggatcgtccacgtg
atgggcccgcagctcggcttgacccagcccgggatgacgattgtgtgtggcgacagccac
acctccacccacggcgcgttcggcgcgatcgcgatgggcatcggcacttccgaagtggag
catgtgcttgccacccagacacttccgctgcagccgttcaagacgatggcggtcaacgtc
gacggtgtgctgccgccgggagtgagcgccaaggacatcatcctggcggtgatcgccaag
atcggcaccggtggcggccagggctacgtcatcgaataccggggcagcaccatcgaatcg
ctgtcgatggagagccggatgaccatctgcaatatgagcatcgaggccggcgcccgcgca
ggattggtggctcccgacgagatcacctatgaattcctgcgcggccgtccgtacgcaccc
acgggcgcggattgggatgcggcggtggcctcgtgggaggcgctgaagaccgacgagggc
gccgagttcgacaccgaggtctacatcgacgcgacgacgctgagcccctttgtcacatgg
ggcaccaaccccggccagggggttccgctgtccgaggcggtgcccgacccggaaatgatg
accagcgattccgagcggcaggccgctgagaaggcgttggcctacatggaccttcgggcg
ggcactccgatgcgcgacgtcgccgtcgacgcggtgttcgtcgggtcgtgcacgaacggg
cgcatcgaggatctgcgggtggtggccgacgtgctgcgcggccgcacggtcgccgacggc
gtgcggatgctgatcgtgccggggtcgatgcgagttcgcgctcaggccgaatccgaaggg
ctgggcgagatcttcaccgcggccggtgcggattggcgtcaggccggctgctcgatgtgc
ctgggaatgaatcccgatcagctggcaccgggcgagcgttgcgcgtcgacatccaaccgg
aatttcgaaggcaggcagggcaagggtggccggacacacctggtttcgccggctgtcgcc
gccgcgaccgcggtgcgcggaaccctgtcctcacccgccgatctcaaaaactag
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