Micromonospora sp. L5: ML5_3827
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Entry
ML5_3827 CDS
T01379
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
mil
Micromonospora sp. L5
Pathway
mil00300
Lysine biosynthesis
mil00550
Peptidoglycan biosynthesis
mil01100
Metabolic pathways
mil01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
mil00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
ML5_3827
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
ML5_3827
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
ML5_3827
Enzymes [BR:
mil01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
ML5_3827
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
ADU09338
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Position
4032520..4033929
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AA seq
469 aa
AA seq
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MIPLTLAEVAAAVDGRLVGADPDARVTGTVEFDSRKVNRGGLFVAFPGERVDGHDYAAGA
ISAGAVAVLGTREVPGVPMVLVGDALDAMGRLARAVVDRLPGLTVIGLTGSSGKTTTKDL
IAQLAVRLGPTVAPPGSFNNELGHPYTALQATPETRYLVMEKGARGVGHVRYLCDVVPPR
ISVVLNVGVAHLGEFGSVETIALAKGELVEALPDDGLAVLNADDPRVDAMASRTRARVVR
YGESEHADVRAVDVTLDGRGRPSYTLVTPEGSAPVRLGLTGRHQVSNSLAAAAVGRELGL
PLPDLAAALNELGLVSTRRMDVFERPDGVTVIDDSYNANPASTGVALRALASMRGEGRTV
AVLGYMAELGDFELQGHQQVGRLAAELGVDRLLVVGEPAAPIHEGATAVGNWGGESVLLT
DQAAAVEVLRSELRPGDVVLVKGSRYRTWEVADALRADAREGATEGGAA
NT seq
1410 nt
NT seq
+upstream
nt +downstream
nt
gtgatcccgctgacgctggccgaggtggccgccgctgtcgacggccggctcgtcggcgcc
gacccggacgcccgggtcaccggcaccgtggagttcgactcccgcaaggtcaaccggggc
gggctgttcgtcgccttccccggcgaacgggtggacggccacgactacgcggccggtgcg
atctcggccggcgctgtcgcggtgctcggcacccgggaggtgccgggcgtgccgatggtg
ctcgtcggtgacgcgctcgacgcgatgggccggctcgcccgcgcggtggtggaccggctg
cccgggctgaccgtgatcgggctgaccggctcgtccggcaagaccaccaccaaggacctg
atcgcccagctcgcggtgcggctcggcccgacggtggcgccgcccggctcgttcaacaac
gagctggggcacccgtacacggcgttgcaggccacgccggagacccgctacctggtgatg
gagaagggcgcccgcggggtcgggcacgtccgctacctgtgcgacgtggtgccgccgcgg
atctctgtggtgctgaacgtgggcgtggcgcacctgggcgagttcggctcggtggagacc
atcgcgctggccaagggcgaactggtcgaggcgctgcccgacgatgggctggcggtgctc
aacgccgacgacccgcgggtcgacgcgatggcgtcgcgtacccgggcccgggtggtccgc
tacggcgagtcggagcacgccgacgtacgcgccgtggacgtgacactcgacggccgggga
cggccctcgtacaccctcgtcaccccggagggcagcgcgcccgtgcggctcgggctgacc
ggccggcaccaggtgtccaactcgctcgccgccgcggcggtcggccgggagctgggcctg
ccgctgccggacctggcggcggcgctgaacgagctgggcctcgtctcgacccggcggatg
gacgtcttcgagcgtcccgacggggtgaccgtgatcgacgactcgtacaacgccaacccc
gcctccaccggcgtggcgctgcgggcgttggccagcatgcgtggcgaggggcgtaccgtc
gcggtgctcggctacatggccgagctgggtgacttcgaacttcaggggcatcagcaggtc
ggccggctcgcggccgaactgggagtggaccggctgctcgtggtgggcgagccggcggcg
ccgatccacgagggcgcgacagcggtaggtaattggggaggagagtcggtgctgctcacc
gatcaggcggcggccgtcgaggtgctgcggagcgagctgcgtccgggagacgtggtgctg
gtgaagggctcccggtaccggacctgggaggtggccgacgcgctgcgcgcggacgcccgg
gagggtgcgacggagggcggcgccgcatga
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