Methanocaldococcus jannaschii: MJ_1195
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Entry
MJ_1195 CDS
T00003
Name
(GenBank) 2-isopropylmalate synthase (leuA)
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
mja
Methanocaldococcus jannaschii
Pathway
mja00290
Valine, leucine and isoleucine biosynthesis
mja00620
Pyruvate metabolism
mja01100
Metabolic pathways
mja01110
Biosynthesis of secondary metabolites
mja01210
2-Oxocarboxylic acid metabolism
mja01230
Biosynthesis of amino acids
Module
mja_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mja00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
MJ_1195
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MJ_1195
Enzymes [BR:
mja01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
MJ_1195
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
Imm74
Radical_SAM
DUF7799
Motif
Other DBs
NCBI-ProteinID:
AAB99199
UniProt:
Q58595
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All DBs
Position
complement(1137352..1138908)
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AA seq
518 aa
AA seq
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MIIYREENEIIKKALENLNIPDRVYIFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVD
VIEAGFPVSSLGEQEAIKKICSLNLDAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPL
HRKYKLKKSKEEIIDIAVDAIEYIKEHGIRVEFSAEDATRTEIDYLIEVYKKAVDAGADI
INVPDTVGVMIPRAMYYLINELKKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTI
NGLGERGGNAALEEVVMSLMSIYGVKTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENA
FAHESGIHAHGVLAHALTYEPIPPELVGQKRKIILGKHTGTHAIEAKLKELGIEVGKDIN
KDQFDEIVKRIKALGDKGKRVTDRDVEAIVEDVVGKLAKKDRVVELEQIAVMTGNRVIPT
ASVALKIEEEIKKSSAIGVGPVDAAVKAIQKAIGEKIKLKEYHINAITGGTDALAEVIVT
LEGYGREITTKAASEDIVRASVEAVIDGINKILAKREK
NT seq
1557 nt
NT seq
+upstream
nt +downstream
nt
atgataatttatagggaagagaatgaaattataaaaaaggcacttgagaatttaaacatt
ccagatagggtttatatctttgacacaacactcagagatggagagcaaactccaggtgtc
tctttaactccagaggagaaaatagacatagccataaaattagatgatttaggagttgat
gttattgaggctggttttccagtatcatcattaggagagcaggaggctattaaaaaaatc
tgctcattaaacttagatgctgaaatctgcggattggcaagggctgtaaaaaaggatata
gatgtagctatagattgcggagttgatagaatccatacatttatagcaacctctccattg
catagaaaatataaattaaaaaaatcaaaggaagagattattgatattgcagttgatgcc
atagagtacataaaagaacatgggattagagttgagttttcagcagaagatgcaacaaga
acagagattgactatttaatagaagtttataaaaaggcagtagatgctggagcagatata
atcaacgttccagataccgttggagttatgattccaagggctatgtattatctaataaat
gagctaaagaaggaaataaaagtccctatatctgtgcattgccacaacgactttggttta
gctgttgcaaactcattggcagcagttgaagcaggagcagagcaagtacattgtacaata
aacggcttaggagagagaggaggaaatgcagcattggaagaggtagttatgagcttaatg
tcaatctatggagttaaaactaatataaaaacacaaaaactttatgagatatctcagctt
gtatcaaaatacactgaaattaaagtccaaccaaacaaggcaattgttggagagaacgct
ttcgctcatgaaagtggaatacatgcacatggagttttagctcatgctttaacctatgaa
cctatacccccagagttagttgggcagaagagaaaaataatcttaggtaagcacacagga
acacatgcaattgaggcaaagttaaaagaattaggaattgaggttggtaaggatataaat
aaagatcaatttgatgagatagttaagagaattaaagctcttggagataaaggaaagaga
gtcactgacagagatgttgaggcaatagttgaggatgttgttggtaagttggctaaaaaa
gatagagttgttgagttggagcaaatagcggttatgacaggtaatagagttattccaact
gcatcagttgctttaaagattgaagaagagattaagaagagctcagctattggtgttgga
ccagtagatgcggcagttaaggcaatacaaaaagccattggagagaagattaaacttaaa
gagtatcatataaatgccataactggaggaactgatgcattggcggaggttattgtaacc
ttagaaggatatggaagggagataacaacaaaggcagcaagtgaagatatagttagggct
tcagttgaggcagttatagatggaatcaacaaaatcttggcaaaaagagaaaaatga
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