Maniola jurtina (meadow brown): 123878005 Help Entry 123878005         CDS       T09254                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism mju  Maniola jurtina (meadow brown) Brite KEGG Orthology (KO) [BR:mju00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mju04040]     123878005    04990 Domain-containing proteins not elsewhere classified [BR:mju04990]     123878005 Ion channels [BR:mju04040]  Voltage-gated cation channels   Ryanodine receptor    123878005 Domain-containing proteins not elsewhere classified [BR:mju04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    123878005 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 EB1_binding DASH_Spc34 Ste5 Motif Other DBs NCBI-GeneID:  123878005 NCBI-ProteinID:  XP_045780937 LinkDB All DBs Position 25:complement(3303276..3444519) Genome browser AA seq 5131 aa AA seqDB search MAEAEGGASEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGSETGKENLVGKGTGSGHRTLLYGNAILLRHLNSDMY LACLSTSSSQDKLAFDVGLQEHSHGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATER YLHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPS TWSGDGGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVN DQNELYLISREEATTASCAFCLRQEKDDQKVVLEDKDLEIIGAPIIKYGDSTVIVQHSET GLWLSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFT KFITGLETLQENRRHSMFFASVNLGEMVMCLEDLINYFAQPDEDMEHEEKQNKFRALRNR QDLFQEEGILNLILEAIDKINVITSQGFLAGFLAGDESGQSWDMISVYLYQLLAAIIKGN HTNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISL LEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVSSVRPNIF VGRVEGSAVYQKWYFEVTMDHIEKTTHMMPHLRIGWANTTGYVPYPGGGEKWGGNGVGDD LYSYGFDGAYLWSGGRKTAVNRTHEEEPFIRKGDVIGCALDLTIPLINFMFNGVRVTGSF TNFNLEGMFFPAISCSSKLSCRFLLGGEHGRLRYAAPEGYSPLVESLLPQQILSLEPCFY FGNLAKRALAGPPLVQDDTAFVPTPVDTVSITLATYIEQIRDKLAENIHEMWAMNKIEAG WSYGENRDDAHRIHPCLVPFERLPAAEKRYDIQLAVQTLKTILALGYYISLDKPPARIRN VRLPNEPFMQSNGYKPAPLDLSAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNE DSDMQRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEHQEALLAEASKQ KQADFRTYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAHADMPPGMMLGQDENSWAFDGY NSLKWHGGTSDTFGQQLKVGDIVACFLDVTDQTISFSLNGELLMDALGGETTFADVQGDN FVPACTLGVGQKARLSYGQDVNSLKYFTTCGLQEGYEPFCVNMKRDVTHWYTKDQPIFEN TDEMADTRIDVTRIPAGSETPPCMKISHNTFETMEKANWEFLRLSLPVICQTEFIDEQEK ARRWVEIKERQQILMKEAVEAQMPAHIDQIMRSGFTMNDIKGLHYDENQEEMPSSKVKRQ PSKPPRKGSMTRGVTIQSYNLQPGPVNGMHRSTSEAEMAKYELGASLSPEDKKAEKRGRS PFKFFRSKRGESGERGKTRKSKTPDPFSDTEVSPDRGAMRRPNPQIRVSQAVQRHVQGRP SRPNLYGSQSGLNNNLAVATPPQERKQMTAGTLSAAATETVGNEIFDADCLKLINEYFYG VRIFPGQDPTHVYIGWVTTQYHLHSKDFNQNKVTKSSVIITDDYDRVVESVNRQSCYMVR ADELYNEVMAEATGKGASQGMFIGCSVDTSTGTVAFTCEGKDTSIKFKMEPDTKLFPAIF VEATSKEILQIELGRSSTSLPLSAAVLPTSDKHVNPQFPPRLKVQCLKPHQWARVPNQSL QVHALKLSDIRGWSMLCEDAVSMLALHIPEEDRCIDILELIEMDKLLSFHSHTLTLYAAL CYQSNYRAAHALCQHVDQKQLLYAIQSQYMSGPLRQGFYDLLIALHLESHATTMEACKNE FVIPLGPELKSLYEEPEMRHSLRSLQTESVRPQMKMTDIAESITEISNLYSPYFPLEVVR EFVMQALAEAVETNQVHNRDPVGGSNENLFLPLIKLVDRLLLVGMMRDEDVEKLLIMINP ETWDPTFDKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDMQLRHRVEFIIAFAHDFVG DLQSDQLRRYTEIKQSDLPSAVAAKKTKEFRCPPREQMNAILSFKHLEDDDPENCPCGED LITRMNEFHESLMIHVSLNALQEPDGDESSEPETKTGAFGKLYNIINTVKELEEEAKAIE EPVKKSPEEKFRKVLIQTIVTWAEESQIETPKLVREMFSLLVRQYDAVGELIRALEKTYV INAKTKQDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRV HENVMAVMMNTLGRRAQAQSDAPTAAQPTPEDKEKDTSHEMVVACCRFLCYFCRTGRQNQ KAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSR CGLQSNSELIEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECL GPALRGEGEGLLKAIVDANKMSERIADRRKLRDEDGDINFSHPLPQSDDDEDYIDTGAAI LNFYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLEDLQGVLSLRFTLNNPAAG EERPKSDMPSGLIPGHKQSVGLFLERVYGIETQELFYRLLEEAFLPDLRAATMLDRNDGC ESDMALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREA VSDFLVALTAAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYERCAKYYGSTGGQG IYGASSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCALPPDYSLSKNYDD EFYGKENTQATGADNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAWASRKIENGWVY GESWSDSQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSTNRSS MRRQSKSGGVTDSATPFNYNPHPVDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELVT NGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPKTSQGDTEQTTTGVAI ELRFAYSLLEKLISYIDRATINMKLLKPSTTFSRRPSFKTSTRDIKFVSKVVLPLMEKYF STHRNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQVL VKGIDAKSLVKNCPEFIRTSMLTFFNNVADDLGHTIMNLQDGKYSHLRGTHLKTSTSLGY INGVILPVLTAMFDHLANCEYGADLLLDEIQVASYKMLGSLYTLGTDATLTHDRKYLKTE IERNKPALGSCLGAFSSTFPVAFFEPHLNKHNQFSLLNRIADHSLEAKDIMAKMEQSMPT LESILNEVDQFVESDKTYNEAPHIIDVVMPLLCSYLPFWWAQGPDNVTPTAGNHVTMVTA EHMNQLLKNVLKLIKKNIGNESAPWMTRIATYTQQIIINSSEELLRESFLPLAERVRKRT DTMFHKEESLRGFIKSSTDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRN NVPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVLIMPTATRRVTTVVDGTP QGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKM SEQDVAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKTTVTTVETSENKAKLIDDTV ERIVAMSKVLFGLHMIDHPQQMSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRVCNIF ARTYYELWLEEENIGQEVMIEDLTQSFEDAELKKSDLVEEDGKPDPLTQLVTTFCRGAMT ERSGALQEDPLYMSYAHIIAKSCGEEEEEGGEEEEGGGEPEGGDEEGRASIHEQEMEKQK LLFHQKRLANRGVAEMVLLHISASKGQPSDMVMKTLQLGISILRGGNIDIQMGMLNHLKD KKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMHDAEFTCALFRFI QLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGK ANFFKAIGVASQVFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSS QVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKL KDLTSSASFKEIDANNDGWVLPKDFKEKMEQQKSYTPEEIEFLLACCETNHDGKLDYLGF CDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEIMGGSK RIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHA SGLMAVSEEAAGGLKNREAYHVYMGDDEEERAGKDPFRRGFQSVKDGISTAFSSLSPSNI KQRIADLQQMPPAELFIGFFKMFFYLFYYLGYGAVVVIRYIFGVLLGLMRGPVTDEPPPE PTEEEKIGQLKLSLLHRTFPQSPMRHLPALPAADDTGQMQVSAFGLDITKEDNGQIQVKP HESPTASTPSSGEEAEVSPDESTEHTEEQQPPSLIDLLGGEQAKKQAQERMEAQAVQQAA MSAIEAENKKQAVQGPAPSALSQVDLSQYTKRAVSFLARNFYNLKYVALVLAFCINFVLL FYKVSTLEVERGEGSGIGDIISGSGSGQGSGSGDGGSGESEEDEGLEVVLIDEDFFYMEH VINVAALLHSIVSLAILVGYYHLKVPLAIFKREKEIARKLEFDGLYIAEQPEDDDLKSHW DKLVISAKSFPVNYWDKFIKKKVRAKYSETYDFDSISNMLGMEKTSFSAQEEEGSKGFWH YIVNIDWRYQVWKAGVTITDNSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTI LQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYVQEEDDEVNKNCHDMLSCFVFNL YKGVRAGGGIGDELEPPDGDDSEVYRIIFDISFFFFVIVILLAILQGLIIDAFGELRDQL ESVKEDMESNCFICGINKDYFDKVPHGFDTHVQREHNLANYMFFLMHLINKPDTEYTGQE TFVWKMYTQRCWDFFPVGDCFRKQYEDAMGE NT seq 15396 nt NT seq  +upstreamnt  +downstreamnt atggcggaagcggaaggcggagcgagcgagcaagatgatgtttcattcttacgcacggaa gacatggtgtgtctgtcttgcacggcaacgggtgagcgagtgtgtcttgcggctgaaggt tttggtaacaggcactgctttttggagaacatcgcagacaagaacatacctccagacctt tcacagtgtgtgtttgtcatcgaacaggccttgtcagtaagagctctacaagaattagta acagcggctgggtcagaaactggcaaagaaaacttagtaggcaaaggcactggttctgga catagaacgctactttatggcaatgctattctattacgtcatctcaacagtgacatgtac ctggcgtgtctatcaacatcgtcatctcaagacaagttagcgttcgacgtcggtctacag gagcattcgcatggcgaggcgtgctggtggacgctgcaccctgctagcaaacagaggtct gagggtgaaaaggtgcgagttggtgacgatttgattcttgtgtccgttgctacagaaaga tacttgcacacgacaaaagaaaacgaggtatccatagtgaacgcatcattccacgtgacg cactggtccgtacaaccgtacggtactggtatatcgcgcatgaagtacgtggggtacgtg ttcgggggagacgtgctccggttcttccacggcggtgacgagtgccttactataccgagc acgtggagcggagacggcggacaaaatatcgtagtatacgaaggtggatcagtgatgtcg caagctcgctcgctctggcgtctggaactggcgcgcaccaagtgggcgggtggcttcatc aactggtaccaccccatgaggatacgacacatcaccacggggcgatacctcggggtcaac gaccagaatgagctgtatttgattagcagggaagaagcaacaacagcatcttgcgcgttc tgcctccgccaagagaaagacgaccagaaggtggttctggaagacaaagacttggagatc ataggagctcccatcatcaaatatggtgactccactgtcattgtacagcattctgaaacg ggactgtggctgtcttataagtcttacgagacaaagaagaaaggcgtcggtaaagtagaa gagaaacaagctatcctacacgaggagggcaagatggacgacggtctagacttctccaga tcacaggaggaagaatctagaactgctagagttattaggaagtgttcttcattgttcact aaatttattactggccttgaaactctacaagagaaccgacgtcactcgatgttcttcgcg tcagtcaatctgggtgaaatggtgatgtgtttggaggatctaatcaattacttcgcgcaa ccggatgaagatatggaacatgaagagaaacaaaacaaattccgtgcgctccgcaaccgt caagacctgttccaagaggaaggcatcctcaacctgatcttggaagcgatagacaagatc aacgtcatcacgtctcagggtttcctcgctgggttcctggctggggacgagtctgggcag agttgggacatgatatcagtttacttgtaccaacttctggcggcaataatcaaggggaac cacacaaactgcgctcagttcgccaactccaaccgtctaaactggctgttctcccgtctt ggatcgcaagcgtcgggggagggaactggaatgctggacgtactgcattgtgtccttatt gactcgccagaggctctgaatatgatgagggatgaacatataaaagtgatcatatcgctg ttagaaaagcacggtagggaccccaaggttctcgacgtgttgtgttccctctgcgtcggt aacggggtggccgtgaggtcctcgcagaacaacatctgtgactatctgctgccggggaag aatctactgctgcagacccagctggtggatcatgtgtcgagtgtacgcccaaacattttc gttggccgagtggaaggatcagcagtttaccagaaatggtacttcgaagtgaccatggac catattgagaagaccacacatatgatgccacacttgcgtattggatgggccaatactact gggtatgttccatacccgggaggtggcgagaagtggggcggcaatggtgtaggggatgat ctgtactcgtacggttttgatggagcgtacctctggtctggaggcaggaagacggcagtt aacaggactcatgaggaagaaccgtttataagaaaaggtgacgtcatcggctgcgctctg gacttgaccatacctctgataaacttcatgttcaacggcgtacgagtgaccggctccttt accaacttcaatctggaggggatgttcttcccggccatcagttgttccagtaaattaagt tgtcgtttcctcctcggcggagaacacggtcgcctgcgctacgcggctcctgaaggatat tctccactagtggagtcccttcttcctcagcagatcctcagtctggagccgtgcttctac ttcggaaacttggctaagagagccttggctggtccaccgcttgttcaggatgacacagct tttgtaccaacccctgtggacactgtatcgattactttggcaacttacatcgagcaaatc agagacaaactagctgaaaatattcatgaaatgtgggcgatgaataagattgaagccggt tggtcgtacggcgaaaaccgggacgacgcgcaccgcatacacccgtgcctagttcccttt gaacgtctcccggccgccgagaaacgatacgacattcagctagccgtgcagactctcaaa accatcctcgctctcggctactacatcagccttgacaagcccccagcgcggatccgcaac gttcgtctacccaacgaacccttcatgcaatctaatgggtataaaccagccccactggac ctgagcgctgttaccctgacacccaagatggacgagttggtcgaccagttggccgagaac acgcacaatctttgggcgagagaacgcattcagcagggttggacctatggactaaacgag gactccgatatgcagcggtctcctcatttagtaccatatccgaaagtagacgacgcgatc aagaaggcaaacagagataccgcttcagaaactgttagaactctgcttgtctatggatac aacctagatccaccaactggggagcaccaggaagctctattagccgaagcgtcaaaacag aagcaagcggacttcagaacttatagagcagagaaaaactatgctgtcagttctgggaaa tggtattttgagttcgagattcttactgctggacctatgagggttggttgggctcatgcg gacatgccaccaggcatgatgttaggtcaagatgagaactcttgggcttttgatggatac aattcgctaaaatggcacggtgggactagcgacacctttgggcagcaactgaaagttggt gacattgtcgcttgcttccttgacgtaaccgaccagacgattagtttttccttgaacgga gagttgcttatggatgctctcggaggtgaaactacttttgcagacgttcaaggagataat tttgtaccggcatgcactcttggagtgggccaaaaggctaggctatcgtatggtcaggac gtcaactcattgaaatattttaccacttgcggtctacaagagggctatgagccattctgt gttaatatgaaacgtgacgtaacacattggtatacgaaggaccaacctatatttgaaaac acggatgagatggccgacaccagaatcgatgttacaagaataccggctgggtctgagacg ccgccatgtatgaaaatctcccacaacaccttcgaaacgatggagaaagctaactgggaa ttcctcaggctgtcactacctgtaatctgtcagaccgaattcatagatgagcaagagaaa gcccgccgctgggtggagataaaggagcgacaacagattctgatgaaggaggctgtggaa gcgcagatgccagctcacatcgaccagatcatgaggagcgggttcactatgaacgatatc aaaggtctgcactacgatgaaaaccaagaagagatgccgagttccaaagtcaaaagacaa ccttcgaaacctcccagaaaagggtccatgactcgtggggttaccattcagagttataac ttacaaccaggtcctgtaaacggtatgcatcgctctacgagtgaagctgaaatggcaaaa tatgagctcggagccagcctgtctccggaagacaaaaaggcagaaaagaggggaaggtct cctttcaagttcttcagaagcaaacgcggtgaaagcggcgaaaggggcaagacccgtaaa tccaaaacaccagacccattcagtgataccgaagtgtcaccagaccgaggagctatgagg agacctaaccctcaaataagagtatctcaggcagtacaaaggcatgtgcagggtaggcca agtaggccgaatttgtacggaagtcaatctggtttgaataacaacttagcagtagcaacc ccaccacaagagcgcaagcaaatgacagctggtacgttatccgcggccgccactgagacg gtcggcaacgaaatattcgatgcggattgcttgaagctcatcaacgagtacttctatggt gtcagaattttccccggtcaagacccaacgcatgtttacatcggctgggtaacgacacaa taccatttgcactccaaggacttcaaccagaacaaagtcaccaagtcgtccgtcatcatt actgatgattacgatcgcgttgtcgaaagtgtaaatcgacaatcgtgctacatggtccgc gcggacgaactgtacaacgaagtgatggccgaagcgacgggcaaaggcgcgtcgcagggc atgtttataggatgctccgttgatacgtccactgggactgtcgcctttacgtgcgagggg aaagatactagcattaagtttaagatggaaccagataccaaactgttcccggcaatattc gtagaggcaacatcgaaggaaatccttcagattgagctcgggagatcttctacaagtctt ccgctgagtgcggcagtgctgccaactagtgataagcacgtcaacccacagttcccgcct aggctgaaggtccagtgtctgaaaccccaccagtgggctagggtcccaaatcaatcactg caagttcacgccttgaagttgtcagacatccgaggttggtccatgctgtgtgaagatgct gtctccatgctggctcttcacatacctgaggaagaccgttgcattgatatccttgaactg atagaaatggataagctgcttagtttccactcccatacactcacgctgtatgcggcgtta tgctaccagagcaattacagagctgcgcatgctctttgtcagcacgtggatcaaaagcag ctgctctacgccatccagtcccagtacatgtccggtccactccgacagggattctacgat ttgctcatagctttgcatctggagtcacatgccactactatggaggcgtgtaaaaatgag ttcgtgataccgctggggccggaactgaagtcgctttacgaggaaccggaaatgaggcac agcctccgctcgctgcagactgagagcgtgcgcccgcagatgaagatgactgacatagcg gaaagcataacggaaatcagcaatctctactccccgtacttcccactagaagtggtgcga gagttcgtcatgcaagcgctggctgaagccgtggaaactaaccaggtgcataaccgggat cctgttggagggagcaacgagaacttgtttctgccattaatcaaactcgtagaccgtctg ctgttagtgggtatgatgagagatgaagacgtggaaaaactgcttatcatgatcaaccct gagacttgggaccctacttttgataaagagggtaaagatgagcacaggaaaggtttgctg cacatgaagatggcggagggcgcgaagttgcagatgtgctacctgctgcagcatctcaac gatatgcagctgcgtcaccgagtggagttcattatcgccttcgcgcacgactttgtcggc gacctgcagtctgatcagctgagacgttatacagaaatcaagcaatctgatctgcccagt gctgtcgccgccaagaaaactaaagaattccgttgtccaccacgagagcaaatgaacgcc atactgagtttcaaacatctggaagatgatgacccggagaactgcccgtgcggcgaggac ctgatcacacgcatgaacgagttccacgagagcctgatgattcatgtctcgctaaatgct ttgcaagaacctgacggagatgagtcttcagagccagaaacaaaaactggtgcttttgga aaactttacaatattataaacacagtcaaggagctagaagaggaagcgaaggccattgaa gaaccagtgaagaaatcgccagaggaaaagttccgaaaggtgctgatccaaaccatcgtg acttgggctgaggagtcgcagatcgaaactccgaaactagttagagagatgttcagtctg ctcgtgcgccaatatgatgcagtgggtgaactgattcgagctctcgaaaagacatacgtc atcaacgcgaagaccaaacaagatgtagctgaaatgtgggttggcctgagccaaatcaga gctttactgcccgtacagatgagccaagaagaagaggaactcatgaggaagagactatgg aaacttgtcaacaaccatactttcttccagcatcctgatttgattagagttctgcgcgta catgaaaatgtaatggcagttatgatgaacacgttgggaagacgtgcgcaggcgcagtct gacgcgcccaccgctgcgcagcccacgcccgaggataaggaaaaggacacctcccacgag atggtggtagcgtgttgccgcttcctctgctacttctgtcgcacaggcagacagaatcag aaggccatgtttgaccacttcgacttcttgctggagaactctaacattttactgtcaagg ccgtctttgagggggtctactcctttggacgtcgcttattccagtttgatggaaaacact gaactggctttagctttgagagagcattatctagaaaagattgcagtatacctatcacgt tgtggtctgcaaagtaactctgagcttattgagaagggctatcccgaccttggctgggat ccagtggaaggcgagcgatatcttgacttcctacgattttgtgtgtgggtaaacggtgaa agtgtggaagaaaacgccaatctagtaatccgtctcctgattaggagaccggagtgcttg ggtccagcgctgcgcggtgaaggtgaagggttgctgaaggctattgtagatgctaataag atgagcgagaggatcgctgatagacgtaagctgagggacgaggacggcgatataaatttc agccacccacttccccagtcagatgatgacgaagactatattgatacgggtgccgcaata ctcaacttttactgcactctggttgacttgttaggccggtgtgcacctgacgctgctgtt attgctctgggaaaaaacgaatctctacgagcaagagccattcttcgatcactggttcca cttgaagatctacaaggcgttctcagtctacgattcactttaaataacccggcagctggc gaagagaggcccaaatctgatatgccatctggcctaatccctggacacaagcaaagtgtt ggattattcttggaacgtgtctacggtatcgagacgcaagagctattctacagacttctc gaggaagctttcttaccagatcttagagcggccacaatgttggataggaacgatggctgt gaatcagatatggctctatcgatgaaccggtacataggcaactcaatcttaccacttctt atcaagcacgccaacttctacaatgaggcagagaattatgctagcctgttggatgctaca ctacatactgtttatagattgtccaaaaatcgtatgctgacgaaaggccaacgtgaagcc gtatcggacttcctcgtagctctgactgcggccatgcaaccttccatgctgcttaaatta cttcgcaaactcaccgttgatgtctcccgcctgtctgaatataccactgttgcactgcgg ttgctaacactccactacgagcgttgcgctaaatactacggcagtacgggcggtcaaggc atatacggcgcatcatctgatgaagagaagcggctgacaatgatgctgttttctaacatc ttcgactccttgagcaagatggattacgagcctgagctgtttgggaaagccctgccctgt cttattgccattggttgcgctttaccaccagactattcgctgtccaagaactacgacgat gaattctatggaaaagaaaatacgcaggcaacgggtgctgataacccacagtacgaccct caacccatcaacacatcatcagtggctctcaacaatgacctcaacaccattgtgcagaaa ttctccgagcattaccatgatgcttgggcatctaggaaaatcgaaaatggttgggtgtac ggtgaatcttggtcggacagtcaaaaaacgcatcctcgcctaaaaccttacaatatgctg aacgattatgaaaaagagcgttacaaggaaccggtgcgcgaatcgttgaaagcgttgctg gcaatcggttggtccgttgaacattctgaggtggacatacccagtaccaatcgcagctct atgagacggcagtccaaatctggcggcgtcacggactcagcgactccattcaattacaac ccgcaccccgtggatatgaccaacctgacgttgtcgcgtgagatgcaaaacatggcggag aggctcgctgaaaacgcacacgacatctgggctaagaagaaaaaagaggaactggttact aacggaggcggaatccatccccaactcgtcccatacgacctcctcactgacaaagagaaa aagaaggaccgagaacgatcccaagagttcctcaaatacctccaataccaaggatacaaa ctgcaccggcccaaaacatcccagggtgatacagaacagaccactactggcgtagcaata gagctcagattcgcttactcgcttctggagaagttgatttcgtatattgacagagctacg attaatatgaagctattgaaaccatccactacgttcagtagacgaccaagtttcaagacc agcacgagggatattaaattcgtttctaaggtggtactgcctttaatggagaaatacttc tcaacgcatcgcaactacttcatcgcggttgccacggcaaccaacaacgtgggcgcggcc agcttgaaagagaaagagatggtcgccgcactgttctgtaaactggcgagcttattacgg tccaggttagcagcattcggtccagacgtccgcatcacggtccgctgtctccaagtgctg gtgaaaggcatcgacgcgaagtccctcgtcaagaactgtcccgagttcatccgaacttct atgcttaccttcttcaataatgttgctgatgatctcggtcatactatcatgaatttacag gatggcaaatattctcaccttcgaggaacccacctgaagacctcaacgtcactgggttat atcaatggcgtcatactccccgtgctgacagctatgttcgaccacctggccaattgcgag tacggcgctgatctgttgttggacgaaattcaagtggcctcatacaagatgcttgggtcc ttatacacgctgggtaccgatgcgacgctcacacacgacagaaaatatctcaagactgaa attgaaaggaataaacctgcactggggtcatgtttaggcgccttcagttccacgttccca gtggcgttcttcgaacctcatctcaacaagcacaaccagttctctctactgaaccgcata gcggaccactcacttgaagctaaagacataatggccaaaatggagcaatcgatgcctact ctcgagtcgatattaaacgaagtagatcagttcgtagaatcggacaagacttacaacgaa gctcctcacatcattgatgtggttatgccgttgctgtgttcttatctgccgttctggtgg gcccaggggcctgacaatgtcactcccactgctggaaaccacgtaacaatggtaacagca gaacacatgaaccaactcctgaagaacgtcctcaagctcatcaagaagaacattggcaac gaaagtgctccttggatgacccgcatcgcgacatacacgcaacagatcatcatcaacagt tctgaggaattgctgagggagtccttcttacctctcgctgagagagtgagaaagaggacc gataccatgttccataaggaagagagtttgagaggttttattaaatcatcaacggacgac acgtcgcaagtggaatcgcagatacaagaggactggcaacttctagtgcgagatatttac tcattctaccctcttctcatcaaatacgtcgatcttcagaggaaccattggcttcggaac aacgtaccagaggccgaagaactatacaaccacgtggcagaaatattcaacatctggtca aagagtcagtacttccttaaagaggaacaaaacttcatatcggctaacgaaatcgataac atggtgttgatcatgcctactgcaactcgaagagttaccaccgtagttgatgggacacca cagggtggaggaaagaaaaagaagaagcaccgtgacaagaaacgtgacaaagacaaggag gtacaagcatcactaatggtagcttgtctcaagaggttgttacctgttggactcaatctc ttcgcgggaagagagcaagagttagtgcagcattgtaaagatcgcttcttgaagaaaatg tccgaacaagacgtggcggaattcgccaaaactcagctaacgttaccggacaagatcgat ccagcggatgaaatgtcctggcagcattatctgtacagcaagctggggtccaagagcaaa accacagtcacaactgtggagacgtcagagaacaaggccaagcttatagacgacacggtg gaacggatagttgcgatgagcaaagtgttgtttggattgcatatgatcgaccatcctcaa caaatgagtaagaacgtgtaccgttccgtggtatctattcaacgaaaacgtgctgtgatt gcctgcttcaggcagacttcgctacattccttgcccagacatcgagtctgcaatatattc gcgcgaacatactacgagctatggttggaagaagaaaacattggccaagaagtcatgatt gaagatcttacgcaatcgttcgaggatgcggagttgaaaaagagtgatttagtggaagaa gacggaaagcctgatcctctcacacaactcgtcactacattctgtcgtggcgctatgact gaaagatctggggcattacaggaagatccactgtacatgtcgtacgcacatataatagca aagtcgtgtggtgaggaagaagaggaaggcggggaggaagaagaaggtgggggggaacca gagggaggtgacgaagagggccgcgccagtatacatgaacaagaaatggagaaacaaaag ctgttgttccatcaaaaacgattagcgaaccgtggtgtagcagaaatggtgttgctccac atatctgcctccaaagggcaaccgagtgacatggttatgaaaacgctgcaactgggcatc tccatactacggggcggaaatattgatatacagatgggtatgctcaaccacctgaaagac aaaaaagatgtcggtttcttcacatccatcgccggtttgatgaactcatgctccgtactt gacttggatgccttcgaaagaaataccaaagctgaaggacttggagtggggttggaagga gcggccggtgagaagaacatgcacgatgctgagttcacttgtgcgctgttccggttcata caactgacttgtgaaggccataacttggaatggcaaaactacctccgtacgcaagccgga aacacgacaactgtgaacgttgtcatctgcacagtggattacttgctgaggctgcaggag tctattatggacttctactggcactattctagcaaggaactcatcgatccagcgggcaag gcgaacttcttcaaagccatcggagtagcgtctcaagtgttcaacaccctcactgaagtt atccagggtccttgtacgcagaatcaacaggccttagctcattccagattgtgggacgcg gtgggcggtttcctgttcctcttctctcacatgcaggacaagttgtccaaacattcctca caagtggatctgctgaaggaactcctcaatttgcagaaggacatgatcactatgatgctg tctatgcttgagggaaatgttgtcaatggtacaatcggcaaacagatggtagatactcta gtagaatccgcatctaacgtggaactgatcctcaaatacttcgacatgtttctgaagcta aaggacctgacttccagcgcaagcttcaaggaaattgatgccaataatgatggatgggtt cttccgaaggactttaaggagaagatggaacagcagaagagttatacaccagaagaaata gagttcctgctcgcgtgctgcgaaacgaaccatgatggcaaactggactacctgggcttc tgcgaccgcttccacgagccagccaaggaaatcggcttcaacctcgccgttttgctcacc aacttgtccgaacacatgcctaatgaacccaggctcgctcggtttctggagacggctgga tctgtgctgaactatttcgagccattcttgggtcgtatcgagataatgggtggatccaag aggatcgagcgtgtttacttcgagatcaaggagtccaatattgaacagtgggagaaacct cagatcaaggaatcgaaacgcgcgttcttctatagcattgtaacagaaggtggtgataag gagaagttggaagcctttgtcaacttctgtgaagacgccatctttgaaatgacgcatgct tctggtctgatggccgtgtcagaggaagcggctggtggtctgaagaacagggaggcttat catgtatatatgggtgacgatgaggaagaaagagcgggaaaagatccattccgccgtggt ttccagtcggtcaaggacggcatctccacggcattttcgtctctatccccctccaacata aagcagagaatcgcagatctacagcagatgccgcctgctgaattatttattggcttcttc aaaatgttcttctatctcttctactatttaggctatggcgctgtcgttgttatcaggtac atcttcggagtcctcctcgggttgatgcgagggccggtgacggacgagcctccgccggag ccgacggaagaggagaaaatcggtcagttgaagctctcgctcctacacagaacattcccg caaagtcctatgagacacctgccggcattgccagcggcggacgacaccgggcaaatgcaa gtttcggctttcggactggatattactaaagaagacaatggccagatacaagtgaagccg cacgagtctccgaccgcgtccactccgtcatcaggcgaggaagcggaagtgtcaccagat gagagcactgagcatacagaggaacagcaaccaccttctcttattgatctacttggtggc gagcaagctaagaagcaggctcaggaacgaatggaagcccaggcggtacaacaagctgcc atgtccgctatcgaagccgaaaacaaaaagcaggcagtacaaggccccgctccgtcagcg ttatctcaagtggatctgtcgcaatacacaaagcgcgccgtgtctttcctcgcgagaaat ttctacaacctgaagtacgtggctctcgtactcgccttctgtatcaacttcgtgctgctc ttctataaggtatcaacattagaagtggaaaggggtgagggttcgggaatcggagatatc atcagcggatctggttcaggacaagggtctggaagtggtgacggtggtagtggtgaaagc gaagaggacgagggtctagaagtggtgctgatagacgaagacttcttctacatggagcac gtcatcaatgttgccgccttgctgcattccatagtgtctctagctatactcgtcggctat tatcatctcaaggtgccgttagctatattcaagcgtgagaaagagatagcgcgtaaactg gagttcgacggtctgtacatcgcggagcagccagaagatgacgacttgaagagccattgg gacaagcttgtcatttctgctaaatcattcccagtgaactactgggacaagttcatcaag aagaaagtgcgcgcgaaatattccgagacctacgacttcgactctatatccaacatgctc ggaatggaaaagacctctttctcggcgcaggaagaggagggcagcaagggattctggcat tacatcgtcaacatcgactggcgctaccaagtctggaaggctggagtgacgataactgac aactccttcctctattctctatggtacttctccttctccgtgatggggaacttcaacaac ttcttcttcgccgcacacttgctagacgttgctgtgggcttcaagactttgaggaccatc ttgcagtctgtcacgcataacggaaaacagctggtgttgacggtgatgttgctgacaatc atcgtgtacatctatacggtgatcgcgttcaacttcttccgcaagttctacgtgcaggaa gaggacgacgaagtcaacaagaactgccacgacatgctttcctgtttcgtgttcaaccta tacaaaggcgtgagagcgggtggtggtatcggagacgagctggagcccccagacggtgat gactcggaggtgtaccgcatcatatttgacatctcgttcttcttcttcgtcatcgtcatc ctgctggctatcttgcagggtctgatcatcgacgcgttcggtgagctccgtgaccagctg gagtccgtcaaagaggacatggagtccaactgcttcatatgcggcatcaataaggactac tttgataaagttccgcacgggttcgacacgcacgtgcagcgggagcacaacctcgcgaac tacatgttcttccttatgcatcttatcaacaaacccgacaccgagtatactggtcaagaa acgtttgtatggaaaatgtacacacaaagatgctgggatttcttccccgttggtgactgc ttcaggaaacagtacgaagacgcgatgggcgaatag

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