KEGG   Manis javanica (Malayan pangolin): 108384893
Entry
108384893         CDS       T06054                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04024  cAMP signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04137  Mitophagy - animal
mjv04140  Autophagy - animal
mjv04141  Protein processing in endoplasmic reticulum
mjv04210  Apoptosis
mjv04215  Apoptosis - multiple species
mjv04217  Necroptosis
mjv04310  Wnt signaling pathway
mjv04380  Osteoclast differentiation
mjv04510  Focal adhesion
mjv04530  Tight junction
mjv04620  Toll-like receptor signaling pathway
mjv04621  NOD-like receptor signaling pathway
mjv04622  RIG-I-like receptor signaling pathway
mjv04625  C-type lectin receptor signaling pathway
mjv04657  IL-17 signaling pathway
mjv04658  Th1 and Th2 cell differentiation
mjv04659  Th17 cell differentiation
mjv04660  T cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04668  TNF signaling pathway
mjv04722  Neurotrophin signaling pathway
mjv04723  Retrograde endocannabinoid signaling
mjv04728  Dopaminergic synapse
mjv04750  Inflammatory mediator regulation of TRP channels
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04917  Prolactin signaling pathway
mjv04920  Adipocytokine signaling pathway
mjv04926  Relaxin signaling pathway
mjv04930  Type II diabetes mellitus
mjv04931  Insulin resistance
mjv04932  Non-alcoholic fatty liver disease
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv04936  Alcoholic liver disease
mjv05010  Alzheimer disease
mjv05012  Parkinson disease
mjv05016  Huntington disease
mjv05017  Spinocerebellar ataxia
mjv05020  Prion disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05132  Salmonella infection
mjv05133  Pertussis
mjv05135  Yersinia infection
mjv05142  Chagas disease
mjv05145  Toxoplasmosis
mjv05152  Tuberculosis
mjv05161  Hepatitis B
mjv05162  Measles
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05169  Epstein-Barr virus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05171  Coronavirus disease - COVID-19
mjv05200  Pathways in cancer
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05212  Pancreatic cancer
mjv05231  Choline metabolism in cancer
mjv05415  Diabetic cardiomyopathy
mjv05417  Lipid and atherosclerosis
mjv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    108384893 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108384893 (MAPK8)
   04012 ErbB signaling pathway
    108384893 (MAPK8)
   04014 Ras signaling pathway
    108384893 (MAPK8)
   04310 Wnt signaling pathway
    108384893 (MAPK8)
   04668 TNF signaling pathway
    108384893 (MAPK8)
   04068 FoxO signaling pathway
    108384893 (MAPK8)
   04071 Sphingolipid signaling pathway
    108384893 (MAPK8)
   04024 cAMP signaling pathway
    108384893 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108384893 (MAPK8)
   04137 Mitophagy - animal
    108384893 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    108384893 (MAPK8)
   04215 Apoptosis - multiple species
    108384893 (MAPK8)
   04217 Necroptosis
    108384893 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108384893 (MAPK8)
   04530 Tight junction
    108384893 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    108384893 (MAPK8)
   04621 NOD-like receptor signaling pathway
    108384893 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    108384893 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    108384893 (MAPK8)
   04660 T cell receptor signaling pathway
    108384893 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    108384893 (MAPK8)
   04659 Th17 cell differentiation
    108384893 (MAPK8)
   04657 IL-17 signaling pathway
    108384893 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    108384893 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108384893 (MAPK8)
   04920 Adipocytokine signaling pathway
    108384893 (MAPK8)
   04912 GnRH signaling pathway
    108384893 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    108384893 (MAPK8)
   04917 Prolactin signaling pathway
    108384893 (MAPK8)
   04926 Relaxin signaling pathway
    108384893 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    108384893 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    108384893 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    108384893 (MAPK8)
   04722 Neurotrophin signaling pathway
    108384893 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    108384893 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108384893 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108384893 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    108384893 (MAPK8)
   05231 Choline metabolism in cancer
    108384893 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108384893 (MAPK8)
   05212 Pancreatic cancer
    108384893 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108384893 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    108384893 (MAPK8)
   05161 Hepatitis B
    108384893 (MAPK8)
   05171 Coronavirus disease - COVID-19
    108384893 (MAPK8)
   05162 Measles
    108384893 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108384893 (MAPK8)
   05169 Epstein-Barr virus infection
    108384893 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108384893 (MAPK8)
   05135 Yersinia infection
    108384893 (MAPK8)
   05133 Pertussis
    108384893 (MAPK8)
   05152 Tuberculosis
    108384893 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    108384893 (MAPK8)
   05142 Chagas disease
    108384893 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108384893 (MAPK8)
   05012 Parkinson disease
    108384893 (MAPK8)
   05016 Huntington disease
    108384893 (MAPK8)
   05017 Spinocerebellar ataxia
    108384893 (MAPK8)
   05020 Prion disease
    108384893 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    108384893 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108384893 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    108384893 (MAPK8)
   05415 Diabetic cardiomyopathy
    108384893 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108384893 (MAPK8)
   04936 Alcoholic liver disease
    108384893 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    108384893 (MAPK8)
   04931 Insulin resistance
    108384893 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108384893 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    108384893 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108384893 (MAPK8)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     108384893 (MAPK8)
Protein kinases [BR:mjv01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   108384893 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 108384893
NCBI-ProteinID: XP_036855144
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVTSGSQRPSSASSANDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattc
acagtcctgaaacggtatcagaatttaaagcctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaacgttgcaatcaagaagctaagccggcca
tttcagaatcaaactcatgctaagcgggcttatagagagctagttctaatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcataccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tcagactgcactttgaagattcttgactttggactggcaaggactgcaggaactagtttt
atgatgacaccttatgtagtgactcgctactacagagcacctgaggtcatcctaggaatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccttgtcctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtacttttc
ccggctgactcagagcacaacaaacttaaagccagtcaggcaagggatctattatccaaa
atgctggtaattgatgcatctaaaaggatctccgtagatgaagctctccagcacccatat
atcaatgtctggtatgacccttctgaagcagaagctccaccaccaaagatccctgacaag
cagttagatgaaagagagcacacgatagaagagtggaaagaactgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcaaccctctcccttaggt
gcagcagtgaccagcggctctcagcgcccatcatcagcatcatctgccaatgatgtgtct
tcaatgtcaacagacccgactttggcctcagatacagacagcagtctcgaagcatcagct
ggacctctgggctgctgcagatga

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