KEGG   Manis javanica (Malayan pangolin): 108390365
Entry
108390365         CDS       T06054                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv00562  Inositol phosphate metabolism
mjv01100  Metabolic pathways
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv01524  Platinum drug resistance
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04024  cAMP signaling pathway
mjv04062  Chemokine signaling pathway
mjv04066  HIF-1 signaling pathway
mjv04068  FoxO signaling pathway
mjv04070  Phosphatidylinositol signaling system
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04081  Hormone signaling
mjv04140  Autophagy - animal
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04152  AMPK signaling pathway
mjv04210  Apoptosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04218  Cellular senescence
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04380  Osteoclast differentiation
mjv04510  Focal adhesion
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04611  Platelet activation
mjv04613  Neutrophil extracellular trap formation
mjv04620  Toll-like receptor signaling pathway
mjv04625  C-type lectin receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04666  Fc gamma R-mediated phagocytosis
mjv04668  TNF signaling pathway
mjv04670  Leukocyte transendothelial migration
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04750  Inflammatory mediator regulation of TRP channels
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04923  Regulation of lipolysis in adipocytes
mjv04926  Relaxin signaling pathway
mjv04929  GnRH secretion
mjv04930  Type II diabetes mellitus
mjv04931  Insulin resistance
mjv04932  Non-alcoholic fatty liver disease
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv04960  Aldosterone-regulated sodium reabsorption
mjv04973  Carbohydrate digestion and absorption
mjv05010  Alzheimer disease
mjv05017  Spinocerebellar ataxia
mjv05020  Prion disease
mjv05100  Bacterial invasion of epithelial cells
mjv05132  Salmonella infection
mjv05135  Yersinia infection
mjv05142  Chagas disease
mjv05146  Amoebiasis
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05162  Measles
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05168  Herpes simplex virus 1 infection
mjv05169  Epstein-Barr virus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05171  Coronavirus disease - COVID-19
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05207  Chemical carcinogenesis - receptor activation
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05218  Melanoma
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05222  Small cell lung cancer
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mjv05415  Diabetic cardiomyopathy
mjv05417  Lipid and atherosclerosis
mjv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108390365 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    108390365 (PIK3CD)
   04014 Ras signaling pathway
    108390365 (PIK3CD)
   04015 Rap1 signaling pathway
    108390365 (PIK3CD)
   04370 VEGF signaling pathway
    108390365 (PIK3CD)
   04630 JAK-STAT signaling pathway
    108390365 (PIK3CD)
   04668 TNF signaling pathway
    108390365 (PIK3CD)
   04066 HIF-1 signaling pathway
    108390365 (PIK3CD)
   04068 FoxO signaling pathway
    108390365 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    108390365 (PIK3CD)
   04072 Phospholipase D signaling pathway
    108390365 (PIK3CD)
   04071 Sphingolipid signaling pathway
    108390365 (PIK3CD)
   04024 cAMP signaling pathway
    108390365 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    108390365 (PIK3CD)
   04152 AMPK signaling pathway
    108390365 (PIK3CD)
   04150 mTOR signaling pathway
    108390365 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    108390365 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108390365 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    108390365 (PIK3CD)
   04218 Cellular senescence
    108390365 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108390365 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    108390365 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108390365 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108390365 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    108390365 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    108390365 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    108390365 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    108390365 (PIK3CD)
   04660 T cell receptor signaling pathway
    108390365 (PIK3CD)
   04662 B cell receptor signaling pathway
    108390365 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    108390365 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    108390365 (PIK3CD)
   04670 Leukocyte transendothelial migration
    108390365 (PIK3CD)
   04062 Chemokine signaling pathway
    108390365 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108390365 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    108390365 (PIK3CD)
   04929 GnRH secretion
    108390365 (PIK3CD)
   04915 Estrogen signaling pathway
    108390365 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    108390365 (PIK3CD)
   04917 Prolactin signaling pathway
    108390365 (PIK3CD)
   04926 Relaxin signaling pathway
    108390365 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    108390365 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    108390365 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    108390365 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    108390365 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    108390365 (PIK3CD)
   04722 Neurotrophin signaling pathway
    108390365 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    108390365 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    108390365 (PIK3CD)
   04380 Osteoclast differentiation
    108390365 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    108390365 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    108390365 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108390365 (PIK3CD)
   05206 MicroRNAs in cancer
    108390365 (PIK3CD)
   05205 Proteoglycans in cancer
    108390365 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    108390365 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    108390365 (PIK3CD)
   05203 Viral carcinogenesis
    108390365 (PIK3CD)
   05230 Central carbon metabolism in cancer
    108390365 (PIK3CD)
   05231 Choline metabolism in cancer
    108390365 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108390365 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108390365 (PIK3CD)
   05212 Pancreatic cancer
    108390365 (PIK3CD)
   05225 Hepatocellular carcinoma
    108390365 (PIK3CD)
   05226 Gastric cancer
    108390365 (PIK3CD)
   05214 Glioma
    108390365 (PIK3CD)
   05221 Acute myeloid leukemia
    108390365 (PIK3CD)
   05220 Chronic myeloid leukemia
    108390365 (PIK3CD)
   05218 Melanoma
    108390365 (PIK3CD)
   05211 Renal cell carcinoma
    108390365 (PIK3CD)
   05215 Prostate cancer
    108390365 (PIK3CD)
   05213 Endometrial cancer
    108390365 (PIK3CD)
   05224 Breast cancer
    108390365 (PIK3CD)
   05222 Small cell lung cancer
    108390365 (PIK3CD)
   05223 Non-small cell lung cancer
    108390365 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108390365 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    108390365 (PIK3CD)
   05161 Hepatitis B
    108390365 (PIK3CD)
   05160 Hepatitis C
    108390365 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    108390365 (PIK3CD)
   05164 Influenza A
    108390365 (PIK3CD)
   05162 Measles
    108390365 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    108390365 (PIK3CD)
   05163 Human cytomegalovirus infection
    108390365 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108390365 (PIK3CD)
   05169 Epstein-Barr virus infection
    108390365 (PIK3CD)
   05165 Human papillomavirus infection
    108390365 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108390365 (PIK3CD)
   05135 Yersinia infection
    108390365 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    108390365 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108390365 (PIK3CD)
   05142 Chagas disease
    108390365 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108390365 (PIK3CD)
   05017 Spinocerebellar ataxia
    108390365 (PIK3CD)
   05020 Prion disease
    108390365 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108390365 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    108390365 (PIK3CD)
   05415 Diabetic cardiomyopathy
    108390365 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108390365 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    108390365 (PIK3CD)
   04931 Insulin resistance
    108390365 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108390365 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108390365 (PIK3CD)
   01524 Platinum drug resistance
    108390365 (PIK3CD)
   01522 Endocrine resistance
    108390365 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mjv04131]
    108390365 (PIK3CD)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     108390365 (PIK3CD)
Membrane trafficking [BR:mjv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    108390365 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 108390365
NCBI-ProteinID: XP_036856035
LinkDB
Position
Unknown
AA seq 1069 aa
MPPGVDCPMEFWTKEESQNVAVDFLLPTGVYLNFPVSRNANLSAIKKELWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVARQGDRVKKLVNSQISLL
IGKGLHEFDSLNDPEVNDFRTKMRQFCEDAAAHRQQLGWEAWMQYSFPLQLEPSARSWGA
GTLRVPNRALLVNVKFEGSEDSFTFQVSTKDEPLALMACALRKKATVFRQPLVEQPQDYT
LQVNGKHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPTSQVQKPR
TKPPPIPMKKPSSVSLWSLEKPFSIDLVQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPAGTVQSNPNTESAAALVICLPEVAS
HPVYYPALDKILELGRQGEHGHFTEEEQLQLQEILERRGSGELYEHEKDLVWKMRHEVQG
CFPEALARLLLVTKWNKHEDVAQVRGGGGAGQGAEPGRTAARLTAAPQMLCLLCSWPELP
VLSALELLDFSFPDRHVSSFAIKSLRKLTDDELFQYLLQLVQVLKYEAYLDCELTKFLLD
RALANRKIGHFLFWHLRSEMHVPSVALRFGLLMEAYCRGSTHHMKVLMKQGDALSKLKAL
NDIVKVSSQKTAKPQTKELMHLCMRQETYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSK
MKPLWVVYSNDEAGGDGGVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGC
LSTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEF
TLSCAGYCVATYVLGIGDRHSDNIMIRENGQLFHIDFGHFLGNFKTKFGINRERVPFILT
YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDI
QYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgcccccgggggtcgactgccccatggaattctggaccaaggaggagagtcagaacgtg
gcggtcgactttctgctgcccacaggagtctatctgaacttccctgtgtcccgaaatgcc
aacctcagcgccatcaagaaggaactgtggcaccgagcccagtatgagccgctcttccac
atgctcagcgatcccgaggcctacgtgttcacctgtgtcaaccagacggcagagcagcag
gagctggaggacgagcagcggcggctgtgcgacatccagcctttcctgccggtgctgcgc
ctggtggcccgccagggtgacagggtgaagaagctcgtcaacagccagatcagcctcctc
atcggcaaaggcctccacgagtttgactccttgaatgacccggaagtgaatgactttcgc
accaagatgcgccagttctgtgaggacgcggccgcccaccggcagcagctgggctgggag
gcctggatgcagtacagcttccctctgcagctggagccctcggcacggagctggggagcg
ggcaccctgcgggtccccaaccgggccctcctggtcaacgtcaagttcgagggtagtgag
gacagcttcaccttccaggtgtccaccaaggatgaacccctggcactgatggcctgtgct
ctccggaagaaggccacggtgttccggcagcccctggtggagcagcctcaggactacacg
cttcaggtgaacggaaagcacgagtacctgtacggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccccacctgaccatggtgcactcctca
tccatcctcgccatgagagacgagcagagcaaccccacctcccaagtccaaaaaccgcgc
actaaaccaccccccattcccatgaagaagccctcctctgtgtcgctgtggtccttggag
aagcccttctccatcgacctggtccagggcagcaaagtgaatgcggacgagcggatgaag
ctggtggtacaggctgggcttttccacggcaatgagacgctgtgcaagaccgtgtccagc
tcagaggtgagcgtgtgctcagagcccgtgtggaagcagcggctggagtttgacatcaac
gtctgtgacctgcctcgcatggcccgtctctgctttgcactttacgctgtgattgagaag
gctaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgtttgactacaaggaccagctcaagacgggtgaatgctgcctctac
atgtggccgtctgtcccagatgagaagggggagctgctgaatcctgcgggaaccgtgcag
agtaaccccaacactgagagcgccgccgccctggtcatctgcctccccgaggtggcctcc
catcctgtgtactaccctgccctggacaagatcctggagctggggcggcagggggagcac
ggtcacttcacagaggaggagcagctgcagctgcaggagatcctggagcggcgggggtcg
ggggagctgtatgagcatgagaaggacctggtgtggaagatgcggcacgaggtgcagggg
tgcttcccggaggccctggcccggctgctgctggtcaccaagtggaacaagcacgaggac
gtggcccaggtgcgtggcgggggaggggccgggcagggggcggagcctgggcggactgcc
gcccgcctgactgccgccccgcagatgctctgcctgctgtgctcgtggcccgagctgcct
gtcctgagcgccctggagctgctggacttcagcttccccgaccgccacgtgagctccttt
gccatcaagtccctgcgcaaactgacggacgatgagcttttccagtacctgctgcagctg
gtacaggtgctcaagtacgaggcctacctggactgcgagctgaccaagttcctgctcgac
cgggcgctggccaaccgcaagatcggccacttcctcttctggcacctccgctccgagatg
cacgtgccctcggtggccctgcgcttcggcctcctcatggaggcctactgcaggggcagc
acccaccacatgaaggtgctgatgaagcagggggatgcgctgagcaaactgaaggctctg
aacgacatcgtgaaagtgagctcccagaagaccgccaagccgcagaccaaggagctgatg
cacctgtgcatgcgccaggagacctacctggaggccctctcccacctgcagtccccgctc
gaccccagcaccctgctggctgaagtctgcgtggagcagtgcaccttcatggactccaag
atgaagcccctgtgggtcgtgtacagcaacgacgaggccggcggtgatggcggcgtgggc
atcatctttaagaacggcgatgacctccgccaggacatgctgaccctgcagatgatccag
ctcatggatgtcctgtggaagcaggaggggctggacctgagaatgaccccctacggctgt
ctctccactggggaccgcacgggcctcattgaggtggtgctccactcagacaccattgcc
aacatccagctgaacaagagcaacatggcagccacggccgccttcaacaaggatgctctg
ctcaactggctcaaatccaagaaccctggggaagccctggaccgagccattgaggagttc
acgctctcctgtgctggctactgtgtggccacctatgtgctgggcattggtgaccggcac
agtgacaacatcatgatccgggagaatgggcagctgttccacattgattttggccacttc
ctggggaatttcaagaccaagtttggaatcaaccgtgagcgggtcccattcatcctcacc
tatgactttgtgcatgtgatccagcaggggaagacgaataacagtgagaaatttgaaaga
ttccggggctactgcgagcgagcctacaccatcctgcggcgccatgggctgcttttcctg
cacctcttcgccttgatgcgggcagcaggcctacctgagctcagctgctccaaagacatc
cagtatcttaaggactctctggcactgggaaaaacagaggaggaggctctaaagcacttc
cgagtgaagttcaacgaagccctgcgggagagctggaaaaccaaagtgaactggctggcc
cacaacgtgtccaaagacaacaggcagtag

DBGET integrated database retrieval system