KEGG   Manis javanica (Malayan pangolin): 108392139
Entry
108392139         CDS       T06054                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04022  cGMP-PKG signaling pathway
mjv04024  cAMP signaling pathway
mjv04062  Chemokine signaling pathway
mjv04066  HIF-1 signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04114  Oocyte meiosis
mjv04140  Autophagy - animal
mjv04148  Efferocytosis
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04218  Cellular senescence
mjv04270  Vascular smooth muscle contraction
mjv04370  VEGF signaling pathway
mjv04371  Apelin signaling pathway
mjv04380  Osteoclast differentiation
mjv04510  Focal adhesion
mjv04540  Gap junction
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04613  Neutrophil extracellular trap formation
mjv04620  Toll-like receptor signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04666  Fc gamma R-mediated phagocytosis
mjv04668  TNF signaling pathway
mjv04720  Long-term potentiation
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04921  Oxytocin signaling pathway
mjv04926  Relaxin signaling pathway
mjv04928  Parathyroid hormone synthesis, secretion and action
mjv04929  GnRH secretion
mjv04934  Cushing syndrome
mjv04935  Growth hormone synthesis, secretion and action
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05132  Salmonella infection
mjv05135  Yersinia infection
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05200  Pathways in cancer
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05207  Chemical carcinogenesis - receptor activation
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05216  Thyroid cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108392139 (MAP2K1)
   04012 ErbB signaling pathway
    108392139 (MAP2K1)
   04014 Ras signaling pathway
    108392139 (MAP2K1)
   04015 Rap1 signaling pathway
    108392139 (MAP2K1)
   04370 VEGF signaling pathway
    108392139 (MAP2K1)
   04371 Apelin signaling pathway
    108392139 (MAP2K1)
   04668 TNF signaling pathway
    108392139 (MAP2K1)
   04066 HIF-1 signaling pathway
    108392139 (MAP2K1)
   04068 FoxO signaling pathway
    108392139 (MAP2K1)
   04072 Phospholipase D signaling pathway
    108392139 (MAP2K1)
   04071 Sphingolipid signaling pathway
    108392139 (MAP2K1)
   04024 cAMP signaling pathway
    108392139 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    108392139 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    108392139 (MAP2K1)
   04150 mTOR signaling pathway
    108392139 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108392139 (MAP2K1)
   04148 Efferocytosis
    108392139 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    108392139 (MAP2K1)
   04210 Apoptosis
    108392139 (MAP2K1)
   04218 Cellular senescence
    108392139 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108392139 (MAP2K1)
   04540 Gap junction
    108392139 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    108392139 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108392139 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    108392139 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    108392139 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    108392139 (MAP2K1)
   04660 T cell receptor signaling pathway
    108392139 (MAP2K1)
   04662 B cell receptor signaling pathway
    108392139 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    108392139 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    108392139 (MAP2K1)
   04062 Chemokine signaling pathway
    108392139 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108392139 (MAP2K1)
   04929 GnRH secretion
    108392139 (MAP2K1)
   04912 GnRH signaling pathway
    108392139 (MAP2K1)
   04915 Estrogen signaling pathway
    108392139 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    108392139 (MAP2K1)
   04917 Prolactin signaling pathway
    108392139 (MAP2K1)
   04921 Oxytocin signaling pathway
    108392139 (MAP2K1)
   04926 Relaxin signaling pathway
    108392139 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    108392139 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    108392139 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    108392139 (MAP2K1)
   04916 Melanogenesis
    108392139 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    108392139 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    108392139 (MAP2K1)
   04726 Serotonergic synapse
    108392139 (MAP2K1)
   04720 Long-term potentiation
    108392139 (MAP2K1)
   04730 Long-term depression
    108392139 (MAP2K1)
   04722 Neurotrophin signaling pathway
    108392139 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108392139 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108392139 (MAP2K1)
   05206 MicroRNAs in cancer
    108392139 (MAP2K1)
   05205 Proteoglycans in cancer
    108392139 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    108392139 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    108392139 (MAP2K1)
   05230 Central carbon metabolism in cancer
    108392139 (MAP2K1)
   05231 Choline metabolism in cancer
    108392139 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108392139 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108392139 (MAP2K1)
   05212 Pancreatic cancer
    108392139 (MAP2K1)
   05225 Hepatocellular carcinoma
    108392139 (MAP2K1)
   05226 Gastric cancer
    108392139 (MAP2K1)
   05214 Glioma
    108392139 (MAP2K1)
   05216 Thyroid cancer
    108392139 (MAP2K1)
   05221 Acute myeloid leukemia
    108392139 (MAP2K1)
   05220 Chronic myeloid leukemia
    108392139 (MAP2K1)
   05218 Melanoma
    108392139 (MAP2K1)
   05211 Renal cell carcinoma
    108392139 (MAP2K1)
   05219 Bladder cancer
    108392139 (MAP2K1)
   05215 Prostate cancer
    108392139 (MAP2K1)
   05213 Endometrial cancer
    108392139 (MAP2K1)
   05224 Breast cancer
    108392139 (MAP2K1)
   05223 Non-small cell lung cancer
    108392139 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108392139 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    108392139 (MAP2K1)
   05161 Hepatitis B
    108392139 (MAP2K1)
   05160 Hepatitis C
    108392139 (MAP2K1)
   05164 Influenza A
    108392139 (MAP2K1)
   05163 Human cytomegalovirus infection
    108392139 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108392139 (MAP2K1)
   05165 Human papillomavirus infection
    108392139 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108392139 (MAP2K1)
   05135 Yersinia infection
    108392139 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108392139 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    108392139 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    108392139 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    108392139 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108392139 (MAP2K1)
   01522 Endocrine resistance
    108392139 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108392139 (MAP2K1)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     108392139 (MAP2K1)
Protein kinases [BR:mjv01001]
 Serine/threonine kinases: STE group
  STE7 family
   108392139 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr
Other DBs
NCBI-GeneID: 108392139
NCBI-ProteinID: XP_036865843
LinkDB
Position
Unknown
AA seq 390 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRGAKLGMTGSDLLTSFPNFSGHHAVTQAQVGMPHWWGWVTPERLQGTHYSVQ
SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD
SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR
SDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgcctaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgccgtc
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtt
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggttttcaaagtctcccacaagccatccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaattcggaaccagatcataagggagctgcaggttctgcatgag
tgcaactccccctacatcgtgggcttctacggtgctttctacagtgatggcgaaatcagt
atctgcatggagcacatggatgggggttcattggatcaggttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaagggcctgacatatctg
agagagaagcacaagattatgcatagaggggctaagctaggaatgacggggagcgacctg
ttgacctcctttcccaacttctccggtcatcatgcagtgacccaggcgcaagtggggatg
cctcactggtggggctgggtcaccccagaaagactccaggggactcactactcggtgcag
tcagacatctggagcatggggctctctctggttgagatggcagttgggaggtatcccatt
cctcctccagatgccaaggagctggagctcatgtttgggtgccaggtggaaggagatgcg
gctgagacaccacccaggccaaggacccctggaaggcccctcagctcttatggaatggac
agccgacctcccatggcaatttttgagttgttggattatatagtcaatgaacctcctcca
aaactgcccagcggagtattcagtctggaatttcaagattttgttaataagtgcttaata
aaaaaccctgcagagagagcagatctaaagcagctcatggttcatgcttttatcaagaga
tctgatgctgaggaagtggattttgcaggctggctctgctccaccattggccttaaccag
cccagcacaccaacccacgcagctggcatctaa

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