Manis javanica (Malayan pangolin): 108394566 Help Entry 108394566         CDS       T06054                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv05165   Human papillomavirus infection mjv05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:mjv00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     108394566 (UBR4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     108394566 (UBR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:mjv04121]     108394566 (UBR4) Enzymes [BR:mjv01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      108394566 (UBR4) Ubiquitin system [BR:mjv04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     108394566 (UBR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  108394566 NCBI-ProteinID:  XP_036855817 LinkDB All DBs Position Unknown AA seq 5181 aa AA seqDB search MATSGGEETVAAAPAPGAPGPGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESE SEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDE ACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKDLASPV SPELRQKEVQMNFLNQLTSVFNPRTVASPPVGPQTPVEGENEEQSSTDQAFAIKTKNVFI AQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFH SLVIDVTMALDTLSLPVLEPLSPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT GSTSSKEEDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFL ILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHA VKLLTSLFQDLQVEALHKGWETDGPPAVLSIMAQSTSIQRIQRLIDSVPLTNLLLTLLST AYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS PSKEKVAPPPPPPPPPLESSPRVKSPSKQVPGEKGNILASRKDPELFLGLASNILNFITS SMLNSRNNFIRNYLSISLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTS DLQSPHLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQDDPDVPECL KVWDRFLSTVKQNALQGVAPSETEDLNVEHLQLLLLIFHNFTEKGRRAILTHFVQIIQEL SANMDVQMRSVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWSNGSQDSSS RRATTPLYHGFKEVEENWSKHFSSDAVPQPRFYCVLSPEASEDDLNRLDSVACDVLFSKL IKYDGLYTALTCLLAAGSQLDTVRRKENKNVTVLEACALQYYFLILWRILGILPPSKTYM NQLAMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHAGSLLELAVTKCS SVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAVSKVQVSLDEHFSK MAAETEPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGSTEKPSQEKLHGFAAV LAIGSSRCKANSLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESY ISAVQAAHLGTLCGQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLES STESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECL QYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKS PNPSLLHLCGSLAQLACVEPVRLQAWLTRMTASPPKDSDQLDMIQENRQLLQLLTTYIVR ENSQVGEGVCAVLLGTLIPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAV DWLSRCKKYLSQKNVVEKLNANVMHGKHVIVLECTCHIMSYLADVTNALSQSNGQGPSHL SVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHT CKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGLGSSMK ESAFQSEPRVSESLVRHTSASPADKAKVTISDGKAADEEKPKKSSLCRTVEGCREELQNQ ANFSFAPVVLDMLSFLMDAIQTNFQQASAVGSSSRAQQALRELHTVDKVVEMTDQLMVPT LGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKIT VLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSS SGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSTDALSPTFYFLLP SSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDS NSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFSINIKSSNGGSKSSP ALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTAC NEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRRRKTAAITTRTS SQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISN NNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLN LFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASISNICPSNLNQSNGTGDS DSAAPATTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPTSVQ QQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAI MRPNNLVHFTESKLPQMETEGVDEGREPQKQLEGDCCSFITQLVSHFWKLHASKPKNAFL APACLPGLTHIEATVNALVDIIHGYCTCELDCINTAARIYMQMLLCPDPAVSFSCKQALI RVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEV DHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIAL SLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTL RTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATVEGHPAGPGSISSSTGAIST TAGHQEGDGSEGEGEGEGEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQV ILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVF MSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQSDEDPVAPS QLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTNSRIP PPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKK LLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLY FLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAVLAASVAASSASSSSAPVAAGSGQAVAQ AKASTKKSKKEEKEKEKEGESSGSQEDQLCTALVNQLNKFADKETLVQFLRCFLLESNSS SVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQT EKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPF CYIKLSSIKVDTRYTTTQQVVKLIGSHTVSKVTVKIGDLKRTKMVRTINLYYNNRTVQAI VELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPR CSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCA VDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTA GGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKS SRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVS QGLIRELFDYNLRRGSAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANP DLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQK LIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPIRGVDG NGKSPNKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAAR QAACTIVEALATIPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLITSAHWKVYLAA RGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRL VGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNL DDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPL MRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVY RMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIKDFKQGR HLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQV LSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSSPSVLQGLLRIIPY LSFGEVEKMQILVERFKPYCSFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLI LQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPATQVLIGT DSITNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQK ALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRV ALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPV WGPHVPESAFATCLARHNTYLQECTGQREPTYQLNVHDIKLLFLRFAMEQSFSADTGGGG RESNIHLIPYMIHTVLYVLNTTRATSREEKSLQGFLEQPKEKWVESAFEVDGPHYFTVLA LHILSPEKWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDL IYNMFKKVPTSNTEGGWSCSLAEHIRHNDMPIYEAADKALRAFQEEFMPVETFSEFLDVA GLLSEITDPESFLKDLLNSIP NT seq 15546 nt NT seq  +upstreamnt  +downstreamnt atggcgacgagcggcggcgaagagacggtggcagcggcgccagcgcccggggccccgggg ccgggggcggacacgaccccgggctgggaggtggcggtgcggcccctcctgtccgcgtcc tattccgccttcgagatgaaggagttgccgcagctggtggcctcagtcatcgagagtgaa tccgaaatcctgcaccatgagaagcagtatgagccattctactcatcttttgttgcactt tccacacactacattacaacagtttgcagcctcattccccggaaccaacttcagtcggtg gcagcagcctgtaaagtcttgattgagttttctcttctacgtctggagaatccagatgag gcttgtgctgtgtcccagaaacacttgattctcctcatcaagggcctgtgcactggctgt agccgactagacagaacggaaatcatcacgtttacagcaatgatgaaatcagccaagctg ccgcagacagtgaagacactctcagatgtggaagatcaaaaagatctggcttcaccagta agcccagaactaaggcagaaggaggtacagatgaattttttgaaccagctgacgtcagtt ttcaaccccagaactgttgcatcaccaccagtaggtccacagactccagtggaaggagaa aatgaagaacagtcatccacagatcaagcctttgcaatcaaaaccaagaatgtgttcata gctcagaatgtggctagcctacaagaacttggtggctcagagaagctactgcgtgtgtgt ttgaacctgccatatttcctgcgctatatcaatcggtttcaggatgcagtgttggccaat tccttcttcattatgcctgcaacagtagcagatgccactgctgttcggaatggttttcat tcattggtgattgatgtaaccatggcattggataccctttctctgcctgtgttggaacct ctcagtccttcccgcctgcaagatgtgacagtcctcagcctaagttgtctatatgcaggt gtgagtgtggcaacttgcatggccatccttcatgtgggtagtgcccagcaagtgcggaca gggtccacaagctccaaagaagaagactatgagagtgatgcagctacaattgtccagaaa tgtcttgaaatctatgatatgattggacaggctatcagcagttcccgccgggctggtggt gagcactatcagaacttccaattgctgggtgcttggtgtttgttaaacagccttttcctc atattgaacctcagtcctacggccctggctgataaggggaaggagaaagatccactggct gcactccgagtcagagacatcctttctcgcacaaaagagggagtgggctctcctaaactg gggcctggaaaagggcatcaaggatttggggtgctctctgtaatattggcaaaccatgct gtcaagctgttaacatctctcttccaagatctgcaagtggaggctcttcacaagggttgg gagacagatggtccccctgcagtcctgagcattatggcccagagcacctccatacagagg attcagcggctgattgactctgtccctctgacgaacttgctactgacattactctcaact gcctacagaaaggcatgtgtcctgcagcgtcagaggaagggctccatgagcagtgatgcc agtgcctctactgactcaaacacctactacgaggatgatttcagcagcacagaggaggac agcagccaagatgacgacagtgagcctattttgggccagtggtttgaggaaaccatctct cccagtaaagagaaagtggcacctccacctcctcccccaccccctcctctggagagctca cctcgagttaaaagccccagtaaacaggttcctggtgagaagggcaacattttggctagt cgaaaagatcctgagttgttcttaggtctggcttccaacattctgaacttcattacctct tccatgctgaactcccggaacaattttatccgaaactatctgagtatatctctttcagaa caccatatggccaccctggctagtatcattaaggaggtggacaaagatggactcaagggc tcatcagatgaagagtttgctgccgctctgtatcacttcaaccactccctggtgacttct gacctgcagtcacctcacttgcagaacacactgttgcaacagctgggagttgctcctttt tctgagggcccttggcccttgtacattcaccctcaaagcctgtctgtactttcacgcctc ttgctcatttggcaacataaagccagcgctcaagacgaccccgatgtccctgaatgcctt aaagtttgggacaggtttttgtcaacagtgaagcagaatgctcttcaaggggtggcgccc agtgagacggaagatttgaacgtagaacacttgcagctgctccttctcattttccacaac ttcactgagaaaggccggcgggccatactgacccattttgtgcagatcatccaggagttg agtgccaacatggatgtccagatgcgctctgtgccgctcatcctggctcgcctccttttg atctttgattatctgcttcatcagtactccaaagcccctgtgtatctgtttgaacaggtg cagcataacctgctgagtcctccttttgggtggtcaaatggatctcaggacagcagcagc cgccgggcaaccacccctctttatcatggcttcaaagaagtagaagaaaactggtctaag catttttcgtcagatgcagttccacaacccagattctactgtgtcctgtccccagaagcc tcagaggatgacttaaaccgacttgattctgtggcatgtgatgtccttttctccaagctg atcaagtatgatgggctttacactgcactcacatgcctgctcgcagctggatcccagctt gatacagtcaggagaaaggaaaataagaatgtaacagtcctggaggcttgtgcccttcaa tattacttcttgatactgtggaggatcctaggaattttgccaccatcaaagacttatatg aaccagctggccatgaactctccagagatgagtgaatgtgacatcctgcacaccctgcgg tggtcttcccgcctccggattagctcctatgtcaactggataaaggatcaccttatcaag cagggaatgaaggctgaacatgcaggttctctcctagaattggcagtcaccaagtgcagc tcagtgaagtatgacgttgaaattgtagaggaatactttgctcgccagatctcgtcgttc tgtagcatcgactgtactaccatcttgcaactccatgaaatccctagtctgcagtccatc tacacactggacgctgctgtctccaaggtccaggtctctttggatgagcatttttctaag atggctgctgagacagagcctcacaagtcgtctgagatcaccaagaaccttcttccagcc acgctgcagctcattgacacctacgcgtcattcacgagagcctatttgctacagaacttt aatgaagagggatccactgaaaagccttcccaggagaaattacatggctttgctgctgtt ttggctattggctctagtaggtgcaaagcaaacagtctgggtccaacactggttcagaat ttaccatcttcagtgcaaactgtgtgtgaatcctggaacaacatcaacaccaatgagttt cccaacattggatcctggcgcaatgcctttgccaatgacaccatcccttcagagagttac atcagtgcagtgcaggctgctcacctggggactctgtgtggccaaagtctgcccctggct gcttccctgaagcacaccctcctctccctggtcaggttgactggagatcttattgtttgg tctgatgagatgaacccgccacaggtaattcgaaccctgctcccccttcttttggagtcg agcactgagagtgttgctgagatcagtagcaactccctggagcgcatcctgggccctgca gagtctgatgagttcttggctcgcgtttatgagaagttgattactggttgttacaacatt ctggccaatcatgcagatcccaacagtggactggatgaatccatcttggaggaatgtctc caatatttagaaaagcagctggaaagcagccaggctcgtaaagctatggaggaatttttc tctgacagtggagaactcgtacagatcatgatggcaacagccaatgagaacctctctgct aaattctgtaaccgagttttgaaattcttcaccaaactcttccagctgactgagaagagc cctaacccgagccttctgcatctgtgtggctccctggcacagctggcttgtgtggagcct gtgcgtctccaggcctggctcacccgcatgactgcatcacctcccaaagattctgatcag ctggatatgattcaggagaaccggcagctcttgcagttattgaccacgtacattgttcgg gaaaacagccaagttggggaaggtgtgtgtgctgtgcttctgggcaccctgatccctatg gcaacagagatgctggccaacggtgatgggactggtttccctgaactcatggttgtgatg gccaccctggccagtgcaggtcaaggtgctggtcatcttcagcttcacaatgctgctgtg gactggctgagtagatgtaagaaatacctgtcacagaagaatgtggttgaaaaactgaat gctaatgtcatgcatggaaagcatgtgatagtcctggagtgcacatgccatattatgtct tacttggctgatgtcaccaacgccctaagccagagtaatggtcaaggcccaagtcacctc tcggtggatggggaagagcgagccattgaggtggactcagactgggtggaggagttggca gtggaagaggaagactcccaggctgaggattcagatgaagattctctttgtaataaactc tgcacttttaccatcactcagaaagaattcatgaaccagcattggtaccactgtcacacc tgcaaaatggtcgatggggtgggtgtatgcacggtatgtgccaaggtgtgccacaaagac cacgagatttcctatgccaagtatggatcctttttctgtgactgtggcgccaaggaagat ggcagctgtttggcactggtgaagcgaactcctagcagtggcctgggctcctccatgaag gagtcagcgtttcagagcgaacccagagtttcagagagtctggtgcgccacaccagtgcc tccccagcagacaaagccaaggttaccatcagtgacggaaaggcggctgatgaggagaag cccaagaagagcagcctgtgccgcacagtagagggctgccgggaggagctgcagaaccag gccaatttctccttcgctcctgttgtgttagacatgctcagtttcctcatggatgccatt cagaccaactttcagcaggcttcagctgtggggagtagcagccgggctcagcaagccctt cgtgagctgcatacagtggacaaggtggttgagatgacagaccagctgatggttcccacc ttaggctcccaggaaggtgcctttgagaacgttcggatgaattacagtggagaccagggt cagactatccgacagttaatcagcgcccatgtgctcaggcgggtggccatgtgtgtgctt tcctccccacatgggcgccgccagcatttggctgtcagccacgagaaaggcaagatcact gttctgcagctctctgcactcttgaagcaagcagattccagcaaaaggaagttgactctg acccgcctggcctctgccccagtccccttcactgtgctgagcctcactgggaacccttgc aaggaggactacctagctgtgtgtgggctgaaggactgccatgtgctgaccttcagtagc tcgggctctgtttcggatcacttggtcttgcacccccagctggcgacagggaacttcatc atcaaagccgtgtggttgcctggctcccagaccgagttagcgattgtcactgcagacttt gtcaagatttatgacctgtctactgatgccttgagtccaaccttctacttcctattgcca agctcaaagataagagatgttaccttcctcttcaatgaagagggaaagaacatcattgtt ataatgtcttcggctgggtacatctacactcagctcatggaagaggccagcagtgcccag cagggacccttctatgtcactaacgtactagaaatcaaccatgaggacttgaaggacagt aatagccaagtggcaggtggcggtgtatccgtctactactcccacgtgttgcagatgttg ttcttcagttattgtcaaggcaaatcattcgcagctaccatcagcaggacaactctagag gtgttgcagctcttctccataaacatcaaaagttccaatggtggcagtaagtcatcgcct gccctttgccagtggtctgaggtgatgaaccaccctggcttggtgtgttgtgtccagcaa actacaggtgtgcctctggtagttatggtgaaaccagacacgtttcttatccaagagatt aagactcttcctgctaaagcaaagatccaagacatggttgccattaggcacacagcttgc aatgagcagcagcggacaacaatgatcttgctgtgtgaggatggcagcctgcgcatttac atggccaacgtggaaaatacgtcctactggcttcaaccatccctgcagcccagcagtgtc atcagcataatgaaacctgtccggaggcgcaaaactgctgctatcacaacccgcacgtct agccaggtgaccttccccattgacttctttgaacacaaccagcagctgacagatgtggag tttggtggtaatgacctcttgcaggtctacaatgcacaacagataaagcaccggctgaat tccactggcatgtatgtggccaacaccaagcctggtggcttcaccattgagatcagtaac aacaacagcacgatggtaatgacaggcatgcggatccagattgggactcaggcgattgaa cgggctccatcgtacattgagatcttcggcagaactatgcagcttaacctgagtcgctca cgctggtttgacttcccctttaccagagaagaagccctgcaggctgataagaaactgaac ctcttcattggtgcctcagtggatccagcaggtgtcaccatgattgatgctgtgaagatt tatggcaagactaaggagcagtttggctggccggatgagcccccagaagaattcccctct gcctccatcagcaacatctgtccttcaaacctgaaccagagcaatggcactggagacagc gactcagctgcccctgctaccaccagtggaactgtcctggagaggctggtcgtgagttct ttagaagccttggaaagctgctttgctgttggcccaatcatcgagaaggagagaaacaag aacgctgcacaggagctggccactctgctgctgtccctgccagcacccaccagtgtccag cagcagtccaagagccttctggccagcctgcacaccagccgctcggcctaccacagccac aaggatcaggccctgctgagcaaagctgtgcagtgtctcaacacatccagcaaggaaggc aaggatttggaccctgaggtcttccagaggctggtgatcacagctcgctccattgccatc atgcgtccaaacaacctggtccactttacggagtcaaagctgccccagatggaaacagaa ggagtggatgaggggagagaaccccagaagcagctggaaggagattgctgtagtttcatc acccaactggtgagccacttctggaaactccatgcatccaagcccaagaatgccttcttg gcacctgcctgcctgccaggcctaactcatattgaagctactgtcaatgctctggtagac attatccacggctactgtacatgtgaactggactgtattaatacagcagccagaatctac atgcagatgctcttgtgtcctgatcctgctgtgagcttctcttgtaaacaagctctgatt agagtcctaaggcccaggaacaagaggagacacgtgacattgccctcctcccctcgaagc aacactccaatgggagacaaggatgatgatgatgatgatgacgcagatgagaaaatgcag tcgtcagggatcccaaatggtggtcatatccgtcaggaaagccaggaacagagtgaggtg gaccatggagattttgagatggtgtctgagtcgatggtcctggagacagctgaaaatgtc aacaatggcaacccctctcccctggaagccctgctggcaggtgcagagggctttcccccc atgctggacatcccgcctgatgcagatgacgagaccatggttgaactagccattgccctg agcctgcagcaagaccaacaaggcagcagcagcagtgcactgggcctgcagagcctggga ctgtccggccaggcacccagctcttcctctctggatgcagggaccctctctgacaccaca gcatcagctccagcctcagatgacgaaggcagtaccgcagcaactgatggctccaccctt cggacctcccctgctgaccacggtggaagcgtgggctcggagagcgggggaagtgcagtg gactctgtggctggcgagcacagtgtatctggccggagcagtgcttatggggatgccact gtggagggccatccggctggaccaggaagcatcagctcaagcactggtgccatcagcacc accgccggacaccaggagggagatggctccgagggagaaggcgaaggcgaaggggaagga gatgttcacactagcaacaggctgcacatggtccgtctgatgctattggagagactcctg caaaccttgccccagttacgaaatgtcggaggtgttcgggccatcccatacatgcaggtc attctgatgctcactacagatctggatggagaagatgagaaagacaagggtgccctggac aacctgctgtcccagctgattgctgaactgggcatggataaaaaggatgtctccaagaag aatgagcgcagtgccctgaatgaagtccatctggtggtaatgagacttctgagtgtcttc atgtcccggaccaaatccggatccaagtcttccatatgtgagtcgtcttccctcatctct agtgccacagcagcagccctgctcagctctggggctgtggactactgcctgcatgtgctc aagtccctgctggagtattggaagagccaacagagcgacgaggatcccgtggctcccagc cagttgctgaaaccgcatactacttcatccccacctgacatgagccccttcttcctccgc cagtatgtgaagggtcatgctgctgatgtgtttgaggcctatactcagcttctaacggag atggtactgcggcttccataccaaatcaagaagattgcagacaccaattctcgaatccca cctcctgtctttgatcattcatggttttactttctctcagagtatctgatgatccagcaa actccatttgtgcgccgtcaagtccgcaagctgctgctcttcatctgcggatccaaggag aaataccgccagctccgggatttgcacaccctggactcccacgtgcgtggaatcaagaag ctgctggaggagcagggcatattcctccgggcgagtgtggttacagcgagctcaggctct gccttgcaatatgacaccctcatcagcctgatggagcacctgaaagcctgtgcagagatt gctgcccagcgaaccatcaactggcagaaattctgcatcaaagatgactctgtcctgtac ttcctgctccaagtcagcttcctggtggacgagggtgtgtcccccgtgctgctgcagctg ctctcctgcgccctgtgcggcagcaaagtgcttgctgtgctggcggcctctgtggcggcc tccagtgcttcctcctcctcagcccctgtggccgctggttctgggcaagccgtggcacag gcgaaggcatccactaagaagagcaagaaggaagaaaaggaaaaggagaaggaaggtgag agctcaggcagccaggaggaccagctgtgcacagctctggtgaaccagctgaacaaattt gcagataaggagaccttggtccagtttctgcgctgcttcttgttagagtccaattcttcc tccgtgcgctggcaggcccactgcctgacactgcatatctacagaaactcaagtaaatct cagcaggagctcctgctagatctgatgtggtccatatggccggaactcccagcctatggt cgtaaggctgcccagtttgtggatctactaggatatttctccttgaaaaccccacagaca gagaagaagttgaaggaatattcacagaaagctgtggagattctgcggactcaaaaccat attctcaccaaccaccccaactcaaacatttacaacaccttgtctggcttagtggagttt gatggctattacctggagagtgatccctgcctggtgtgcaataatccagaagtgccattt tgttatatcaagctgtcttccattaaagtggacacgcggtataccaccacccagcaggtt gtgaagctcattggcagccacactgtcagtaaagtgacagtgaaaattggagacctgaaa cggaccaagatggtgcggactatcaacctctattacaacaaccgaactgtgcaggccatc gtggagttgaagaacaagccggctcgctggcacaaagccaagaaggttcaactgactcct gggcagacagaggtgaagattgacctacccttgcccattgtggcttccaacctgatgatt gagtttgcagacttctatgaaaactaccaggcctccacagagaccctgcagtgcccacgc tgtagtgcctccgtccctgccaacccaggggtgtgtggcaactgtggagagaatgtctac cagtgtcataaatgcagatccatcaactatgatgaaaaggatcccttcctctgcaatgcc tgtggcttctgtaaatatgcgcgctttgacttcatgctctatgccaagccttgctgtgca gtggatcccattgagaatgaagaagacaggaagaaggctgtttccaacatcaatacactt ctggacaaagcagatcgagtgtatcatcagctgatgggacatcggccacagctggagaac ctgctctgcaaagtgaatgaggcagctcccgaaaagccgcaggatgactcaggaacagct gggggtatcagctccacttcagcgagtgtgaaccgttacatcctgcagttggctcaggag tactgtggcgattgcaagaactcttttgacgaactctccaaaatcatccagaaagtcttt gcttcacgcaaagagttgttggaatatgacctgcagcagagggaagcggctaccaaatca tctcggacctccgtgcagcccaccttcactgccagccagtaccgtgccttatctgttctg ggctgtggccacacctcctccaccaagtgctatggctgtgcctccgcggtcacggaacat tgcatcacgctgctccgggccctggccaccaaccctgccctgaggcacatccttgtctca cagggccttatccgggagctctttgattacaatcttcgccgaggctctgcggccatgcgg gaggaggtccgccagctcatgtgcctcctaactcgagacaatccagaagccacccagcaa atgaacgacctgattattggcaaagtctccacagccctgaagggccactgggccaaccct gatctggcaagtagccttcagtatgaaatgctgttgctgacagattctatctcgaaggag gatagctgctgggagctccggttacgctgtgctctcagtcttttcctcatggcggtgaac attaagactcctgtggttgttgagaacattaccctcatgtgcctgcggatcttgcagaag ctgattaaaccacctgctccaaccagcaaaaagaacaaggatgttcctgttgaggccctc accacagtcaagccatactgcaacgaaatccacgcccaggcccagctgtggctcaagaga gaccccaaagcatcctatgaagcctggaagaagtgtcttcctatcagaggggtagatggc aatgggaagtcccccaacaaatcagagctccgccatctctatttgactgagaagtacgtg tggcggtggaagcagttcctgagtcgtcgggggaagaggacctctcccttggatctcaaa ctgggccataacaactggctgcggcaagtgctcttcactccagcgacacaggctgcacga caggcagcctgcaccattgtggaagccctcgccaccattcccagccgcaagcagcaggtc ctcgacctcctcaccagttacctggatgagctgagcgtggctggcgagtgtgctgccgag tacctggctctgtaccagaagctcatcacctcggctcactggaaagtctacctggcagct cggggagtcctgccctacgtgggcaacctcatcaccaaggaaatagcccgcttgctggca ctggaggaggccactctgagcactgatctgcagcagggctatgccctcaaaagtctcaca ggccttctttcctcctttgttgaggtggaatccatcaaaaggcactttaaaagtcgcttg gtgggcactgtgctgaatggatatctgtgcttgcgaaagctggtggtgcagaggaccaag ctgattgatgagacccaggatatgctgctggagatgctggaggacatgaccacaggtaca gaatcggaaaccaaggccttcatggctgtgtgcattgagacagccaagcgctataatctg gatgactaccggactcctgtcttcatctttgagaggctctgcagcatcatttatcctgag gagaatgaagtcactgagttcttcgtgaccctggagaaggatccccagcaagaagacttc ttacagggcaggatgcctgggaacccatatagcagtaatgagccaggcattgggccgctt atgagggacataaagaacaagatttgccaggactgtgacttggtggctctcctggaggat gacagtgggatggagcttctggtgaataataagatcattagtttggacctccctgtggct gaggtttacaagaaggtctggtgtaccacaaatgagggagaacccatgaggattgtttat cgaatgcgagggctgttgggtgatgccactgaggaattcattgagtccctggactccacc acagatgaagaagaagatgaagaagaagtgtacaagatggctggtgtgatggcccagtgt gggggtctagaatgcatgctcaacaggctggcagggatcaaagatttcaagcagggccgc caccttctcacagtgctgctgaaattgttcagttactgcgtaaaggtgaaagtcaaccgg cagcaactggtcaagctggaaatgaacactttgaatgtcatgctgggaactctaaacctg gccttggtagctgagcaagaaagcaaggacagtgggggtgcagctgtggctgagcaggtg cttagcatcatggagatcattctggatgaatccaatgctgagcccctgagtgaggacaag ggcaaccttctcctgacaggtgataaagatcaactggtgatgctcttggaccagattaac agcacctttgttcgctccagccctagtgtgctccagggcctgcttcgcatcatcccgtac ctttcctttggagaggtggagaaaatgcagatcttggtggagcgcttcaaaccatactgc agctttgataagtatgatgaagatcacagtggtgatgataaagtcttcctggactgcttc tgtaaaatagcagccggcattaagaacaacagcaatgggcatcagctaaaggacctgatt ctccagaagggaatcacccaaaatgcacttgactacatgaaaaagcacattcccagcgcc aagaatttggatgctgacatctggaagaagtttttgtctcgcccagccctgccatttatc ttgcggctcctccgggggctggccatccagcatcctgccacccaggttctgattggaacg gactctatcacaaacctccataaactggagcaggtgtccagcgatgaaggcattgggacc ctggcagagaacctgctggaggcattacgggagcatcctgatgtaaacaaaaagattgat gcagcccgcagggagacccgggctgagaagaagcgcatggccatggcgatgaggcagaag gctctagggaccctgggcatgacgacaaatgaaaagggccaggtggtgacaaagacagca ctcctgaagcagatggaagagctcatcgaggagccgggcctcacgtgctgcatctgcagg gaggggtacaagttccagcccacaaaagtcctgggcatttataccttcaccaagcgggta gccttggaggagatggagaataaaccccggaagcagcagggctacagcaccgtgtcccac ttcaacattgtgcactatgattgccacctggctgctgtcaggctggctcgaggccgggaa gagtgggaaagtgccgcccttcaaaatgccaacactaagtgcaatgggctccttccagtc tgggggccccatgtccctgaatcggcttttgccacctgcttggcaaggcacaacacttac ctccaggaatgtacaggccagcgggagcccacgtaccagctcaacgtccatgacatcaaa ctgctcttcctgcgcttcgccatggagcagtcgttcagtgcggacaccggtgggggtggc cgggagagcaacatccacctcatcccgtacatgattcacactgtgctttacgtcctgaac acgacccgagcgacttcccgagaggagaagagcctccagggctttctggagcagcccaag gagaagtgggtggagagcgcctttgaagtggacgggccccactatttcacagtcctggcc cttcacattctgtcacccgagaagtggagggccacacgtgtggaaatcctgcggaggctg ctggtgacctctcaggcccgggcagtggctccagggggagctaccaggctgacagacaag gcagtgaaggactactctgcttatcgctcttcccttctcttctgggcccttgttgacctc atctacaacatgtttaagaaggtgcctaccagcaacacggagggaggctggtcctgctct ctcgcggaacacatccgccacaacgacatgcccatctacgaggctgctgacaaagccctg agggccttccaggaggagttcatgccggtggaaaccttctcggagttcctcgatgtggct ggtctgttatcagaaatcaccgatccagagagcttcctgaaggacctgttgaactcaatc ccctga

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