KEGG   Manis javanica (Malayan pangolin): 108398550
Entry
108398550         CDS       T06054                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04068  FoxO signaling pathway
mjv04270  Vascular smooth muscle contraction
mjv04650  Natural killer cell mediated cytotoxicity
mjv04720  Long-term potentiation
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04928  Parathyroid hormone synthesis, secretion and action
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05200  Pathways in cancer
mjv05205  Proteoglycans in cancer
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108398550 (ARAF)
   04012 ErbB signaling pathway
    108398550 (ARAF)
   04068 FoxO signaling pathway
    108398550 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108398550 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    108398550 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108398550 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    108398550 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    108398550 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    108398550 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    108398550 (ARAF)
   04720 Long-term potentiation
    108398550 (ARAF)
   04730 Long-term depression
    108398550 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108398550 (ARAF)
   05205 Proteoglycans in cancer
    108398550 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    108398550 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108398550 (ARAF)
   05212 Pancreatic cancer
    108398550 (ARAF)
   05225 Hepatocellular carcinoma
    108398550 (ARAF)
   05226 Gastric cancer
    108398550 (ARAF)
   05214 Glioma
    108398550 (ARAF)
   05221 Acute myeloid leukemia
    108398550 (ARAF)
   05220 Chronic myeloid leukemia
    108398550 (ARAF)
   05218 Melanoma
    108398550 (ARAF)
   05211 Renal cell carcinoma
    108398550 (ARAF)
   05219 Bladder cancer
    108398550 (ARAF)
   05215 Prostate cancer
    108398550 (ARAF)
   05213 Endometrial cancer
    108398550 (ARAF)
   05224 Breast cancer
    108398550 (ARAF)
   05223 Non-small cell lung cancer
    108398550 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    108398550 (ARAF)
   05160 Hepatitis C
    108398550 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108398550 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    108398550 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    108398550 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108398550 (ARAF)
   01522 Endocrine resistance
    108398550 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108398550 (ARAF)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     108398550 (ARAF)
Protein kinases [BR:mjv01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   108398550 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 108398550
NCBI-ProteinID: XP_017518124
LinkDB
Position
Unknown
AA seq 605 aa
MEPLRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHEAPSNRPVNEQL
TPQGPSSCTQRCDPEHFPFPVPANAPLQRIRSTSTPNVHMVSTTAPMDSGLMQLTTQSFG
TDAAGSRGGDAASRGSPSLASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSGY
YWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKT
RHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLH
AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ
DPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISNNCPKA
MRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSA
ARLVP
NT seq 1818 nt   +upstreamnt  +downstreamnt
atggagccactacggggcccccctgctaacggggccgagccgtcccgagcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagacagttactgcctgggacacagccattgccccc
ctggatggtgaggagctcatcgtggaggtccttgaagatgtcccactaaccatgcacaat
tttgtacggaagacattcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtt
cccaccgtctgtgttgacatgagtaccaaccgccgacagttctatcacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccgtcaaaccggcctgtgaatgagcagcta
acccctcagggtcccagctcctgcacccagcgctgtgaccctgagcatttccccttccct
gtcccggccaatgcccccctccagcgcatccgctccacatccacccccaacgtccacatg
gttagcaccacagcgcccatggactctggtctcatgcagctcactacccagagttttggc
actgacgctgctgggagtagaggtggtgatgcagcctcccgggggagccccagcctagcc
agcgtgtcctcggggaggaagtccccacattccaagtccccatcagagcagcgggagcgg
aagtccttggccgatgacaagaagaaagtgaagaatctagggtaccgggactcaggctat
tactgggaggtgccacccagtgaggtgcagctgctgaagaggattgggacaggctcattc
ggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtggcc
caacccacagctgagcaagcccaggccttcaagaatgagatgcaggtgctcaggaagaca
cgtcacgtcaacatcttgctgttcatgggcttcatgacccggccgggatttgccatcatt
acacagtggtgtgagggctccagcctctaccaccacctacatgtggctgacacacgcttt
gacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccat
gccaagaacatcattcaccgagatctcaagtctaacaacatcttcctacatgaggggctc
acagtgaagattggtgacttcggcctggccacggtgaagacaaggtggagcggggcccag
cccttggagcagccctcgggctctgtgctatggatggcggctgaggtgatccgtatgcag
gacccaaacccctacagcttccagtctgatgtctatgcctatggagttgtgctctatgag
ctcatgaccggctcgctgccttacagtcacattggcagccgtgaccagattatctttatg
gtgggccgtggctatctgtccccggacctcagcaaaatctccaacaactgccccaaggcc
atgcggcgcctgctgtctgactgcctcaagttccagcgcgaggagaggcccctcttcccc
cagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagtgcc
tccgaaccctccttgcaccgaacccaggctgatgagttgcctgcctgcctcctcagcgca
gcccgccttgtgccttag

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