Manis javanica (Malayan pangolin): 108400680 Help Entry 108400680         CDS       T06054                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv04064   NF-kappa B signaling pathway mjv04066   HIF-1 signaling pathway mjv04145   Phagosome mjv04151   PI3K-Akt signaling pathway mjv04217   Necroptosis mjv04613   Neutrophil extracellular trap formation mjv04620   Toll-like receptor signaling pathway mjv04621   NOD-like receptor signaling pathway mjv04936   Alcoholic liver disease mjv05132   Salmonella infection mjv05133   Pertussis mjv05134   Legionellosis mjv05135   Yersinia infection mjv05140   Leishmaniasis mjv05142   Chagas disease mjv05144   Malaria mjv05145   Toxoplasmosis mjv05146   Amoebiasis mjv05152   Tuberculosis mjv05161   Hepatitis B mjv05162   Measles mjv05164   Influenza A mjv05170   Human immunodeficiency virus 1 infection mjv05171   Coronavirus disease - COVID-19 mjv05205   Proteoglycans in cancer mjv05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mjv05321   Inflammatory bowel disease mjv05323   Rheumatoid arthritis mjv05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mjv00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     108400680 (TLR4)    04066 HIF-1 signaling pathway     108400680 (TLR4)    04151 PI3K-Akt signaling pathway     108400680 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     108400680 (TLR4)   09143 Cell growth and death    04217 Necroptosis     108400680 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     108400680 (TLR4)    04620 Toll-like receptor signaling pathway     108400680 (TLR4)    04621 NOD-like receptor signaling pathway     108400680 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     108400680 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     108400680 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     108400680 (TLR4)    05161 Hepatitis B     108400680 (TLR4)    05171 Coronavirus disease - COVID-19     108400680 (TLR4)    05164 Influenza A     108400680 (TLR4)    05162 Measles     108400680 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     108400680 (TLR4)    05135 Yersinia infection     108400680 (TLR4)    05133 Pertussis     108400680 (TLR4)    05134 Legionellosis     108400680 (TLR4)    05152 Tuberculosis     108400680 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     108400680 (TLR4)    05144 Malaria     108400680 (TLR4)    05145 Toxoplasmosis     108400680 (TLR4)    05140 Leishmaniasis     108400680 (TLR4)    05142 Chagas disease     108400680 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     108400680 (TLR4)    05321 Inflammatory bowel disease     108400680 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     108400680 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     108400680 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mjv04131]     108400680 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:mjv04054]     108400680 (TLR4)    04090 CD molecules [BR:mjv04090]     108400680 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:mjv00536]     108400680 (TLR4) Membrane trafficking [BR:mjv04131]  Endocytosis   Phagocytosis    Toll-like receptors     108400680 (TLR4) Pattern recognition receptors [BR:mjv04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    108400680 (TLR4) CD molecules [BR:mjv04090]  Proteins   108400680 (TLR4) Glycosaminoglycan binding proteins [BR:mjv00536]  Hyaluronan   Cell surface receptors    108400680 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 TIR LRR_4 LRR_14 TIR_2 LRR_Zer-1 LRR_EndoS LRR_9 ThsB_TIR ANG-1 LRR_LRWD1 LRR_R13L1-DRL21 Motif Other DBs NCBI-GeneID:  108400680 NCBI-ProteinID:  XP_036878135 LinkDB All DBs Position 2:complement(16131755..16143229) Genome browser AA seq 838 aa AA seqDB search MMSPTRLAGTLIPAMAFLTCLRPESWDPCIQVVPNITYQCMELNFYKIPDNIPRSTKELD LSFNPLRHLGSHSFSSFPELQVLDLSRCEIQMIEDDAYQGLEHLSTLILTGNPIQRLALG AFSGLSSLQTLVAVETNIVSLEDFPIGHLRTLKELNVAHNLIHSFKLPEYFSNLSHLKNL DLSDNKIQNIYLKDLQVLHQMPLHKLSLDLSLNPLDFIQPGAFREIKLRELTLRSNFHST DVMKTCIQGLVGLTTNRLVLGEFRNERNVEKFDKSVLEGLCNLTIEKFQISYFNYFSVDT SDLFNCLANVSAISLAHLHSNQLEGPWKGFRCQYLELFKCKFEQFPILELDSLTTFVFTA NKGMNTFTELKLPRLEFLDLSRNGLNFKGCCSETDFGTTSLKYLDLSFNYIITMHSNFMG LEQLEYLDLQHSNLKQANDFSIFLSLKNLRYLDISYTQTRIVFHGIFDGLVSLEVLKMAG NSFQNNILPNIFSDLTNLTTLDLSKCQLEEVSQMAFDSLSRLQLLNMSHNNLLSLDILIY KPLHSLQILDCSFNRIVASRVQETQHFPSSLASLNLSWNDFACVCEHQGFLQWVKDQRQL LVEVEQLVCAKPLDMQDVPLLSFRSTTCQISKTIISVSVLTVLILCVAVVLVYKFYFHLM LLAGCKKYGRGESTYDAFVIYSSLDEDWVRNELVKNLEEGVPPFHLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLGSHAGIIFIVLQKLEKSLL RQQVELYRLLSRNTYLEWDDSVLGRHIFWRRLRKALLDGKPWSPEGTADAESSQPKDS NT seq 2517 nt NT seq  +upstreamnt  +downstreamnt atgatgtctcccacccgcctggctgggactctgatcccggccatggccttcctcacctgc ctgcgccctgagagctgggacccttgcatacaggtggttcctaacattacttaccaatgc atggagttgaatttctacaaaatccctgacaacattcccagatcaaccaaggaactggac ctgagctttaaccccctgaggcatttaggcagccatagcttctccagcttcccagaactg caggtgctggatttatccaggtgtgaaattcagatgattgaagatgatgcatatcagggc ctagagcacctctccaccttgatattaacgggaaaccctatccagaggttggccctggga gccttttcaggactatcaagtttacaaacactggtggccgtggagacaaacatagtatct ctagaggacttccccattggacatctcagaactctgaaggagcttaatgtggctcacaat cttatccattctttcaagttacctgagtatttttctaacctgtcccacctgaagaacttg gacctttccgataacaagatccaaaatatttaccttaaagacttgcaggtgctacatcaa atgcccctacacaaactctctttagacttgtccctgaatcctctggactttatccaacca ggtgcctttagagaaattaaactccgtgaactgactttgagaagtaattttcacagtaca gatgtaatgaaaacttgtattcaaggtctggttggtttaacaaccaatcggttggttctg ggagaatttagaaatgaaaggaatgtggaaaaatttgataaatctgtcctggaggggctg tgcaatttgaccattgaaaaattccagatatcatacttcaattacttctcagttgatact tctgacttatttaattgtttggcaaatgtttctgcaatttctctggcgcatctgcattca aaccaactagaaggcccttggaaaggtttcagatgtcaatacttagaactgtttaaatgt aaatttgaacaatttcccatactggagctcgactctctcacaacgtttgttttcactgcc aacaaagggatgaacacttttactgaacttaagctaccaaggcttgagtttctagatctc agtagaaatggcttaaatttcaagggttgctgttctgagactgattttgggacaaccagt ctcaagtatttagatctgagcttcaattatattattaccatgcattcaaacttcatgggc ttagagcagctggaatatctggatctccagcattccaatctgaaacaggccaatgacttt tcaatatttctatcactcaaaaacctccgttaccttgatatttcttatacacaaacccga attgtcttccatggcatctttgatggcttggtcagcctcgaagtcttgaaaatggctggc aattcttttcagaacaacatccttccaaatattttctcagatctgactaacctgaccaca ctggacctctctaagtgtcaactggaagaggtgtcccagatggcatttgactcactctct agacttcagttgctaaatatgagtcacaacaacctcttgtcattggatatacttatttat aaacctctccactccctccagattctggactgcagcttcaatcgtatagtagcctccagg gtgcaagaaacacagcattttccaagtagtctagcttccttaaatcttagttggaatgac tttgcttgtgtttgtgaacaccagggtttcctgcagtgggtcaaggaccagaggcagctc ttggtggaagttgaacaactggtgtgtgcaaagcctttagatatgcaggatgtacctttg ctgagttttaggagtaccacctgtcagataagcaagactatcattagtgtgtcagttctc actgtactcatactgtgtgtggcagtagttttagtctataagttctatttccacctgatg cttcttgctggctgcaaaaagtatggcagaggtgaaagcacctatgatgcctttgttatc tactcaagcctggatgaagactgggtgaggaatgaattagtaaagaacttggaggaagga gtgccccctttccatctttgccttcactacagagactttattcctggtgtggccatcgct gccaacatcatccaggaaggtttccacaaaagccggaaggttattgtcgtggtgtcccag cacttcatccagagccgatggtgcatctttgagtatgagattgcccagacctggcagttc ctgggcagtcacgctggcatcatcttcatcgtcctgcagaagctggagaagtccctgctc cggcagcaggtagagctgtatcgcctcctcagcaggaacacttacctcgagtgggacgac agtgtcctggggcggcacatcttctggagacggctcagaaaagccttgctggatgggaag ccatggagtccagaaggaacagcagatgcagagagcagccagcccaaagacagctga

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