Manis javanica (Malayan pangolin): 108400973 Help Entry 108400973         CDS       T06054                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv04020   Calcium signaling pathway mjv04371   Apelin signaling pathway mjv04713   Circadian entrainment mjv04921   Oxytocin signaling pathway mjv04970   Salivary secretion mjv05010   Alzheimer disease mjv05012   Parkinson disease mjv05020   Prion disease mjv05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mjv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108400973 (RYR3)    04020 Calcium signaling pathway     108400973 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     108400973 (RYR3)   09154 Digestive system    04970 Salivary secretion     108400973 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     108400973 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     108400973 (RYR3)    05012 Parkinson disease     108400973 (RYR3)    05020 Prion disease     108400973 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     108400973 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mjv04040]     108400973 (RYR3) Ion channels [BR:mjv04040]  Voltage-gated cation channels   Ryanodine receptor    108400973 (RYR3) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  108400973 NCBI-ProteinID:  XP_036854313 LinkDB All DBs Position 8:complement(83987050..84493140) Genome browser AA seq 4863 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEATSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGESGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLSFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDPQHRRIFYEGGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLLLQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSICFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEDMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILKLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQMDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKENMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNLDAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYVLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGTDDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITSKGSELAFADYEIENGFVPICCLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAVRVFAGQDPSCIWVGWVTPDYHLYSDKFDRSKNCAVTVTLGDERGRVHE SVKRSNCYMVWGGDAVATSQRSSRSNVDLEIGCLMDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVEMERVSERHGWAVQCLEPLQMMALHIPEENRCVDILELCEREDLMWFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYTIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRRICLYPDESKRHGLPGVGLRTCLKPGFRFSTPCYVMTSEEHQ KQSPEIPLEILKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHCGETEEGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPGEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWTGKLRALVYKIRGPPMPEKEQPAEEEERSPTTLKELISQTMIHWAQEDQIQDSELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVGDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALGLQEPDLE KVVTYLAGCGLQSCPALLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVAVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDSEDEEEMVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGESLRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPNVVASFCPDHKAPMVLFLDRVYGIKDQAFLLHLLEVGFLPDLRASASLDT VFLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTVYRLSKGRSLTKA QRDTIEECLLAICNHLKPSMLQQLLRRLVFDVPQLNEYCMMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGVFDSLSHKKYNPDLFRMALPCLSAIAGALPPDYVDAR ISTTLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVAKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFRTLTEKEKEIYRWPARESLKTMLAVGWTVERAKEGEALVQQRES EKLRSVPQASQGNSYTPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGSG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIMVSRGMKDLELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVGSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQQQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSIFNTKTLRERSILGMPDLVEEMCPDIPQLEGLMKEIHDLAESG ARYTEMPHVIEVTLPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADTK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKVHLRNNLHLQGKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEET ERQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEDKEKTFEEK EMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKM LDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQ NDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIIATVDYLLRLQESISDFYWY YSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVF ANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVE MILKFFDMFLKLKDLTSSDTFKEYDSDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAK ADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLSYFEP YLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVN FCEDTIFEMQLASQISESDSVDRPEEEEEEDDNSSYPVDIEGDEEDDKALESASAFAVAC ASVQRSVAGFLKRATLKNLQKQYRKVKRMPVKELVKVSFSFFWMLFVGLLHLFFTILGGV FQILWNTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAAEAERAEGPEPGVTAGLVR FTKGEKGDADIMSDLLGFHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRRAQ AAEMKVAHEAEGKVGPEKADMEDGEKEDRDKEEQVEALWAEVTKKKKRWHGSRVEKPEAF MANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPSEEETEDIAN LWNSFNDEEEEEAMVFFVLQESTGYMAPMLRALAVIHTVISLVCVVGYYCLKVPLVVFKR EKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYG AERIAELLGLDKNALDFSPVEDTKAEAASLVSWLSSTDMKYHIWKLGVVFTDNSFLYLAW YTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRI VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED QLG NT seq 14592 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtcgttctccagtgcatcgcgaacattcacaaggagcaaaggaagttctgcctggccgct gagggacttgggaatcgcctgtgcttcttggaagccacatcagaagctaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaagtggtggtgaaggggcagcacaagggggcggccac aggaccctgctgtacggccacgcgatcctcctgcggcactctttcagtggaatgtatcta acatgtttgactacatcaagatcccagacagataaactctcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagaggtcc gagggagagaaagttcgaatcggcgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctccatatcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacctgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcatgatgagtgtttgacaataccatctacagac cagaatgatcctcagcacaggagaatattctatgaaggtgggggagctgggacacgagcc agatctctgtggcgagtggaaccccttcggataagctggagtggcagtaacatcaggtgg ggccaggctttccgactccggcatctcaccacaggccactacctggccttgacagaggac caaggccttctactgcaggaccgggcaaagtcagacaccaagtccacagccttctctttc cgggcatcaaaggaaatcaaggagaaattggattctagccataagcgagatatagaaggc atgggagttccagaaatcaagtatggagattccatctgctttgttcagcatatagccagt ggtctgtgggtaacctacaaagcacaagatgccaagacatcccgccttggacctctgaaa agaaaggtcatcctccatcaggaaggccacatggatgacggattaacactgcagagatgc cagcgggaggagtcccaagctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtggaaacaatcgcacagccgcccctgtcaccctgcccatagaagaggtcctg cagaccttacaggacttgattgcctacttccagccccccgaggaggacatgcagcatgaa gacaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttggcccttgtgttaaattgcattgatcgcttaaatatctacaacagcgtagcacac tttgcagggattgcaagggaagagagcggcatggcctggaaagaaatcttgaagctcctg tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgactggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gtcttgcactgcatcttgattgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgctggataagcatgggcggaaccataaggttctggatgtg ctgtgctccctatgtctctgcaacggggttgcagtgagagccaatcagaatctgatctgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgacgtcaca agtattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtgg tacttcgaactcatcatcgaccagatggaccccttcctaacagcagagcccacgcacctg cgggtgggctgggcctcttcctcaggctatgctccataccccggaggcggagaaggatgg ggaggcaatggtgtcggcgatgacctgtactcctatggctttgatggtcttcacctttgg tcaggccgcatacctcgagccgtggcctccatcaaccagcacctcttgaagtctgacgat gtggtgagctgttgccttgacctcggcgtgcccagcatctctttccgaatcaatgggcag cctgtgcaaggaatgtttgagaacttcaatactgacggcctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgcttcctactgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaatatgaga ttggagcctgtcaaagaatataaacgcgatgctgaaggcgttagagatctgctgggtacc acccagttcctctcccaagcctctttcatcccatgccccattgacaccagtcaggttgtt ttgccaccccacctagagaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagctgggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgtggagttttcaaagctgcctgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaaaactctcctggccctagggtgccatattgctcatgtt aatctggatgctgaggaggatctcaagaaagttaaattgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttatctgatgtgaagctgttaccccctcaagaa attttagtagataagctcgcagaaaatgcacataatgtttgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaagaaacccccgtctcgtg ccatatgtattactggatgagcgtaccaagaagtccaacagggacagccttcgtgaagct gttcggacctttgttggttatggctataacattgagccatcagaccaagaattagctgac cctgctgtggagaaagtcagcatagacaagatccgatttttccgtgtagaacggtcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcgt gttggctgggccaggccaggctgtcggcctgacattgagctggggacagatgaccaagcc tttgtgtttgagggcagcaggggccagcgttggcatcaagggagtgggtattttggacgc acctggcagccaggagatgtggttggatgtatgattaacctggacgacgcgtcaatgatc ttcacactgaatggggagctgctgatcaccagcaaaggctctgaacttgccttcgcagac tacgagattgaaaatggctttgtgcccatctgctgtctggggctgtctcagatcggtcgc atgaatctcgggatggacgccagtacttttaagttttataccatgtgtggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagatgttgcaatgtggttcagcaagcgc cttccaacctttgtcaacgtgccaaaggatcatccacatatagaggttgtgaggatcgat ggcaccatggacagccctccatgcctcaaggtgacccacaagacatttggcacacagaat agcaatgccaacatgatctactgccgtctgagcatgcccgtcgagtgccactcctccttc agccacagcccctgtctggacagtgatgctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactacgcagtccgcgtctttgctggccaggacccc tcctgcatctgggtcggatgggtcactccggactatcacttgtacagtgacaagtttgac cggagtaaaaactgtgcagtgactgttactctaggggatgaaagaggccgggtccacgaa agtgtgaagcgcagcaactgctacatggtctggggtggggatgctgtggccacttcccaa agatcaagccggagcaatgtggacctggagattggctgcctcatggacctggcgatgggc atgctgtctttctcagctaatgggagagaactcggcacctgctaccaggtggaacccaat accaaagtgtttccagccgttttcctgcagccgacaagcacttctttgtttcagtttgaa cttgggaagctgaagaatgcgatgcccctgtcagctgccatatttaagagtgaagagaag aacccagtcccacagtgtccccctcggctggatgtccagaccatccagcctgtgctgtgg agccgcatgcccaacagcttcctgaaggtggagatggagcgggtgagcgagcgccatggc tgggcggtgcagtgcctggagcccctacagatgatggcgctccacatccctgaggagaac aggtgtgtggatatcctggagctctgtgagagggaggacctgatgtggttccattaccac acgctgagactctatagtgccgtgtgtgccctgggaaacagccgagtggcttatgcgctg tgcagccatgtggacctctcccagctcttctacaccattgacaacaagtacctccccggc ctccttcggtctggtttctatgacctgctcatcagcatccacctggccagtgctaaggaa aggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccaggagaatc tgcctgtatccagatgagtccaagaggcatgggctgcccggggtgggcctgagaacatgc ctcaaaccagggttcaggttctccaccccttgctatgtcatgaccagtgaggagcaccag aagcagagcccagagattcccttggagattctcaagaccaaggcgctaagcatgctgacg gaggcagtgcagtgcagtggggctcacatccgggaccctgtcggggggtcagtggagttc cagtttgtgcctgtgctgaaactcattggaaccctgctagtcatgggggtgtttgatgat gacgacgtccggcagatcctcctcctgattgatccctctgtgtttggcgagcactgtggg gagacagaggagggagcagagaaggaggaggtgacccaggtggaggagaaggcagtggag gctggagaaaaggccagcaaggaggctccagtcaaaggcttgttgcagacccgattgcca gagtctgtcaagctacagatgtgtgaactcctcagctatctctgtgactgtgagctgcag caccgagtggaggccattgtggcatttggtgacatttatgtctccaagctccaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtcggcagccctgactgcc cggaagaccagagagttccgttcacccccacaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccaggtgagatccgggaggagctgtatgacttccat gaggacctccttatccactgtggggttcccctggaggaggaggaagaggaggaggaagac acctcctggactggaaagctccgtgccctggtgtataaaatcagaggccctcccatgcct gagaaggagcagccggcagaggaagaagagagaagccctacaacactgaaggagctcatc tcacagactatgatccactgggcacaggaggaccagatccaggactctgagctggtccgg atgatgttcaacctcctgcggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccaggcctctgtgggcgataccatcaacctgctggccgcc ctgggccagattcgctgcctcctcagtgtcaggatgggcaaggaggaggagctgctcatg attaatgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg cgtgtcctcggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtgctgag aaatctcagattgcttttccaaagatggttgccagttgttgccgcttcctttgctacttt tgtcgaattagccggcaaaaccagaaggccatgtttgaacatctgagttacctgctggag aacagcagtgttggcctagcctccccatcaatgaggggatccactccactggatgtggca gctgcctccgtgatggacaataatgagttggcgctgggcttacaggaaccagacctcgag aaggtggtgacctacttagcaggctgcggcctccagagctgccccgcactgctggccaaa ggctaccctgacgtcggctggaaccccatcgagggggagcgttacctgtccttcctgagg tttgccgtcttcgtgaacagcgagagtgtggaggaaaatgctagtgtcgcagtcaagctg ctcatcagacgccccgagtgcttcggcccagccctgcgtggtgagggaggaaacggtctg ctggcagccatgcaaggtgccattaagatctccgagaacccggccctcgacctgccttct cagggatacaagagagaagtcacggaggacagtgaagatgaagaagaaatggtgcacatg ggcaacgcaattatgtcattttattcggctcttatagatctgctgggccgctgtgctcct gaaatgcaccttatccaaacaggaaagggggaatccctgcggatcaggtcgatcctgcgt tccctggtccccaccgaggacctggttggcatcatcagcattcccctgaaactgccatcc ctgaataaagacggatcggtcagcgagcccaacgtggtggccagtttctgccctgaccac aaggcacccatggtactgttcttggaccgtgtttacggcattaaggatcaagcttttctg ctccacttgctcgaggttggatttttacctgacttaagagcctctgcctctctggacaca gttttcctgagcaccacagaggctgcacttgcactgaataggtatatatgctcggctgtg ctcccactgctcacaagatgcgcccctctctttgctggaacagagcactacacctctttg atcgactctacactacagacagtatacaggctttccaaggggcgttccctcaccaaagct cagagggacaccatagaggaatgcctgcttgccatttgcaatcacctgaagccttccatg ctgcagcagctcctacgccgtcttgtttttgatgtgccgcaactgaacgaatactgcatg atgcccctgaagcttctgacgaatcactatgagcagtgctggaagtattactgcctgccg tcgggttgggggagctacggactggccgtggaggaggagctgcacctgacggagaagctc ttctggggggtctttgactccctgtcccataagaagtacaacccagatcttttccgaatg gccctgccttgtctcagtgccatagctggggccttgccaccagattacgtagatgccagg atctccaccacgttggagaagcagatctcagtggatgcagatggcaactttgaccccaaa cctattaacaccatgaatttctccttgcctgagaaattggaatacatcgtcgccaagtat gctgagcactcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggacgaaaacgtgaagactcatccgctgataaggcctttcaggactttaaca gagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaactatgctggct gtgggctggactgtagagagggccaaggaaggagaagccctagtccaacagcgggaaagt gagaagcttcgaagtgtgccccaggccagccagggcaacagctacacacctgcccccctg gacctctccaacgttgtgctctcgagagagcttcagggaatggtggaggttgtggctgag aattatcacaacatctgggccaagaagaagaagctggagctggagagcaaaggtagtggc agtcacccccttttggtgccatatgacaccttgactgccaaggaaaagttcagggaccga gagaaggcacaggacttgtttaaattcctccaagtgaacggcattatggtttctaggggt atgaaggatctggagctggacgcctcctccatggaaaagaggtttgcctataagtttttg aagaagatcctgaaatatgttgattctgctcaagagtttattgctcatttggaagccatt gttggtagtgggaaaacagaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggtggaccagtacttcaccaatcaccacctctacttcctgtcatcc cctctgaagccccttagcagcagcgggtatgcctcccacaaggagaaagaaatggtggcc agcctattctgcaaactcgctgctcttgttcggcatcggatttccctcttcgggagcgat tctactacaatggtgagctgtcttcacatcttagctcagacacttgacaccaggactgtc atgaagtcaggctcagagctggtgaaggctgggttacgagcgttctttgaaaatgctgca gaggacttagagaagacttcagaaaacctgaagcttgggaagtttacccattccagaacc cagattaaaggtgtttctcagaatattaactatacaacagtggctctgctccccatcttg acgtccatctttgagcacgtggctcagcaacaatttggaatggatttactcttgggtgat gtacagatttcatgctaccacatactgtgcagcctctactcccttgggacaggaaagaac atctatgttgaaagacagcgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccagtggcattcctggagcccacccttaaccgctacaatccactctccatcttcaac accaaaactctccgggagaggtccattctgggaatgccagacctggtggaagagatgtgt cctgacatcccccagctggaaggcctgatgaaggaaatccacgacctggccgagtcgggg gcccggtacacggagatgccccatgtcatcgaggtgaccttgcccatgctctgcaactac ctgtcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctggtgc accaaggtcacctctgagcacctcagtgtcatcctgggaaacattctgaaaatcatcaac aacaacctgggcatagatgaggcctcctggatgaagcgcattgcagtgtacgcccagcct atcatcagcaaagccaggcctgacctgctgagaagccacttcatcccaaccctggaaaag ctgaaaaaaaaggccgtcaaaaccgtgcaggaggaggagcagctgaaagccgacaccaaa ggggacactcaggaggccgagctcctcatcttggatgagttcgcagtcctctgcagagac ctctacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggctc aaaagccctgacgctgattctgaccagctcttccgcatggtggcagaggtcttcatcttg tggtgtaaatctcataacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatctggcatttttaactggagacagcaaaagcaagatgtcaaaatctggaggacag gaccaggaacggaagaagacaaagcggaggggagacttgtattccatccagacctccctc atcgtggctgcactcaagaaaatgctgcccattggattgaatatgtgcacccccggcgat caggagctgatctccctcgcaaaatcgcgatacagctatagggatacagatgaagaggtg aaggtgcatctgaggaataacttgcacttgcaaggaaagtctgatgacccagctgtaaag tggcaactgaatctctacaaagatgttttgaagagtgaagaaccttccaatccagaaaag acagtagaacgtgtgcagagaatttcagcagctgtcttccacctggagcaggtggaacag cctttgaggtccaagaaggcagtctggcataaactgctgtcaaaacagcggaaacgggca gtggtagcctgtttcaggatggcgcctctctacaacctgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggatttggctaaatcccccaaggtggaagaggaggaggaggaggagacg gaaaggcagccagacccacttcatcaaatcattctctattttagccgcaatgctctcacg gagaggagcaaattagaagatgaccctttgtacacctcctattccagcatgatggctaag agttgtcagagtggggaggatgaagaagaggaagacaaggagaaaacatttgaagagaaa gaaatggaaaagcagaaaaccctgtaccagcaagcgcgtttgcatgagcgcggagccgca gagatggtcctccagatgataagtgccagcaaaggtgagatgagccccatggtggttgag actctgaagctggggatcgccattctgaatgggggcaatgctggtgtgcaacagaaaatg ctagactacctaaaggagaaaaaggatgctggattctttcagagcctttctggtcttatg cagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggcctg gggatggttactgaggaaggaacactcattgttcgtgagcgtggtgaaaaagtactccag aatgacgagtttacacgagatctctttagattcctacagttactttgtgaaggacataac agtgactttcagaacttcctgagaactcagatgggcaacaccaccaccgtgaatgtcatc atcgccactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctactggtat tattcaggaaaggacatcattgatgaatctggacagcacaatttttccaaagctctggca gtcacaaagcagattttcaattctcttacagaatacatccagggcccatgcattgggaac cagcagagcctggctcacagtaggctgtgggacgcggtggtcggcttcctccatgtgttc gctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaactc ttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggta aatggaactattggcaagcagatggttgacacactggtagagtcatctaccaatgtggaa atgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagacacc ttcaaagaatatgattcagatggtaaagggatcatctccaaaaaagaattccagaaggcc atggaagggcagaaacagtacacacagtcagagattgactttctcctttcgtgtgcaaaa gctgatgagaatgacatgtttaattacattgattttgtagaccggttccatgagccggcc aaggacataggatttaatgtggccgtgttattgacaaatctctccgaacatatgcccaat gattctcgccttaaatgtctgttggacccagcagaaagtgtgctaagctacttcgaaccc tacctgggacggattgagatcatgggtggggccaagaaaatcgagcgcgtttattttgag atcagtgaatccagtcgaactcaatgggagaagccccaggtgaaggaatctaagcggcag ttcatttttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgtttgtgaac ttctgtgaggataccatctttgagatgcagttagcgtcacagatctctgaatctgactca gtcgacaggccagaagaggaggaggaagaagatgacaattcttcttacccggtagacatc gagggtgacgaggaagatgacaaggctcttgagtctgcctctgcgtttgctgtggcctgc gcctcggtgcagagaagcgttgccggctttctgaagagggccaccctgaagaacctccag aagcagtaccggaaggtgaagaggatgcctgtgaaggagctggtgaaggtgtccttctca ttcttctggatgttgtttgtggggctcttgcacctgttcttcaccatcttgggtggggtc tttcagatcctctggaacacggtgtttggagggggcctcatagaaggggcgaagaacatc agagtgaccaagatcctgggggacatgcccgacccaacccagttcggcatccatgatgat gctgcagaggccgagcgggcagaagggcctgagccgggtgtcacggcgggcctagtgcgc ttcaccaagggcgagaagggcgacgcagacatcatgtcagatctcttgggattccatcca aagaaagaagggagcttaaagcatgggccagaagtgggtttgggtgacctctctgagatc attggcaaggatgagcccccaactctagagagtactgtacagaagaaaaggagagcacag gcagcagagatgaaggtggcacatgaagcagaaggaaaagttggacctgagaaggcagac atggaagatggggagaaggaggatagagacaaagaagagcaggtcgaggcactgtgggca gaggtgacaaaaaagaagaagcgatggcatggatccagagttgagaagcctgaagccttc atggccaatttctttaaagggctggaaatctatcagaccaagttactgcattacctggcc aggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaacttcatc ctgctcttttacaaggtcactgaagaaccttcagaggaagagacagaggacatcgcgaac ctgtggaattcctttaatgacgaggaagaggaagaagcaatggtgttctttgtcctgcag gagagcactgggtatatggcccctatgctgcgggcgctggccgttatccacactgtcatc tccttagtctgtgtggtgggttattactgcctgaaggttcctttggtggtattcaaaagg gaaaaagaaattgccaggaagctggagtttgatgggctgtatatcactgaacaaccctct gaagatgacatcaaggggcaatgggaccgtttggtcatcaacacaccatcttttcctaat aactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggggatctctacgga gcggaacgcattgctgaactcctgggtttggacaaaaatgcccttgattttagcccagta gaagacaccaaagcagaggcggcctctctggtgtcatggctgagttccactgacatgaag taccatatctggaaactgggagttgtttttactgacaactcttttctctaccttgcctgg tatacaaccatgtcgatcttgggccactacaacaacttcttctttgcggctcatctgctg gatattgcaatgggcttcaagacactgaggacaattctgtcatctgtaactcacaatggc aaacagctggttctgactgtcggtctcctggctgttgtggtttatctctacacggtggtg gctttcaacttcttccgcaagttctacaacaaaagtgaggacgacgacgagcctgatatg aagtgtgatgacatgatgacgtgttacctcttccacatgtatgtgggagtgagagctgga gggggcatcggcgatgaaattgaagaccccgccggtgacccctatgaaatgtaccgcatt gtcttcgacatcacctttttcttctttgttattgtcatcctactggccatcattcaaggt cttattattgatgcttttggagaattaagagaccagcaggaacaagtacgagaagatatg gagactaaatgtttcatctgtgggattggcaatgactactttgacacgacccctcatggt tttgaaacacataccttacaagagcacaacttagccaactatttgttcttcctgatgtat ttaattaataaagatgaaacagagcacacaggtcaggaatcttacgtctggaagatgtac caagaaaggtgttgggatttcttcccggctggtgactgctttcgcaaacaatatgaagat cagcttggataa

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