Manis javanica (Malayan pangolin): 108400975
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Entry
108400975 CDS
T06054
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
mjv
Manis javanica (Malayan pangolin)
Pathway
mjv04140
Autophagy - animal
mjv04141
Protein processing in endoplasmic reticulum
mjv04210
Apoptosis
mjv04932
Non-alcoholic fatty liver disease
mjv05010
Alzheimer disease
mjv05012
Parkinson disease
mjv05014
Amyotrophic lateral sclerosis
mjv05016
Huntington disease
mjv05017
Spinocerebellar ataxia
mjv05022
Pathways of neurodegeneration - multiple diseases
mjv05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mjv00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
108400975 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
108400975 (ERN1)
09143 Cell growth and death
04210 Apoptosis
108400975 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
108400975 (ERN1)
05012 Parkinson disease
108400975 (ERN1)
05014 Amyotrophic lateral sclerosis
108400975 (ERN1)
05016 Huntington disease
108400975 (ERN1)
05017 Spinocerebellar ataxia
108400975 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
108400975 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
108400975 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
108400975 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mjv01001
]
108400975 (ERN1)
Enzymes [BR:
mjv01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
108400975 (ERN1)
Protein kinases [BR:
mjv01001
]
Serine/threonine kinases: Other
IRE family
108400975 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
Beta-prop_ACSF4
PQQ_2
Pkinase_fungal
Kdo
APH
Myc_N
Band_3_cyto
Motif
Other DBs
NCBI-GeneID:
108400975
NCBI-ProteinID:
XP_036852818
LinkDB
All DBs
Position
Unknown
AA seq
937 aa
AA seq
DB search
MPARLLLALLLGGPGIFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQ
VPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQD
IWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYA
ASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHI
NVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSGMWEGHPIVSE
RRPLLSHLVLPAHGELCSWKVLFPPIGHHETPLSASTKMLERFPNNLPKHRENVIPADSE
KKSFEEVINLVDQSSENTPTTISQDVEEKFTHAPAKPEAPVDTVLKDIATIILSTFLLIG
WVAFIITYPLSMHQLRHQQFQKELEKTQCLQHQQLPFHPPGDSAQDTGLQDSSGLYSESS
GASSPSTSPRASNHSLHSSGSTSKAGSSPFLEQDDEDEEISVVMVGKISFCPKDVLGHGA
EGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIA
IELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNA
HGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAG
CVFYYVISEGSHPFGKSLQRQANILLGAYSLGCLHPEKHEDVIARELIEKMIAKDPQKRP
SAKHVLKHPFFWSLEKQLQFFQDVSDRIEKECLDGPIVKQLERGGRAVVKMDWRENITVP
LQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLL
SHTYHAMELCSHERLFQPYYYCHESPEPQPPVTPDAL
NT seq
2814 nt
NT seq
+upstream
nt +downstream
nt
atgccggcccggctgctgctggcgctgctgctgggcggccccgggatttttggaagtccc
agcacagtgacacttcctgaaaccttgctgtttgtgtcaaccctagatggaagtttgcat
gccgtcagcaagaggacaggctcgatcaagtggactttaaaagaagatccagttctgcag
gttccaacacacgttgaagagcctgccttcctccctgatcccaatgatggcagcctctat
acactggggagcaagaataatgaaggcctgacgaaacttccatttaccatcccggagttg
gtacaggcatccccatgccgaagttcagatggaattctctacatgggtaaaaagcaggac
atttggtacgtcattgaccttctgaccggggagaagcagcagactttgtcgtcggccttt
gcagacagtctctgcccatccacctctcttctgtatctcgggcgaacagagtacaccatc
accatgtacgacaccaaaacccgcgagctccgctggaacgccacctacttcgactacgca
gcctctctgcctgaggatgacgtggactacaagatgtcccactttgtgtccaatggcgat
gggctggtggtgaccgtggacagtgaatctggcgacgtcctatggatccaaaactatgct
tcccctgtggtggccttttatgtctggcagcgggagggtctgaggaaggtgatgcacatc
aacgtcgctgtggagaccctgcgctatctgaccttcatgtctggggaggtggggcgcatc
accaagtggaagtacccattccccaaggagacagaggccaagagcaagctgacgcccacc
ctgtatgttgggaaatactctaccagtggcatgtgggagggccaccctattgtctcagag
cgaaggcctcttttgtcgcatcttgtgcttccagcgcatggggagctgtgttcatggaag
gttttgtttcctcccataggacaccatgaaaccccactgtctgcatctaccaagatgctg
gagaggttccccaacaatctgcccaaacatcgggaaaatgtgattcctgccgattcagag
aagaagagctttgaggaagttatcaacctggttgaccagagttcagaaaacacgcctacc
accatttctcaggatgtggaagagaagttcactcacgcccctgccaagcccgaggccccc
gtggacaccgtgctcaaagacatagccaccatcatcctgagcaccttcctgctcatcggc
tgggtggccttcatcatcacctaccccttgagcatgcatcagctgcggcaccaacagttc
cagaaggaactggagaaaacccagtgcctgcaacatcagcagctgcccttccacccgcct
ggagacagcgctcaagacacggggctccaggactcgtctggcctgtactctgagagctca
ggcgccagcagccccagcacatcccccagggcctccaaccactcgctccactccagcggc
tctacctccaaggctggcagcagccccttcctggagcaggacgacgaggatgaggaaatc
agcgtggtgatggttggaaaaatttcattctgtccgaaggatgtccttggccatggagct
gagggcacaattgtgtaccggggcatgtttgacaaccgtgacgtggctgtcaagaggatc
cttcccgagtgttttagcttcgcagaccgtgaggtccagctgcttcgcgaatcagacgag
caccccaacgtgatccgctacttctgcacggagagggaccggcagttccagtacatcgcc
atcgagctgtgcgcggccaccctgcaggagtacgtggagcagaaggattttgcccacctc
ggcctggagcccatcaccttactgcagcagaccacctcaggcctggcccacctgcactcc
ctcaatattgttcatagagacctgaagccccacaacattctcctctccatgcccaatgca
cacggtaggatcaaggccatgatctccgactttggcctctgcaagaagctggcagtgggc
aggcacagcttcagccgccgttcaggggtgcctggcacagaaggctggatcgctccggaa
atgctgagcgaagactgcaaggagaaccccacctacacagtggacatcttctcggcaggc
tgcgtcttttactatgtgatttctgagggcagccacccttttggcaagtctctgcagcgg
caggcaaacatcctcctgggcgcctacagcctcggctgcttacaccccgagaagcacgag
gacgtcatcgcccgggagttaatagagaagatgattgcgaaggacccgcagaagcgcccc
tcggcgaagcacgtgctaaagcaccccttcttctggagcctagagaagcagctccagttc
tttcaggatgtgagtgaccgaatagaaaaggagtgcctggacggcccgatagtgaagcag
ctggagagaggcgggagagctgtggtgaagatggactggagggagaacatcactgtcccc
ctgcagacagatctgcgtaaattcagaacctacaaaggcggctcggtcagagacctcctc
cgggccatgagaaacaagaagcaccactaccgggagctccccgcggaggtgcgggagacc
ctgggctccctgcccgacgacttcgtgtgctacttcacgtcgcgtttcccccatctcctc
tcgcacacctaccacgccatggagctgtgcagccacgagaggctcttccagccctactac
tactgccacgagtccccagagccccagcccccggtgactccagatgccctctga
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