Manis javanica (Malayan pangolin): 108405993 Help Entry 108405993         CDS       T06054                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv01521   EGFR tyrosine kinase inhibitor resistance mjv04151   PI3K-Akt signaling pathway mjv04217   Necroptosis mjv04380   Osteoclast differentiation mjv04550   Signaling pathways regulating pluripotency of stem cells mjv04620   Toll-like receptor signaling pathway mjv04621   NOD-like receptor signaling pathway mjv04630   JAK-STAT signaling pathway mjv04658   Th1 and Th2 cell differentiation mjv04659   Th17 cell differentiation mjv05140   Leishmaniasis mjv05145   Toxoplasmosis mjv05152   Tuberculosis mjv05160   Hepatitis C mjv05161   Hepatitis B mjv05162   Measles mjv05163   Human cytomegalovirus infection mjv05164   Influenza A mjv05165   Human papillomavirus infection mjv05166   Human T-cell leukemia virus 1 infection mjv05167   Kaposi sarcoma-associated herpesvirus infection mjv05168   Herpes simplex virus 1 infection mjv05169   Epstein-Barr virus infection mjv05171   Coronavirus disease - COVID-19 mjv05200   Pathways in cancer mjv05203   Viral carcinogenesis mjv05212   Pancreatic cancer mjv05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mjv00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     108405993 (JAK1)    04151 PI3K-Akt signaling pathway     108405993 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     108405993 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     108405993 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     108405993 (JAK1)    04621 NOD-like receptor signaling pathway     108405993 (JAK1)    04658 Th1 and Th2 cell differentiation     108405993 (JAK1)    04659 Th17 cell differentiation     108405993 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     108405993 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     108405993 (JAK1)    05203 Viral carcinogenesis     108405993 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     108405993 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     108405993 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     108405993 (JAK1)    05161 Hepatitis B     108405993 (JAK1)    05160 Hepatitis C     108405993 (JAK1)    05171 Coronavirus disease - COVID-19     108405993 (JAK1)    05164 Influenza A     108405993 (JAK1)    05162 Measles     108405993 (JAK1)    05168 Herpes simplex virus 1 infection     108405993 (JAK1)    05163 Human cytomegalovirus infection     108405993 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     108405993 (JAK1)    05169 Epstein-Barr virus infection     108405993 (JAK1)    05165 Human papillomavirus infection     108405993 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     108405993 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     108405993 (JAK1)    05140 Leishmaniasis     108405993 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     108405993 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mjv01001]     108405993 (JAK1) Enzymes [BR:mjv01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      108405993 (JAK1) Protein kinases [BR:mjv01001]  Non-receptor tyrosine kinases   JAK family [OT]    108405993 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 Motif Other DBs NCBI-GeneID:  108405993 NCBI-ProteinID:  XP_036880273 LinkDB All DBs Position 4:complement(53233094..53366324) Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLLLGIGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKIWYAPNHTITVDDKTTLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLVISSENEMN RFHPNDSGNILYYEVMVTGNLGIQWRQKPNVITVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLYSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGGEEGMYVLRWSCTDFDNILMTVT CFEKSEMLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQSEHLGRGTRTHIYSGT LVDFKDDEGASEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDCKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPQTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagactgaagtgaatctggaggcccctgaaccaggggtagaagtgctcttc tatctgtctgatagggagccactcctgctgggcatcggagaatacacggcagaggagctg tgcatcagggctgctcaggaatgctgtatctctcctctttgtcacaacctctttgccctg tatgatgagaacaccaagatttggtatgctcctaatcacaccatcactgttgatgataag acaacactccggctccactaccggatgaggttttatttcaccaattggcatgggaccaat gataatgagcagtcagtatggcgacattctccaaaaaagcagaaaaatggctatgagaaa aaaaaagttccagatgcaactcccctccttgatgccagctccctggagtatctgtttgct caggggcagtatgatttggtcaaatgcctggctcccattcgagaccccaagactgagcag gatgggcacgacatcgagaatgagtgtctgggaatggctgtcctggccatctcccactat gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttcttaccaggatgcggata aataatgttttcaaggatttcctaaaggaatttaacaacaagactatttgtgacagcagt gtgtccacacatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgttagtgatttcatcagaaaatgagatgaat cgatttcatccaaatgacagtggaaacattctctactatgaagtgatggtaactggaaat cttggaattcagtggaggcagaaaccaaatgttataactgttgaaaaggaaaaaaataaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaagagaaaaacaaaatccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtgt gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctattcccatgag gaggccttgtcctttgtgtccctggtagacggctacttccggcttacagcagacgcccat cattacctctgcaccgatgtggctcccccgttgattgtccacaacatacagaatggttgt catggtccaatctgcacagaatatgccatcaataaattgcggcaagaaggaggtgaagag gggatgtacgtgctaaggtggagctgcactgacttcgacaacattctcatgaccgtcacc tgctttgaaaagtctgagatgcttggtggccagaaacagttcaagaactttcagattgag gtgcagaagggccgctacagcctgcatggctcagaccgcagcttccccagtctgggggac ctcatgagccacctcaagaagcagattctgcgcacggacaacatcagctttgtgctgaag cggtgttgccagcccaagccccgagaaatctccaatctgctggtggctactaagaaagct caggagtggcagcctgtctatcccatgagccagctgagtttcgatcggatcctcaagaaa gatattgtgcaaagtgagcaccttgggagaggcacacggacacacatctactctgggacc ttggtggatttcaaggatgatgaaggagcttctgaagagaagagaatcaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggctttttttgaggcagccagcatg atgagacaggtctcgcacaaacacatcgtatacctctatggcgtctgtgtccgagacgtg gagaatatcatggtggaagagtttgtggagggggggcccctggatctcttcatgcaccgg aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggctagtgcc ctgagttacttggaggataaggacctggtccatggaaatgtgtgcactaaaaacctcctc ctggcccgtgagggcattgacagcgagtgtggcccgttcatcaagctcagtgaccccggc atccccattactgtactgtccaggcaagagtgcatagaacgaatcccgtggattgctcct gagtgtgtggaagactgcaagaacctgagcgtggccgcagacaaatggagctttggaacc accctctgggaaatctgctacaatggcgagatccccctgaaagacaagacactgatcgag aaagagagattctatgaaagccgatgcaggccagtgacaccatcttgtaaggagctggct gaccttatgacccgctgcatgaactatgaccccaatcagagacctttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacattgtttcagagaaaaagcca caaactgaagtggatcccacacattttgaaaagcggttcttaaagagaatccgtgacttg ggagagggccactttgggaaggttgagctctgcaggtatgaccctgagggggacaatacg ggggagcaggtagctgtcaaatccctgaagcctgagagtggtggtaaccacatagctgat ctgaagaaggaaatagaaatcttaaggaacctctatcatgagaacattgtgaagtacaaa ggcatctgtacggaagacggaggaaatggcattaagctcatcatggaatttctgccttcg ggaagccttaaagagtatcttccaaagaataagaacaaaataaacctcaaacagcagttg aaatatgctgttcagatttgtaaggggatggactacttgggttctcggcagtatgttcac cgggacttagcagcgagaaatgtccttgttgagagtgaacaccaagtgaaaattggagac tttggtttaaccaaagcaattgaaactgataaggagtactacacagtcaaggacgaccgg gacagccctgtgttttggtatgctccagagtgtttgattcagtgtaaattttatatcgcc tctgatgtctggtcttttggagtaactctgcacgagctgcttacttactgtgattcagat tccagtcccatggcgttgttcctgaaaatgataggtccaactcatggccagatgacagta acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgcccacctaactgtcca gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttttaaaataa

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