Mycobacterium sp. KMS: Mkms_4753
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Entry
Mkms_4753 CDS
T00442
Name
(GenBank) Mur ligase, middle domain protein
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
mkm
Mycobacterium sp. KMS
Pathway
mkm00300
Lysine biosynthesis
mkm00550
Peptidoglycan biosynthesis
mkm01100
Metabolic pathways
mkm01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
mkm00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
Mkms_4753
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
Mkms_4753
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
Mkms_4753
Enzymes [BR:
mkm01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
Mkms_4753
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PGA_cap
Mur_ligase_M
Mur_ligase_C
VWA_3_C
Motif
Other DBs
NCBI-ProteinID:
ABL93944
UniProt:
A1UM86
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All DBs
Position
complement(4981457..4985356)
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AA seq
1299 aa
AA seq
DB search
MENSADRSHDCEDRPDIGRFLARANPGESVATAQPCDIRLTRADVDAAIALGGRYLVSAQ
REDGSFVYEVDWMTGEESADDNVVRQAGATWGVALLHRETREPDHRAAVDRSLRKWDTAV
REIDGRRWLADGEFRSGKLGAVALIGLSLLERLAVPEGLDDPARMRASLDALCRFVEDAR
SPSGGFQKAFDTRTGNHSGAADPYSSGEALLLLARSGIELGEPDRLERALAWAEEDYHEF
VVRPLADEPDPDVTKGYYQWGSMTWFAFATAGHAPETWGRRLIEQALWMVDVHRTLSRKR
NTGYAYEGIVPAWEWARRTGNEDTARKLACVVHQGLRKLCAWQLGHPLASSALRSAPEQF
HGAVQNHARQSALRIDVTQHQLHALMYARRFSVDAAEHLCATDISAAPAVSVQTGNRNHK
APSSDLNAHELAEITQGVWEVMPPDGWTMKAVAFVKKRLEPQALVLPHCRTYRYGVDRDT
VRGLNGNGYALLADATPLAFPHGVPRLKVASVRNALTNLALATRASYPGRIVAVTGSAGK
TSTCNMIEDLLQVFGVPKRPTKNFNTFDGVNGEVANLTNEAIAVIEVAASFLSQRGGPRP
NVLRPEVAMITSIGEAHLEYFGSPQGVAEVKSNVFDLMSRGTAVIPRDADTYDYMVQRAR
AAGATTVSFGAHPSADAHLLSYSAADGVVEAEIFGERITYELGALGRHFARNSVGALGVV
AALGLDWRRAAGALASSREVTGRGMTFDVGSASGRFTLIDDAYNANPSSVRAAIEMLSER
ATPPRGRRIAVLADMLELGPRSEEFHRALAEPLLGAAIDRVYLVGDQMRALWDDLPSEIR
GQYYPTVDGLQAALDREFADGDVVLFKGSNGTELHKVVAHFKRATKRRSDAPKDLARSED
TGFVQPAGRRRLEVRARHPKSSQSGSRRTSLVFVGDLSMGDCYLKRPHLSVARHRLEENP
WSFVELLAPLVQDKSLLVANLETVLAERPADPFRGMKKYQGWDDPVRTLAVMQRLGVDAV
SLANNHTMDFGVAPLRRTIAHLESTNIVPFGAGENEVQAARPLSVSAPFGNVHIFAGYEF
RTGYARKWNFYASGDAAGVNPLTGRATGSLIADIARTRTDDPASVIVVYPHWSGARNYQW
ATDEMIGMNSEFLDAGADFVIGHGAHRMQEIVSGREGTTVFSLGNFVFNSPGRYAKFGSP
TFSLVARLEIEDGDPVTGIGADLHIYPIMSDNRETGFRPRPVRKSEAVQVYNILAGQSGA
RFREDFDLEHGDRGWYIGRTIPLSMAGGQRRRDAVTSPA
NT seq
3900 nt
NT seq
+upstream
nt +downstream
nt
atggaaaatagcgctgatcgttctcacgattgcgaggaccggcccgacatcggccgattc
ttggcgcgtgcgaatccgggtgaatccgtcgctaccgcacagccatgcgatattcgcctc
acacgcgcagatgtcgacgcggcgatcgctctgggcgggcgatacctcgtctcggcccag
cgggaggacggcagcttcgtctacgaggtcgactggatgacgggggaggagtcggcggat
gacaacgtcgtccgccaagccggcgcaacctggggtgtcgcattgctgcaccgagagacg
cgcgaacccgatcatcgggccgccgtggaccgatcgcttagaaagtgggataccgcggta
cgggagatcgatggtcggcgctggctggccgatggggagttcaggtcagggaagctcggc
gccgtcgctctgatcggcctctccctgctcgagcgccttgctgtcccagagggtctcgat
gaccctgcgcggatgcgcgcctcgctcgacgcgctctgccgattcgtcgaggatgcccgg
tcgcccagtggaggatttcagaaggcgttcgacaccagaactggaaaccactccggcgcc
gcggatccgtactcttctggtgaagcgcttctgctactcgcgcgcagcggtatcgaactc
ggtgagcccgatcgactggaacgggcactcgcttgggctgaggaggactatcacgagttc
gtcgtgcgtccgctcgccgacgaaccggacccagatgtcactaaaggctattaccagtgg
gggtcgatgacttggttcgctttcgcgactgccgggcacgctccggagacttggggtcgc
cgccttatcgagcaagcgttgtggatggtcgacgtgcaccgcacgttgtcccgcaaacgg
aacaccgggtacgcctacgaagggatcgtgccagcatgggagtgggctcgtcgcacaggc
aacgaagacaccgcccgtaagctcgcatgcgtcgtgcaccaggggctccgcaagctctgt
gcgtggcaactcgggcacccactcgcgtcatctgcgttacggtctgcgccggaacagttt
catggggcggtccaaaaccacgcgcgccagtccgcgctacgtatcgacgtcacccagcac
caactccacgcgctgatgtatgcgcggcgattcagcgtcgatgcagccgagcatttgtgc
gcgacggacatctcggcggcgccggcggtatctgtccagacagggaaccggaatcacaaa
gcgccctcgtcggacttgaatgcgcatgagttggctgagatcacgcaaggagtgtgggaa
gtcatgccacccgacgggtggaccatgaaggcggtcgcgttcgtcaagaaacggctggag
ccccaagcgctggtgctaccgcattgtcgaacgtacagatatggggtagatcgagacacg
gtgcggggattgaacgggaatggttacgccctgctcgctgacgccacgccgctggccttc
ccgcacggtgttcctcgcctgaaggttgcgtcggtgcggaacgccttgaccaacctcgca
ttggccaccagagccagctatcccgggcggattgtggccgtcacgggcagtgctggaaaa
accagcacctgcaacatgatcgaagatctgctccaggtctttggagtaccgaaacggccg
acgaagaacttcaacacctttgacggggtcaacggcgaggtggccaatctgaccaacgag
gcgatcgccgtcatcgaagtggcggccagcttcctgtctcagcgcggcgggccccgtccg
aacgtacttcgtcccgaagtggcgatgattaccagtatcggcgaggcgcatctggagtac
ttcggatcgccgcaaggggtcgctgaggtgaagagcaacgtgttcgatctgatgtcgcgg
ggcacagcggtcatcccccgtgacgccgacacgtacgactacatggtgcaacgcgcacgt
gcggcaggcgctacgaccgtctccttcggggcccatcccagtgccgacgcccaccttctc
tcatactcagcggcagacggagtggtcgaagcggagatcttcggcgagagaatcacttat
gaactcggggcacttggtcggcattttgcgcgcaacagtgtcggagcgttgggcgtcgtc
gcggcccttgggctggactggcggcgggccgccggcgcactggcgtcgagtcgggaagtc
actggtcgcggcatgacgtttgacgtcggttcagcgagcggtcgtttcacgttgatcgac
gacgcatacaacgcgaatccgagttcggtacgggccgcgatcgagatgctctccgaacgg
gccactcctccgagggggcgccgaatcgccgttctcgcggacatgctggaactgggccct
cgaagcgaggagtttcaccgagccctggctgagcccttactcggcgcagcgattgatcgt
gtgtacctggtcggtgatcagatgcgcgcgttgtgggacgacctgccttccgaaatccgt
ggccagtactaccccactgtggacggtctccaggcagcgctcgatagagagttcgccgac
ggagatgttgtcttgttcaagggttcgaacggcaccgaactccacaaagtcgtggcgcac
ttcaagagagcaacaaagcgtaggtcagacgctccgaaggacctggctcgtagcgaggac
acgggctttgtgcaacccgcaggccgtcgacggctggaagtgcgcgctcggcatccgaag
tcatcacagtcaggctcacggcgcaccagtctcgtcttcgtcggcgacttgagcatgggt
gattgttacctcaaacgcccacacctctctgtcgctcgccatcgactcgaggagaatccg
tggagcttcgtcgaactcttggctcctctcgtgcaggacaagtcactccttgtcgccaat
cttgaaaccgtcctggccgaaaggccggctgatccgttccgggggatgaagaaataccag
ggatgggacgatccggttcggacgcttgcggtcatgcagcgtttgggcgtagacgcggtg
tcgctcgcgaacaatcacacgatggatttcggagtggcgcccttgaggcggacgatcgcc
cacctcgagtcgaccaacatcgtgccattcggtgctggcgagaatgaggtgcaggccgct
cgaccactgagtgtttcggctcctttcggcaatgttcacatattcgccggttacgagttc
cggactggttatgcacggaagtggaatttctacgcgtcgggtgatgcggccggcgtgaat
cctctcaccggccgcgcgacaggaagtctcatcgccgatattgcgcggaccaggactgac
gacccggcgtcggtcatcgtcgtctatccacactggagtggcgcacggaattatcaatgg
gccacggatgaaatgatcgggatgaacagcgagttcctcgatgccggcgccgacttcgtt
atcgggcacggggcgcatcgaatgcaggagatagtctcgggaagagaaggaacgacggtg
ttctcgctgggcaatttcgtgttcaactcgcccggccggtatgccaaattcggctcacct
actttcagtcttgttgcacgcctagagattgaggatggcgatccggtgacgggaatcggg
gcggatctacatatctatcccataatgtcggacaatcgtgagacgggttttcgcccgagg
ccggtccggaaatccgaggcggttcaggtgtacaacatcctcgccggacagagtggcgca
cgcttcagagaggacttcgacctcgaacacggtgaccgggggtggtacatcggtcggacg
attccactgagcatggccggcggccaacgacgacgtgatgcggtcacttcgcccgcgtga
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