KEGG   Macrotis lagotis (bilby): 141490744
Entry
141490744         CDS       T11097                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mlao  Macrotis lagotis (bilby)
Pathway
mlao00562  Inositol phosphate metabolism
mlao01100  Metabolic pathways
mlao01521  EGFR tyrosine kinase inhibitor resistance
mlao01522  Endocrine resistance
mlao01524  Platinum drug resistance
mlao04012  ErbB signaling pathway
mlao04014  Ras signaling pathway
mlao04015  Rap1 signaling pathway
mlao04024  cAMP signaling pathway
mlao04062  Chemokine signaling pathway
mlao04066  HIF-1 signaling pathway
mlao04068  FoxO signaling pathway
mlao04070  Phosphatidylinositol signaling system
mlao04071  Sphingolipid signaling pathway
mlao04072  Phospholipase D signaling pathway
mlao04081  Hormone signaling
mlao04140  Autophagy - animal
mlao04145  Phagocytosis
mlao04150  mTOR signaling pathway
mlao04151  PI3K-Akt signaling pathway
mlao04152  AMPK signaling pathway
mlao04210  Apoptosis
mlao04211  Longevity regulating pathway
mlao04213  Longevity regulating pathway - multiple species
mlao04218  Cellular senescence
mlao04360  Axon guidance
mlao04370  VEGF signaling pathway
mlao04380  Osteoclast differentiation
mlao04510  Focal adhesion
mlao04517  IgSF CAM signaling
mlao04518  Integrin signaling
mlao04550  Signaling pathways regulating pluripotency of stem cells
mlao04611  Platelet activation
mlao04613  Neutrophil extracellular trap formation
mlao04620  Toll-like receptor signaling pathway
mlao04625  C-type lectin receptor signaling pathway
mlao04630  JAK-STAT signaling pathway
mlao04650  Natural killer cell mediated cytotoxicity
mlao04660  T cell receptor signaling pathway
mlao04662  B cell receptor signaling pathway
mlao04664  Fc epsilon RI signaling pathway
mlao04666  Fc gamma R-mediated phagosome formation
mlao04668  TNF signaling pathway
mlao04670  Leukocyte transendothelial migration
mlao04722  Neurotrophin signaling pathway
mlao04725  Cholinergic synapse
mlao04750  Inflammatory mediator regulation of TRP channels
mlao04810  Regulation of actin cytoskeleton
mlao04910  Insulin signaling pathway
mlao04914  Progesterone-mediated oocyte maturation
mlao04915  Estrogen signaling pathway
mlao04917  Prolactin signaling pathway
mlao04919  Thyroid hormone signaling pathway
mlao04923  Regulation of lipolysis in adipocytes
mlao04926  Relaxin signaling pathway
mlao04929  GnRH secretion
mlao04930  Type II diabetes mellitus
mlao04931  Insulin resistance
mlao04932  Non-alcoholic fatty liver disease
mlao04933  AGE-RAGE signaling pathway in diabetic complications
mlao04935  Growth hormone synthesis, secretion and action
mlao04960  Aldosterone-regulated sodium reabsorption
mlao04973  Carbohydrate digestion and absorption
mlao05010  Alzheimer disease
mlao05017  Spinocerebellar ataxia
mlao05020  Prion disease
mlao05100  Bacterial invasion of epithelial cells
mlao05132  Salmonella infection
mlao05135  Yersinia infection
mlao05142  Chagas disease
mlao05146  Amoebiasis
mlao05160  Hepatitis C
mlao05161  Hepatitis B
mlao05162  Measles
mlao05163  Human cytomegalovirus infection
mlao05164  Influenza A
mlao05165  Human papillomavirus infection
mlao05166  Human T-cell leukemia virus 1 infection
mlao05167  Kaposi sarcoma-associated herpesvirus infection
mlao05168  Herpes simplex virus 1 infection
mlao05169  Epstein-Barr virus infection
mlao05170  Human immunodeficiency virus 1 infection
mlao05171  Coronavirus disease
mlao05200  Pathways in cancer
mlao05203  Viral carcinogenesis
mlao05205  Proteoglycans in cancer
mlao05206  MicroRNAs in cancer
mlao05207  Chemical carcinogenesis - receptor activation
mlao05208  Chemical carcinogenesis - reactive oxygen species
mlao05210  Colorectal cancer
mlao05211  Renal cell carcinoma
mlao05212  Pancreatic cancer
mlao05213  Endometrial cancer
mlao05214  Glioma
mlao05215  Prostate cancer
mlao05218  Melanoma
mlao05220  Chronic myeloid leukemia
mlao05221  Acute myeloid leukemia
mlao05222  Small cell lung cancer
mlao05223  Non-small cell lung cancer
mlao05224  Breast cancer
mlao05225  Hepatocellular carcinoma
mlao05226  Gastric cancer
mlao05230  Central carbon metabolism in cancer
mlao05231  Choline metabolism in cancer
mlao05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlao05415  Diabetic cardiomyopathy
mlao05417  Lipid and atherosclerosis
mlao05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlao00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    141490744 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    141490744 (PIK3CA)
   04014 Ras signaling pathway
    141490744 (PIK3CA)
   04015 Rap1 signaling pathway
    141490744 (PIK3CA)
   04370 VEGF signaling pathway
    141490744 (PIK3CA)
   04630 JAK-STAT signaling pathway
    141490744 (PIK3CA)
   04668 TNF signaling pathway
    141490744 (PIK3CA)
   04066 HIF-1 signaling pathway
    141490744 (PIK3CA)
   04068 FoxO signaling pathway
    141490744 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    141490744 (PIK3CA)
   04072 Phospholipase D signaling pathway
    141490744 (PIK3CA)
   04071 Sphingolipid signaling pathway
    141490744 (PIK3CA)
   04024 cAMP signaling pathway
    141490744 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    141490744 (PIK3CA)
   04152 AMPK signaling pathway
    141490744 (PIK3CA)
   04150 mTOR signaling pathway
    141490744 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    141490744 (PIK3CA)
   04517 IgSF CAM signaling
    141490744 (PIK3CA)
   04518 Integrin signaling
    141490744 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    141490744 (PIK3CA)
   04140 Autophagy - animal
    141490744 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    141490744 (PIK3CA)
   04218 Cellular senescence
    141490744 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    141490744 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    141490744 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    141490744 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    141490744 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    141490744 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    141490744 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    141490744 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    141490744 (PIK3CA)
   04660 T cell receptor signaling pathway
    141490744 (PIK3CA)
   04662 B cell receptor signaling pathway
    141490744 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    141490744 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    141490744 (PIK3CA)
   04670 Leukocyte transendothelial migration
    141490744 (PIK3CA)
   04062 Chemokine signaling pathway
    141490744 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    141490744 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    141490744 (PIK3CA)
   04929 GnRH secretion
    141490744 (PIK3CA)
   04915 Estrogen signaling pathway
    141490744 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    141490744 (PIK3CA)
   04917 Prolactin signaling pathway
    141490744 (PIK3CA)
   04926 Relaxin signaling pathway
    141490744 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    141490744 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    141490744 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    141490744 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    141490744 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    141490744 (PIK3CA)
   04722 Neurotrophin signaling pathway
    141490744 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    141490744 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    141490744 (PIK3CA)
   04380 Osteoclast differentiation
    141490744 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    141490744 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    141490744 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    141490744 (PIK3CA)
   05206 MicroRNAs in cancer
    141490744 (PIK3CA)
   05205 Proteoglycans in cancer
    141490744 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    141490744 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    141490744 (PIK3CA)
   05203 Viral carcinogenesis
    141490744 (PIK3CA)
   05230 Central carbon metabolism in cancer
    141490744 (PIK3CA)
   05231 Choline metabolism in cancer
    141490744 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    141490744 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    141490744 (PIK3CA)
   05212 Pancreatic cancer
    141490744 (PIK3CA)
   05225 Hepatocellular carcinoma
    141490744 (PIK3CA)
   05226 Gastric cancer
    141490744 (PIK3CA)
   05214 Glioma
    141490744 (PIK3CA)
   05221 Acute myeloid leukemia
    141490744 (PIK3CA)
   05220 Chronic myeloid leukemia
    141490744 (PIK3CA)
   05218 Melanoma
    141490744 (PIK3CA)
   05211 Renal cell carcinoma
    141490744 (PIK3CA)
   05215 Prostate cancer
    141490744 (PIK3CA)
   05213 Endometrial cancer
    141490744 (PIK3CA)
   05224 Breast cancer
    141490744 (PIK3CA)
   05222 Small cell lung cancer
    141490744 (PIK3CA)
   05223 Non-small cell lung cancer
    141490744 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    141490744 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    141490744 (PIK3CA)
   05161 Hepatitis B
    141490744 (PIK3CA)
   05160 Hepatitis C
    141490744 (PIK3CA)
   05171 Coronavirus disease
    141490744 (PIK3CA)
   05164 Influenza A
    141490744 (PIK3CA)
   05162 Measles
    141490744 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    141490744 (PIK3CA)
   05163 Human cytomegalovirus infection
    141490744 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    141490744 (PIK3CA)
   05169 Epstein-Barr virus infection
    141490744 (PIK3CA)
   05165 Human papillomavirus infection
    141490744 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    141490744 (PIK3CA)
   05135 Yersinia infection
    141490744 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    141490744 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    141490744 (PIK3CA)
   05142 Chagas disease
    141490744 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    141490744 (PIK3CA)
   05017 Spinocerebellar ataxia
    141490744 (PIK3CA)
   05020 Prion disease
    141490744 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    141490744 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    141490744 (PIK3CA)
   05415 Diabetic cardiomyopathy
    141490744 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    141490744 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    141490744 (PIK3CA)
   04931 Insulin resistance
    141490744 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    141490744 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    141490744 (PIK3CA)
   01524 Platinum drug resistance
    141490744 (PIK3CA)
   01522 Endocrine resistance
    141490744 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlao04131]
    141490744 (PIK3CA)
Enzymes [BR:mlao01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     141490744 (PIK3CA)
Membrane trafficking [BR:mlao04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    141490744 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15 Sll1247_N
Other DBs
NCBI-GeneID: 141490744
NCBI-ProteinID: XP_074047070
LinkDB
Position
6:39946694..40041453
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASTKSLWGVNSALRIRILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SNPVKFPDMSVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVNIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLDKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatctggtgaattgtggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactgcctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacatgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagtgttactcaagaagcagaaagagaa
gaattttttgatgaaacacggcgactttgtgatctgcggctttttcagccttttctaaaa
gtcattgaacctgtaggcaaccgagaagaaaagattctcaatcgagaaattggttttgct
attggtatgcctgtttgtgaatttgatatggttaaagatccagaagtacaagacttccga
agaaatattcttaatgtttgtaaagaagctgtggacctaagggatgtccatgcaccccat
agtagggcgttatatgtctatcctccaaatgtagaatcgtcaccagaattgccaaagcac
atatacaataaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aataatgacaagcaaaagtacactttaaaaatcaatcatgattgcgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacacggagtatgttgctgtcatcggagcagttgaag
ctctgtgttttagagtatcagggcaaatatattttaaaagtgtgtggatgtgatgagtat
ttgttagaaaaatatcctcttagccaatataagtacataagaagctgtataatgcttggt
cggatgcccaatctgatgctgatggctaaagaaagtctttacacccagctaccactggat
acttttacaatgccatcttattccaggcgaatctccacagctacaccatacatgaatgga
gaggcttcaaccaaatccctttggggcgtaaatagtgcactccgcataagaattctttgt
gcaacttatgtaaatgttaatattcgagacattgacaagatctatgttcgaacaggtatc
tgccatgggggagagccattatgtgacaatgtgaatactcaaagagtaccttgttccaat
cccagatggaatgaatggttaatgtatgatatttacatacctgatcttccacgtgctgct
cgactttgcctttctatttgttctgttaaaggcaggaaaggggcaaaagaggaacattgc
ccattggcttggggaaatattaacctctttgattatacagacactctagtatcaggaaaa
atggctttgaatctgtggcctgtacctcatggattagaagatttgctgaatcctattgga
gttactggatcaaatcccaataaggaaactccatgtttagagctggaatttgactggttc
agcaatcctgtaaagttcccagatatgtcagtgattgaagaacatgctaattggactgta
tctcgagaactaggattcaactattcccatgctggtttgagcaataggatagctcgagat
aatgaattgagagaaaatgacaaagaacaactacgggccatttgtacacgagaccccctc
tctgagatcactgagcaagaaaaggacttcctgtggagtcacaggcattattgtgtcaat
ataccagaaattctacctaaacttcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcccccaatcaaaccagaacaggccatggaa
cttttggactgtaattatccagatcctatggttcgagcttttgctgttcgatgcttagac
aaatatttaactgatgacaaactttctcagtacttaattcaactagttcaggttctgaag
tatgaacagtatttggataacttgcttgtgagatttttgctcaagaaagcactaacaaat
caaaggataggacactttttcttttggcatttaaagtctgaaatgcataataagactgtc
agccagagatttggcttgcttttggagtcatactgccgagcatgtgggatgtatctaaag
catttgaatcggcaggtagaggccatggagaagctgattaacctcactgacattctcaaa
caggagaagaaggatgagacacaaaaggtacagatgaagttcttggttgagcagatgaga
cggcctgattacatggatgctttacaaggctttatctctccccttaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcggattatgtcctctgcaaaaagacctctgtgg
ttgaattgggagaacccagacatcatgtcagaattactatttcagaacaatgagatcatc
tttaaaaatggtgatgacttacggcaggatatgctaacccttcagatcattcggattatg
gaaaatatctggcaaaatcagggtctcgatcttcggatgctaccttatggttgtctgtcc
attggagactgtgttggcctcattgaggtggtcagaaattctcacaccatcatgcagatt
cagtgtaaaggtggactgaaaggagccttgcaattcaacagccatacattacatcagtgg
ctcaaagacaagaataaaggagaaatatacgatgctgccattgacttgtttacacgttcg
tgtgctggctactgtgtggctaccttcatcctgggaattggggatcgtcacaatagcaat
atcatggtgaaagatgatggacaactatttcatatagactttggacactttctagatcac
aagaagaagaaatttggctataaacgagagcgtgtgcccttcgtcttgactcaagatttc
ttaattgtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagagattt
caggaaatgtgctataaggcttaccttgctattcggcaacatgccaatcttttcatcaat
cttttctctatgatgcttggctctggaatgcctgaactacaatcttttgatgatatcgca
tatattcgaaagaccctggccttggataagactgagcaggaggctttggagtatttcatg
aagcagatgaatgacgctcatcatgggggctggaccaccaaaatggattggattttccat
acaataaagcagcatgctttgaactga

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