Macrotis lagotis (bilby): 141493447
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Entry
141493447 CDS
T11097
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mlao Macrotis lagotis (bilby)
Pathway
mlao05012
Parkinson disease
mlao05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mlao00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
141493447 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
141493447 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mlao01001
]
141493447 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mlao04131
]
141493447 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mlao04147
]
141493447 (LRRK2)
Enzymes [BR:
mlao01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
141493447 (LRRK2)
Protein kinases [BR:
mlao01001
]
Serine/threonine kinases: TKL group
LRRK family
141493447 (LRRK2)
Membrane trafficking [BR:
mlao04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
141493447 (LRRK2)
Exosome [BR:
mlao04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
141493447 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_1
LRR_9
LRR_14
LRR_13
Arf
Ank_2
LRR_6
LRR_NXF1-5
T2SSE
CARF_Card1
AAA_7
nSTAND3
PduV-EutP
AAA_16
AAA_22
cobW
Septin
GTP_EFTU
FtsK_SpoIIIE
ResIII
Kdo
TrwB_AAD_bind
Beta-prop_EML_2
Arm
Motif
Other DBs
NCBI-GeneID:
141493447
NCBI-ProteinID:
XP_074050931
LinkDB
All DBs
Position
7:complement(215000832..215263549)
Genome browser
AA seq
2552 aa
AA seq
DB search
MASARSLGDEEKEDETLKKLIVRLQNVQEGKQIETLIQILEDMLVFTYSDHASKLFQDKN
VHMPLLLVLDSYMRVAGVQQVGWSLVCKLTEICPDIMQNLMGPQDVGKDWEVLGVHQLIL
KMLTVHNANITLSVTGLKALDQLLTSDLMTLRILEEDCSDVFTLIFDAMHTFTTNEEIQK
FGCKILHVLFEKVSEEQLTEFIENKDYVFLLNALKRCNQEEEVVLYVLHSLHSLALPSSN
VEVLMSGNVRCYNIVVEAMKMFSSSEKIQEIGCCLLHRLTLDNFFNILVLNEVHEVIVKA
VKKYSENATLQIAALSCLALLTETIILNQDLEEKKNNHDDDDNKLYWLESSYRALTLHRK
NTDVQEAACWALNNLLMYQRNLHENIGDGDNQYPVHRELLLAMLMHSSSKEVFQATANAL
STLSEQNVNIRKALLSKGIYWNVLLLMMKHLHFPEVVESGCKMLNHLLDGSNLHLDVMAS
VTSNIIKVMKNHKTSSAVQLEAFRTILHIIVPESKKEPEEDALLNINIKVVKNQCLLNDI
HKLVLSALNKFIGNPGIQVCGLRIISSLANCSGALEMFSQQGALDSVLHTLQMYPDDRVI
QCLGLNLLGCLITKKNLCTETQDLLANILVSSLQRFKDIVEVQISGFQTILAILELSRCF
ARLLLSHHSYDSLIFYQMSRCFTEQTDHQFQKLCCKFFAKITSDDDIKNVLLVRACEENN
NNMAECLLLLGADINKVTGKTSLICQVCEKESSPKLVELLLNNGSREQEIRKALKISIKK
NNSQIISLLLRKLALDLANSSICLGGFCIGKIEPSWLCPLFSDKVSNSRKQTNTGSAMAR
MILRYQMKSLSEDGSILGSDGSFPEDHLDKFDDWTFIYDSSAGCVFGHSDDPDSEGSEGS
FLMKKKSSSFNVGALQHSSPTLESDSNSMEASFDQEELLKEKRNLISSDNTIQKSSKLQS
LLKQSDSLFPLTSEKEYIKSLDLSANELEDIDSISNKCCLSDHLARLEKLELHQNALTRV
PQQLCESLKCLTYLDLHGNKITSIPAYLLKMNCIVNLDISRNDIGPLIIMDPTIRCTTLK
HLNLSYNQLSSVPEFLANVTENLEQLLLEGNKISEIYSPLCLKELKILNLSKNHILSITE
DFFEACGKLEVFTARMNSLVAVPYLPSSITILNLSQNKFTCIPEVILSLPHLRSLDLSCN
EIHILPGPAYWKSLNLRELLFNHNQIRILDLSEKAYTWSRMEKLHLSHNKLKEIPPEIGF
LENLTSLDVSYNLELRSFPNEMGKLTKIWDLPLDELHLNFDFKHIGYKTRDIIRFLQQRL
KKAVPYNRMKLMVVGNTGSGKTTVLQQLMKYKRTDLSPLSTTVGIDVKDWSIQVKNKGKK
ELFLNVWDFSGREEFYSTHPHFMTQRALYLAVYDLSKGLAEVDAMKPWLFNIKARASSSP
VILVGTHLDVSDEKQRKASISKITKELLNKRGFPEIRDYHFVNATEESEALVKLRKSIVK
ESLNFKIRDQPVVGQLIPDCYLELEKKISLERKNVPTEFPVISQKRLVQLVKESQLQLDE
NELPHAIHFLNESGVLLHFQDPALQLSDLYFVEPQWLCKMMAQILTVKVEDFAKYPKGII
LRSDVEKFLSKKNRFPKNYMSQYFKLLEKFQIALPIGEEHLLVPSSLSDQRPVIELPHCE
NSEVIVRLYEMPYFPMGFWSRLISRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEA
YCLVESSILDNSSESFLKITVPSCRKGCIILGQVVDHIDSLMEEWFPGLLEIDVCGEGET
LLKKWALYSFNDGEEQQKILLDDLMKKTEEGDLLFNPDQPRHAIPIGHIAPDLILADLPR
NIMLNDNELEFEQAPEFLLGDGGFGSVYRASYKGEEVAVKIFNKHTSLRLLRQELVVLCH
LHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH
ASMIIYRDLKPHNVLLFTLYPNSAIIAKIADYGIAQYCCRMGIKTSEGTAGFRAPEVARG
NVIYNQQADVYSFGLLLYDILTTGGRILEGLKFPNEFDELAINGKLPDPVKEYGCTPWPK
VENLIKKCLKENPQERPTSAQVYENLNSAELLCLMRYILIPKISVAECMVATNQNNKNAL
IWLGSGNNDMGQLSCLEMNTERHISKDVTESRILCLALVYLLVEKESWIVAGTQSGTLLA
IKTEDDKKSHMLQRMTDSVTCLYCNSFSKQSSFFCFGTPPGHMFSYCEVISTIVIIAFFS
NSTQKNFLLVGTANGRLAIFEDRNVKFEGAPPLKTLNIGNVNTPLMCLNESIYSSEKNII
WGGCGTKIFSLSNDFSIQKLIETRTNQLFSYATFSDSNIISIVVDKAIYVAKKNSHFVEV
WDKKTEKLCVLIDCVQFLKEHAVILTKESKHKMTYSGRVKTLCLQKNTALWIGTGGGHIL
LVDLSTHCIMHIIQNFCNSIRALMTVQLGSLKNVMLVLGYCQKSNESTPNQKETESCLSI
WDINLPHEIENLEKHTEVRKELAEKMKIISME
NT seq
7659 nt
NT seq
+upstream
nt +downstream
nt
atggccagtgctcgcagcctgggggatgaagaaaaagaagatgaaactctgaagaagttg
atagttaggctacaaaatgtccaggaaggaaaacagatagaaacactgatccaaatccta
gaggatatgctggtgtttacgtattctgatcatgcttccaagttatttcaagacaaaaat
gtccatatgcctttgctacttgttttggattcctacatgagagtcgcaggtgtacaacag
gtgggttggtcacttgtctgcaaattgacagaaatttgtcctgatataatgcaaaactta
atgggcccccaggatgttggaaaggattgggaagtccttggtgttcaccagctgattctt
aaaatgctcactgttcacaatgctaatataactctttcagtgactggactgaaggcatta
gatcagctcctgacatcagatttgatgactttgcggatcctggaagaagattgcagtgat
gtgtttactttaatttttgatgccatgcatacatttaccactaatgaagagatccaaaag
tttgggtgtaaaattttacatgttctctttgaaaaagtttcagaagagcaactgactgaa
tttattgagaacaaagattatgtgtttttgctgaatgcattaaaaagatgtaatcaggaa
gaagaagttgttctctatgttcttcacagcttacattccttagcactcccatccagtaat
gttgaagtcctaatgagtggaaatgtcagatgttacaatattgtggtagaagccatgaaa
atgttttctagcagtgaaaaaattcaagaaattggttgctgtttgttacacaggcttaca
ttggacaatttctttaatatcctggttttaaatgaggttcatgaggtcatcgtgaaagct
gttaaaaaatattcagaaaatgcaaccttacagatcgcagcactaagctgtttggctctc
ctcactgaaactattattttaaaccaagatttagaagaaaagaaaaacaatcatgatgat
gatgacaataaattatactggttagaatccagttacagagcattgaccttgcatagaaag
aacacagatgtgcaggaggctgcatgctgggctttaaacaacctccttatgtaccagcgc
aatttacatgaaaatattggtgacggagataaccagtatccagtgcatagagaactgcta
cttgccatgctgatgcattcttcatcaaaagaagtgtttcaggcaactgctaatgcattg
tcaactctatcagaacaaaatgttaatatcagaaaagccctgttgtcaaaaggaatatac
tggaatgtactgctattaatgatgaagcatttacacttccctgaagtggttgaaagtgga
tgtaaaatgttaaatcatcttttggatggaagtaaccttcacctagatgtaatggcatca
gtgacatctaacattataaaagttatgaaaaatcacaaaacttcatcagcagtacagctg
gaggcatttcgaactattttacatattattgtcccagaatcaaagaaggaacctgaagaa
gatgctttgttaaatataaatataaaagtggttaaaaaccaatgccttttgaatgacatt
cacaaactggttctaagtgctttaaacaagtttataggaaatcctggaattcaagtatgt
ggattaagaataatttcttctttagcaaattgttctggtgcattagaaatgttttctcaa
caaggggcccttgattcagtgcttcatacactacagatgtatccagatgacagagtaatt
cagtgcctgggtttgaatctgctaggatgtttgattacaaaaaagaatttgtgcacagaa
actcaggatctgcttgcaaatattctggtttccagcttacaacgatttaaggacattgtt
gaagtacagataagtggatttcaaactattttggcaatacttgaattatcacgttgcttt
gcaaggctgctactaagccatcattcatatgactcactgattttctatcagatgtccagg
tgtttcactgaacaaactgatcatcagtttcagaaactttgttgcaaattctttgccaaa
ataacttctgatgatgatattaaaaatgtcctactggtaagagcttgtgaggaaaacaat
aacaatatggctgaatgcctcctccttttaggagctgatattaataaagtgaccggaaaa
acttctttaatctgccaggtttgtgaaaaagaaagcagtcccaaattagtagaactctta
ttaaataatggatcacgggagcaagagattcggaaggccttgaagatcagcataaagaaa
aataacagtcaaatcatcagtttacttttacggaagcttgccctggatcttgccaatagc
agcatttgtcttggaggattttgtattggaaaaattgaaccttcatggctttgtccttta
ttttcagataaagtatctaattcaagaaaacaaacaaacacaggatctgcaatggcaaga
atgatactaagatatcaaatgaaaagtttatcagaagacggatcaatactaggtagtgat
ggaagttttcctgaagatcatcttgataaatttgatgattggacctttatatatgacagt
tctgcaggctgtgtatttggtcacagtgatgatcctgatagtgaaggaagtgaaggttca
tttcttatgaaaaagaaatcgtcttcttttaatgtaggagccttgcagcatagctcacca
actttggaaagtgattcaaattcaatggaagccagttttgatcaagaagaattgttgaaa
gaaaaaagaaacttaatttcttcagataatactatccagaaatcttccaaactccaatcc
cttttgaaacaatcagacagtttgtttcctctaacctcagaaaaagaatatataaagtca
ttagacctttcagcaaatgaactagaggatattgacagtataagcaataaatgctgttta
agtgatcatttggcacgtcttgagaaactggaacttcaccagaatgcacttacaagagtt
ccacaacaactctgtgaatctttaaaatgtttgacatatttagatttacatggtaacaaa
atcacttcaattcctgcctatttattgaaaatgaattgcattgtgaatcttgatatttcc
cgtaatgatattggacctttgataattatggatccaactatcagatgtacaaccctgaag
catctcaatttgtcatacaatcaactatcctctgtccctgaatttcttgcaaatgtcaca
gaaaatctggaacagcttcttctggaaggaaacaaaatatcagaaatatattcacctttg
tgcctgaaggaattgaagattttaaaccttagtaaaaaccacatactatccataactgaa
gatttttttgaggcatgtggtaaattggaagtgtttactgctagaatgaattcacttgtt
gctgtgccttacttgccctctagcataacaattctgaatttgtcacaaaacaaatttaca
tgtattccagaagtaattctcagtcttccgcatttgcggtcattagatttgagctgcaat
gaaattcacattctacctgggcctgcatactggaaatcgttaaacttaagggaactcttg
tttaatcataatcagatcaggattttggacttaagtgaaaaagcatacacatggtcacga
atggagaaattacacttgtcccataataaactgaaggagattcctccagaaatcggtttt
cttgaaaatttaacatctcttgatgtgagttacaatttggaactgagatcctttcctaat
gaaatgggaaaattaactaaaatttgggacctccctttggatgaattgcatcttaatttt
gattttaagcatataggatacaagaccagagatatcataaggtttcttcagcagaggtta
aagaaggcagtgccctataatcgaatgaaacttatggttgtgggaaatactggcagtgga
aaaactacagtgttgcaacagttaatgaaatataaaagaacagatttgagccccctgagt
actacagtaggcatcgatgtaaaagactggtctatccaggtgaagaacaaagggaagaaa
gagttattcctaaatgtctgggatttttcaggacgagaagaattctacagcacccaccct
cactttatgacacaacgagcattatatcttgctgtatatgatcttagcaaaggacttgct
gaagtggatgctatgaagccatggctcttcaacataaaggctcgagcttcttcctcacca
gtgattctggttggtacccatttggatgtttctgatgagaaacaacgaaaggcctccata
agcaaaattactaaggagctcttaaacaaaagaggtttcccagaaatacgagattaccat
tttgtgaacgctactgaagaaagcgaggcattggtaaaacttcggaaaagtatcgtaaaa
gaaagtctgaacttcaagatcagagaccagcctgttgtaggacagctaattccagattgc
tatttggaactcgaaaagaaaatttcgttggagcgaaaaaatgttcccactgaatttcca
gtaatcagtcagaagcgattggtacagctagtaaaagaaagtcaactgcagttagatgag
aatgaacttcctcatgctattcattttctaaatgaatcaggtgtcctgctccatttccaa
gacccagcactgcagttaagtgacttgtatttcgtggaacctcaatggctatgcaaaatg
atggcacagattttgacagtgaaagtagaagactttgctaaatatcctaagggtattatt
ctacgctcagatgtggaaaagttcctatcaaagaaaaaccgttttcccaagaactatatg
tctcagtactttaaactcctggaaaaatttcagattgctttaccaataggagaagaacat
ttgctagttccaagcagtttgtctgatcaaagacctgtgatagaacttccccactgtgaa
aactctgaagtcattgttagattgtatgaaatgccttattttcccatgggattttggtcc
agactgatcagtcgattacttgaaatttctccttatatgctctcaggcagagaacgggcc
cttcgccccaacagaatgtattggagacaaggaatctatctgaattggtctcctgaagcc
tattgtctggtagaatcttcaattttagacaacagctcagagagtttcttgaaaattaca
gtaccttcatgcagaaaaggctgtattattttgggccaagttgtagatcacatagattct
ctcatggaagaatggtttcctggtttactggaaatagatgtctgtggtgaaggagaaaca
ttgttaaagaaatgggctttatatagttttaatgatggtgaagaacaacaaaaaatatta
cttgatgatttaatgaagaaaactgaagaaggagatctcttatttaatccagatcaacca
agacatgctattccaataggtcatattgctcctgatttaattttggctgatctgcctaga
aatatcatgttgaatgataatgagctggaatttgaacaagcaccagaatttcttttaggt
gatggtggtttcggatctgtttatcgtgcatcctataaaggagaagaagtggctgtgaag
atttttaataaacatacgtcacttcgtctattaagacaagagctagtagtcctttgccac
ctccaccaccctagtctgatatctttgcttgctgctggtattcgtccccgtatgttggta
atggaattagcctcgaagggttccctggatcggttgcttcaacaagacaaagctagctta
accagaacactccagcacaggatagcactacatgttgctgatggcttaagatatctccat
gcatcaatgattatttaccgggatctgaagcctcataatgtactgctttttacgctatat
cccaattctgcaatcattgccaagattgcagactatggaattgctcagtactgctgtaga
atggggataaagacatctgaaggaacagcaggatttcgagcacctgaagttgccagagga
aatgtaatttacaaccaacaggctgatgtttattcatttggcttactactctatgacatt
ttaacaacaggaggtagaattcttgaaggattgaaattcccaaatgagtttgacgagtta
gctataaatgggaaattgccagatccagtcaaggaatatggttgtactccatggcctaaa
gtagaaaacttaattaagaagtgtctgaaagaaaatcctcaggaaagaccaacatctgcc
caggtatatgaaaatttgaactcagctgaattattatgtctgatgagatatattttaata
cccaaaatatctgtagcagaatgcatggttgctacaaaccaaaacaacaagaatgcactc
atctggctgggtagtgggaacaatgatatggggcagttatcttgtcttgagatgaatact
gaaagacatatctctaaggatgtgacagagagtagaatattgtgccttgctcttgtgtat
cttctggttgaaaaggaaagctggattgtagcaggaacacagtctggcactctgttggca
atcaagacggaagatgataaaaagagccacatgcttcaaagaatgactgactctgttact
tgtttatactgcaattctttttctaaacaaagttcctttttctgttttggcactccacct
gggcatatgttctcgtactgtgaagttatatcaactattgtgataatagctttcttttct
aacagcacacaaaagaattttcttctggttggaactgcaaatggcagactagctattttt
gaagacagaaatgttaagtttgaaggagctcctcctttgaagacattaaatataggaaat
gtcaacactccactgatgtgtttaaatgaatccatatattcatcagaaaaaaatataatc
tggggaggatgtggcacaaagattttctccctttctaatgatttctccattcagaaacta
attgagacaaggacaaatcaactgttttcttatgcaacattcagtgattccaatatcatt
tcaattgtggtggacaaagctatctatgtagctaagaaaaacagccatttcgttgaagtt
tgggacaagaagacggagaaactttgcgtcctaatagactgtgtacagtttttaaaggag
catgcagtaatattaaccaaggaatcaaaacataaaatgacttattctggaagagtgaaa
accctctgtctacagaaaaatactgccctttggataggtacaggaggaggtcacatttta
ctggttgatctttcaacacattgcatcatgcacataattcagaacttttgtaattctatt
agagcactgatgacagtccagttagggagcctaaaaaatgtaatgctggttttggggtac
tgccagaaaagtaatgaaagtactccgaatcaaaaagaaacagagtcttgtttgtctatt
tgggacattaacctaccacatgagattgaaaacttggaaaagcacacagaagttagaaaa
gaattagctgaaaaaatgaaaattatttccatggagtaa
DBGET
integrated database retrieval system
