Macrotis lagotis (bilby): 141501000
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Entry
141501000 CDS
T11097
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
mlao Macrotis lagotis (bilby)
Pathway
mlao00310
Lysine degradation
mlao01100
Metabolic pathways
mlao05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
mlao00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
141501000 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
141501000 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
mlao03036
]
141501000 (DOT1L)
Enzymes [BR:
mlao01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
141501000 (DOT1L)
Chromosome and associated proteins [BR:
mlao03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
141501000 (DOT1L)
HMT complexes
Dot1-containing complex
141501000 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
141501000
NCBI-ProteinID:
XP_074060729
LinkDB
All DBs
Position
X:complement(646941895..647058656)
Genome browser
AA seq
1752 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNTTTPTKVQ
ESKGAVALEPRGDSGAEEDKNGTAPLKKPSPSKPRKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKAKKTPTALELLHAQTVSQAAASSPQDAYKSPHSPYYQLPPKVQRHSSNQLLATPT
PPALQKLLESFKVQYLQFLAYMKTPQYKANLQQMVEQEKEKNTQLLGTAQQLFSHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLESDNSELRNQSLQLL
KARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELLQLK
SYAPTDEALSVHLRSKSSFSRELETDPARFQLELECSKLSLPHVSSMSPELSMNGHAANY
EIHNMLSRPSSKQNTPQYLTSHLDQEIVPCTPIHNNRQKADKLSSLSLPDYTRYSPAKLA
LRRHLNQDHVVHGKATTNEIHHRVEHAKENGLTYQSPAMSNGLKLSPQETRPSSPSALQI
AGEKSSDKVLKERAYASNGETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAEKVRNT
PSPVHQNRESTSATLEKQFGANSHNGMTSAVGNKSLALATSGFSYSGSLAVNGTLSSSPA
HLNHGAEQAALDDSSNSGSLFNSVGSRSSTPQHPSLLMMQSRTSGQNSPAHPLAASPRLN
GASQSMMGILQYSDTTKLFSEGNMGDLPLDSGFSDAENEVKRRILFAISTNTGNLKQSPS
NKHSPLTASIRTDCGQACVQEGKKRGRRKRSSTGNPSANSAVSPKRKPLASVAGLFTQSS
GSPLNINSMVNNINQPLEITAISSPENSLKNSPIPYQDNDQPPVLKKEKPLIQTNGAHYS
PLTSDEEQGSEDEHNSIRIERKIATISLESKSPQKTENGGGLTGRKQTQLTEGINSSKWK
STFSPISDINITKTSDSPLQSASSLSQNSLFAFRPSSEDTMAIDAKISVHTRKNFSSSLS
GSGGLSPNTNSSNGFSYTGGLSAADMSLHSFHDGASLSHKTTEVAGLSSPLGFQAQRSKD
SSDVNPFLNKRQLDGLGSMKGEELQRVGGRSKEVLDLALQLGGPSDKGSLQHNGKAGKGR
DRELEFKNGHNLFISAAAAVPPGGLLNGKGLSTATSATGHTASSVSTHHPFLNTFTTGSQ
FPLGPMSLQANLSSVAGSSVLQSLFNSMPAAASLVHVSSAATRLTNSHSMGNFSSGVTGG
TVGGVFPHAVPSASSHQFGASFSSSAVCSSTMLSLNPVQAVVTPTSSSFQAPAPSVGSCS
EARAPQPPTRGPPQSLPHPTPPAPATLAPPPPFLAASNPEPLAALPVPQASGPPSGAAAL
QANASLSIKLAALPHKVSRPSFTVHHQPLPRLTLAPAAPGAPQSTAAGPPALWLTLGMQS
PYASHLSGVKPR
NT seq
5259 nt
NT seq
+upstream
nt +downstream
nt
atgggtgagaagctggaactgaggctcaagtcgcccgtgggagccgagcccgccgtgtac
ccgtggcccctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
attcgatgggtctgcgaagaaatacctgatctcaagcttgccatggaaaattatgtttta
attgactatgataccaaaagctttgaaagcatgcagagactctgtgacaagtacaatcga
gccattgatagcattcatcaactgtggaaaggaacaacccagcccatgaaactgaacact
cggccatccaatgggcttcttcgccatattttacagcaagtatataaccactctgtcaca
gatccagagaaactcaacaactatgagcccttttctccagaggtgtatggagaaacctca
ttcgacttagttgcccaaatgattgatgagattaaaatgacagaggatgatttgtttgtt
gatttgggcagtggagtggggcaggttgttttgcaagtggctgcagccacaaactgtaaa
catcattatggtgtggaaaaagcagacatcccggcaaagtatgctgagacaatggataga
gaattcagaaaatggatgaaatggtatgggaagaagcatgcagaatacacactggaaaga
ggcgacttcctttctgaagagtggcgggaaagaatcgccaacacaagtgttatttttgtg
aataattttgcctttggtcctgaggtggatcaccaactgaaggagcgatttgctaacatg
aaggaaggtggtagaatcgtgtcctccaaaccttttgcacctctaaactttagaataaac
agtagaaacttgagtgatattggcactataatgagagttgtggaactatcaccactgaaa
gggtcggtttcatggactggcaagccagtttcttactacctgcatactattgatcgaacc
atacttgaaaactatttttctagtctcaaaaatccaaaactcagggaggagcaggaggcg
gcccgccgccgccagcagagggaaagcaagagcaacactacgactccgacaaaagtccaa
gaaagcaagggagctgttgccttggagcctcgaggggattctggtgctgaagaagataaa
aatgggacagctcctcttaaaaagccatctccttccaagcctcgaaaaaagaaattaaac
aagaaaggaaggaagatggcaggaagaaagcgtggacgccctaagaaaatgagtgctgca
aatccagaacggaaagccaagaagactcccactgccctggagcttttgcatgctcagact
gtgtcccaggcagctgcatcctctcctcaggatgcatacaagtcacctcatagtccatat
tatcaactacctcctaaagtacaacggcattcctccaaccagctattggcaacaccaacc
ccacctgcactccagaagctgttagaatcatttaaggttcagtacctgcagttccttgcc
tatatgaaaacccctcagtacaaggccaacctgcagcagatggtggagcaggagaaggaa
aagaacactcagttgttaggtactgcccagcagttgttcagtcactgccaggctcagaaa
gaggagatcaagagactgtttcagcagaaacttgatgagttgggagttaaggctctgacc
tacaatgatctgatacaagctcagaaagagatctctgctcacaaccagcaactaaaagaa
cagacaaagcagctagaaagtgataatagtgaactcaggaaccaaagtttgcagctgctt
aaggctcggtgtgaagagctgaagctggattggtctactctctcactggaaaatttgctg
aaggagaagcaggcactgaagaatcaaatttcggaaaaacaaaagcactgtctggagctt
cagatcagcattgtggagcttgagaaaagccaaaggcagcaggaactactgcagctgaaa
tcctacgcaccaactgatgaggccctgtccgtccacctgcggagtaaaagcagcttcagc
cgcgagctggagactgaccctgccaggttccagctggagctcgaatgctccaagttgtct
ttgccccacgtcagtagcatgagccccgaactctctatgaatggccatgctgccaactat
gagattcataatatgcttagccgaccttcttccaaacaaaacactccacagtatctgacc
tctcacctggaccaagaaatagttccttgtacccccattcataacaacagacagaaggca
gacaaactgtccagcttgtccttacctgattacaccaggtattcccccgctaagttagcc
ctaaggagacacttgaatcaggatcatgtagtccatggaaaagctacaactaatgaaata
caccacagagttgaacatgcaaaagagaacggcctgacatatcagagtcctgctatgtca
aatggcctaaagctgagccctcaggaaactcggccttcttccccctccgccttacagatt
gcaggagagaagagcagtgacaaggttttaaaagagagagcctatgccagcaatggagaa
acaatcaccagcctacctatcagtattcctctcagcacagtgcagcccaataagcttccc
gtcagtatcccactggccagtgtagtcttgcctagccgtgcagagaaagtgaggaacaca
cctagtccagttcatcagaatcgagagtcgacttcagcaacacttgaaaaacagtttggt
gctaattcccataatggtatgaccagtgctgtaggaaacaagtcgcttgctttggctacc
tcaggtttttcttatagtggttccttggcggtcaatggcacactttccagtagcccagcc
catcttaaccatggcgctgagcaggcagccctagatgattcctccaattcagggagcctc
tttaattcagtgggttcccggagttctacgccacagcatccttctttactcatgatgcag
tcccggacctccggtcagaactctccagcccacccacttgctgccagcccccgactcaat
ggagcttcccaaagcatgatggggattttgcagtactcggatactacaaaattgttttct
gaaggtaacatgggggatctcccactagattcaggcttttcagatgctgaaaatgaagtc
aagagaagaatcctctttgcaatctcaaccaatacaggaaacctgaagcagtctccttcc
aacaaacacagccctctgacagctagcatccgcacagactgcggtcaggcttgtgtgcaa
gagggcaagaagaggggcaggaggaagcgatcttccacggggaaccccagcgccaactct
gcagtatctcccaagcgcaaacccttggcatctgtggctggcctcttcacccagtcttca
ggctcgcccctcaacatcaactctatggtcaataacattaatcaacctttagaaataaca
gccatttcctcccctgaaaactccctgaagaactctcctattccttaccaggacaacgac
cagcctcctgtgctgaaaaaggagaagcccttgatccagacgaatggggcgcattactct
cctctgacctcggatgaagagcaaggatctgaagatgagcacaacagtatcaggattgaa
cggaaaattgcaacaatctctctagagagcaaatctccccaaaaaacagaaaatggtggt
ggccttacaggaaggaagcaaacccagctgactgaaggcatcaacagtagtaaatggaag
tctaccttttcaccgatatcagacatcaacattactaaaacatccgacagccccttacag
tcagcttcatccctgagccagaactccctgtttgccttccggccatcctcagaagacaca
atggccattgatgccaagatctccgtgcacacaaggaaaaacttctccagttctttgtca
gggtccggtggtctcagccccaacaccaactcctccaatggattttcctatacagggggg
ctgtctgctgctgatatgagtttacacagctttcacgatggtgcttctctttctcacaag
accaccgaggtggccggcttaagctcccctttgggttttcaggcccagcggagcaaggac
agttcagatgtcaacccttttctgaataagagacagctggatggtctcggaagtatgaag
ggggaagagttacagagggtcggaggccggagcaaagaagtactagacctggccctgcag
ctgggggggccttccgacaagggctccctgcagcacaacggcaaggctggcaaagggcgg
gaccgggagttggagttcaaaaacggccacaatctcttcatttccgccgctgctgctgtg
cctcctggaggcctcctcaacggcaagggcctttccacagcgacctctgccacaggccac
actgcttcttccgtctcgacgcaccaccctttcctcaacacttttaccactggatcccag
ttccccctgggccctatgtccctgcaggccaacctcagctcggtggcaggctcttcagta
ttgcagtctttatttaattccatgcctgctgctgccagtttggtccacgtgtcatcagct
gcgaccagattgacaaattctcactctatgggaaacttctcttctggggttacaggtgga
acagttggaggtgttttcccccatgcggtgccttctgcctcttctcatcagtttggagcc
agtttcagcagcagtgctgtctgtagcagcaccatgctaagcttaaacccagtgcaggct
gtggtcacccccacctcctcctccttccaggcccctgcccctagcgtaggatcatgtagc
gaggctcgagccccccagccccctacccgagggccgccacagtcccttccgcaccccact
ccccccgctccagccaccctagctcccccccctcccttcctggctgcttctaaccccgag
cccctggcagcccttcctgttccccaggcctcaggaccaccctccggggccgctgctctg
caggctaacgcttctctgtctatcaagctggcggccctcccccacaaggtttcccggccc
tccttcacagtccaccatcagcctctgccccgcctgaccctggccccggctgcgcctggg
gccccacagtccaccgctgctggcccacctgctctgtggcttaccctgggcatgcagtct
ccttacgcttcgcacctttctggggttaagccgcgataa
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integrated database retrieval system
