Macrotis lagotis (bilby): 141506565 Help Entry 141506565         CDS       T11097                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism mlao  Macrotis lagotis (bilby) Pathway mlao01521   EGFR tyrosine kinase inhibitor resistance mlao01522   Endocrine resistance mlao04010   MAPK signaling pathway mlao04012   ErbB signaling pathway mlao04014   Ras signaling pathway mlao04062   Chemokine signaling pathway mlao04068   FoxO signaling pathway mlao04072   Phospholipase D signaling pathway mlao04150   mTOR signaling pathway mlao04151   PI3K-Akt signaling pathway mlao04510   Focal adhesion mlao04540   Gap junction mlao04630   JAK-STAT signaling pathway mlao04650   Natural killer cell mediated cytotoxicity mlao04660   T cell receptor signaling pathway mlao04662   B cell receptor signaling pathway mlao04664   Fc epsilon RI signaling pathway mlao04714   Thermogenesis mlao04722   Neurotrophin signaling pathway mlao04810   Regulation of actin cytoskeleton mlao04910   Insulin signaling pathway mlao04912   GnRH signaling pathway mlao04915   Estrogen signaling pathway mlao04917   Prolactin signaling pathway mlao04926   Relaxin signaling pathway mlao04935   Growth hormone synthesis, secretion and action mlao05034   Alcoholism mlao05160   Hepatitis C mlao05161   Hepatitis B mlao05163   Human cytomegalovirus infection mlao05165   Human papillomavirus infection mlao05200   Pathways in cancer mlao05205   Proteoglycans in cancer mlao05206   MicroRNAs in cancer mlao05207   Chemical carcinogenesis - receptor activation mlao05208   Chemical carcinogenesis - reactive oxygen species mlao05210   Colorectal cancer mlao05211   Renal cell carcinoma mlao05213   Endometrial cancer mlao05214   Glioma mlao05215   Prostate cancer mlao05220   Chronic myeloid leukemia mlao05221   Acute myeloid leukemia mlao05223   Non-small cell lung cancer mlao05224   Breast cancer mlao05225   Hepatocellular carcinoma mlao05226   Gastric cancer mlao05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:mlao00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     141506565 (SOS2)    04012 ErbB signaling pathway     141506565 (SOS2)    04014 Ras signaling pathway     141506565 (SOS2)    04630 JAK-STAT signaling pathway     141506565 (SOS2)    04068 FoxO signaling pathway     141506565 (SOS2)    04072 Phospholipase D signaling pathway     141506565 (SOS2)    04151 PI3K-Akt signaling pathway     141506565 (SOS2)    04150 mTOR signaling pathway     141506565 (SOS2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     141506565 (SOS2)    04540 Gap junction     141506565 (SOS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     141506565 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     141506565 (SOS2)    04660 T cell receptor signaling pathway     141506565 (SOS2)    04662 B cell receptor signaling pathway     141506565 (SOS2)    04664 Fc epsilon RI signaling pathway     141506565 (SOS2)    04062 Chemokine signaling pathway     141506565 (SOS2)   09152 Endocrine system    04910 Insulin signaling pathway     141506565 (SOS2)    04912 GnRH signaling pathway     141506565 (SOS2)    04915 Estrogen signaling pathway     141506565 (SOS2)    04917 Prolactin signaling pathway     141506565 (SOS2)    04926 Relaxin signaling pathway     141506565 (SOS2)    04935 Growth hormone synthesis, secretion and action     141506565 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     141506565 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     141506565 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     141506565 (SOS2)    05206 MicroRNAs in cancer     141506565 (SOS2)    05205 Proteoglycans in cancer     141506565 (SOS2)    05207 Chemical carcinogenesis - receptor activation     141506565 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     141506565 (SOS2)    05231 Choline metabolism in cancer     141506565 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     141506565 (SOS2)    05225 Hepatocellular carcinoma     141506565 (SOS2)    05226 Gastric cancer     141506565 (SOS2)    05214 Glioma     141506565 (SOS2)    05221 Acute myeloid leukemia     141506565 (SOS2)    05220 Chronic myeloid leukemia     141506565 (SOS2)    05211 Renal cell carcinoma     141506565 (SOS2)    05215 Prostate cancer     141506565 (SOS2)    05213 Endometrial cancer     141506565 (SOS2)    05224 Breast cancer     141506565 (SOS2)    05223 Non-small cell lung cancer     141506565 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     141506565 (SOS2)    05160 Hepatitis C     141506565 (SOS2)    05163 Human cytomegalovirus infection     141506565 (SOS2)    05165 Human papillomavirus infection     141506565 (SOS2)   09165 Substance dependence    05034 Alcoholism     141506565 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     141506565 (SOS2)    01522 Endocrine resistance     141506565 (SOS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH PH_19 RHG20_PH PH_10 PH_13 Motif Other DBs NCBI-GeneID:  141506565 NCBI-ProteinID:  XP_074069539 LinkDB All DBs Position 1:complement(448952810..449071212) Genome browser AA seq 1328 aa AA seqDB search MQPPPQPYDFLSEENHPKWRGLFVPALRKVQHQVHPNLSAKEDSLYYIEELILQLLSKLC IAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRTPLLLPVDKIHPLLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLVLLCEDEPFSSGELNYYDLVRTEIAEERQYLRELNLIIKVFREAFLSNKKLFASSDI EGIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPQFHERFNTLMAKPAVSLHFQSIADGFKEAVQYVLPRLMLVPVYHCSHYFELLEQLQE CSEEQEDRECLKQAITALLNFRCSMERICNKHSPRRRPADPVCRFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLMRIGAKHERHIFLFDGLMISCKTNHGQSRIPG YSNAEYRLKEKFVMRKIQICDKDDTSEYKHAFELISKDENSIIFAAKSTEEKNNWMAALI SLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSGIPIIKGG TVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLKLLIERFEIPEPEPTEADKLAME KGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLEKLESFISSVKGK TMKKWVESIVKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQYETFDLMTLHPIEI ARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAEN FDERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVPVYRLDHTFEALQERKRKILDEA VELSQDHFKKYLAKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKQGKELINFSKRRKV AEITGEIQQYQNQPYCLRIESEIRRFFENLNPMGNASDKEFADYLFNKSHEIEPRNCRQP PRFPRKTTFSLKSPGIRPHAGRHGSTSGTLRGHPTPLEREPCKISFSRINEAEHETAASA PTSPNTPSTPPVSASSDLSVFLDIDLNSSYGNNSIFAPVVLPHSKPFFSSCGSLHKLTEE PLVPPPLPPRKKFDQDVSTSKGNLKYDEDPPAIPPRQPPPPKIRPRVPAYSGPFEGPLPS PPPPPPPRDPLPETPPPVPLRPLEQFMNYPSNNLQPPTTLRDPDWFREASTCPNSPNTPP STPSPRVPRRCVLSSSQNNLSHSQAPPIPPRQNSSPHLPKLPPKTYKRDLCQPPIYRFSL LEPAETPQ NT seq 3987 nt NT seq  +upstreamnt  +downstreamnt atgcagccgccgccgcagccctacgacttcctaagcgaggagaaccacccgaaatggcgg ggactcttcgtccctgccctgcggaaggttcagcatcaagttcaccccaatctctcagca aaagaagattctttatattatattgaagagttgatccttcaactgctaagtaaattatgc attgcacagccaaggactgttcaagatgtagaggaacgtgttcaaaagacttttcctcat ccaattgacaaatgggctattgctgatgcacagtctgccatagaaaaacgaaaacgaagg actcctctcttgttacctgtggataaaattcatcctttattgaaggaagttttaggatat aaagtagactatcatgtttctctttatattgttgctgtattggagtatatctcagctgat attctgaaattggctggtaattatgtttttaatatcagacattatgaaatatcccagcag gacattaaagtatctatgtgtgcagataaggttttaatggacatgtttgatcaggatgat attggtttggttttgctgtgtgaagatgaacccttttcttcaggtgaactaaattactat gacctagtcagaactgaaattgcagaagaaagacaatatctacgagaattaaatctgata ataaaagtatttcgcgaagcttttctttcaaacaaaaagttgtttgcatcttctgatatt gaaggaatattcagcaacattttagatattcatgaattgactgtaaaacttttaggctta attgaggacacagttgaaatgactgatgaaagcagtcctcatcccttagctggcagctgt tttgaagatctagcagaggaacaagcatttgatccatatgaaaccttgtcacaggatatt ctctcaccacaatttcatgagcgtttcaatactttgatggccaaacctgctgtttctctg cattttcagtccattgctgatggctttaaagaagctgtgcagtatgttcttccacgcctt atgctagtgccagtttaccattgttcacactactttgaattattagagcaattgcaagaa tgcagtgaagagcaagaagacagagaatgtttgaagcaagctattactgctcttctgaat ttccgatgtagcatggaacgaatttgcaacaagcattcacctagacggcgacctgcggat cctgtttgtcgattttataatcgtcaattacggagcaagcacctggccataaaaaaaatg aatgaaattcaaaaaaatattgatggatgggaaggcaaagatattggacaatgttgtaat gaatttataatggaaggcccattgatgagaataggagctaagcatgagcgtcatattttt ctttttgatggtttaatgattagctgtaaaactaatcatggacaatcccggattccaggc tatagcaatgcagaatacagattgaaagaaaaatttgtcatgaggaaaatacaaatctgt gataaagatgacacttctgaatacaagcatgcctttgagttgatttccaaagatgaaaac agcattatatttgctgctaagtccactgaagaaaaaaataattggatggcagccttaatt tctcttcagtatcgtagtacactagatcgaatgttagattcagtattattaaaagaagaa aatgagcaacccctgaggttgccaagtccagaagtttatcgctttgttgtgaaagactca gaagaaaacattgtttttgaagacaatttgcaaagtggaatccctatcattaaaggagga actgtggtgaaattaattgaaaggctaacctaccacatgtatgcagatcccaattttgtg cgtacttttcttacaacctatcgttcattttgtaaaccacaggagttgttgaagttattg attgaacggtttgaaattcctgaaccagaacctactgaagcagataaattggcaatggag aaaggagagcaaccaatcagtgcagatctgaaacggtttcgcaaggaatatgtccaacca gtacaacttaggatactaaatgtttttcggcactgggtagaacatcatttttatgatttt gagagagatctggagttacttgaaaaattagaatcctttatttcaagtgtaaaaggaaaa accatgaagaagtgggtagagtcgattgttaaaatcatcaagaggaaaaaacaagctcag gcaaatggaattagccataatattacttttgaaagtccaccaccaccaatagagtggcat attagcagaccaggacagtatgaaacatttgatctcatgacccttcatccaatagaaatt gcgcgtcaactaacacttctggaatctgatctctacagagcagttcaaccttctgaactt gtgggaagtgtgtggactaaagaagataaggaaataaattccccaaatttattgaaaatg attcggcatactacaaatcttactctctggtttgaaaaatgcatagtagaagcagaaaac tttgatgaacgagtggcagtattaagtaggattatagaaattctgcaagtttttcaagac ttgaacaatttcaatggtgtattagaaatagttagtgcagtaaattcagtgcctgtgtac agattggaccacacatttgaagcattacaggaaagaaaacggaagattttagatgaagct gtagaactaagccaagatcactttaaaaaatacctagcaaaacttaaatcaatcaaccca ccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaagggaat aatgatttccttaaaaaacaagggaaagaattaatcaactttagtaaaagaaggaaagta gcggaaattactggagagattcagcagtatcagaatcagccatattgtttacggatagaa tcagaaataaggaggttctttgaaaatctcaaccctatgggaaatgcatcagataaagaa tttgcagactatttattcaataagtcacacgaaattgaaccccgaaactgtagacaacca cctcgatttcctaggaaaacaactttctccttaaaatctcctggtataaggccacatgct ggcagacatggctctacttcaggcactttacgaggtcacccaacaccattagaaagagaa ccgtgtaaaataagcttcagtaggataaatgaagcagagcatgaaacagcagcatcagca ccaacctctccaaatacaccatctactccaccagtctctgcttcttcagaccttagcgtg tttttagatatagatcttaacagttcttatggaaacaacagcatttttgccccagtggtt ttaccacattcaaaacctttcttcagttcatgtggtagtttacataaattaactgaagaa ccactggttcctcctcctcttcctcctcgtaaaaagtttgatcaagatgtttcaacttct aagggaaatttgaaatatgatgaggatcctcctgctattccaccaaggcaaccaccacct ccaaagataaggcctcgagttcctgcttacagtggtccatttgaagggcctttacctagt ccaccaccaccaccacctccacgagaccctcttcctgagactcctccaccagtaccactt cggcctcttgaacagttcatgaactatccatctaataatcttcagccaccaacaactctc agagatccggattggttccgagaagccagtacatgtccaaactcaccaaatactcctcca agcacaccctctcctagagtgccacgtcgctgtgtgcttagttccagtcaaaataatctt tctcattctcaagcacctcctatcccaccaagacagaattcaagccctcacttaccaaaa ctgccaccaaagacttacaaaagagatctttgtcaacctcctatatacagattttcattg ttagaacctgcagaaactcctcagtga

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