Macrotis lagotis (bilby): 141507705
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Entry
141507705 CDS
T11097
Symbol
PDE11A
Name
(RefSeq) dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
KO
K13298
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [EC:
3.1.4.17
3.1.4.35
]
Organism
mlao Macrotis lagotis (bilby)
Pathway
mlao00230
Purine metabolism
mlao01100
Metabolic pathways
mlao04934
Cushing syndrome
mlao05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
mlao00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
141507705 (PDE11A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
141507705 (PDE11A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
141507705 (PDE11A)
Enzymes [BR:
mlao01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
141507705 (PDE11A)
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
141507705 (PDE11A)
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Motif
Pfam:
PDEase_I
GAF
GAF_3
HD-CE
HD
Motif
Other DBs
NCBI-GeneID:
141507705
NCBI-ProteinID:
XP_074071729
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Position
1:683641866..684110445
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AA seq
933 aa
AA seq
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MSTSCLDFGEVESFLDRHPELFEDYLLRKGRQELVQKWLKKHGQNQRVSVPGHFLSEART
LEITAAAGGGSVGVTVQQGSMNSQPSPGVGDCSSVPMNPNWASSHGDGGLQRRASQKELR
KSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNL
PQYPPTAIDYKCHLKQHNERQFFLELVKEISNDLDLTSLSYKILIFVCLMVDADRCSLFL
VEGTASGKKSLVSKFFDVHAGTPFLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDA
YKDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEIIGVAQAINKTPEGVPFTDDDEKVMQMY
LPFCGIAIANAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER
CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKDSMEKSSYSDWLINNSIAELVAST
GLPVNITDAYQDPRLDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDA
DQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKTEVDKFKAANIPL
VSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL
YHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA
LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDITLYFE
RRTEFFELVSKGDYNWNVKTQRDIFRSMLMTACDLGAVTKPWEISRQVAELVTNEFFEQG
DRERAELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNEKLKPMLDSVAVNR
SKWEELHQKMLLSQTPSLPSSSSGLSASVEDIN
NT seq
2802 nt
NT seq
+upstream
nt +downstream
nt
atgtcaacttcctgcctggactttggggaggtggaaagttttctggacaggcatccagag
cttttcgaagactatttgttgagaaaggggaggcaggagctggtgcagaagtggctgaag
aaacatgggcaaaaccaaagggtctccgtcccaggccactttctttctgaggccaggacc
ttagagatcactgctgctgcaggtggtggtagtgttggtgtcactgttcagcaggggtct
atgaacagtcagcccagtccaggtgtaggagactgtagcagtgttcccatgaatcccaac
tgggccagtagccatggagatgggggcctccaacggagggcttcccagaaagagctgaga
aagagctttgccaggtccaaagccatccatgtgaataggacctatgatgagcaagtgaca
tctagggcccaagagccactgagtagtgtgaggaggagggctctgcttcgaaaggccagc
tccctacctccaactactgcccacattctcagtgccctcctggagtctagggtcaactta
ccccaatatcccccaacagccattgattataagtgccatctcaagcagcacaacgaacgc
cagttcttcctggagctggtcaaggagatttccaatgacctggatctcaccagtctcagc
tacaagatcctcatctttgtctgcctcatggtggatgctgaccgatgctcccttttcttg
gtggagggaacagcctcaggcaagaagagcctggtctctaaattttttgatgtgcatgct
gggaccccattccttccctgcagcagcaccgagaactctaatgaggtgcaggtgccttgg
ggaaaaggcatcattggctatgttggggaacatggggagacagtcaacattcctgatgct
tacaaggacagaagattcaatgatgagatcgacaaactgactggatacaagacaaagtca
ttgttgtgtatgcccatcagaaacagtgatggggagatcattggtgtagcacaagcaatc
aataaaactccagagggtgttcccttcactgatgatgatgaaaaagttatgcagatgtat
cttccattttgcgggattgccatagctaatgctcaactatttgctgcctcaaggaaggag
tatgacagaagcagggctctgctggaagtggttaatgatctctttgaagaacaaactgac
ctggagaaaattgttaagaaaatcatgcaccgggcccagactctgttaaaatgtgagcgc
tgctcagttttgctcctagaggacattgaatcacctgtggtgaagtttaccaaatccttt
gaattgatgtctcccaaatgcagtgctgatgcagagaacagtttcaaagacagcatggag
aaatcttcctattcagactggctcatcaataatagcattgctgagctggtcgcttccacg
ggccttccagtgaacattactgatgcttatcaggatcctcgcttggatgccgaagctgat
cagatatctggttttcatataagatctgtgctctgtgtccctatctggaacagcaatcac
caaataattggggttgcgcaagtcctaaatagacttgatgggaaaccttttgatgatgct
gatcaacgacttttcgaggcctttgtcattttttgtggtcttgggatcaacaacacaata
atgtatgatcaagtaaagaagtcctgggccaagcaatctgttgctcttgatgtgctgtct
tatcatgcaacatgttcaaaaactgaagttgacaaatttaaggcagccaacatccctcta
gtctcagagcttgccattgatgacatacattttgatgacttctccctcgatgttgatgcc
atgatcactgctgctctgcggatgttcatggagcttgggatggtacagaaatttaaaatt
gactatgagacactatgtaggtggcttttgacagtgagaaagaactatcgaatggtcctg
taccacaattggagacatgctttcaatgtgtgccagctgatgtttgcaatgctaactacg
gctgggtttcaggagattttgactgaggtggaaattttagcggtgattgtgggctgccta
tgtcatgacctcgaccacaggggaaccaacaatgccttccaagctaagagtggatctgct
ttggcccagctttatggaacttctgctaccttggagcaccatcactttaatcatgctgtg
atgattctgcaaagtgagggtcacaacatctttgctaatttgtcttccaaagaatacagt
gatctcatgcaacttttgaagcaatccatattggcaacagacataactctgtattttgag
aggagaactgaattctttgaacttgtcagcaaaggagattacaactggaatgtcaaaacc
caacgtgatatatttcgatcaatgctaatgacagcctgtgaccttggagctgtgaccaaa
ccgtgggagatctcaagacaggtggctgaactagtaaccaatgaattctttgaacaagga
gacagagagagagctgaactcaaactcaccccttcagctatttttgatcgaaaccgaaaa
gatgaactacctcggttacaattggaatggattgatagcatctgtatgcctctgtatcag
gccttagtaaaagtaaatgagaaattgaagcccatgctggattctgttgctgtgaacagg
agtaaatgggaggagctgcaccagaaaatgttgctttctcagacaccttccctaccttct
tcctcttctggcctctctgcatcagtggaagacatcaattaa
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