Macrotis lagotis (bilby): 141509062 Help Entry 141509062         CDS       T11097                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism mlao  Macrotis lagotis (bilby) Pathway mlao05165   Human papillomavirus infection mlao05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:mlao00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     141509062 (UBR4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     141509062 (UBR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:mlao04121]     141509062 (UBR4) Enzymes [BR:mlao01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      141509062 (UBR4) Ubiquitin system [BR:mlao04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     141509062 (UBR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  141509062 NCBI-ProteinID:  XP_074074374 LinkDB All DBs Position 1:873291590..873452407 Genome browser AA seq 5225 aa AA seqDB search MATSGGEDAVVAAAVVAAAGTAAMAAVGVASAAPAQAPAPAPTPAPAPTPAPAPAPAPAP AAAPGWEVAVRPLLSASYSAFEMKELPQLVASVIESELEILHHDKQYEPFYSSFVALSTH YITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRL DRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTTVFNP RAVATPSLTPVIQVEGENDDQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNL PYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNP ARLQDVTVLSLSCLYAGVSVATCMAILHVGSTQQVRTGSTSSKEEDYENDAATIVQKCLE IYEMIGQAISQSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALR VRDIIARAKEGVGSPKLGPGKGHQGFGVLSVVLANHSIKLLTSLFQDLQVEALYKGWEAD GPPATLSIMAQSTSIQRIQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASAS TDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKVAPPPPPPPPPLESSPRV KSPNKPAAGEKGNILASRKDPELFLGLASNILNFLTSSMLNSRNNFIRNYLSVSLTEQHM ATLASIIKDVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPTLQNTLLQQLGIAPFSDG PWPLYIHPQSLSVLSRLLLIWQHRASAQGDPDVPECLKVWERFVATLKQNALQGVLPSDT EDLNVEHLQLLLLLFHNFSEKGRRSILALCIQTILELTAGLDSQLRSVPLLLARLLLVLD YLLHQYSKAPTYLFEQVQYNLLSPPFGWVTGSQESGRRATVPLYHGFKEVEENWTKHCSS DAVPQPRFYCVLSPEASEDDLNRLDNMICEVLFSRAVKYDELYSALTSLLAAGSQFDTTR RKESKNVTALEACALQYYFLILWRILGILPPSKKYMNQLAMNTPEMSECDILHTLRWSSR LRIGSYVSWIKDHLVQQGMKADHASSLIELASTKCSCVKYDVEIAEEYFARQISSFCGID CTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKLAAETDPHKSSEITKNLLPATLQL IDTYASFTRSYLLQSLSEEGSPENKPSEDKLGGYSAVLAIGSSRCKSNTLGSTLVQNLPS SVQALCESWNNIHTNEFPNIGSWRNAFANDTIPAESYISAVQAAHLGTLCSQSLPLAASL KHTLLSLVRLTGDLIVWSDELNPPQVIRTLLPLLLETSTESVAEMSSNSLERILGPAESD EFLARVYEKLITGCYNILANHADPNSGLDESILEECLQHLEKQLESSQARKAMEEFFSES GELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPIRL QAWLTRMTTSPPKESDQLEVVQENRQLLQLLTTYIVRENSQVGEGVCTVLLSTLIPMATE MLANGDGAGFPELMVVMATLASAGQGAGHLQLHGAAVDWLSRCKKYLSQKNVVEKMNANV MHGKHVTILECTCHIVSYLADVTNALSQGSGQGTSHLSVDGEERAIEVDSDWVEELAVEE EDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEI SYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVSENVVRHSSSTSP ADKAKVTISDGKVADEEKPKKSSLCRSVEGCREELQTQANFSFAPLVLDMLGFLMEAIQI NFQQASAMGSSSRAQQALNELHTLDKMVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQT IRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTR LASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIK AVWLPGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVAFLFNEEGKNIIVIM SSAGYIYTQLMEEASSAQHGPFYVTNVLEVNHEDLKDSNSQVAGGGVSVYYSHVLQMLFF SYCQGRSFAATISRSTLEVLRLFPINIKSTNGGSKTSPALCQWSEVMNHPGLVCCVQQTT GVPLVIMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMA NVENTSYWLQPSLQPSSVISIMKPVRKRKAAAITTRTSSQVTFPIDFFEHNQQLTDVEFG GNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEVNNNNSTMVMTGMRLQIGTQAIERA PSYIEIFGRTMQLNLTRSRWFDFPFTREEALQADKKLSIFIGASVDPAGVTMIDAVKIYG KTKEQFGWPDEPPEDFPSASVSNICPPNVNQGNGTGESDTAAPTTSSGTVLERLVGSSLE ALESCFAVGPVSEKEKSKAAAQELATMLLSMPAPSSVQQQTKSLLASLHTSRSAYHNHKD QALLSKAVQCLNSSSRDGKELDPEVFQRLVITARSIAIMRPNNLVHFTESKMPSVETEGV DEGKEPQKHTEGDGCTFITQLINHFWKLHASKPKNAFLAPACLPGLTHVEATVNALVDII HGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNT PMGDKDDDDDDDADEKMQSSGIPESGHIRQESQEQNEVDHGDFEMVSESMVLETAENVNN GNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLS GQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDS VAGEHSVSGRSSAYGDTTAEGHPAGPGSVSSSTGAISTATGQQEGDGSEGEGEGEAEGDV NTSNRLHMVRLMLLERLLQTLPQLRSVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNL LSQLIAELGMDKKDVSKKNERCALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSA TAAALLSSGAVDYCLHVLKSLLDYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQY VKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTNSRIPPPVFDHSWFYFLSEYLMIQQTP FVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSAL QYDTLISLMEHLKACAEIATQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLS CALCGSKVLTVASSSGASSATSGSSSSSSSSAPVASGSGQTTTQSKSSTKKSKKEEKEKE KEGDCSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLALHIYRN SNKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILR TQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTT TQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKV QLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCG ENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTN INTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSSSAGGISSTSASVNRYILQ LAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTTVQPTFTASQYRA LSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGA ASMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSAALKGHWANPDLASSLQYEMLLLTDS ISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVP VEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPTRGMDSNGKSSTKAELRQLYLT EKYVWRWKQYMSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSR KQQVLDLLTSYLDELSIAGECAAEYLALYQKLIKPAHWKVYLAARGVLPYVGNLITKEIA RLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVV QRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSI IYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVA LLEDDSGMELLVNNKIISLDLPVAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIES LDSTTDEEEDEEEVYKMAGVMAQCGGLDCMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKV KVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPL SEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEMEKMQILVDRF KPYCNFDKYDEDHTGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKH IPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPSTQVLIGTDSITNLHKLEQVSSDE GIGTLAENLLEALREHPEVNKKIDAARKETRAEKKRMAMAMRQKALGTLGMTTNEKGQVV TKTALLKQMEELIEEPGLTCCICREGYKFQPAKVLGIYTFTKRVALEELENKPRKQQGYS TVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLAR HNTYLQECTGQREPTYQLNVHDIKLLFLRFAMEQSFSVDTGGGGRESNIHLIPYIIHTVL YVLNTTRATSREEKNLQSFLEQPKEKWVESAFEVDGPHYYTVLALHILPPERWRAIRVEI LRRLLVISQARAVSPGGASRLTDKSVKDYSVYRSALLFWALVDLIYNMFKKVPTSNTEGG WSCSLAEFIRHNDMPIYEAADKALKMFQEEFMPVETFSEFVDVAGLLSEISLADNFLKDL LNSIP NT seq 15678 nt NT seq  +upstreamnt  +downstreamnt atggcgacgagcggcggggaagacgctgtggtggcggcggcggtggtggcggcggcgggg acggcggccatggcggcggtgggggtggcttccgccgccccggcgcaggccccggccccg gccccgaccccggccccggccccgaccccggccccggccccggccccggccccggccccg gccgcggccccgggctgggaggtggcggtgcggccgctgctctccgcctcctactccgcc ttcgagatgaaggagctgccgcagctggtggcctcagtcatcgagagtgaattagaaatc ctgcaccacgacaagcagtatgagcccttctactcctcctttgtcgcactttccacacac tatatcacaacggtctgcagcctcattccccggaatcagcttcagtcagtggcagctgcc tgcaaagtcctgattgagttctctctcctgcgcctagagaatccagatgaggcctgtgct gtatcccagaaacacttgattctccttatcaaaggcctgtgtactggctgtagccggctg gatcgaactgaaatcattactttcactgcaatgatgaaatctgccaagctcccacagaca gtgaagacactctcagatgtggaagatcagaaggagctggcttcacccgtcagtccagag ctgaggcaaaaggaggtacaaatgaactttctgaaccagttaacaacggtcttcaatcct agagcagtagcaacaccatccctcacgccagtgattcaggtggaaggagaaaatgatgac cagtcttcaacagaccaagcctctgccatcaagaccaagaatgtgttcatagctcagaat gtggctagtctacaggagcttggtggctcagagaagctgctccgtgtgtgtctcaacctg ccatatttcctacgctacatcaatcggttccaagatgccgtgttggctaattccttcttc attatgcctgcaacagtggcagatgccactgctgtccgtaatggttttcattcattagtc attgatgtaaccatggcattggataccctttcactccctgttttggaaccccttaatcct gctcgattacaagatgtgactgtgctcagcctcagctgcctatatgcaggtgtgagtgtg gccacctgtatggccattcttcatgtgggcagcacccagcaggtgcggacaggctccaca agctccaaagaagaagattatgaaaatgatgctgctacgattgtccagaaatgtcttgaa atctatgagatgattgggcaggccatcagccaatcccgacgagctggtggtgagcattac cagaactttcagctgttgggtgcctggtgtttgctgaacagcctcttcctcatcttgaat ctcagcccaactgccttagctgataagggaaaagagaaagatccactggctgctctcaga gtacgagacatcattgctcgtgctaaggaaggtgtgggctctcccaaactgggacctggg aaagggcatcaaggatttggggtcctctctgtagtgttggcaaatcattcaatcaaatta ttaacatctctttttcaagacctgcaagtagaggctctctataagggttgggaggcagat ggtccccctgcaaccctgagcatcatggcccagagtacatcaatacagagaattcagcga ttgattgactctgtcccactcacaaatctgctgctgaccttgctctctacctcatacaga aaggcatgtgtcttgcagcgtcagaggaagggttccatgagtagtgatgccagtgcctct actgactccaacacatactatgaggatgattttagcagcacagaggaggacagtagccaa gatgatgacagcgagcccatcctcggacagtggtttgaggaaaccatctctccgagcaag gagaaagtggcacctcccccccctcccccccctccacctctggagagttcacctcgagtc aagagcccaaataaaccagctgctggtgagaagggcaacatcctggccagtcgcaaggac cctgagctgtttttaggtctggcttctaacattttgaacttcctcacctcctccatgctg aactctcgaaataacttcatccgaaattacctgagtgtgtctctgactgagcagcacatg gctactttagctagcatcatcaaggatgtagataaggatggactcaagggttcatcagat gaagaatttgctgctgcactttatcactttaatcactctcttgtcacgtcagatcttcag tctcctaccctgcagaatactctgttgcaacaactgggaattgctcccttttctgatggc ccgtggcctttgtacatccaccctcagagcttatctgtgctctcacgccttctgctcatc tggcagcacagagccagtgctcaaggagaccctgatgttcctgaatgccttaaagtttgg gagaggtttgtggccacattgaaacagaatgctttgcaaggggtgcttcccagtgataca gaagacttgaatgtggagcatttgcaattgctcctccttcttttccataacttctcagag aaaggccgtcgctccatattggccctttgcatccagaccatcctggagctgacagctggc ttggattctcagctgcggtcagtgccactgctcctagcacgccttctcctggtcttggac tatctgcttcatcagtactccaaagcccccacatacctttttgaacaggtgcaatataac ctccttagtcctccttttggctgggtaactggatctcaggaaagtggccgcagggccact gtgcccttgtatcatggcttcaaagaagtggaagaaaactggaccaagcattgttcatca gatgctgttccacagcccagattttattgtgtcctgtcaccagaagcttcagaagatgac ttaaatcgccttgataatatgatctgtgaggtcctattctccagagcagtgaaatatgat gagctgtacagtgcactgacatctttgctagcagccggatctcagtttgacaccaccagg agaaaggagagcaagaatgtaacagccctggaggcatgtgctctccaatattactttttg atactctggaggatcctgggaattttgccaccatcaaagaaatatatgaatcagttggcc atgaacacccctgagatgagtgagtgtgacatcctgcatactttgcgctggtcttcccgc cttcggattggctcttatgtcagctggatcaaggatcatcttgtccagcagggcatgaaa gctgaccatgctagttctctcatagaactggcctctaccaagtgcagttgtgtgaaatat gatgtggaaatagcagaggagtactttgctcgacagatctcatcattctgtggcatcgac tgtactaccatcttgcagttacatgagattcctagtctgcaatccatctatacccttgat gcagccatttccaaggtccaggtttctctggatgagcatttttccaaattggcggctgag actgaccctcataagtcatcggagataactaagaatcttctgcctgctacattacagctt attgatacctacgcatcattcactaggtcttatttgttgcaaagcctctctgaagaggga tcccctgagaataaaccttctgaagataaactgggaggttattctgctgtcttggcgata ggctcaagccggtgcaagtccaacaccttgggttctacacttgttcagaacttaccatca tctgtgcaggccctatgtgaatcatggaacaatattcacacaaatgagtttcccaatatt ggatcctggcgtaatgcttttgccaatgacacaattccggcagagagttacattagtgct gtgcaggctgcccacctggggaccctctgcagccagagtcttcctttggccgcatccttg aagcacacactcctttctctggtcagattgactggggatcttattgtttggtccgatgag ttaaaccctcctcaggtgatccgtacactgctgccccttcttttggagacaagcactgag agtgtggcagagatgagcagcaactccctagaaaggatcttgggcccagcggagtcagat gagtttttggctcgagtttatgagaagctgatcactggatgttacaatattttggccaat catgcagaccctaatagtggattagatgagtccatcttggaagagtgtctccagcatctg gagaagcaattggaaagtagccaggctcgcaaggctatggaggagtttttttcagagagc ggagaacttgtccagatcatgatggccacagctaatgagaacctttctgctaaattctgt aaccgagttctgaaattcttcaccaaactcttccagctgactgagaagagccctaaccct agcctgctccatctctgtggctcccttgcccagctggcttgtgtggagcctataaggctc caggcttggcttacccgtatgaccacatcaccccccaaggagtctgatcagttggaggtg gtgcaggagaaccggcagctgttgcagttactgactacatacattgttcgggaaaacagc caagttggagaaggtgtttgcactgtgctgctgagcaccctgatccctatggcgacagaa atgctggccaatggggatggtgctggctttcctgagctcatggtcgtaatggcaacgcta gccagtgcgggccaaggtgctggccacctccagcttcatggtgctgctgtggattggttg agcagatgtaagaaatacttgtctcagaagaatgtagttgaaaaaatgaatgctaatgta atgcatgggaagcatgtgactattctggaatgtacctgtcatatcgtatcttacttggct gatgtcaccaatgccctgagccagggcagtggtcagggtactagtcatctgtcagtggat ggagaggagcgggccatcgaagttgactcagactgggtagaggaactggctgtagaagaa gaagactctcaggctgaggactcagatgaagattctctttgcaacaagctatgcacattc actatcacacagaaagaattcatgaatcagcattggtaccactgtcacacctgcaagatg gtggatggggttggcgtgtgcacagtgtgtgctaaggtctgccacaaggatcacgagatt tcctatgccaaatacgggtcattcttctgtgattgtggagccaaggaagatggcagttgc ttggctttggtgaagaggacacccagcagtggcatgagctccaccatgaaggaatcggca tttcagagtgaaccccgagtttctgagaatgtggtacgtcattccagcagcacgtctcca gcagacaaggccaaggtcactatcagtgatggcaaagttgctgatgaagagaagcctaag aagagcagtttgtgccggagtgtggaaggttgccgggaggaacttcagacccaggcgaac ttctccttcgctcccttggtgttagacatgcttggcttcctcatggaggccattcagatc aacttccagcaggcttcagccatgggcagcagcagccgggcccagcaggcactcaatgag ttacacaccttggacaagatggtggagatgacagaccaactgatggtccctaccttaggt tctcaggaaggtgcctttgaaaacgtccggatgaactacagtggagaccagggccagacc attcgccagctcattagtgcgcatgtgctgagacgtgtggcaatgtgtgtgctgtcttca ccccatgggcgacgccagcatttagctgtcagccatgaaaagggcaagattactgttttg cagctctctgcgctcctcaaacaagcagattccagtaaaaggaagctgaccctcacccgc ctggcatcagcaccagtccctttcactgtattaagtctcactggaaatccttgtaaggag gactatcttgctgtgtgtggactgaaggattgccacgtgctgacctttagtagctcaggc tctgtttctgaccacttggtgctacatcctcagttggcaacaggaaactttatcatcaaa gctgtgtggttacctggctcacagacagagcttgctatcgttactgcagactttgtcaag atatacgacctctctgtcgatgccttgagcccaaccttctatttcctcttgccaagttca aagatcagagatgttgcttttctcttcaatgaagagggcaagaacattattgttataatg tcctcagctggctacatctacactcagctcatggaggaggctagcagtgcccagcatggg cctttctatgtcacaaatgtgctggaagtcaatcatgaagacctgaaggacagcaatagc caggtggcaggaggaggtgtatctgtgtactactcccacgtgctgcagatgcttttcttc agctactgtcaagggagatcctttgctgccaccatcagcaggtctactctggaagtgctg cggctcttccctatcaacattaagagtactaatggtggcagcaaaacttccccggctctt tgccagtggtctgaggtgatgaaccaccctggtttggtgtgttgtgtccagcaaactaca ggtgtgccactggtgatcatggtgaaaccagatacctttctcatccaggagatcaagacc ttgccagctaaagcaaagattcaggacatggttgctatccggcacacagcctgcaatgag cagcagaggacaaccatgattctgttatgtgaggatggcagccttcgcatttacatggcc aatgtggagaacacatcctactggctccaaccttccctgcagcccagcagtgtcatcagc atcatgaaacctgtccgaaaacgcaaggcagccgctattactactcgaacttctagccag gtcaccttccccatcgacttcttcgaacataaccagcagctgacagatgtggagtttggt ggcaatgatctcttacaggtctacaatgcacagcagataaaacaccgccttaactccaca ggcatgtatgtggccaacaccaagcctggaggcttcaccattgaagtaaataacaacaac agcactatggtgatgacaggcatgcgcctacagattggaacccaggccattgaacgcgcc ccatcatacatcgagatctttggccgcaccatgcagctcaacctgacacggtcccgctgg tttgactttccatttacccgagaagaagccttacaggctgacaagaagctgagcatcttc attggggcttcagtggatccagcaggagtcactatgatagatgctgtcaagatttatggc aagaccaaggagcagtttggctggcctgatgaacccccagaggatttcccttctgcctct gtcagtaatatctgcccccccaatgtgaaccagggaaatggcactggagagagtgacaca gcagcccccaccacctccagcgggactgtcctggagaggctagtggggagttctttagaa gccctcgaaagctgctttgctgtgggccctgtcagtgagaaggaaaagagcaaggctgca gctcaggagctggctacaatgttgctatccatgccagcaccatccagtgtccagcagcag acgaagagcctccttgctagccttcacaccagccgctcggcctatcacaaccacaaggac caggccttgttgagtaaagctgtgcagtgcctcaactcctccagcagagatgggaaggag ctggatccagaggtgtttcagcgtctcgtgatcactgctcgctctattgccatcatgcgc cccaacaatttggtccatttcaccgagtccaagatgccctcagtggaaacagaaggagtg gatgaggggaaagaaccccagaaacatacagaaggggatggctgtactttcattacccag cttatcaatcatttctggaaactgcatgcgtctaaacccaagaatgcgtttttggcacct gcctgtttaccaggtttgacccatgttgaagctactgtcaatgcattggtggacatcatc catggctactgtacttgtgagctagactgtatcaacacagcctccaagatctatatgcaa atgctcctgtgccccgatcctgctgtgagcttctcctgcaaacaggctctgatccgagtg ctaaggcccaggaacaagcggagacatgtgacgctgccctcctctcctcggagcaatacg cccatgggagacaaggatgatgatgatgatgatgatgctgatgagaagatgcagtcctca gggatcccagagagtggacacatccgccaagagagccaagagcagaatgaggtggaccat ggagactttgagatggtgtctgagtccatggtgctggagacagccgagaacgtgaacaat ggcaacccttctcccctggaggctctcctggctggtgcagagggtttccctcccatgctg gacatcccgcctgatgcagatgatgagactatggtggagctggctattgccttgagcctg caacaggaccagcaaggcagcagcagcagtgccctgggcctgcagagcctgggactgtcc ggccaggcacccagctcttcctccctggacgcaggaaccctttctgacaccacagcatca gctccagcatcagatgacgaaggcagcacagccgcaactgatggctccacccttcggact tctcctgccgatcatggtggtagtgtgggctctgagagtggagggagcgccgtggactca gtggctggagaacacagtgtgtcaggaaggagcagtgcttatggtgacaccacagcagag ggacaccctgctgggccaggcagtgtcagctccagtactggagccatcagcaccgctaca ggccaacaggaaggagatggctcagagggagagggagaaggggaagctgaaggagatgtc aacaccagtaacagactgcacatggtccgcctgatgttgttggagaggctgctgcagacc ttgccccagctgcgcagtgtaggtggtgtccgtgccatcccgtatatgcaggtcattctg atgcttacaacagacctggatggggaagacgagaaggataagggtgctctagacaacttg ctgtctcagcttattgcagaattgggcatggacaaaaaggatgtttcaaagaaaaatgaa cgctgtgccctaaatgaggtccatctagtggtgatgaggttgctgagtgtcttcatgtcc aggaccaagtcagggtccaagtcatccatctgtgagtcatcctccctcatctccagtgcc acggcagcagcgctgctgagctctggagcagtggactactgcctacatgtgctcaagtct ttgttggactactggaagagccagcagaatgatgaggagccagtggccaccagccaactg ctgaaaccccatactacctcctccccccctgacatgagtcctttcttccttcggcaatat gtgaagggtcatgcagcagatgtgtttgaagcctacacccagcttctgacagagatggtg ctacggctgccctatcaaatcaaaaagattgctgacactaattctcgtataccacctcct gtatttgatcattcatggttttacttcctatcagagtatctaatgattcagcaaacacca ttcgtacgtcgccaagtccgcaaacttttgctgttcatctgtggctcaaaggagaagtac cgtcagcttcgggacttgcataccctggattcccatgttcgcggaatcaaaaaactgctt gaggagcaaggcatcttccttcgggctagtgtggtcacagccagctcgggctcagccctg cagtatgacacactcatcagcctgatggagcacctcaaagcctgtgcagaaattgccacc cagcgcaccatcaactggcagaaattctgtattaaagatgactcggtcctgtatttcctc ctccaagttagtttcctagtggatgagggagtgtccccagtgctgttgcagctgctctcc tgtgctttgtgtggcagcaaagtactcactgtggcatcttcatcgggagcctccagcgcc acctccggctcttcctcctcctcctcctcctctgcacctgtggcctctggttctgggcaa acaacaacccagagcaagtcatccaccaaaaagagcaagaaggaagaaaaggagaaagag aaggagggggattgctcaggcagtcaagaagatcagctgtgcacagccttggtgaatcaa ctgaacaaatttgctgacaaagagaccttgatacagtttcttcgctgcttcctgctagaa tctaattcctcttctgtgcgctggcaagcccactgcctggcattacacatatacagaaac tccaacaaatcacagcaggagctcctcttggacctgatgtggtccatctggccagaacta ccagcctatggccgcaaggctgcccagtttgtagacctgcttggatatttctcattgaaa accccacaaactgaaaaaaagttgaaagaatattcgcagaaggctgtagaaattctccga acccaaaaccatattcttaccaatcatcccaactccaacatctacaacactctatctggt ttggtggagtttgatggttattacctagagagtgatccctgcttggtgtgtaacaaccca gaagtgccattctgttatatcaagctctcctccatcaaagtggatactcgatacaccact actcagcaggtagtgaagctcattggcagccatactatcagcaaagtgacagtgaagatt ggtgatctgaagcggacgaagatggtgcgaaccattaatctatattacaacaatcgaaca gtacaagccatcgtggagctgaaaaataagccagctcgttggcacaaagccaagaaggta cagttgactccagggcagacagaggtgaagattgacctgccgctgcctattgtggcctct aatctgatgattgagtttgcagatttctatgaaaactaccaggcttccacagagaccctg cagtgccctcgatgcagtgcctctgttcctgccaacccaggagtctgtggcaactgtggg gagaatgtctaccagtgtcataagtgcaggtccatcaactatgatgagaaggatcccttc ctgtgcaatgcctgtggtttctgtaaatatgctcgctttgacttcatgctttatgccaag ccctgctgtgctgtggatcccattgagaatgaagaagaccgaaaaaaggctgtgaccaac atcaacactctcctggataaagctgaccgagtatatcaccagctaatgggacacagacca cagctggaaaatctactttgcaaagtcaatgaggcagctcctgaaaagcctcaggatgat tcaagtagtgctgggggcatcagctccacatcagccagtgtaaatcgctacatcctacag ttggcccaagagtattgtggagactgtaagaattcttttgatgaactctccaaaatcata cagaaagtctttgcttcacggaaggagctcttagagtatgatctgcagcagagggaggca gctaccaagtcatcgcggacaacagtgcagccaacattcactgctagccagtaccgagcc ctttctgtcctcggctgtggccacacctcttccaccaagtgctacggatgtgcctctgcg gtcaccgaacactgtatcacactcctccgggccctggccacgaacccagccttgcgccac atccttgtctcgcagggcctcatccgggagctctttgattacaatttgcggcggggggcg gcctctatgcgggaggaagttcgccagctcatgtgtctccttaccagggataatccagaa gcaactcagcaaatgaatgacttgatcattggcaaggtgtcagcagctctgaaaggccat tgggccaaccctgatctggcaagcagccttcaatatgaaatgctcttactgactgactct atctcaaaggaggatagctgctgggaacttcgcttacgctgtgctctcagtcttttcctc atggctgtaaacatcaaaactccggtcgtcgtggagaacatcaccctcatgtgcctccga atcctgcagaagctgatcaagccgcctgctccgaccagcaagaaaaacaaggatgttcct gttgaagcacttaccacggttaaaccctactgcaatgagatccatgcacaggctcagctg tggctcaagcgagacccaaaagcatcctatgaagcctggaagaaatgccttcccactaga ggtatggattccaatgggaaatcctccactaaggcagagcttcgacagctctacttaaca gagaagtacgtttggaggtggaaacagtacatgagccgtcgggggaagagaacctccccc ttagacctcaagttgggtcacaacaactggcttcggcaggtgctgttcactccagcaacc caagcagcccgacaggcagcctgcaccatcgtggaggctctggcaaccatccccagccgt aaacagcaggtccttgatctcctcaccagttacctggatgagttgagtattgctggagag tgtgcagctgagtacttggccctctaccaaaagctaatcaaaccagcacactggaaggtc tacctggctgctcggggtgtcttgccctatgttggcaacctcatcaccaaggaaattgcc cgattgttggccctggaggaggctaccctgagcactgacttacagcagggctatgctctc aagagccttacaggtctcctttcctcctttgtggaagtagagtccattaagaggcacttc aaaagtcgtctggtgggcactgtgttaaatggctacttgtgcttgcgtaaactggtcgtg cagaggaccaagctgattgatgagacccaggatatgctgttggagatgctagaggacatg accacaggcacagaatcagaaacaaaagccttcatggcagtgtgcattgaaacagccaaa cgttacaatctggatgactatcggactcctgttttcatctttgagaggctctgcagtatc atctatcctgaagaaaatgaagtaacggagttctttgtgactctggagaaggatccccaa caggaagatttcttacagggtcgcatgcccggcaacccttacagcagcaatgagccaggc atcgggcctctcatgagagacattaagaacaagatctgccaagactgtgatctggtggcc ctgcttgaagatgatagtggaatggagcttctggtgaacaataaaattatcagcttggat cttcctgtggcagaggtttataagaaggtctggtgccccacaaatgagggagaacctatg aggatcatctaccgcatgcggggcttgttgggtgatgccactgaggaattcattgagtcc ctggactccactacagatgaagaagaagatgaggaagaagtctataagatggctggtgtg atggcccaatgtgggggcttggattgcatgctcaacagactggctgggattagggatttc aaacagggccgacatcttctgacggtactgcttaaactgttcagttactgtgtgaaggtg aaagtgaatcggcagcaactggtcaagcttgagatgaacactttaaatgtcatgctgggg actctaaacttggccctggtggctgagcaggaaagcaaggacagtggaggggcagctgtg gcagagcaggtgctcagtatcatggagatcattctagatgagtcaaatgcggagcctctg agtgaggacaagggcaaccttctcctgacaggggacaaggaccagctggtgatgttgctg gaccagatcaatagcacttttgtgcgctctaatcccagtgtccttcagggcttattgcga attatcccgtatttgtcctttggagaaatggagaaaatgcaaatcctggtggaccgattc aagccgtactgcaactttgacaagtatgatgaggatcacactggtgatgataaagtcttc ctggactgtttctgcaaaatagctgctggcatcaaaaacaacagcaatgggcaccagcta aaagacctgattctccaaaagggaattacgcagaatgccctagactatatgaagaaacat atccctagtgccaagaatttggatgctgacatttggaagaagtttttatctcgccctgcc ctccccttcatcttaagacttcttcgtgggctagctattcagcacccttccacccaggtg ctaattggtacagactctattacaaacctgcacaaattggagcaggtatccagcgatgag ggaattgggaccctggcagagaacttgttggaggcacttcgagaacaccctgaggtgaac aagaagatcgacgcagcccgaaaggagacgcgggcagagaagaagcgtatggccatggcc atgagacagaaggccttggggaccctgggcatgacgacaaatgagaagggtcaagttgtg actaagacggccctgctgaagcagatggaggaattaattgaagagccaggcctcacttgc tgcatctgcagggagggctacaagttccagcctgcaaaagtattgggcatttacaccttc actaagcgggtggcactggaagagctggagaataagccccggaagcagcagggctatagc accgtgtcccacttcaatatcgtccattacgactgtcacttggctgctgtcagattggcc cgggggcgagaggaatgggagagtgctgcccttcagaatgccaataccaagtgtaacggc ctcctcccggtctggggaccccatgtcccagagtcagcttttgctacttgcttggcaaga cataacacatacctccaggagtgcacaggacaacgagaacccacttatcaacttaatgtc catgacatcaagttactcttcctccgttttgccatggaacagtcattcagtgtagacaca ggaggtggcggcagagagagcaacatccacctcatcccgtacatcattcacaccgtgctt tatgtcctcaacacaaccagggcaacttcccgagaagagaaaaacttgcagagcttttta gaacagcccaaggaaaagtgggtagagagtgcctttgaggtggatgggccccactactac actgttctggccctgcacatcttgcccccagagagatggagagccatccgagtggagatt ctacggaggctcttggtgatctcccaggcccgagcggtgtcgccagggggagccagcaga ctgactgataagtcggtgaaggactactcagtttatcgctctgcacttctcttttgggcc ctagttgatctcatttacaacatgtttaagaaggtgcctaccagtaatacagagggaggc tggtcctgctctctagctgagtttatccgtcacaatgacatgcccatctatgaagctgca gacaaggccctgaaaatgttccaggaggagttcatgcctgtggaaacattctcagagttc gtggatgtggctggacttctctcagaaatcagtttagctgacaacttcctgaaggatctt ttgaactctatcccctga

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