Macrotis lagotis (bilby): 141512373 Help Entry 141512373         CDS       T11097                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism mlao  Macrotis lagotis (bilby) Pathway mlao01521   EGFR tyrosine kinase inhibitor resistance mlao04151   PI3K-Akt signaling pathway mlao04217   Necroptosis mlao04380   Osteoclast differentiation mlao04550   Signaling pathways regulating pluripotency of stem cells mlao04620   Toll-like receptor signaling pathway mlao04621   NOD-like receptor signaling pathway mlao04630   JAK-STAT signaling pathway mlao04658   Th1 and Th2 cell differentiation mlao04659   Th17 cell differentiation mlao05140   Leishmaniasis mlao05145   Toxoplasmosis mlao05152   Tuberculosis mlao05160   Hepatitis C mlao05161   Hepatitis B mlao05162   Measles mlao05163   Human cytomegalovirus infection mlao05164   Influenza A mlao05165   Human papillomavirus infection mlao05166   Human T-cell leukemia virus 1 infection mlao05167   Kaposi sarcoma-associated herpesvirus infection mlao05168   Herpes simplex virus 1 infection mlao05169   Epstein-Barr virus infection mlao05171   Coronavirus disease - COVID-19 mlao05200   Pathways in cancer mlao05203   Viral carcinogenesis mlao05212   Pancreatic cancer mlao05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mlao00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     141512373 (JAK1)    04151 PI3K-Akt signaling pathway     141512373 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     141512373 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     141512373 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     141512373 (JAK1)    04621 NOD-like receptor signaling pathway     141512373 (JAK1)    04658 Th1 and Th2 cell differentiation     141512373 (JAK1)    04659 Th17 cell differentiation     141512373 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     141512373 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     141512373 (JAK1)    05203 Viral carcinogenesis     141512373 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     141512373 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     141512373 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     141512373 (JAK1)    05161 Hepatitis B     141512373 (JAK1)    05160 Hepatitis C     141512373 (JAK1)    05171 Coronavirus disease - COVID-19     141512373 (JAK1)    05164 Influenza A     141512373 (JAK1)    05162 Measles     141512373 (JAK1)    05168 Herpes simplex virus 1 infection     141512373 (JAK1)    05163 Human cytomegalovirus infection     141512373 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     141512373 (JAK1)    05169 Epstein-Barr virus infection     141512373 (JAK1)    05165 Human papillomavirus infection     141512373 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     141512373 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     141512373 (JAK1)    05140 Leishmaniasis     141512373 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     141512373 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mlao01001]     141512373 (JAK1) Enzymes [BR:mlao01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      141512373 (JAK1) Protein kinases [BR:mlao01001]  Non-receptor tyrosine kinases   JAK family [OT]    141512373 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 RIO1 SH2 Motif Other DBs NCBI-GeneID:  141512373 NCBI-ProteinID:  XP_074077354 LinkDB All DBs Position 2:13715131..13855118 Genome browser AA seq 1152 aa AA seqDB search MQYLNFKEDCNAMAFCAKMRSYKKNEVNQDVLAPGLEVVFYLPDRKPLHYFSGEYTMEDL CIKAAQECCISPLCHNLFALYDEKTKLWYAPNHCIKIEEKTSLRLHYRMRFYFTNWHGTN ESEQSVYRHSPKKQKNGYERRRVLDATPLLDAYSLEYLFAQGQYDLVKCLAPVRDPKTDQ EVHEIENECLGMAVLAISHYAMKNNIQLPDLPKDVSYKRYIPETLNRTIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVTPHDLKVKYLSTLETLTKHYGAEIFETSLLSISSENEMN KLNSKDCGNIIRYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKQDSKHRKDDERNKAR EEWNNFSYFPEITHVVIKECMVSINKQDNKKMELGLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIENGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEILTSQKQYKNFQIEVKKGNYSLHGSDRVFPSLRDLMDHLKKQILKTDNISFVLK KCCQPKPREISNLLVATKKAQECLPVYTMSQLSFHRILKEDIIQGEHLGRGTRTQIYSGT LDYKDDEGSSDEKKMKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEYMEFGPLDLFMHRKSELLTTPWKFKVAKQLASALSYLEDKDLVHGNVCAKNVLL AREGLDGECSPFIKLSDPGIPITVLSRQECVERIPWIAPECVDDSKNLSVAADKWSFGTT LWEICYNGEIPLKNKTLAEKERFYEGRVMPVTPSCKELANLMTQCMNYNPSQRPFFRAIM RDINKLEEQNPDILSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNQIADLKKEIEILKKLYHENIVKYKGICTEDGGNRIKLIMEFLPSG SLKEYLPRNKSKINLKQQLKYAVQICKGMDYLGACQYVHRDLAARNVLVENEHRVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLVQCKFYIASDVWSFGVTLHELLTYCDSES SPMAMFLKMIGPTQGQMTVTRLVRALKEGKRLQRPSNCPEEVYQLMSKCWEYHPSNRTSF QNLIRGFEALIK NT seq 3459 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatttcaaagaggactgcaatgccatggcgttctgtgcaaaaatgagg agctacaaaaagaacgaagtgaatcaggatgtgctggcacctgggctggaggtggtattt tacctgcccgataggaagcctctccactacttcagtggcgagtacaccatggaagaccta tgtattaaagccgctcaagaatgctgcatctctccattatgccacaacctctttgccctg tatgatgagaagactaagctgtggtacgctccaaatcactgcatcaagattgaagagaaa acatcgctgcggctgcattatcgaatgagattctatttcaccaattggcatgggaccaat gagagtgagcaatctgtgtatagacactccccaaagaagcaaaaaaatggctatgaaagg agacgggtcctggatgccactccccttcttgatgcctattcactggagtatctgtttgct cagggacaatatgacttggtaaagtgcttggctcctgttagagacccaaagactgatcag gaagtgcacgagattgaaaatgaatgtctggggatggcagtgctggccatatcccactac gccatgaagaataacatacaacttccagatctgccaaaggatgtcagttataagcgatat atcccagaaacgctgaatagaaccatcagacaaaggaatctcttaaccagaatgcgaata aataatgtcttcaaggatttccttaaggaattcaacaataagaccatttgtgacagtagt gtgactccccatgacctgaaggtgaaatacctatcgaccttggagacgctaaccaaacat tatggagctgaaatttttgagacttccctcttgtcgatttcttctgaaaatgaaatgaat aaattaaactcaaaagactgtggaaacatcatacgttatgaagtgatggtgactggaaat ctggggatacagtggaggcaaaaaccaaatgttcttcctgttgaaaaagagaaaaataag ctgaagaggaagaaacaggacagcaaacacaggaaagatgatgagagaaacaaagcccgg gaggaatggaacaacttctcctacttccctgaaatcacccatgttgtcatcaaggaatgc atggttagcattaacaagcaggacaacaagaagatggagctaggcctgtcttcccatgag gaagccttgtctttcgtgtctctggtggacggttatttccggctcacagcggatgcccat cattacctctgcacagatgtcgcacctccgctgattgtacacaacatagaaaatggctgc catggcccaatctgtacggagtatgcaatcaataagttgagacaagaaggaagtgaggaa ggaatgtatgttctgcgttggagctgcacagactttgacaacatcctcatgaccgtgacc tgctttgagaaatcggagattctcaccagccagaaacagtacaagaatttccagattgaa gtgaagaaggggaactattccctgcatggctcggatcgagtcttcccctctctcagagac ctgatggaccatctcaagaagcagatcctgaaaacagacaacatcagttttgtcctgaag aaatgctgtcagccgaaacccagagaaatttcaaatctgcttgtggccaccaagaaggcc caggaatgcttgccagtctatacgatgagccaactgagtttccaccgaattctcaaggaa gacatcattcagggagagcacttgggacgaggcactcgcacccagatctactcaggaacc ctggactacaaggatgacgaaggcagctctgatgagaaaaagatgaaggtcattctcaag gtcttggaccccagtcatagggacatttctctggcatttttcgaggcggccagcatgatg cgacaagtctcccacaaacacatcgtgtatctctatggcgtctgtgttcgggatgtggaa aacatcatggtggaggagtatatggagtttgggcccctggatcttttcatgcatcggaaa agtgaacttctcaccacaccatggaaatttaaggttgccaaacagctggctagcgccctg agttacttggaagacaaagatttagtccatggaaatgtatgtgctaaaaatgtcctcttg gccagagagggcttggatggtgaatgcagccccttcatcaaactcagcgatcctggcatc cccatcactgtgctgtctcggcaggaatgtgtggaacggatcccatggattgccccagag tgtgtagatgactccaagaacttgagtgtggctgctgataagtggagttttggcacaacc ctctgggagatctgttacaatggagaaattcctttgaaaaataagactctagcagagaaa gagcgattttatgaaggtcgagttatgccggtcacaccctcatgcaaggaactggccaac ctgatgactcagtgcatgaactacaatcctagtcagagacccttcttccgggccatcatg agagatatcaataagctagaagaacagaatccggatatcctttcagagaaacaaccaaca actgaggtagatcccacccattttgagaaacggttcttgaagaggatccgagacttggga gagggccactttgggaaagttgaactctgtagatatgaccctgagggggacaacaccggt gagcaggttgcagtcaagtctctaaagccagagagcgggggtaaccagatcgctgacctg aagaaggaaatcgaaatcttgaagaaactgtatcatgaaaatattgtgaaatacaagggg atttgtacagaggatggaggaaataggattaaactcattatggagttcctgccttctggg agccttaaggaatatcttccaagaaataagagcaaaatcaacctcaaacagcagttgaag tatgcggttcagatttgtaaggggatggattatctgggggcctgtcagtatgtccaccga gatctggcagcaaggaatgtccttgttgagaatgagcaccgtgtgaagattggtgatttt ggcttaacgaaagccatcgaaacggataaggaatactacacagtgaaagacgatcgagac agccctgtcttctggtatgctccagaatgtttagtgcagtgcaaattttatatcgcttct gacgtctggtcatttggggtcacgttacacgaactgctcacctactgcgattcggaatcc agtcccatggcgatgttcttgaagatgattggcccaactcaaggtcagatgactgtcaca cgacttgtgcgtgcattaaaggaaggaaaacgtttgcagcgcccatccaactgcccagaa gaggtttatcaactaatgagtaaatgctgggagtaccatccaagcaaccgaacatccttt cagaacctcatccggggatttgaagcacttataaaataa

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