Macrotis lagotis (bilby): 141513265 Help Entry 141513265         CDS       T11097                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism mlao  Macrotis lagotis (bilby) Pathway mlao04020   Calcium signaling pathway mlao04024   cAMP signaling pathway mlao04260   Cardiac muscle contraction mlao04261   Adrenergic signaling in cardiomyocytes mlao04371   Apelin signaling pathway mlao04713   Circadian entrainment mlao04911   Insulin secretion mlao04921   Oxytocin signaling pathway mlao04972   Pancreatic secretion mlao05020   Prion disease mlao05022   Pathways of neurodegeneration - multiple diseases mlao05410   Hypertrophic cardiomyopathy mlao05412   Arrhythmogenic right ventricular cardiomyopathy mlao05414   Dilated cardiomyopathy mlao05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mlao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     141513265 (RYR2)    04020 Calcium signaling pathway     141513265 (RYR2)    04024 cAMP signaling pathway     141513265 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     141513265 (RYR2)    04921 Oxytocin signaling pathway     141513265 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     141513265 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     141513265 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     141513265 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     141513265 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     141513265 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     141513265 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     141513265 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     141513265 (RYR2)    05414 Dilated cardiomyopathy     141513265 (RYR2)    05415 Diabetic cardiomyopathy     141513265 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mlao04040]     141513265 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:mlao04990]     141513265 (RYR2) Ion channels [BR:mlao04040]  Voltage-gated cation channels   Ryanodine receptor    141513265 (RYR2) Domain-containing proteins not elsewhere classified [BR:mlao04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    141513265 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  141513265 NCBI-ProteinID:  XP_074079033 LinkDB All DBs Position 2:complement(145018870..145785695) Genome browser AA seq 4983 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKAEGRIDIEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGSDILHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLIDDKSLLLMDKEKADVKSTAFSFRSSKEKLDIGMRKEIDGMGISEIKYGDSV CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKSPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCVARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRTYSRDLLGPTVSLSQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNNLERTSSYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIR QGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAT RTEVCSGTGEKFRIFRAEKTYAVKTGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDER AFAFDGFKAQRWHQGSEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFK DFEVVDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSK RLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFSSQNSSTDIMFYRLSMPIECAEV FSKTAAGGLPGNSLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVEKEKEATKPEFNNH KDYSQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIF PGQEPANVWVGWITSDFHQYDTVFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGES MSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVF QFELGRIKNVMPLSAGLFKSEHKNPIPQCPPRLHVQFLTHVLWSRMPNQFLKVDVSRISE RQGWLVQCVDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNNRVA HALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMMNNEFIVPMTDET KSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNEYYQYSPEFPLDILKSKTIQ MLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFNNEDLKHILQLIEPSVFKE AASLEEENEVLEKELNTEDPVLEGGSEEETKGKKLPKEGLLQMKLPEPVKLQMCLLLQYL CDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQI NMLLNFKDEKNECPCPEDIRDQLLDFHEDLMTHCGIELDEDGALDGNSDLTIRGRLLYLV EKVTYLKKKQTEKPVEDDSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYD GIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKA MFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCG LQSCQMLVTKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGP ALRGEGGNGLLSAMEEAIKIAEDPSRDGPSPTNGSSKTLDLTAEEDDTIHMGNAIMTFYA ALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVE PDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMA LALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEICL LSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAA SEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQS SMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKLANGWIYGEIYSDSSKV QPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYTRTRRISQTSQV SIDTAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLV PYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRY VDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLST GGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDASSIVNCLHILGQTLDARTVMKTGMES VKTALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHI GQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLE THLNKHNTYSIYNTKTTRERAALNLPTSVEEVCPNIPSLEKLMDEIVELAESGIRYTQMP HVMEVILPMLCSYMSRWWEHGPESNPDKADTCCTALNSEHMNTLLGNILKIIYNNLGIDE GAWMKRLAVFSQPIINKVKSQLLKSHFLPLMEKLKNKAAIVVSDEDHLKAEARGDMSEAE LLILDEFTTLARDLYAFYPLLIRFVDFNRAKWLKEPNSEAEELFRMVAEVFIYWSKSHNF KREEQNFVVQNEINNMSFLITDTKSKMSKAAVTDQERKKMKRKGDRYSMQTSLIVAALKR LLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYK DLPNRTEETSDPEKTVERVLDIANVLFHLEQKSTNVGRRYYSMVEHPQRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGVEPP EEEEGIKKVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVK SFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIA ILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEG SGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES ISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLV ESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKRDFHKAMESHKHYTQSETE FLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAES VLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKE KMELFVNFCEDTIFEMQLAAQISESDLNERSVNKEETEKEKPEEQEPRMGFFSIMTVKSA LLALRYNILTLLRMLSLKSLKKQMKKVKKMTMKDLVMALFSSYWSILICLLHFITSVFRG FFRIMCSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKAIEMALPTEDLT DLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPVPEVQEKCQEQKV KEDEKEEKEETKSEPEKAEGEDGEKEEKSKEDKGKQKLRQLHTHRYGEPEIPESAFWKKI IAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEIPSPSASENSRI SSLDSTSHRLITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREK EVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRD RISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAW YMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRI IFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYED QLN NT seq 14952 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgatgacgaagtc gttttacaatgtactgcaaccatccacaaagaacagcagaaactatgtttggcagctgag ggatttggcaacaggctctgtttcttggagtctacctctaattctaagaatgtccctcca gatctatctatatgtacctttgtgttggaacaatccctatctgtccgagctcttcaggag atgctggccaacacgatggagaaagcagaagggcgtattgatatagaaaaatggaaattt atgatgaagaccgcccaaggtggtggccatcggacactcctttatggacatgccatatta ttgcgacattcttacagtggtatgtacctctgctgcctttctacttcccgatcttcaaca gataaactagcctttgatgttgggttgcaagaagacacaacaggtgaagcatgttggtgg accattcaccctgcttccaaacaacgttcagaaggagaaaaagtacgagttggagatgac ctaatcttagtcagtgtgtcctctgagagatacttgcatttgtcttatggcagtgacatc ttacatgtagatgctgcattccagcagactctctggagtgtggctccaatcagttcagga agtgaagcagcccaaggatacttgattggaggtgatgtgctcaggttgcttcatggtcat atggatgaatgtttgaccgtaccttcaggggagcatggagaggaacaacgaagaacagtt cattatgaaggtggtgctgtatcgattcatgcccgttccctttggagacttgagacccta agagttgcatggagtgggagccacatcagatggggtcagccattccgactacggcatgta acaacagggaaatacttaagtctcatagatgacaaaagccttctgctaatggacaaagag aaagctgatgtcaaatcaacagcatttagtttccggtcttctaaggaaaagctagacata ggaatgagaaaagaaatagatggtatgggaatatcagaaataaagtatggtgattcagtg tgctacatacagcatgtagatacaggcctctggcttacttatcagtctgtggatgtgaaa tctgttcgaatgggatccatacagcgtaaggctatcatgcaccatgaaggccatatggat gacggcttaaatttatccaggtctcagcatgaagagtcacgtacggcacgagtaatccgt agcacagtcttccttttcaataggtttataaggggccttgatgctctgagcaagaaagtg aagtctcctacaatagatttaccaatagagtcagtaagtctgagtctgcaggatctgatt ggctacttccatccaccagatgaacatttagagcacgaagataagcagaaccggttaaga gctctaaagaatcgacagaatctcttccaagaagagggtatgattaaccttgtccttgag tgcatagatagattacatgtgtatagcagtgcagcccattttgctgatgtagctgggaag gaagcaggagaatcttggaagtctatactaaactctttgtatgagttactagcggctctc atcagaggaaatcgcaaaaattgtgctcaattttctggctccctggactggctaatcagc agattggaaagactggaggcatcctcagggattctagaggttttacactgtgtattggtg gaaagtccagaagctctgaatattattaaagaaggacatattaaatccattatctcactt ttagacaaacatggacgaaatcacaaggttttggatgtcttgtgttctctctgtgtttgc catggagttgctgtccgctctaatcagcatttaatttgtgacaacctcctaccaggaaga gatctactgctacagactcgtcttgtgaatcacgtgagcagcatgaggcccaatattttc cttggcatcagtgaagggtcagctcaatataggaaatggtattatgaactcatggtagac cacacagaaccttttgtgacagctgaagcaactcacctccgagtaggttgggcttcaaca gaaggctattcgccctaccctgggggtggtgaagaatggggcggaaatggtgttggagat gatttgttctcctatggatttgatggacttcatttatggtcaggttgtgttgcacggaca gtgagttcaccaaaccaacacctgttgagaactgatgatgtcattagctgctgtttagat ctaagtgccccaagcatttcattccgaatcaatggacaaccagtacaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctcagcaggaataaaggta cgttttctcctggggggtcgacatggagagttcaagtttcttcctccacctggttatgct ccttgctttgaagctgtcctgccaaaagaaaagttgaaagtagagcacagtcgagaatat aaacaagaccgaacatactcaagagatctcttgggccctactgtttctttatcacaagca gccttcacaccaatcccggtggatactagtcagattgttttgcctcctcatctggaaaga atcagagaaaagctggctgagaacatccatgagttatgggttatgaataaaattgaactt ggctggcagtatggaccggtcagagatgataacaagagacagcacccctgcttggtagaa ttctctaagcttccagaacaggaacgtaattataatttacagatgtcccttgagacccta aagactctattggccttaggctgtcatgtgggaatttcagatgagcatgctgaagaaaaa gtgaaaaaaatgaaacttccgaagaataatttggagagaacaagcagttatcagttaaca agtggttacaagcctgctccaatggatctgagttttataaaacttaccccttcccaagaa gcaatggtggacaagttggctgaaaatgctcacaatgtatgggcacgagatcgcatcaga caaggttggacttatggcatccagcaggatgtaaagaacagaagaaaccctcgcctagtt ccctatgcacttctagatgatcgtaccaagaaatcaaataaagatagcctcagggaggct gtccgtacactattgggttatggttacaacctagaagctcctgatcaagatcatgcgact agaactgaagtgtgcagtggcactggagaaaagttcagaatcttccgtgctgagaagact tatgctgtgaagacaggaagatggtattttgaatttgaggctgtcactgctggagacatg agagttggttggagtaggcctggttgccaacctgatcaggagcttggctctgatgaacgt gcttttgcttttgatggcttcaaagcacagcgttggcatcagggcagtgagcattatggg cgctcctggcaagcgggagatgttgtaggatgtatggttgacatgaatgaacacaccatg atgttcaccctgaatggtgaaatcctcctggatgactctggttcagaactagctttcaag gattttgaggttgttgatggattcataccagtatgcagcctaggtgtggctcaagtaggt cgcatgaactttgggaaggatgtcagcaccttgaaatattttaccatctgtgggttgcaa gaaggctatgaaccatttgctgttaatacaaacagggatattacaatgtggttgagcaaa agattgcctcagtttcttcaagtaccttcaaaccatgaacatattgaggtgaccaggata gatggcactatagacagctctccatgtttaaaggttactcagaaatctttcagttcacag aacagcagcactgatatcatgttttaccggctgagcatgcctattgagtgtgcagaagtg ttctccaaaactgctgcgggagggctaccaggcaatagcctttttggtccgaagaatgat ttggaggattatgatgcggattctgattttgaagttctaatgaagacagctcatggtcat ttggtgcctgacagggtagaaaaagaaaaagaagccacaaaaccagagttcaataaccac aaagattattctcaggagaaaccttctcgtctgaaacaaaggtttatgctcagaagaaca aaaccagattatagcacaagccattctgcaagactcactgaagatgttcttgcagatgac agggatgattatgattacttgatgcagacttctacgtattattattcagtgcgaattttt cctgggcaagaacctgctaatgtttgggttggctggattacatcagattttcatcagtat gacacagtctttgacttggacagagttcgaacagtaacagttactctaggagatgaaaaa ggaaaagtacatgaaagcatcaaacgcagcaactgctatatggtgtgtgcgggtgagagc atgagccctgggcaaggacgcaacaataatggattggagatcggctgtgtagtggatgct gccagtggtttgcttacctttactgcaaatggcaaggaactgagcacatattaccaggtc gaaccaagtacaaaattatttcctgcagtttttgcacaagctacaagccctaatgttttc cagttcgagttaggaaggataaagaatgtaatgccactatcagctggattattcaagagt gaacataaaaatcccattccacagtgccctccacgtctccatgtacagtttctcacacat gttctttggagcaggatgccaaaccagtttctgaaagttgatgtttcccgaatcagtgaa cgccaaggatggctggtgcagtgtgtagatcctttgcagttcatgtcccttcacatccca gaggagaacaggtctgtagatatattagaattgacagaacaagaggaattgttgaagttt cattatcacaccctccgcttgtactcagctgtctgtgctctcgggaacaacagagtggcc catgccttatgcagtcatgtggatgagccccagcttctctatgccattgaaaacaaatac atgccaggcctgttgcgcacaggctattatgacctgctcattgacatccaccttagctcc tatgccacagccaggctaatgatgaacaatgaattcattgtccccatgacagatgagaca aagagtatcacccttttccctgatgagaacaagaagcatggcctcccagggataggcctt agcacttccctgagacccaggatgcagttttcatctcccagttttgtaagcattagtaat gagtattaccaatatagtcctgagttccccctggacatcttaaaatccaagactatacag atgctgacagaagctgtgaaggagggaagcctccatgctcgggaccctgtaggggggacc actgaattcctctttgtacctctcattaaactcttctacaccttactgatcatggggatc tttaacaatgaggacttgaaacacattttacagctgattgagcccagtgtttttaaagaa gctgctagtctggaggaagagaatgaagtgcttgagaaggaacttaacactgaagaccca gtgctggaaggagggagtgaagaagagaccaaaggaaaaaagctgcccaaggaaggattg cttcaaatgaaacttcctgagcctgttaaattgcagatgtgtcttctattgcagtacctc tgtgactgccaagtacggcacaggatagaagccattgttgccttctcagatgattttgta gctaagcttcaagataatcaacgttttcgatataatgaagttatgcaagccttaaacatg tctgcagcattaacagcaagaaaaacaaaagaatttcgatctccacctcaagagcagatc aatatgctcttgaattttaaggatgagaaaaatgaatgtccatgtccagaagatattagg gaccaactcttagactttcatgaagatttgatgacacactgtggaattgaactggatgaa gatggagctctggatggaaatagtgatttaacaatcagaggacggctgctttacttggta gaaaaagtgacatacttaaaaaagaaacaaacagagaaaccagttgaagatgactccaaa aagccctctacccttcagcagttgatatctgagacaatggtccgatgggctcaggagtct gtcattgaagaccctgagttggtgagggccatgtttgtattactacatcgccaatatgat ggtattggtggtttggttcgggcattaccaaagacttataccataaatggagtgtcagtg gaagatactatcaacttgttggcatcccttggacaaattcgttctctactaagtgtcagg atgggcaaagaagaagagaagcttatgatccgtggattaggagatatcatgaacaacaaa gtattttaccaacatcccaatctgatgcgggccctgggaatgcatgaaacagtaatggaa gtaatggtcaatgttcttggaggtggcgagtccaaggaaatcacctttcctaagatggtg gccaactgttgtcgttttctatgttatttctgccgtataagtcgtcagaatcagaaagca atgtttgatcatcttagttatttactggaaaacagcagtgttggtcttgcttccccagca atgaggggctcaacaccacttgatgtggcagcagcatcagtaatggataataatgaattg gctttagctttacgtgagcctgacctggaaaaggtagttcgttacctggctggttgtgga ttgcagagctgccagatgctggttaccaagggttacccagacattgggtggaatccagtt gaaggggagagatatttggacttcctaagatttgccgtcttctgtaatggggagagtgtg gaagaaaatgcaaatgttgtggtcagattgttaattcggaggcccgaatgttttggtcca gccttaagaggggaaggtggcaatggtcttctttcggccatggaagaagctataaaaata gcagaggatccttctagagatggcccatcacctactaatggatccagcaaaacccttgat ttgacagcagaagaagatgatactatccacatgggaaatgcaataatgaccttttatgct gctttgattgatctcctaggccgctgtgctcctgaaatgcatttgatccatgctggcaaa ggagaagctattaggatcaggtccattctgagatccttaattccattgggagatttggtg ggagtcatcagcattgctttccagatgccaacaatagctaaagatggaaatgtggtggaa cctgacatgtcagcagggttttgcccagatcacaaggcagctatggttttgttccttgac agggtctatggaattgaggttcaagattttctccttcatcttcttgaggttggcttcttg ccagacctccgagctgctgcttctttagacacggctgctcttagtgccacagacatggcc ttggctctcaatcgatatctttgcactgcagtcttacctttattgacaaggtgtgctcct ctttttgctggcactgagcaccatgcttcactcatagactcactgcttcatacagtgtac aggctatccaagggctgttctctcacaaaagctcagcgggattccatagaaatctgtctt ctctctatttgtggccagttgagaccttccatgatgcaacacttgttaagaagattagtt ttcgatgttccattattaaatgaacatgctaagatgcctcttaagctgctgacaaatcat tatgagagatgctggaagtattattgcttgcctggaggctgggggaactttggtgctgcc tcagaagaagaacttcatttgtcaaggaagttgttctggggcatttttgatgcactatct caaaagaaatatgaacaggaattattcaagctggccttgccctgtcttagtgctgttgca ggagctctgcctcctgactacatggaatccaactatgtcagtatgatggaaaaacagtca tcaatggattctgaaggaaactttaacccacagcctgtcgatacctcaaacattacaatt cctgaaaagttagaatacttcattaacaaatatgcagaacattcacatgacaaatggtca atggaaaagttggcaaatggatggatttatggtgaaatatattcagactcttctaaagtt cagccattaatgaagccatataaacttttatctgaaaaggaaaaagaaatttatcgttgg ccaatcaaggagtctttaaaaacaatgcttgcgtggggatggagaattgaaagaaccaga gagggagacagcatggctctttatactaggacacgccgcatctcccagacaagtcaggtt tctattgatactgcccatggttatagtccccgagctattgacatgagcaatgttaccctt tcaagagatcttcatgcaatggcagaaatgatggctgaaaattatcataacatatgggca aagaaaaagaaactggaactggaggctaaagtaggaggtggcaaccatcctcttctggta ccctatgatactttgacagcaaaagaaaaagccaaagatagagagaaagcacaggatatt ctcaagtttttacagataaatggctatgcagtatcgaggggatttaaagatttggaattg gacacaccttcaattgagaaacgttttgcctatagtttccttcagcagctcatcagatat gtggatgaagctcatcaatatattttggagtttgatggtggcagcagaagcaaaggggaa cattttccttatgaacaggaaataaaattcttcgctaaagttgtacttcctttaatcgat caatatttcaaaaatcatcgtttatacttcttatctgcagcaagcaggcctcttagcact ggaggacacgcatccaacaaggaaaaagaaatggtgactagcctattctgcaaacttgga gttcttgtcaggcataggatttcactgtttggaaatgatgcctcttcaattgtcaactgc cttcatattttgggtcagactttggatgcaaggactgtgatgaagactggcatggagagt gttaaaacagcattaagagcttttttggataatgcagctgaagatttagaaaaaactatg gaaaatcttaaacaaggacaattcactcatactagaaaccagccaaaaggagtgactcaa attattaattatactacagttgctcttttgccaatgctgtcttcactgtttgaacacatt ggacagcatcaatttggagaagacctaatattggaagatgtacaggtttcttgttacagg attctgactagcttatatgcactgggaaccagcaaaagtatctatgtggaaaggcaacga tctgcattaggagaatgtttagctgcatttgctggtgctttccctgtggcttttttggaa acacacctgaacaaacataatacttattcaatctataacactaagactacaagagaaaga gcagctctcaatttgccgactagtgtggaagaggtttgtccaaatataccatcgttggag aaacttatggatgaaattgtagaacttgcagaatctgggattcgctatacacagatgccg catgtcatggaagtgattctgcccatgttatgtagctatatgtcccgttggtgggaacat ggacctgaaagcaatcctgacaaggcagatacatgctgtacagccctgaattcagaacac atgaacacacttctggggaatatactgaaaatcatttataataacctggggattgatgaa ggagcctggatgaagaggttagcagtgttttcccagcctatcataaacaaagtgaaatcc caactcttgaagtcgcatttcctgccactgatggagaagctcaagaataaagcagctata gtagtatctgatgaagaccacctcaaagctgaagccagaggtgacatgtctgaggctgag cttcttattctagatgaatttaccaccctggcacgagatctttatgccttctatcctctg ttaattagatttgtggattttaatagagcaaagtggctaaaagaaccaaattctgaagca gaggaattattccgcatggtggctgaagtgtttatctactggtcaaaatctcataatttc aaaagagaagagcagaactttgtggttcaaaatgaaatcaacaacatgtcttttctcatt actgataccaagtcaaagatgtcaaaggcagcagtcacagatcaggaaaggaagaaaatg aaacgcaaaggagacagatattctatgcagacctctcttatcgtagcagccctgaaaaga ttactgcctattggattgaatatttgtgcacctggagaccaagaattaattgccctagcc aaaaatcggtttagtatgaaagacacagaagatgaagtgcgtgatgttatccgcagtaat cttcatctacagggcaagttagaggatccagctattaggtggcagatggcactttacaaa gacttaccaaatagaaccgaagaaacctcagaccccgagaagacagtagaaagagtattg gatatagctaatgtactttttcaccttgaacagaaatctacaaatgtgggccggcgctat tacagtatggtagagcatccacagcggtctaaaaaggctgtatggcacaaacttctttct aaacagagaaaacgagcagtcgtggcctgtttccgaatggctccattatataatctccca aggcatcgggctgtcaatctctttcttcaaggatatgaaaagtcttggattgaaacagaa gaacattattttgaggataaactgatagaagatttagcaaaacctggagtagaaccacct gaagaagaggaaggcataaagaaagttgatcctttgcatcagctgattctcctgtttagt agaacagccttaacagagaaatgcaaattggaagaagatttcctgtatatggcttatgca gatattatggccaagagctgtcatgatgaggaagatgatgatggtgaagaagaagttaag agttttgaagtcacaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaaactc ctctaccagcaagcacgattacatgacagaggggctgctgaaatggttctacagacaatc agtgccagcaaaggtgaaactggaccaatggtagctgctaccctgaaacttggaattgcc atcttaaatgggggaaattctacagtacaacagaaaatgcttgactacctcaaggagaaa aaggatgtgggcttctttcagagccttgctggcctgatgcagtcatgtagtgtccttgac ctaaatgcctttgagagacaaaacaaagcagaaggacttggaatggtgacagaggaagga tcaggagagaaagtactgcaggatgatgaattcacctgtgacctcttccgtttcctccaa ttgctttgtgaaggacacaattcagattttcagaattatctgagaactcagactggtaat aatacaactgttaatataatcatctccacagtggactatctattgagagtacaggaatca attagtgatttttactggtattactctgggaaagatgtaattgatgaacaaggacagcga aatttttccaaagcaattcaggtggcaaaacaggtctttaatactcttacagaatatatc cagggtccatgcactggaaatcagcagagtttggcacacagcagactttgggatgcagtt gttggttttcttcatgtatttgcccatatgcaaatgaagttgtctcaggattccagccaa attgagctgttgaaagaattaatggatcttcaaaaggacatggtggtcatgttgctgtcc atgttggaaggtaacgttgttaatggaaccattggcaaacagatggttgatatgctggta gagtcttccaacaatgtagagatgattctaaaatttttcgacatgtttttaaaactaaag gatttaacttcttcagatacattcaaagaatatgacccagatggcaaaggcatcatttcc aagagagacttccataaagcaatggagagtcataagcactatactcaatctgaaactgaa tttcttctgtcttgtgcggaaacagatgaaaatgaaaccttagattatgaagagtttgtg aaacgtttccatgaaccagccaaggacattggcttcaatgttgctgtcctcctgaccaac ctttctgaacatatgcccaatgatacccggctccagactttccttgaattagcagaaagt gtactgaattattttcagccttttctaggccgcattgagattatgggcagtgcaaaacgc attgaaagagtttattttgaaattagtgagtctagtagaacccagtgggagaagccacag gtcaaagaatctaaaaggcagtttatttttgatgtggtcaatgaaggaggggagaaagaa aagatggaactttttgttaatttttgtgaggataccatctttgaaatgcagcttgctgca cagatctcagaatcagatttgaatgaacgatcagtgaacaaagaagaaactgagaaagag aagcctgaagaacaggaacctcgaatgggctttttttccattatgactgttaaatctgct ctccttgcccttaggtacaatatcttaactctgctgagaatgctcagtttaaagagcctg aaaaaacagatgaagaaagtaaagaaaatgactatgaaggacctggttatggccctcttt tcatcctactggagtattttgatatgcctcttgcatttcataaccagtgtttttagaggc ttctttcgtatcatgtgcagcttgctgctgggaggtagcctggtagaaggtgctaaaaag atcaaagttgcagaacttttggccaatatgccagaccctacccaggatgaggtacggggt gagggagaagagggagaaaggaaagctatagaaatggccctgcctacggaagatctaact gacctaaaggaattaacagaggaaagtgatttactgtcagatatttttggtttagatctg aagagagaaggaggacaatataagctaattcctcacaatccaaatgctggtttgagtgat ttaatgagcaatcctgtccctgtccctgaagttcaagaaaaatgtcaggaacagaaagtg aaagaagatgaaaaggaagagaaagaagaaacgaaatccgaacctgaaaaagcagaggga gaagatggagaaaaggaggaaaaatccaaagaagataaaggcaagcaaaagttaaggcag cttcacacacatagatatggagaaccagaaattcctgaatcagcattttggaaaaaaatc atagcctatcaacagaaactcttaaactactttgctcgcaacttttacaatatgaggatg ttagccctatttgttgcatttgcaatcaactttatcctgctcttctataaggtctctact tcttctgtggtagaaggaaaggaaattccttcccccagtgcaagtgaaaattccagaata agtagtctggacagcacatcacatcgactcattacagtacactatgttctagaggagagc agtggctacatggagcctacacttcggatccttgctattcttcatacagttatctccttc ttctgcatcattggatactactgcttgaaagttccactggttatttttaagcgagaaaag gaagtagcacggaaattggaatttgatgggctttacattacagaacaaccttctgaagat gatattaaaggccagtgggatagacttgtaatcaatactcagtcatttcccaacaactac tgggacaaatttgtaaaaagaaaggttatggataagtatggagagttctatggccgagat agaatcagtgaattactaggtatggataaagcagctctagatttcagtgatgctcgagaa aagaaaaagccaaagaaagacagctccttatcagctgtgcttaattcaattgatgtgaaa tatcagatgtggaaactaggagttgttttcactgacaattcatttctctatttagcctgg tacatgaccatgtctgtccttggacattacaataatttcttttttgctgcacatcttctc gacattgctatgggattcaaaacattacgtaccatcttgtcttcagtgacccacaatggt aaacagcttgtattgactgtgggattgctggcagttgttgtttatctatacacagttgtg gcattcaattttttccgaaaattctacaataaaagtgaagatggagatacaccagatatg aaatgtgatgatatgctaacgtgctatatgttccatatgtatgttggggtacgtgctggt ggtggtattggagatgaaattgaagatccagcaggagatgaatatgagatctatcgaatc atctttgatatcaccttcttcttttttgtaattgtcattcttctggccatcatacaaggt ttaattattgatgcctttggtgaattaagagaccagcaagaacaagttaaagaagatatg gagactaagtgcttcatctgtgggataggcaatgattattttgatacagtgcctcatggt tttgaaactcacacactacaggagcacaacttggctaattatctgttttttctgatgtat ctcataaacaaagatgaaacagagcatacaggacaggaatcttacgtatggaagatgtat caagaaaggtgttgggagtttttcccagcaggcgactgcttccgaaaacagtatgaagac caactcaattaa

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