KEGG   Macrotis lagotis (bilby): 141513829
Entry
141513829         CDS       T11097                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
mlao  Macrotis lagotis (bilby)
Pathway
mlao01521  EGFR tyrosine kinase inhibitor resistance
mlao01522  Endocrine resistance
mlao01524  Platinum drug resistance
mlao04010  MAPK signaling pathway
mlao04012  ErbB signaling pathway
mlao04020  Calcium signaling pathway
mlao04066  HIF-1 signaling pathway
mlao04151  PI3K-Akt signaling pathway
mlao04510  Focal adhesion
mlao04520  Adherens junction
mlao04530  Tight junction
mlao05200  Pathways in cancer
mlao05205  Proteoglycans in cancer
mlao05206  MicroRNAs in cancer
mlao05212  Pancreatic cancer
mlao05213  Endometrial cancer
mlao05215  Prostate cancer
mlao05219  Bladder cancer
mlao05223  Non-small cell lung cancer
mlao05224  Breast cancer
mlao05226  Gastric cancer
mlao05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mlao00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    141513829 (ERBB2)
   04012 ErbB signaling pathway
    141513829 (ERBB2)
   04066 HIF-1 signaling pathway
    141513829 (ERBB2)
   04020 Calcium signaling pathway
    141513829 (ERBB2)
   04151 PI3K-Akt signaling pathway
    141513829 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    141513829 (ERBB2)
   04520 Adherens junction
    141513829 (ERBB2)
   04530 Tight junction
    141513829 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    141513829 (ERBB2)
   05206 MicroRNAs in cancer
    141513829 (ERBB2)
   05205 Proteoglycans in cancer
    141513829 (ERBB2)
   05230 Central carbon metabolism in cancer
    141513829 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    141513829 (ERBB2)
   05226 Gastric cancer
    141513829 (ERBB2)
   05219 Bladder cancer
    141513829 (ERBB2)
   05215 Prostate cancer
    141513829 (ERBB2)
   05213 Endometrial cancer
    141513829 (ERBB2)
   05224 Breast cancer
    141513829 (ERBB2)
   05223 Non-small cell lung cancer
    141513829 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    141513829 (ERBB2)
   01524 Platinum drug resistance
    141513829 (ERBB2)
   01522 Endocrine resistance
    141513829 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlao01001]
    141513829 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mlao04147]
    141513829 (ERBB2)
   04090 CD molecules [BR:mlao04090]
    141513829 (ERBB2)
Enzymes [BR:mlao01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     141513829 (ERBB2)
Protein kinases [BR:mlao01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   141513829 (ERBB2)
Exosome [BR:mlao04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   141513829 (ERBB2)
CD molecules [BR:mlao04090]
 Proteins
  141513829 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Haspin_kinase ABC1 PDGLE
Other DBs
NCBI-GeneID: 141513829
NCBI-ProteinID: XP_074080127
LinkDB
Position
2:complement(189559196..189588738)
AA seq 1255 aa
MDLSGCCCWGLLLVLLPPAVWGTQVCTGTDMKLQYPASIENHLDTLSHLYQGCQVVQGNL
ELTYLPADANLSFLQDIQEVQGYVLIAHSLVKSFPLQRLRIIRGTQLFEDKYALVVLDNG
IPLGTAPPTPEGPSGLRELPLRSLTEILKGGVQIQNNPQLCHQDTVLWTDIFHKNNYLGT
TSIDRNHSRTCSPCSSACKSGWCWGEGPDNCQSLTSTICASGCARCKGPLPTDCCHEQCA
AGCTGPKHSDCLACLHFNHSGICEQHCPPLVIYNSDTFESMPNPDGRYTFGSSCVKSCPY
NYLATDVGSTSCTLVCPLHSQEVTAEDGTHRCEKCSKACPKVCYGLGMGHLRSVRAVNST
NIQDFAGCKKIFGSLAFLPETFAGDMATNTSPLMPEDLKVFENLEEITGYLYISAWPDSL
SDLSIFQNLRVIRGRVLHNGVYSLTLEHLGIGWLGLRSLRELGSGLALIHHNDHLCFVHT
VPWNQLFRNPRQALLYSANRPSQECAREGLACYSLCAQGHCWGPGPTQCLNCSQFLRGQE
CVEECRVMQGYPREYVKDRRCFPCHGECQPQNGTETCFGSEADKCVACAHFKDSLACVAQ
CPSGVKPDLSFIPIWKYPDDEGICQTCPTNCTHSCTVLDDKGCPAEQKPSPVTSIIAAVV
GVLLALIIGLLIGILIKRRKQQERKHTMRRLLQETELVEPLTPSGALPNQAQMRILKETE
LRKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS
PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLCSQDLLNWCVQIAKGMNYLEEV
RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILCRRF
THQSDVWSYGVTVWELMTFGAKPYEGIPAREIPDLLEKGDRLPQPPVCTIDVYMIMVKCW
MIDSECRPRFRELVTEFSRMARDPQRFVVIQNEDSGPASPLDSTFYRSLLEEDDMGDLVD
AEEYLVPQQGFFCPDPPLAPGPGGTTHRRHRSSSTRSGGELPGVLEGSEEDPPQSPAEPW
EGTGSDVFDGEPGGSLKGLQGIPPRDLSPLQRYSEDPTRPLSPEMDGYVVPPTCGPQPEY
VNQPEVHLPPPSPLEGTLTPPHPSSSTLEHPKLPPPGKNGVVKDIFTFGAAVENPEYLAP
HGGGPHHLSPTAFSPAFDNLYYWDQDPSDRGAAPNGFAGTPTAENPEYLGLDMTV
NT seq 3768 nt   +upstreamnt  +downstreamnt
atggacctgtccggctgctgctgttgggggcttcttctggtcctcctgcccccagcagtc
tggggaacccaagtgtgcacaggcacagacatgaagttgcagtatcctgccagtattgag
aatcaccttgatacattgagccacctgtaccaaggatgccaggttgtacaaggcaacctg
gagctcacttacttacctgctgatgccaacctctccttcctccaggacatccaagaagta
cagggctatgtgctgatagcccacagccttgtgaagagtttcccactgcagaggctccgc
atcatccgaggcacccagctctttgaggacaaatatgccttggtcgttctggacaatggg
attccccttgggactgctcctcccacacccgagggcccctctggtctccgggagctgcca
cttcgaagcctcacagagattctgaaaggtggggtacagatccagaacaacccccagctg
tgtcaccaggacacagtgctgtggactgacatcttccataagaacaactacttgggcacc
acctccatcgatagaaatcacagccgaacttgcagcccttgttcttcagcatgtaaatct
ggctggtgctggggggaaggacctgacaactgtcagagcttgaccagcacaatctgtgcc
agtggctgtgcccgttgcaaggggcccctccccacagactgctgccatgagcaatgtgct
gctggctgcactggccccaagcattctgactgcctggcctgcctccacttcaaccacagt
ggcatctgtgagcagcattgcccaccgctggtcatctacaactcagacacctttgagtca
atgcctaatcctgatgggcgatacacctttgggtccagttgtgtgaaatcatgtccctat
aattacttggctacagatgtgggctccacatcctgcacccttgtgtgtcccctacacagt
caagaggtgactgctgaggatggaacccatcggtgtgagaaatgcagcaaggcctgcccc
aaagtgtgttatggcctgggcatggggcacttgcggtcagtgagagctgtcaacagtacc
aacatccaggactttgctggttgcaagaagatctttggaagtctggctttcctgcctgag
acctttgcaggggacatggccaccaatacttcaccactaatgcctgaagacctcaaggtc
tttgagaacctggaggagattacaggttacctgtacatctcagcctggcctgacagtctc
tctgacctcagcatctttcaaaatctaagggtgatcaggggaagggtgttgcacaatggt
gtctactccctgactctggagcatctgggtattggctggctagggctgcggtcactgaga
gagctgggcagtgggttggcactcatccatcacaatgaccacctatgctttgtccacacg
gtgccttggaaccaactcttccgtaacccccgccaggccctgctctacagtgccaaccga
ccttcccaggagtgtgcaagggagggactagcatgctactccctgtgtgctcaggggcac
tgctggggccctggaccaacccagtgtctcaactgcagccaatttctgcgaggacaggag
tgtgtggaggagtgccgggtcatgcaggggtacccccgagaatatgtcaaggacaggcgc
tgcttcccatgccatggggagtgccagccccaaaatggtactgagacctgctttggatcg
gaggctgacaaatgtgtagcctgtgcacacttcaaggactctcttgcctgtgtggcccaa
tgccccagtggggtgaagccagatctttccttcatacctatctggaagtacccagatgat
gaaggcatttgccagacttgccctaccaactgtacccactcctgtactgtactggatgac
aaaggctgtcctgctgaacagaaacccagccctgtgacctccatcattgcagcagtggtt
ggggtgctcctagctctcatcataggcctgctcattggcatcttgattaagcgtcggaaa
cagcaggaacgaaagcacaccatgagaaggctgctacaggagaccgagctggtggaaccc
ttgacgcctagtggagcattgcccaaccaagctcagatgcgtatcctaaaagagaccgag
ctgaggaaagtgaaggttcttggttctggagcttttggcactgtctacaagggtatttgg
atccctgatggtgaaagtgtgaagattccagtggctatcaaggtgttgagggaaaacaca
tcccccaaagccaacaaggagatcttggatgaagcgtacgtgatggcaggtgttggttct
ccatatgtttctcgacttctgggcatctgcttgacatccacggtgcagctggtgacccag
cttatgccctatggctgccttctggaccatgtgcgtgaaaaccgagggcggctctgctcc
caggacctcctcaactggtgtgtgcagattgccaaggggatgaactatctggaggaggtt
cggctagtacatagagacctggctgccaggaatgtgctagtcaaaagtcccaaccacgtc
aagatcactgactttggactcgcaagactcttggacattgatgagacggagtaccatgca
gatgggggcaaggttcccatcaagtggatggcactagaatccattctctgccgaagattc
acccatcagagtgatgtgtggagctatggggtgacagtgtgggaactgatgacctttggg
gctaagccatatgaggggattcctgcccgagagattcctgacctgttggagaagggtgac
cggctaccacagcccccagtctgcaccattgatgtctacatgatcatggtcaaatgttgg
atgattgactctgagtgtcggcctcggttccgggagcttgttactgaattctcacgaatg
gcccgagaccctcaacgctttgttgtcattcagaacgaggattctggtccagccagtccc
ctggacagcactttctaccgttctttgttggaagaagatgacatgggtgacttggtggat
gcagaagaatacctggtgccccagcaaggtttcttctgccctgaccctcccttggctcca
ggtcccgggggtactacccaccggagacacagaagttcttctacaaggagtggtggggag
cttccaggagtactggaaggctcagaagaggaccctccccaatctccagcagagccctgg
gaagggactggttcagatgtgtttgatggggagcctggcgggagccttaaggggctccag
ggaatccctcctcgagacctcagccccctgcagcgctacagtgaggatcccacacgacca
ctatcccctgagatggatggctacgttgtcccacctacctgtggtccccagcctgaatat
gtgaaccagccagaggtgcacctaccacccccttcacccctggaagggaccctgacacca
cctcacccatccagctccactctggaacatcccaagttgcctcctccagggaagaatgga
gtggtgaaagacatatttacctttggtgcagctgtggagaaccccgagtacttggccccc
catggagggggaccccatcatctttccccaactgccttcagcccagcctttgacaacctc
tattactgggaccaggatccttctgatcgaggggcagctcctaatggctttgcagggacc
cccacagctgagaaccctgagtacttgggtttggatatgactgtgtga

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