KEGG   Mycobacterium leprae TN: ML0200
Entry
ML0200            CDS       T00047                                 
Symbol
topA
Name
(GenBank) putative DNA topoisomerase I
  KO
K03168  DNA topoisomerase I [EC:5.6.2.1]
Organism
mle  Mycobacterium leprae TN
Brite
KEGG Orthology (KO) [BR:mle00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:mle03032]
    ML0200 (topA)
   03400 DNA repair and recombination proteins [BR:mle03400]
    ML0200 (topA)
Enzymes [BR:mle01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.1  DNA topoisomerase
     ML0200 (topA)
DNA replication proteins [BR:mle03032]
 Prokaryotic type
  DNA Topoisomerases
   ML0200 (topA)
DNA repair and recombination proteins [BR:mle03400]
 Prokaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    SHIIR (short-homology-independent illegitimate recombination)
     Facilitator
      ML0200 (topA)
SSDB
Motif
Pfam: Topoisom_bac Toprim_C_rpt Toprim Toprim_4
Other DBs
NCBI-ProteinID: CAC29708
Pasteur: ML0200
UniProt: O69548 A0AAD0P4C5
LinkDB
Position
266033..268876
AA seq 947 aa
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAK
FKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWH
LMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVL
WKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVAR
LTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLY
TRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAAR
TQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYEL
VWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGE
ADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIK
TVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTN
WLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKT
GPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIV
AKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTIT
LEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALK
IYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSI
TDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
NT seq 2844 nt   +upstreamnt  +downstreamnt
atgaagggccccaggggttctaggagcggcagaaatgggagcccgcggcgacttgttata
gtcgagtcgccgacgaaagcgcgcaaattgtccggctatctaggatctgcgtacatagtc
gaatcatcccgggggcatatccgtgacctgccgcggacggcggctgatgtgcccgcgaag
ttcaagtctgagccgtgggctcggctgggcgtaaacgtcgacgcagactttgaaccgctc
tacatcatcacccccgagaagaagagcaccgtcactgaactcaaaggtctgctccaagga
gtcgacgagctctatctggccacagatggtgaccgcgagggcgaagccatcgcctggcac
ctgatgcagactctgaaaccgcgagttccggtcaagcggatggttttccacgagatcacc
gagcacgcgatcctcgccgccgctgcgcatccccgtgaactggatattgacctggttgac
gcgcaggagacccgacgcatcctggaccggctgtacgggtatgaagttagtccggtactg
tggaagaaggtagcgcctaagctttcggcgggccgagtgcaatcggtggccacccgcatc
atcgtgcagcgtgaacgcgaccggatggcgttctgcagcgcggtgtactgggacattgtt
gccaagctggacgccagcgtgtccgatccgaccgcccagccgctcacctttgtcgcccgt
ctgacggctgtagatggcttgcgggtcgccaccggccgcgatttcggtgcgatgggcacg
ctgcgtggagactgtgaggtctccaaaatcattgtcctcgacgacctgaccgcaaccacg
ttggccgcaggattgcgcggcgctcagcttaccgtggcctcagcggaagagaagctctac
actcggcgaccgtatccgccattcatgacgtcgacgctgcaacaggaagccggacgcaag
ttgcgattctctgcggaacgcacgatgagcatcgcccagcggctatatgagaacggttac
attacctacatgcgtaccgactcgaccacgttgtctgagtcggctatcaacgccgctcgt
acgcaggcgcgtcagctctacggcgaggagtacgtctctgactcgccgcgtcagtacacc
cgcaaggtaaagaacgcacaggaagcccacgaggccatccggcctgcaggagagacgttc
gctaccccggacgcggtgtgtaatgaactcgacggtgacgaattccggatctacgagctg
gtatggcggcgtactgtagcttctcagatggccgacgctcgcggtaccacgctgagcttg
cggatcgagggccgagccggcgagcaacacgttgtcttctcagcttccgggcgcaccctg
accttccccggcttcctgaaggcctatgtggaaaccgtggacgagctggccggcggcgag
gctgacgacgctgagcgtcgactaccgcatctgacctctggtcagctgctggatgtcatc
gatctgactccggacgggcacgccaccaaccctccggcccgctatacggaagcttctttg
gttaaagcgttggaggagttgggtatcggccgcccgtcgacgtactcatcgatcataaag
accgtccaggaccgcggctatgtgcagaagaagggcagcgccctggtgccgtcgtgggtc
gcgttcgcagttaccggccttttggagcagcatttcggccgtctcgtcgactacgatttc
accgccgcgatggaagacgagctcgatgagatcgctaacgggaatgagcaacgtaccaac
tggctcaacaacttctactttggtggcaaccacggtgtgtccgattcaatagcccgctcc
ggcggcttgaagaagttggtcggcgtgaatattgaagggattgatgcacgagaggtcaat
tccatcaaactgtttgacgatgagcacggtcgtcctgtctatgttcgggtaggcaagact
gggccgtatctggaacgcttgttggcaggcgatgatggtgaacttaccccgcagcgggca
aacctcaacggcacactcactccggatgagctcaccttggaggttgccgaggagcttttc
gccacaccgcacgaggggcgcgttctgggggtggatcccgaaactggccacgagatcgtc
gccaaagacggtcggtacgggccttatgtgactgaggtcctgcctaagcacgatgacgac
tatggtgcagcggatcagggaactaagaaaactaagaagggtaggagggcttccgcttct
caaggccccaaaccgaggaccgggtctttgctgcggagcatggatttgcaaacgatcact
ctcgaggatgcattgaaactgttgttgctgcctcgggttgtcggtgtggaccctgcgtcc
ggtgaagagatcaccgcgcagaacgggcgttatggtccatatctgaagcgcggcaaagat
tctcgaccactaacaactgaagaccagatgttcatcattactctcgacgaggcgttaaag
atctacgctgaaccgaaacgtgctggtcgacaaagtacttcgccgccgcctttgcgtgag
ctggggactgatccgacgtcgggcaagccaatgctgatcaaggacggccggttcggcccg
tatgtcaccgacggtgagaccaacgctagcctgcgcaagggtgatgacgtggtgtcgata
accgatgaacgtgccgccgaattgttggctgaccgacgggcccgaggtccggttaagcgg
cctgctaagaaggctcgcaaggtcccggcgaagaaggcagctagactggctccggcccgc
gggatcagccagtcacctcgctag

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