Mycobacterium leprae TN: ML0910
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Entry
ML0910 CDS
T00047
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme)
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
mle
Mycobacterium leprae TN
Pathway
mle00300
Lysine biosynthesis
mle00550
Peptidoglycan biosynthesis
mle01100
Metabolic pathways
mle01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
mle00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
ML0910 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
ML0910 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
ML0910 (murF)
Enzymes [BR:
mle01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
ML0910 (murF)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
CAC31291
Pasteur:
ML0910
UniProt:
O69556
A0AAD0KRF8
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Position
1077590..1079143
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AA seq
517 aa
AA seq
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MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVGPGGLFLALPGARSDGHDH
AASAIAAGAVAVLAARPVGVPAIVVAPDPRTGDGGLTGVLEHDADGSGAAVLAALAKLAK
AVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELLGEVVAPPESFNNELGHPWTVLRAT
RSTDYLILEMSARRPGNIAALAAIAPPKIGVVLNVGTAHLGEFGSREAIARTKTELPQAI
MQSGVVILNVDDPAVAAMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRF
TLHTRDPRAGATEIQLGVYGDHQVANALCAAAVGLECGASVEEVAVALAATGPVSRHRMQ
VTTRADGVTVIDDTYNANPDSMRAGLQALAWIAHGGTHDKNQPGSCARRSWAVLGEMAEL
GEDSITEHDRIGRLAVRLDVSRLVVVGGGRSINAMHRGAVMEGSWGLETVNVADPAAALT
LLRAEVRPGDVVLIKASHSVGLGALADVLVGDGAIRP
NT seq
1554 nt
NT seq
+upstream
nt +downstream
nt
atgatcgacctgacggttgcccgggttaccgagatcgtcggtggcgcgttggtcgatatc
tctcccgaggaggccgccgagcgtcgcgtcaccggcagcgtggaatttgattcgcgggct
gttggccccggcggtctattcctggccttgccgggggcccgctcggacggacatgaccat
gctgcttcggcgatagcggccggtgcggtggctgtgttggctgcccggccggtcggcgtt
cccgccatcgtagttgctcctgaccctcgcacgggtgacggcgggctgactggggtgctt
gagcacgatgcagacggatcgggcgcggcggtgctggccgccttggctaagttggccaag
gcggtggccgcggagctggtagctggcgggctgactatcattgggattaccggatcgtcg
gggaagacatccaccaaagatttggtggccgtcgtgctggagttgctcggtgaggtggtg
gcgccacccgagtcgttcaacaatgaactgggtcatccctggacagtgttgcgtgcaacc
cgtagcacggactatttgattctggagatgtcggcacgccgtcccggtaatattgccgcg
ttggcggcgatcgccccaccaaagataggggttgtcctcaacgtcggcactgcgcaccta
ggtgagtttggctcccgggaagccatcgcgcgaactaaaaccgagcttccgcaagctatt
atgcagtccggtgtggtcatactcaacgtcgatgacccggcggtggcggcgatggctgac
gcgaccgtggcccgcgtgattcgggttagtcgcggtagttatagccatccggggtcacca
aacagcccagacgtttggactggtccggtgtcgctcgacgaacttgctaggccgcgcttc
acgctgcatactcgagatccacgcgccggcgccaccgaaatccaactcggcgtgtacggc
gatcatcaggtcgccaacgccttgtgcgcggctgcggtcggactggaatgcggtgctagc
gtcgaggaagtggcggtcgcgcttgccgcgacagggccggtgtcgcggcatcggatgcag
gtgaccacgcgcgctgacggggtgacggtgatcgacgacacctacaacgccaaccccgac
tcgatgcgggccgggctacaggctttggcctggatcgcgcatggtgggacccatgataag
aaccagccaggttcttgtgctcgacgaagctgggcggtgttgggtgagatggccgagctt
ggagaggactcgataaccgaacacgatcgcatcggccggctagcggtgcgcttagatgtg
tctcgactcgttgtcgtgggagggggaaggtcgataaacgccatgcaccgcggagcggtt
atggaaggttcttggggtttagagacggttaatgtggccgaccccgctgctgccctgaca
ttgttgcgggctgaagtacgacccggcgacgtggtcctgatcaaggcgtcgcattcggtc
ggcctaggagcgctggctgatgtactggtgggcgacggggccatccgcccatga
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