Mycobacterium leprae TN: ML2420
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Entry
ML2420 CDS
T00047
Symbol
hemD
Name
(GenBank) possible uroporphyrin-III C-methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mle
Mycobacterium leprae TN
Pathway
mle00860
Porphyrin metabolism
mle01100
Metabolic pathways
mle01110
Biosynthesis of secondary metabolites
mle01120
Microbial metabolism in diverse environments
mle01240
Biosynthesis of cofactors
Module
mle_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mle00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
ML2420 (hemD)
Enzymes [BR:
mle01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
ML2420 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
ML2420 (hemD)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
CAC31936
Pasteur:
ML2420
UniProt:
A0AAD0P8S1
Q9CB60
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Position
complement(2894835..2896526)
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AA seq
563 aa
AA seq
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MVGATMTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIG
KDLPPVSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLT
AEARSGVDVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSS
HTVADVRGDVDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQ
RSVETTLEGLADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPR
TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR
AVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYD
SVFDPVNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFD
AVCFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDAL
AEHVARLRAEGALPPPRKKSRRR
NT seq
1692 nt
NT seq
+upstream
nt +downstream
nt
gtggtgggagcgacaatgacgacgcgagggcgtaagcttagaccaggtcgcatcacattt
gtgggcgccggtccaggagccccagggttactaactgctcaggctgtagcggtgctagca
aacgccgcccttgtttttatcgaccccgatgtacctgaaccggtgctggcgctgattggc
aaggacttgccaccggtctctggtccggcgcctgccggtccggctgccgtgaccgccggc
agggctgctgacggtaccctcgagggggatcactaccaagccgcaccgatggtcatgtcc
ggaggcgccgacatccgccctgcgttgggtgaccctactgaggtcgccaaaacgctgacc
gccgaggctcgttccggtgttgatgtggtgcgcttagtggcgggtgatccgttgacggtg
gacgcggtcatagccgaggtgaacgctgtggcacgcaccaatctacaaatcgagatcgtg
cccggcttggtcaccagcagcgtcgtaccaacctatgccgggctacccttgggttcgtcg
cacacggtggctgatgtacgtggcgacgtggactgggaagcgctagccgcggctcctggg
ccgttgattctgcaagccaccgcatcacatcttgccgacgcggcgcacatcttgatcgac
cacgggctggacgacgccacaccctgcgtggtgaccgctcagggcacgacctgccagcaa
cgttctgtcgaaaccacattggagggattggctgactcggctgtcctggtcggcaccgat
accgcaggcccgctgaccgggccgctggtggtgaccataggcaagacggtgaccagtcga
gctagactgaactggtgggaaagccgtgcactctacggctggaccgtgttggtaccgcgt
accaaggaccaggccggcgagatgagcgagcggctgacgtcgtacggtgcgttgccggtt
gaggtgccgaccatcgctgtcgagccgccgcgcagtcccgctcagatggaacgtgctgtc
aaggggctggtcgacggtcgtttccaatgggtggtgttcacctccaccaacgcggtgcgc
gcggtgtgggagaagtttggcgagttcggtctggatgcccgcgccttctccggggtgaag
atcgcctgtgtcggagaagcgactgccgacagggtccgtgcattcgggatcagcccggag
ctggtgccggctggggaacagtcttccctcggtctactggacgaattcccgccttatgac
agcgttttcgacccggtgaaccgtgttttgctgccgcgcgctgacattgccaccgaaacc
ctggctgagggactgcgcgggtgtggctgggagatcgaggacgtcaccgcttatcggacg
gtgcgggcggcaccgccgccggcggccacccgggaaatgatcaagacgggtggcttcgat
gcagtgtgcttcacctccagctccacggtgcgtaacttggttggtattgccggcaaaccg
cacgcgcggacggtcattgcctgcatcggacccaagactgctgagaccgcttccgaattt
ggtttgcgggtggatgtccagcccgaaaccgccgcggttggaccgttagttgatgcgttg
gccgaacatgtcgctcgactgcgcgccgaaggcgcgctgcctccaccgcgcaagaagagc
cgcaggcgctag
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