Mandrillus leucophaeus (drill): 105529594 Help Entry 105529594         CDS       T08763                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism mleu  Mandrillus leucophaeus (drill) Pathway mleu01521   EGFR tyrosine kinase inhibitor resistance mleu01522   Endocrine resistance mleu03272   Virion - Hepatitis viruses mleu04010   MAPK signaling pathway mleu04012   ErbB signaling pathway mleu04014   Ras signaling pathway mleu04015   Rap1 signaling pathway mleu04020   Calcium signaling pathway mleu04066   HIF-1 signaling pathway mleu04068   FoxO signaling pathway mleu04072   Phospholipase D signaling pathway mleu04144   Endocytosis mleu04151   PI3K-Akt signaling pathway mleu04510   Focal adhesion mleu04520   Adherens junction mleu04540   Gap junction mleu04630   JAK-STAT signaling pathway mleu04810   Regulation of actin cytoskeleton mleu04912   GnRH signaling pathway mleu04915   Estrogen signaling pathway mleu04921   Oxytocin signaling pathway mleu04926   Relaxin signaling pathway mleu04928   Parathyroid hormone synthesis, secretion and action mleu04934   Cushing syndrome mleu05160   Hepatitis C mleu05163   Human cytomegalovirus infection mleu05165   Human papillomavirus infection mleu05171   Coronavirus disease - COVID-19 mleu05200   Pathways in cancer mleu05205   Proteoglycans in cancer mleu05206   MicroRNAs in cancer mleu05207   Chemical carcinogenesis - receptor activation mleu05208   Chemical carcinogenesis - reactive oxygen species mleu05210   Colorectal cancer mleu05212   Pancreatic cancer mleu05213   Endometrial cancer mleu05214   Glioma mleu05215   Prostate cancer mleu05218   Melanoma mleu05219   Bladder cancer mleu05223   Non-small cell lung cancer mleu05224   Breast cancer mleu05225   Hepatocellular carcinoma mleu05226   Gastric cancer mleu05230   Central carbon metabolism in cancer mleu05231   Choline metabolism in cancer mleu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mleu00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     105529594 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     105529594 (EGFR)    04012 ErbB signaling pathway     105529594 (EGFR)    04014 Ras signaling pathway     105529594 (EGFR)    04015 Rap1 signaling pathway     105529594 (EGFR)    04630 JAK-STAT signaling pathway     105529594 (EGFR)    04066 HIF-1 signaling pathway     105529594 (EGFR)    04068 FoxO signaling pathway     105529594 (EGFR)    04020 Calcium signaling pathway     105529594 (EGFR)    04072 Phospholipase D signaling pathway     105529594 (EGFR)    04151 PI3K-Akt signaling pathway     105529594 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     105529594 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     105529594 (EGFR)    04520 Adherens junction     105529594 (EGFR)    04540 Gap junction     105529594 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     105529594 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     105529594 (EGFR)    04915 Estrogen signaling pathway     105529594 (EGFR)    04921 Oxytocin signaling pathway     105529594 (EGFR)    04926 Relaxin signaling pathway     105529594 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     105529594 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105529594 (EGFR)    05206 MicroRNAs in cancer     105529594 (EGFR)    05205 Proteoglycans in cancer     105529594 (EGFR)    05207 Chemical carcinogenesis - receptor activation     105529594 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     105529594 (EGFR)    05230 Central carbon metabolism in cancer     105529594 (EGFR)    05231 Choline metabolism in cancer     105529594 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105529594 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     105529594 (EGFR)    05212 Pancreatic cancer     105529594 (EGFR)    05225 Hepatocellular carcinoma     105529594 (EGFR)    05226 Gastric cancer     105529594 (EGFR)    05214 Glioma     105529594 (EGFR)    05218 Melanoma     105529594 (EGFR)    05219 Bladder cancer     105529594 (EGFR)    05215 Prostate cancer     105529594 (EGFR)    05213 Endometrial cancer     105529594 (EGFR)    05224 Breast cancer     105529594 (EGFR)    05223 Non-small cell lung cancer     105529594 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     105529594 (EGFR)    05171 Coronavirus disease - COVID-19     105529594 (EGFR)    05163 Human cytomegalovirus infection     105529594 (EGFR)    05165 Human papillomavirus infection     105529594 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     105529594 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105529594 (EGFR)    01522 Endocrine resistance     105529594 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mleu01001]     105529594 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mleu04147]     105529594 (EGFR) Enzymes [BR:mleu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      105529594 (EGFR) Protein kinases [BR:mleu01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    105529594 (EGFR) Exosome [BR:mleu04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    105529594 (EGFR)   Exosomal proteins of pancreatic cancer cells    105529594 (EGFR)   Exosomal proteins of bladder cancer cells    105529594 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like GAPT ABC1 Motif Other DBs NCBI-GeneID:  105529594 NCBI-ProteinID:  XP_011822163 Ensembl:  ENSMLEG00000035929 LinkDB All DBs Position Unknown AA seq 1157 aa AA seqDB search MFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYY ENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSEFL SNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCH NQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK KCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINA TNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPEN RTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYAN TINWKKLFGTSSQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCQNVSRGR ECVDKCNILEGEPREFVENSECIQCHPECLPQVMNITCTGRGPDNCIQCAHYIDGPHCVK TCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCARNGPKIPSIATGMVGA LLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFK KIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPH VCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRL VHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI DADSRPKFRELIVEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDA DEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDP TGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAV GNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAE NAEYLRVAPQSSEFIGA NT seq 3474 nt NT seq  +upstreamnt  +downstreamnt atgttcaataactgtgaggtggtccttgggaatttggaaattacctacgtgcagaggaat tatgatctttccttcttaaagaccatccaggaggtggctggttatgtcctcatcgccctc aacacagtggagcggattcctttggaaaacctgcagatcatcagaggaaacatgtactat gaaaattcctatgccttagcagtcttatctaactatgatgcaaataaaaccggactgaag gagctgcccatgagaaacttacaggaaatcctgcatggcgccgtgcggttcagcaacaac cctgccctgtgcaacgtggagagcatccagtggcgggacatagtcagcagcgagtttctc agcaacatgtccatggacttccagaaccacctgggcagctgccaaaagtgtgatccaagc tgtcccaatgggagctgctggggtgcaggagaggagaactgccagaaactgaccaaaatc atctgtgcccagcagtgctccgggcgctgccgcggcaagtcccccagtgactgctgccac aaccagtgtgccgcgggctgcacgggcccccgggagagcgactgcctggtctgccgcaaa ttccgagacgaagccacgtgcaaggacacctgtcccccactcatgctctacaaccccacc acataccagatggatgtgaaccccgagggcaaatacagctttggtgccacctgcgtgaag aagtgtccccgtaattatgtggtgacagatcacggctcgtgcgtccgagcctgcggggcc gacagctatgagatggaggaagacggcgtccgcaagtgtaagaagtgcgaagggccttgc cgcaaagtgtgtaatggaataggtattggtgaatttaaagacacactctccataaatgct acaaatattaaacacttcaaaaactgcacctccatcagtggcgatctccacatcctgccg gtggcatttaggggtgactccttcacacacactccgcctctggatccacaggaactggat attctgaaaaccgtaaaggaaatcacagggtttttgctgattcaggcttggcctgaaaac aggacggacctccatgcttttgagaacctagaaatcatacgtggcaggaccaagcaacac ggtcagttttctcttgcggtcgtcagcctgaacataacatccttgggattacgctccctc aaggagataagcgatggagatgtgataatttcaggaaacaaaaatttgtgctatgcaaat acaataaactggaaaaaactgtttgggacctccagtcagaaaaccaaaattataagcaac agaggtgaaaacagctgcaaggccacgggccaggtctgccatgccttgtgctcccccgag ggctgctggggcccagagcccagggactgcgtctcctgccagaatgtcagccgaggcaga gaatgcgtggacaagtgcaacatcctggagggcgagccaagggagtttgtggagaactct gagtgcatacagtgccacccagaatgcctgccccaggtcatgaacatcacctgcacggga cggggaccagacaactgtatccagtgtgcccactacattgacggcccccactgcgtcaag acctgcccagcaggagtcatgggagaaaacaacaccctggtctggaagtacgcagacgcc ggccacgtgtgccacctgtgccatccaaactgcacctacggatgcactgggccaggtctt gaaggctgtgctaggaacgggcctaagatcccatccatcgccactgggatggtgggggcc ctcctcttgctgctggtggtggccctggggatcggcctcttcatgcgaaggcgccacatc gttcggaagcgcacactgcggaggctgctgcaggagagggagcttgtggagcctcttacg cccagtggagaagctcccaaccaagctctcttgaggatcttgaaggaaactgaattcaag aagatcaaagtgctgggctctggtgcgttcggaactgtgtataagggactctggatccca gaaggtgagaaagttaaaattcccgtcgctatcaaggaattaagagaagcaacatctccg aaagccaacaaggaaatcctcgatgaagcctacgtgatggccagtgtggacaacccccat gtgtgccgcctgctgggcatctgcctcacctccaccgtgcagctcattacgcagctcatg cctttcggctgcctcctggactacgtccgggaacacaaggacaatatcggctcccagtac ctgctcaactggtgtgtgcagattgcaaagggcatgaactacttggaggaccggcgcttg gtgcaccgcgacctggcagccaggaatgtactggtgaaaacgccacagcatgtcaagatc acagattttgggctggccaaactgctgggtgcagaagagaaagaataccatgcagaagga ggcaaagtgcctatcaagtggatggcattggaatcaattttacaccgaatttatacccac cagagtgatgtctggagctacggggtgaccgtttgggagttgatgacctttggatccaag ccatatgacggaatccctgccagtgagatctcctccatcctggagaaaggagaacgcctc ccccagccacccatatgtaccatcgatgtctacatgatcatggtcaagtgttggatgata gacgcagatagtcgcccaaagttccgtgagttgatcgttgaattctccaaaatggcccga gacccccagcgctacctggttattcagggggatgaaagaatgcatttgccaagccctaca gactccaacttctaccgtgccctgatggatgaagaagacatggatgacgtggtggatgcc gacgagtacctcatcccacagcaaggcttcttcagcagcccctccacgtcacggactccc ctcctgagctctctgagtgcaactagcaacaattccactgtggcttgcattgatagaaat gggctgcaaagctgtcccatcaaggaagacagcttcttacagcgatacagctcagacccc acaggcgccttgactgaggacagcatagacgacaccttcctcccagtgcctgaatacata aaccagtctgttcccaaaaggcccgctggctctgtgcagaatcctgtctatcacaatcag cctctgaaccctgcgcccagcagagacccacactaccaggacccccacagcaccgcagtg ggcaaccccgagtatctcaacactgtccagcccacctgtgtcaacagcacattcgacagc cctgctcattgggcccagaaaggcagccaccaaattagcctggacaaccctgactaccag caggacttctttcccaaggaagccaagccaaatggcatctttaagggctccacagctgaa aatgcagaatacctaagggtcgcaccacaaagcagtgaatttattggagcatga

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