KEGG   Mandrillus leucophaeus (drill): 105530842
Entry
105530842         CDS       T08763                                 
Name
(RefSeq) cholesterol side-chain cleavage enzyme, mitochondrial isoform X1
  KO
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Organism
mleu  Mandrillus leucophaeus (drill)
Pathway
mleu00140  Steroid hormone biosynthesis
mleu01100  Metabolic pathways
mleu04913  Ovarian steroidogenesis
mleu04925  Aldosterone synthesis and secretion
mleu04927  Cortisol synthesis and secretion
mleu04934  Cushing syndrome
Module
mleu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
KEGG Orthology (KO) [BR:mleu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    105530842
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    105530842
   04925 Aldosterone synthesis and secretion
    105530842
   04927 Cortisol synthesis and secretion
    105530842
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105530842
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:mleu00199]
    105530842
Enzymes [BR:mleu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     105530842
Cytochrome P450 [BR:mleu00199]
 Cytochrome P450, animal type
  CYP11 family
   105530842
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 105530842
NCBI-ProteinID: XP_011823932
Ensembl: ENSMLEG00000028556
VGNC: 82672
UniProt: A0A2K5XZF7
LinkDB
Position
Unknown
AA seq 521 aa
MLAKGLPARSVLVKGCQTFLSAPKERLGHLRVPTSEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPETTKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNFSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADMYTENFHWELRQKGNVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
RQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRGYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQE
NT seq 1566 nt   +upstreamnt  +downstreamnt
atgctggccaagggtcttcccgcacgctcagtcttggtcaaaggctgccagacctttctg
agtgcccccaaggagaggctggggcatctcagggtgcccaccagtgagggagctggcatc
tccactcgcagtcctcgccccttcaatgagatcccctctcctggtgacaatggctggcta
aacctgtaccatttctggagggagacaggcacacacaaagtccaccttcaccatgtccag
aatttccagaagtatggcccgatttacagggagaagctcggcaacgtggagtcggtttat
gtcatcgaccctgaagatgtggcccttctctttaagtccgagggccccaacccagaacga
ttcctcatcccgccctgggtcgcctatcaccaatattaccagagacccataggagtcctg
ttgaagaagtcagcagcctggaagaaagaccgggtggccctgaaccaggaggtgatggct
ccagagaccaccaagaactttttgcccctgttggatgcagtgtctcgggacttcgtcagt
gtcctgcacaggcgcatcaagaaagcaggctccggaaatttctcaggggacatcagtgat
gacctgttccgctttgcctttgagtccatcactaacgtcatttttggggagcgccagggg
atgctggaggaagtagtgaaccccgaggcccagcggttcattgatgctatctaccagatg
ttccacaccagcgtccccatgctcaaccttcccccagacctattccgtctgttcaggacc
aagacctggaaggaccatgtggccgcatgggacgtgattttcagcaaagctgacatgtac
accgagaacttccactgggaattgagacagaaaggaaatgttcaccatgattaccgtggc
atcctctacagactcctgggagacagcaagatgtccttcgaggacatcaaggccaacgtc
acagagatgctggcaggaggggtggacacgacgtccatgaccctgcagtggcacttgtat
gagatggcacgcaacctgaaggtgcaggatatgctgcgggcagaggtcttggctgcgcgg
cgccaggcccagggagacatggccacgatgctgcagctggtccccctcctcaaagccagc
atcaaggagacactgagacttcaccccatctccgtgaccctgcagagatatctcgtaaat
gacttggttcttcgaggttacatgattcctgccaagacactggtgcaggtggccatctat
gctctgggccgagagcccactttcttcttcgacccggaaaattttgacccaacccgatgg
ctgagcaaagacaagaacattacctacttccggaacttgggctttggctggggtgtgcgg
cagtgtctgggacggcggatcgccgagctagagatgaccatcttcctcatcaatatgctg
gagaacttcagagttgaaatccaacatctcagcgatgtgggcaccacattcaacctcatc
ctgatgcctgaaaagcccatctccttcaccttctggccctttaaccaggaagcaacccag
gagtga

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