KEGG   Mandrillus leucophaeus (drill): 105539923
Entry
105539923         CDS       T08763                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mleu  Mandrillus leucophaeus (drill)
Pathway
mleu00562  Inositol phosphate metabolism
mleu01100  Metabolic pathways
mleu01521  EGFR tyrosine kinase inhibitor resistance
mleu01522  Endocrine resistance
mleu01524  Platinum drug resistance
mleu04012  ErbB signaling pathway
mleu04014  Ras signaling pathway
mleu04015  Rap1 signaling pathway
mleu04024  cAMP signaling pathway
mleu04062  Chemokine signaling pathway
mleu04066  HIF-1 signaling pathway
mleu04068  FoxO signaling pathway
mleu04070  Phosphatidylinositol signaling system
mleu04071  Sphingolipid signaling pathway
mleu04072  Phospholipase D signaling pathway
mleu04081  Hormone signaling
mleu04140  Autophagy - animal
mleu04150  mTOR signaling pathway
mleu04151  PI3K-Akt signaling pathway
mleu04152  AMPK signaling pathway
mleu04210  Apoptosis
mleu04211  Longevity regulating pathway
mleu04213  Longevity regulating pathway - multiple species
mleu04218  Cellular senescence
mleu04360  Axon guidance
mleu04370  VEGF signaling pathway
mleu04380  Osteoclast differentiation
mleu04510  Focal adhesion
mleu04550  Signaling pathways regulating pluripotency of stem cells
mleu04611  Platelet activation
mleu04613  Neutrophil extracellular trap formation
mleu04620  Toll-like receptor signaling pathway
mleu04625  C-type lectin receptor signaling pathway
mleu04630  JAK-STAT signaling pathway
mleu04650  Natural killer cell mediated cytotoxicity
mleu04660  T cell receptor signaling pathway
mleu04662  B cell receptor signaling pathway
mleu04664  Fc epsilon RI signaling pathway
mleu04666  Fc gamma R-mediated phagocytosis
mleu04668  TNF signaling pathway
mleu04670  Leukocyte transendothelial migration
mleu04722  Neurotrophin signaling pathway
mleu04725  Cholinergic synapse
mleu04750  Inflammatory mediator regulation of TRP channels
mleu04810  Regulation of actin cytoskeleton
mleu04910  Insulin signaling pathway
mleu04914  Progesterone-mediated oocyte maturation
mleu04915  Estrogen signaling pathway
mleu04917  Prolactin signaling pathway
mleu04919  Thyroid hormone signaling pathway
mleu04923  Regulation of lipolysis in adipocytes
mleu04926  Relaxin signaling pathway
mleu04929  GnRH secretion
mleu04930  Type II diabetes mellitus
mleu04931  Insulin resistance
mleu04932  Non-alcoholic fatty liver disease
mleu04933  AGE-RAGE signaling pathway in diabetic complications
mleu04935  Growth hormone synthesis, secretion and action
mleu04960  Aldosterone-regulated sodium reabsorption
mleu04973  Carbohydrate digestion and absorption
mleu05010  Alzheimer disease
mleu05017  Spinocerebellar ataxia
mleu05020  Prion disease
mleu05100  Bacterial invasion of epithelial cells
mleu05132  Salmonella infection
mleu05135  Yersinia infection
mleu05142  Chagas disease
mleu05146  Amoebiasis
mleu05160  Hepatitis C
mleu05161  Hepatitis B
mleu05162  Measles
mleu05163  Human cytomegalovirus infection
mleu05164  Influenza A
mleu05165  Human papillomavirus infection
mleu05166  Human T-cell leukemia virus 1 infection
mleu05167  Kaposi sarcoma-associated herpesvirus infection
mleu05168  Herpes simplex virus 1 infection
mleu05169  Epstein-Barr virus infection
mleu05170  Human immunodeficiency virus 1 infection
mleu05171  Coronavirus disease - COVID-19
mleu05200  Pathways in cancer
mleu05203  Viral carcinogenesis
mleu05205  Proteoglycans in cancer
mleu05206  MicroRNAs in cancer
mleu05207  Chemical carcinogenesis - receptor activation
mleu05208  Chemical carcinogenesis - reactive oxygen species
mleu05210  Colorectal cancer
mleu05211  Renal cell carcinoma
mleu05212  Pancreatic cancer
mleu05213  Endometrial cancer
mleu05214  Glioma
mleu05215  Prostate cancer
mleu05218  Melanoma
mleu05220  Chronic myeloid leukemia
mleu05221  Acute myeloid leukemia
mleu05222  Small cell lung cancer
mleu05223  Non-small cell lung cancer
mleu05224  Breast cancer
mleu05225  Hepatocellular carcinoma
mleu05226  Gastric cancer
mleu05230  Central carbon metabolism in cancer
mleu05231  Choline metabolism in cancer
mleu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mleu05415  Diabetic cardiomyopathy
mleu05417  Lipid and atherosclerosis
mleu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mleu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105539923 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105539923 (PIK3CA)
   04014 Ras signaling pathway
    105539923 (PIK3CA)
   04015 Rap1 signaling pathway
    105539923 (PIK3CA)
   04370 VEGF signaling pathway
    105539923 (PIK3CA)
   04630 JAK-STAT signaling pathway
    105539923 (PIK3CA)
   04668 TNF signaling pathway
    105539923 (PIK3CA)
   04066 HIF-1 signaling pathway
    105539923 (PIK3CA)
   04068 FoxO signaling pathway
    105539923 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    105539923 (PIK3CA)
   04072 Phospholipase D signaling pathway
    105539923 (PIK3CA)
   04071 Sphingolipid signaling pathway
    105539923 (PIK3CA)
   04024 cAMP signaling pathway
    105539923 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    105539923 (PIK3CA)
   04152 AMPK signaling pathway
    105539923 (PIK3CA)
   04150 mTOR signaling pathway
    105539923 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105539923 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105539923 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    105539923 (PIK3CA)
   04218 Cellular senescence
    105539923 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105539923 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    105539923 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105539923 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105539923 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    105539923 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    105539923 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    105539923 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    105539923 (PIK3CA)
   04660 T cell receptor signaling pathway
    105539923 (PIK3CA)
   04662 B cell receptor signaling pathway
    105539923 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    105539923 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    105539923 (PIK3CA)
   04670 Leukocyte transendothelial migration
    105539923 (PIK3CA)
   04062 Chemokine signaling pathway
    105539923 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105539923 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    105539923 (PIK3CA)
   04929 GnRH secretion
    105539923 (PIK3CA)
   04915 Estrogen signaling pathway
    105539923 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    105539923 (PIK3CA)
   04917 Prolactin signaling pathway
    105539923 (PIK3CA)
   04926 Relaxin signaling pathway
    105539923 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    105539923 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    105539923 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105539923 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105539923 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    105539923 (PIK3CA)
   04722 Neurotrophin signaling pathway
    105539923 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105539923 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    105539923 (PIK3CA)
   04380 Osteoclast differentiation
    105539923 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    105539923 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    105539923 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105539923 (PIK3CA)
   05206 MicroRNAs in cancer
    105539923 (PIK3CA)
   05205 Proteoglycans in cancer
    105539923 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    105539923 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    105539923 (PIK3CA)
   05203 Viral carcinogenesis
    105539923 (PIK3CA)
   05230 Central carbon metabolism in cancer
    105539923 (PIK3CA)
   05231 Choline metabolism in cancer
    105539923 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105539923 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105539923 (PIK3CA)
   05212 Pancreatic cancer
    105539923 (PIK3CA)
   05225 Hepatocellular carcinoma
    105539923 (PIK3CA)
   05226 Gastric cancer
    105539923 (PIK3CA)
   05214 Glioma
    105539923 (PIK3CA)
   05221 Acute myeloid leukemia
    105539923 (PIK3CA)
   05220 Chronic myeloid leukemia
    105539923 (PIK3CA)
   05218 Melanoma
    105539923 (PIK3CA)
   05211 Renal cell carcinoma
    105539923 (PIK3CA)
   05215 Prostate cancer
    105539923 (PIK3CA)
   05213 Endometrial cancer
    105539923 (PIK3CA)
   05224 Breast cancer
    105539923 (PIK3CA)
   05222 Small cell lung cancer
    105539923 (PIK3CA)
   05223 Non-small cell lung cancer
    105539923 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105539923 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    105539923 (PIK3CA)
   05161 Hepatitis B
    105539923 (PIK3CA)
   05160 Hepatitis C
    105539923 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    105539923 (PIK3CA)
   05164 Influenza A
    105539923 (PIK3CA)
   05162 Measles
    105539923 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    105539923 (PIK3CA)
   05163 Human cytomegalovirus infection
    105539923 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105539923 (PIK3CA)
   05169 Epstein-Barr virus infection
    105539923 (PIK3CA)
   05165 Human papillomavirus infection
    105539923 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105539923 (PIK3CA)
   05135 Yersinia infection
    105539923 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    105539923 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105539923 (PIK3CA)
   05142 Chagas disease
    105539923 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105539923 (PIK3CA)
   05017 Spinocerebellar ataxia
    105539923 (PIK3CA)
   05020 Prion disease
    105539923 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105539923 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    105539923 (PIK3CA)
   05415 Diabetic cardiomyopathy
    105539923 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105539923 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    105539923 (PIK3CA)
   04931 Insulin resistance
    105539923 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105539923 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105539923 (PIK3CA)
   01524 Platinum drug resistance
    105539923 (PIK3CA)
   01522 Endocrine resistance
    105539923 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mleu04131]
    105539923 (PIK3CA)
Enzymes [BR:mleu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     105539923 (PIK3CA)
Membrane trafficking [BR:mleu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105539923 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 105539923
NCBI-ProteinID: XP_011835763
Ensembl: ENSMLEG00000034006
UniProt: A0A2K5YVM5
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcgccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacagctaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgaccttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagctattcccacgcaggactgagtaacaggctagctagagac
aatgagttaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagactggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaaaaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacactctacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatattgtgtcgctaccttcattctgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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