KEGG   Mandrillus leucophaeus (drill): 105541693
Entry
105541693         CDS       T08763                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mleu  Mandrillus leucophaeus (drill)
Pathway
mleu01521  EGFR tyrosine kinase inhibitor resistance
mleu01522  Endocrine resistance
mleu04010  MAPK signaling pathway
mleu04012  ErbB signaling pathway
mleu04068  FoxO signaling pathway
mleu04270  Vascular smooth muscle contraction
mleu04650  Natural killer cell mediated cytotoxicity
mleu04720  Long-term potentiation
mleu04726  Serotonergic synapse
mleu04730  Long-term depression
mleu04810  Regulation of actin cytoskeleton
mleu04910  Insulin signaling pathway
mleu04914  Progesterone-mediated oocyte maturation
mleu04928  Parathyroid hormone synthesis, secretion and action
mleu05010  Alzheimer disease
mleu05022  Pathways of neurodegeneration - multiple diseases
mleu05034  Alcoholism
mleu05160  Hepatitis C
mleu05161  Hepatitis B
mleu05200  Pathways in cancer
mleu05205  Proteoglycans in cancer
mleu05208  Chemical carcinogenesis - reactive oxygen species
mleu05210  Colorectal cancer
mleu05211  Renal cell carcinoma
mleu05212  Pancreatic cancer
mleu05213  Endometrial cancer
mleu05214  Glioma
mleu05215  Prostate cancer
mleu05218  Melanoma
mleu05219  Bladder cancer
mleu05220  Chronic myeloid leukemia
mleu05221  Acute myeloid leukemia
mleu05223  Non-small cell lung cancer
mleu05224  Breast cancer
mleu05225  Hepatocellular carcinoma
mleu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mleu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105541693 (ARAF)
   04012 ErbB signaling pathway
    105541693 (ARAF)
   04068 FoxO signaling pathway
    105541693 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105541693 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    105541693 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105541693 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    105541693 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    105541693 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105541693 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    105541693 (ARAF)
   04720 Long-term potentiation
    105541693 (ARAF)
   04730 Long-term depression
    105541693 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105541693 (ARAF)
   05205 Proteoglycans in cancer
    105541693 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    105541693 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105541693 (ARAF)
   05212 Pancreatic cancer
    105541693 (ARAF)
   05225 Hepatocellular carcinoma
    105541693 (ARAF)
   05226 Gastric cancer
    105541693 (ARAF)
   05214 Glioma
    105541693 (ARAF)
   05221 Acute myeloid leukemia
    105541693 (ARAF)
   05220 Chronic myeloid leukemia
    105541693 (ARAF)
   05218 Melanoma
    105541693 (ARAF)
   05211 Renal cell carcinoma
    105541693 (ARAF)
   05219 Bladder cancer
    105541693 (ARAF)
   05215 Prostate cancer
    105541693 (ARAF)
   05213 Endometrial cancer
    105541693 (ARAF)
   05224 Breast cancer
    105541693 (ARAF)
   05223 Non-small cell lung cancer
    105541693 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    105541693 (ARAF)
   05160 Hepatitis C
    105541693 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105541693 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    105541693 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    105541693 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105541693 (ARAF)
   01522 Endocrine resistance
    105541693 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mleu01001]
    105541693 (ARAF)
Enzymes [BR:mleu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105541693 (ARAF)
Protein kinases [BR:mleu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   105541693 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like TUG-UBL1
Other DBs
NCBI-GeneID: 105541693
NCBI-ProteinID: XP_011838240
Ensembl: ENSMLEG00000037066
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPRPHTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGGDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNSIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacagtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccaggccccacactcagcactgtgacccggagcacttccccttccct
gccccggccaacgcccccctgcagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtggtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgtgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaagtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaagctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccaggattcgccatc
atcacacagtggtgtgaaggctccagcctctaccatcacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacagtatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctatgcctacggggttgtgctctac
gagctcatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctctagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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