Mandrillus leucophaeus (drill): 105543512 Help Entry 105543512         CDS       T08763                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism mleu  Mandrillus leucophaeus (drill) Pathway mleu01521   EGFR tyrosine kinase inhibitor resistance mleu04151   PI3K-Akt signaling pathway mleu04217   Necroptosis mleu04380   Osteoclast differentiation mleu04550   Signaling pathways regulating pluripotency of stem cells mleu04620   Toll-like receptor signaling pathway mleu04621   NOD-like receptor signaling pathway mleu04630   JAK-STAT signaling pathway mleu04658   Th1 and Th2 cell differentiation mleu04659   Th17 cell differentiation mleu05140   Leishmaniasis mleu05145   Toxoplasmosis mleu05152   Tuberculosis mleu05160   Hepatitis C mleu05161   Hepatitis B mleu05162   Measles mleu05163   Human cytomegalovirus infection mleu05164   Influenza A mleu05165   Human papillomavirus infection mleu05166   Human T-cell leukemia virus 1 infection mleu05167   Kaposi sarcoma-associated herpesvirus infection mleu05168   Herpes simplex virus 1 infection mleu05169   Epstein-Barr virus infection mleu05171   Coronavirus disease - COVID-19 mleu05200   Pathways in cancer mleu05203   Viral carcinogenesis mleu05212   Pancreatic cancer mleu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mleu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     105543512 (JAK1)    04151 PI3K-Akt signaling pathway     105543512 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     105543512 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     105543512 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     105543512 (JAK1)    04621 NOD-like receptor signaling pathway     105543512 (JAK1)    04658 Th1 and Th2 cell differentiation     105543512 (JAK1)    04659 Th17 cell differentiation     105543512 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     105543512 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105543512 (JAK1)    05203 Viral carcinogenesis     105543512 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105543512 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     105543512 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     105543512 (JAK1)    05161 Hepatitis B     105543512 (JAK1)    05160 Hepatitis C     105543512 (JAK1)    05171 Coronavirus disease - COVID-19     105543512 (JAK1)    05164 Influenza A     105543512 (JAK1)    05162 Measles     105543512 (JAK1)    05168 Herpes simplex virus 1 infection     105543512 (JAK1)    05163 Human cytomegalovirus infection     105543512 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     105543512 (JAK1)    05169 Epstein-Barr virus infection     105543512 (JAK1)    05165 Human papillomavirus infection     105543512 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     105543512 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     105543512 (JAK1)    05140 Leishmaniasis     105543512 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105543512 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mleu01001]     105543512 (JAK1) Enzymes [BR:mleu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      105543512 (JAK1) Protein kinases [BR:mleu01001]  Non-receptor tyrosine kinases   JAK family [OT]    105543512 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  105543512 NCBI-ProteinID:  XP_011840865 Ensembl:  ENSMLEG00000038239 UniProt:  A0A2K5ZKJ8 LinkDB All DBs Position Unknown AA seq 1154 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEVPEPGVEVIFYMSDREPLRLGSGEYTAEEL CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHSNDSGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEQGQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRIFKKDLVQGEHLGRGTRTHIYSG TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT SFQNLIEGFEALLK NT seq 3465 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagactgaggtgaacctggaggtccctgagccaggggtggaagtgatcttc tatatgtcggacagggagcccctccggctgggcagtggagagtatacagcagaggaactg tgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg tatgatgagaacaccaagctctggtatgctccaaatcgcaccatcaccgttgatgacaag atgtccctccgactccactaccggatgaggttctatttcaccaattggcacggaaccaac gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct cagggacagtatgatttggtgaaatgcctggctcccattcgagaccccaagaccgagcag gatgggcatgatattgaaaacgagtgtctggggatggctgtcctggccatctcacactat gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctaaaggaatttaataacaagaccatttgtgacagcagc gtgtccacgcatgacctgaaggtgaaatacttggctaccttggaaactttgacaaaacat tatggcgctgaaatatttgagacttccatgttgctgatttcatcagaaaatgagatgaat tggtttcattcgaatgacagtggaaacgttctgtactatgaagtgatggtgactgggaat cttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaaaataaa ctgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctctcttcccatgag gaggccttgtcctttgtgtcactggtagatggctacttccggctcaccgcagacgcccat cattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgt catggtccaatctgtacagaatacgccatcaataaattgcggcaagaaggaagcgaggag gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgactgtcacc tgctttgagaagtctgagcaggggcagggtgcccagaagcagttcaagaactttcagatc gaggtgcagaagggccgctacagcctgcatggttcggaccgcagcttccccagcttggga gacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttcatgttg aaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaa gcccaggagtggcagcccgtctaccccatgagccagctgagttttgatcggatcttcaag aaggatctggtgcagggcgagcaccttgggagaggcacgagaacacacatctactctggg accctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatc ctcaaagtcttagaccccagccacagggatatttccctggccttcttcgaggcagccagc atgatgagacaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgcgac gtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcac cggaaaagcgatgtccttactacaccctggaaattcaaagttgccaaacagctggccagt gccctgagctacttggaagataaagacctggtccatggaaatgtgtgtactaaaaacctc ctcctggcccgtgagggcatcgacagcgagtgtggtccgttcatcaagctcagtgaccct ggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccgtggattgct cccgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagctttgga actacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacactgatt gagaaagagagattctatgaaagccggtgcaggccagtgacaccatcatgtaaggagctg gctgacctcatgacccgctgcatgaactacgaccccaatcagaggcccttcttccgagcc atcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaag ccagcaaccgaagtggaccccacgcattttgagaagcgcttcctaaagaggatccgtgac ttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaat acaggggagcaggtggctgtcaaatctctgaagcctgagagtggaggtaaccacatagct gatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtgaagtac aaaggaatctgcacggaagacggaggaaatggtattaagctcatcatggaatttctgcct tcgggaagccttaaggagtatcttccaaagaataagaacaaaattaacctcaaacagcag ctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatatgtt caccgtgacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattgga gacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgac cgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatatc gcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgattca gattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgaca gtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccgcctaactgt ccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggaca agctttcagaaccttattgaaggatttgaagcacttttaaaataa

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