Mandrillus leucophaeus (drill): 105548239 Help Entry 105548239         CDS       T08763                                  Symbol PRKCA Name (RefSeq) protein kinase C alpha type   KO K02677   classical protein kinase C alpha type [EC:2.7.11.13] Organism mleu  Mandrillus leucophaeus (drill) Pathway mleu01521   EGFR tyrosine kinase inhibitor resistance mleu04010   MAPK signaling pathway mleu04012   ErbB signaling pathway mleu04014   Ras signaling pathway mleu04015   Rap1 signaling pathway mleu04020   Calcium signaling pathway mleu04066   HIF-1 signaling pathway mleu04070   Phosphatidylinositol signaling system mleu04071   Sphingolipid signaling pathway mleu04072   Phospholipase D signaling pathway mleu04082   Neuroactive ligand signaling mleu04150   mTOR signaling pathway mleu04151   PI3K-Akt signaling pathway mleu04261   Adrenergic signaling in cardiomyocytes mleu04270   Vascular smooth muscle contraction mleu04310   Wnt signaling pathway mleu04360   Axon guidance mleu04370   VEGF signaling pathway mleu04510   Focal adhesion mleu04540   Gap junction mleu04613   Neutrophil extracellular trap formation mleu04650   Natural killer cell mediated cytotoxicity mleu04664   Fc epsilon RI signaling pathway mleu04666   Fc gamma R-mediated phagocytosis mleu04670   Leukocyte transendothelial migration mleu04713   Circadian entrainment mleu04720   Long-term potentiation mleu04723   Retrograde endocannabinoid signaling mleu04724   Glutamatergic synapse mleu04725   Cholinergic synapse mleu04726   Serotonergic synapse mleu04727   GABAergic synapse mleu04728   Dopaminergic synapse mleu04730   Long-term depression mleu04750   Inflammatory mediator regulation of TRP channels mleu04911   Insulin secretion mleu04912   GnRH signaling pathway mleu04916   Melanogenesis mleu04918   Thyroid hormone synthesis mleu04919   Thyroid hormone signaling pathway mleu04921   Oxytocin signaling pathway mleu04925   Aldosterone synthesis and secretion mleu04926   Relaxin signaling pathway mleu04928   Parathyroid hormone synthesis, secretion and action mleu04929   GnRH secretion mleu04933   AGE-RAGE signaling pathway in diabetic complications mleu04935   Growth hormone synthesis, secretion and action mleu04960   Aldosterone-regulated sodium reabsorption mleu04961   Endocrine and other factor-regulated calcium reabsorption mleu04970   Salivary secretion mleu04971   Gastric acid secretion mleu04972   Pancreatic secretion mleu05017   Spinocerebellar ataxia mleu05022   Pathways of neurodegeneration - multiple diseases mleu05031   Amphetamine addiction mleu05032   Morphine addiction mleu05143   African trypanosomiasis mleu05146   Amoebiasis mleu05161   Hepatitis B mleu05163   Human cytomegalovirus infection mleu05164   Influenza A mleu05170   Human immunodeficiency virus 1 infection mleu05171   Coronavirus disease - COVID-19 mleu05200   Pathways in cancer mleu05205   Proteoglycans in cancer mleu05206   MicroRNAs in cancer mleu05207   Chemical carcinogenesis - receptor activation mleu05214   Glioma mleu05223   Non-small cell lung cancer mleu05225   Hepatocellular carcinoma mleu05231   Choline metabolism in cancer mleu05415   Diabetic cardiomyopathy mleu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mleu00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     105548239 (PRKCA)    04012 ErbB signaling pathway     105548239 (PRKCA)    04014 Ras signaling pathway     105548239 (PRKCA)    04015 Rap1 signaling pathway     105548239 (PRKCA)    04310 Wnt signaling pathway     105548239 (PRKCA)    04370 VEGF signaling pathway     105548239 (PRKCA)    04066 HIF-1 signaling pathway     105548239 (PRKCA)    04020 Calcium signaling pathway     105548239 (PRKCA)    04070 Phosphatidylinositol signaling system     105548239 (PRKCA)    04072 Phospholipase D signaling pathway     105548239 (PRKCA)    04071 Sphingolipid signaling pathway     105548239 (PRKCA)    04151 PI3K-Akt signaling pathway     105548239 (PRKCA)    04150 mTOR signaling pathway     105548239 (PRKCA)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     105548239 (PRKCA)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     105548239 (PRKCA)    04540 Gap junction     105548239 (PRKCA)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     105548239 (PRKCA)    04650 Natural killer cell mediated cytotoxicity     105548239 (PRKCA)    04664 Fc epsilon RI signaling pathway     105548239 (PRKCA)    04666 Fc gamma R-mediated phagocytosis     105548239 (PRKCA)    04670 Leukocyte transendothelial migration     105548239 (PRKCA)   09152 Endocrine system    04911 Insulin secretion     105548239 (PRKCA)    04929 GnRH secretion     105548239 (PRKCA)    04912 GnRH signaling pathway     105548239 (PRKCA)    04921 Oxytocin signaling pathway     105548239 (PRKCA)    04926 Relaxin signaling pathway     105548239 (PRKCA)    04935 Growth hormone synthesis, secretion and action     105548239 (PRKCA)    04918 Thyroid hormone synthesis     105548239 (PRKCA)    04919 Thyroid hormone signaling pathway     105548239 (PRKCA)    04928 Parathyroid hormone synthesis, secretion and action     105548239 (PRKCA)    04916 Melanogenesis     105548239 (PRKCA)    04925 Aldosterone synthesis and secretion     105548239 (PRKCA)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     105548239 (PRKCA)    04270 Vascular smooth muscle contraction     105548239 (PRKCA)   09154 Digestive system    04970 Salivary secretion     105548239 (PRKCA)    04971 Gastric acid secretion     105548239 (PRKCA)    04972 Pancreatic secretion     105548239 (PRKCA)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     105548239 (PRKCA)    04961 Endocrine and other factor-regulated calcium reabsorption     105548239 (PRKCA)   09156 Nervous system    04724 Glutamatergic synapse     105548239 (PRKCA)    04727 GABAergic synapse     105548239 (PRKCA)    04725 Cholinergic synapse     105548239 (PRKCA)    04728 Dopaminergic synapse     105548239 (PRKCA)    04726 Serotonergic synapse     105548239 (PRKCA)    04720 Long-term potentiation     105548239 (PRKCA)    04730 Long-term depression     105548239 (PRKCA)    04723 Retrograde endocannabinoid signaling     105548239 (PRKCA)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     105548239 (PRKCA)   09158 Development and regeneration    04360 Axon guidance     105548239 (PRKCA)   09159 Environmental adaptation    04713 Circadian entrainment     105548239 (PRKCA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105548239 (PRKCA)    05206 MicroRNAs in cancer     105548239 (PRKCA)    05205 Proteoglycans in cancer     105548239 (PRKCA)    05207 Chemical carcinogenesis - receptor activation     105548239 (PRKCA)    05231 Choline metabolism in cancer     105548239 (PRKCA)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     105548239 (PRKCA)    05214 Glioma     105548239 (PRKCA)    05223 Non-small cell lung cancer     105548239 (PRKCA)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     105548239 (PRKCA)    05161 Hepatitis B     105548239 (PRKCA)    05171 Coronavirus disease - COVID-19     105548239 (PRKCA)    05164 Influenza A     105548239 (PRKCA)    05163 Human cytomegalovirus infection     105548239 (PRKCA)   09174 Infectious disease: parasitic    05146 Amoebiasis     105548239 (PRKCA)    05143 African trypanosomiasis     105548239 (PRKCA)   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     105548239 (PRKCA)    05022 Pathways of neurodegeneration - multiple diseases     105548239 (PRKCA)   09165 Substance dependence    05031 Amphetamine addiction     105548239 (PRKCA)    05032 Morphine addiction     105548239 (PRKCA)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     105548239 (PRKCA)    05415 Diabetic cardiomyopathy     105548239 (PRKCA)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     105548239 (PRKCA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105548239 (PRKCA)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mleu01001]     105548239 (PRKCA)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mleu04131]     105548239 (PRKCA) Enzymes [BR:mleu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      105548239 (PRKCA) Protein kinases [BR:mleu01001]  Serine/threonine kinases: AGC group   PKC family [OT]    105548239 (PRKCA) Membrane trafficking [BR:mleu04131]  Endocytosis   Lipid raft mediated endocytosis    Caveolin-mediated endocytosis     105548239 (PRKCA) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C2 C1_1 Pkinase_C ABC1 Kinase-like Motif Other DBs NCBI-GeneID:  105548239 NCBI-ProteinID:  XP_011847540 Ensembl:  ENSMLEG00000034685 LinkDB All DBs Position Unknown AA seq 607 aa AA seqDB search MVQICCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGL IHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIP MDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIW DWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKF EKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELY AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC KEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDE LFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHGFFRRIDWEKL ENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVH PILQSAV NT seq 1824 nt NT seq  +upstreamnt  +downstreamnt atggtgcaaatttgctgttttgtggtccacaagaggtgccatgaatttgttactttttct tgtccgggtgcggataagggacccgacactgatgaccccaggagcaagcacaagttcaaa atccacacttacggaagccccaccttctgcgatcactgtgggtccctgctgtatggactt atccaccaagggatgaaatgtgacacctgcgatatgaacgttcacaagcaatgcgtcatc aatgtccccagcctctgcggaatggatcacacagagaagagagggcggatttacctaaag gctgaggttgctgatgaaaagctccatgtcacagtacgagatgcaaaaaatctaatccct atggatccaaacgggctttcagatccttatgtgaagctgaaacttattcctgatcccaag aatgaaagcaaacaaaaaaccaaaaccatccgctccacactaaatccccagtggaatgag tcctttacattcaaattgaaaccttcagacaaagaccgacgactgtctgtagaaatctgg gactgggatcgaacaacaaggaatgacttcatgggatccctttcctttggggtttcggag ctaatgaagatgccagccagtggatggtacaagttgcttaaccaagaagaaggtgagtac tacaatgtacccattccagaaggggacgaagaaggaaacatggaactcaggcagaaattc gagaaagccaagcttggccctgctggcaacaaagtcatcagtccctctgaagacaggaaa caaccttccaacaacctggaccgagtgaaactcaccgacttcaatttcctcatggtgctg gggaaggggagttttggaaaggtgatgcttgccgacaggaagggcacagaagaactgtat gcaatcaaaatcctgaagaaggatgtggtgattcaggatgacgacgtggagtgcaccatg gtagaaaaacgagtcttggccctgcttgacaaacccccgttcttgacgcagctgcactcc tgcttccagacagtggatcggctgtacttcgtcatggaatatgtcaacggtggggacctc atgtaccacattcagcaagtaggaaaatttaaggaaccacaagcagtattctatgcggca gagatttccatcggattgttctttcttcataaaagaggaatcatttatagggatctgaag ttagataacgtcatgttggattcagaaggacatatcaaaattgctgactttgggatgtgc aaggaacacatgatggatggagtcacgaccaggaccttctgtgggactccagattacatc gccccagagattatcgcttatcagccatatggaaaatctgtggactggtgggcctatggc gtcctgttgtatgaaatgcttgccgggcagcctccatttgatggtgaagatgaggacgag ctatttcagtctatcatggagcacaacgtttcctatccaaaatccttgtccaaggaggct gtttccatctgcaaaggactgatgaccaaacacccagccaagcggctgggctgcgggcct gagggggagagggacgtgagagaacatggtttcttccggaggatcgactgggaaaaactg gagaacagggagatccagccaccgttcaagcccaaagtgtgcggcaaaggagcagaaaac tttgacaagttcttcacacgagggcagcccgtcttaacaccgcctgatcagctggttatt gctaacatagaccagtctgattttgaagggttctcgtatgtcaacccccagtttgtgcac cccatcttacagagtgcagtatga

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